Seismic cluster nodes can be monitored by monitoring system,but thresholds for link failure alarm in monitoring systems are not determined presently,especially in different types of cluster links.Communication link ty...Seismic cluster nodes can be monitored by monitoring system,but thresholds for link failure alarm in monitoring systems are not determined presently,especially in different types of cluster links.Communication link types are discussed in seismic profession.By analyzing the characteristics of various links,the main performance metric,network latency,was proposed,which influenced states of communication links and gave the monitoring results deviation formula for judging the cluster monitoring system at different delay thresholds settings based on multiple-link delay error ratio analysis algorithm we offered.From the final experimental data of the monitoring system,fault alarm thresholds settings were posed under five different communication links,which had the instruction significance to the cluster monitoring in seismic profession.展开更多
Cross-linking of silyl-modified polymers occurs at the alkoxysilane groups attached to the ends of polymer chains by hydrolysis and polycondensation mechanisms in the presence of moisture. During these reactions, thre...Cross-linking of silyl-modified polymers occurs at the alkoxysilane groups attached to the ends of polymer chains by hydrolysis and polycondensation mechanisms in the presence of moisture. During these reactions, three different physical states can be identified (viscous, skin effect and cross-linked state). Knowledge of the evolution of these states at each reaction time is essential to determine the open time for the adhe-sive industry and is generally obtained by a manual method. Automation of this moni-toring could avoid operator error and could be used for very long cross linking reac-tions or to screen a large number of catalysts. Thus, a contactless micro process tech-nology was developed to correlate these physical states with an optical technology, Raman spectroscopy, by monitoring the decrease in intensity of the Si-OCH<sub>3</sub> groups during chemical reactions. This online characterization method can also be used to compare the efficiencies of several catalysts for the cross-linking of silyl-modified polymers, using a minimum amount of chemical materials.展开更多
Afatinib is an oral tyrosine kinase inhibitor(TKI) approved for treating advanced non-small cell lung cancer. It is necessary to develop a simple quantification method for TKIs in order to facilitate therapeutic drug ...Afatinib is an oral tyrosine kinase inhibitor(TKI) approved for treating advanced non-small cell lung cancer. It is necessary to develop a simple quantification method for TKIs in order to facilitate therapeutic drug monitoring(TDM) in clinical settings. This study sought to develop a simple and sensitive competitive enzyme-linked immunosorbent assay(ELISA) to quantify afatinib in plasma for routine pharmacokinetic applications. An anti-afatinib antibody was obtained using(S)-N-4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)-quinazoline-4,6-diamine(CTQD), which has the same substructure as afatinib, as a hapten. Enzyme labeling of afatinib with horseradish peroxidase was similarly performed using CTQD. A simple competitive ELISA for afatinib was developed based on the principle of direct competition between afatinib and the enzyme marker for the anti-afatinib antibody, which had been immobilized on the plastic surface of a microtiter plate. Plasma afatinib concentrations below the limit of quantification of 30 pg/mL were reproducibly measurable. Also, the values of plasma afatinib levels measured from 20 patients were comparable with those measured by high-performance liquid chromatography, and there was a strong correlation between the values determined by both methods(Y=0.976 X – 0.207, r=0.975). As indicated by its specificity and sensitivity, this newly developed ELISA for afatinib is an important tool for TDM and studies of the pharmacokinetics of afatinib.展开更多
Controller Link 是 OMRON 推出的一种 FA 网络,能在 PLC、计算机等节点间方便、灵活地发送和接收大容量数据包,且实时性、可靠性较高。本文对 Controller Link 的组网技术进行深入研究,详细介绍了该网络的性能、硬件配置、网络组态、...Controller Link 是 OMRON 推出的一种 FA 网络,能在 PLC、计算机等节点间方便、灵活地发送和接收大容量数据包,且实时性、可靠性较高。本文对 Controller Link 的组网技术进行深入研究,详细介绍了该网络的性能、硬件配置、网络组态、通讯链接和网络监控设计技术。展开更多
基金National Natural Science Fundations of China(Nos.71171045 and 61301118)Shanghai Science and Technology Committee Program,China(No.15dz1207600)China Scholarship Council(No.201504190015)
文摘Seismic cluster nodes can be monitored by monitoring system,but thresholds for link failure alarm in monitoring systems are not determined presently,especially in different types of cluster links.Communication link types are discussed in seismic profession.By analyzing the characteristics of various links,the main performance metric,network latency,was proposed,which influenced states of communication links and gave the monitoring results deviation formula for judging the cluster monitoring system at different delay thresholds settings based on multiple-link delay error ratio analysis algorithm we offered.From the final experimental data of the monitoring system,fault alarm thresholds settings were posed under five different communication links,which had the instruction significance to the cluster monitoring in seismic profession.
文摘Cross-linking of silyl-modified polymers occurs at the alkoxysilane groups attached to the ends of polymer chains by hydrolysis and polycondensation mechanisms in the presence of moisture. During these reactions, three different physical states can be identified (viscous, skin effect and cross-linked state). Knowledge of the evolution of these states at each reaction time is essential to determine the open time for the adhe-sive industry and is generally obtained by a manual method. Automation of this moni-toring could avoid operator error and could be used for very long cross linking reac-tions or to screen a large number of catalysts. Thus, a contactless micro process tech-nology was developed to correlate these physical states with an optical technology, Raman spectroscopy, by monitoring the decrease in intensity of the Si-OCH<sub>3</sub> groups during chemical reactions. This online characterization method can also be used to compare the efficiencies of several catalysts for the cross-linking of silyl-modified polymers, using a minimum amount of chemical materials.
文摘Afatinib is an oral tyrosine kinase inhibitor(TKI) approved for treating advanced non-small cell lung cancer. It is necessary to develop a simple quantification method for TKIs in order to facilitate therapeutic drug monitoring(TDM) in clinical settings. This study sought to develop a simple and sensitive competitive enzyme-linked immunosorbent assay(ELISA) to quantify afatinib in plasma for routine pharmacokinetic applications. An anti-afatinib antibody was obtained using(S)-N-4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)-quinazoline-4,6-diamine(CTQD), which has the same substructure as afatinib, as a hapten. Enzyme labeling of afatinib with horseradish peroxidase was similarly performed using CTQD. A simple competitive ELISA for afatinib was developed based on the principle of direct competition between afatinib and the enzyme marker for the anti-afatinib antibody, which had been immobilized on the plastic surface of a microtiter plate. Plasma afatinib concentrations below the limit of quantification of 30 pg/mL were reproducibly measurable. Also, the values of plasma afatinib levels measured from 20 patients were comparable with those measured by high-performance liquid chromatography, and there was a strong correlation between the values determined by both methods(Y=0.976 X – 0.207, r=0.975). As indicated by its specificity and sensitivity, this newly developed ELISA for afatinib is an important tool for TDM and studies of the pharmacokinetics of afatinib.
