While their clinical presentation is similar, post-viral rhinosinusitis does not indicate the possible development of bacterial rhinosinusitis which occurs in only 0.5% to 5% of all cases of ARS. However, unreasonable...While their clinical presentation is similar, post-viral rhinosinusitis does not indicate the possible development of bacterial rhinosinusitis which occurs in only 0.5% to 5% of all cases of ARS. However, unreasonable antibacterial therapy is prescribed in 54% to 77% of cases. The perspective is to use delayed antibacterial therapy management. The purpose of the study was to investigate the efficacy of mometasone furoate nasal spray within the delayed prescription approach. Methods: A multicenter, randomized, open-label, comparative, prospective, parallel group study enrolled a total of 156 patients with ARS aged 18 to 60 years, of them 155 patients completed the study. The patients were randomized into the main group of Mometasone Furoate (Flix) Nasal Spray or into the control group of amoxicillin clavulanate tablets while both groups were administered a standard ARS therapy. Findings: The use of MF nasal spray within the delayed antibiotics prescription approach has a significantly higher efficacy compared to the immediate antibiotics prescription in the first days of treatment (p < 0.05). Antibacterial therapy was prescribed to 42.3% of patients in the main group compared to 100.0% of patients in the control group (p < 0.05). It was shown that there were statistically significant differences in the dynamics of changes in the total symptom score between the patients administered antibiotics and the antibiotic-naive patients. Conclusion: The use of MF within the delayed antibiotics prescription approach reliably improves the pattern of symptoms over time at the disease onset and significantly reduces the need for NSAIDs administration and antibiotics prescription frequency.展开更多
Objective: to treat secretory otitis media with mometasone acetate nasal spray and observe its effect. Methods: 106 children with secretory otitis media treated in our hospital were observed. The period was from June ...Objective: to treat secretory otitis media with mometasone acetate nasal spray and observe its effect. Methods: 106 children with secretory otitis media treated in our hospital were observed. The period was from June 2019 to June 2021. The patients were randomly divided into nasal hormone group and traditional treatment group according to the admission number of children with secretory otitis media. The treatment methods were mometasone acetate nasal spray treatment and ephedrine treatment respectively. The recurrence rate, effective rate and inflammatory factors after treatment were compared between the two groups. Results: (1) compared the recurrence rate and effective rate between nasal hormone group and traditional treatment group, the nasal hormone group was 3.77% and 94.33%, while the traditional treatment group was 15.09% and 77.35% (x211.999,p0.020). The results were different. (2) After treatment, TNF-a and IL-6 in nasal hormone group were 1.87±0.21 (ng.l-1), 26.15±3.29(ng.L-1), 3.26±0.36 (ng.l-1) and 35.64±4.32(ng.L-1) in traditional treatment group, respectively. The results were different. Conclusion: the therapeutic effect of mometasone acetate nasal spray for secretory otitis media in children is excellent and can be popularized.展开更多
文摘While their clinical presentation is similar, post-viral rhinosinusitis does not indicate the possible development of bacterial rhinosinusitis which occurs in only 0.5% to 5% of all cases of ARS. However, unreasonable antibacterial therapy is prescribed in 54% to 77% of cases. The perspective is to use delayed antibacterial therapy management. The purpose of the study was to investigate the efficacy of mometasone furoate nasal spray within the delayed prescription approach. Methods: A multicenter, randomized, open-label, comparative, prospective, parallel group study enrolled a total of 156 patients with ARS aged 18 to 60 years, of them 155 patients completed the study. The patients were randomized into the main group of Mometasone Furoate (Flix) Nasal Spray or into the control group of amoxicillin clavulanate tablets while both groups were administered a standard ARS therapy. Findings: The use of MF nasal spray within the delayed antibiotics prescription approach has a significantly higher efficacy compared to the immediate antibiotics prescription in the first days of treatment (p < 0.05). Antibacterial therapy was prescribed to 42.3% of patients in the main group compared to 100.0% of patients in the control group (p < 0.05). It was shown that there were statistically significant differences in the dynamics of changes in the total symptom score between the patients administered antibiotics and the antibiotic-naive patients. Conclusion: The use of MF within the delayed antibiotics prescription approach reliably improves the pattern of symptoms over time at the disease onset and significantly reduces the need for NSAIDs administration and antibiotics prescription frequency.
文摘Objective: to treat secretory otitis media with mometasone acetate nasal spray and observe its effect. Methods: 106 children with secretory otitis media treated in our hospital were observed. The period was from June 2019 to June 2021. The patients were randomly divided into nasal hormone group and traditional treatment group according to the admission number of children with secretory otitis media. The treatment methods were mometasone acetate nasal spray treatment and ephedrine treatment respectively. The recurrence rate, effective rate and inflammatory factors after treatment were compared between the two groups. Results: (1) compared the recurrence rate and effective rate between nasal hormone group and traditional treatment group, the nasal hormone group was 3.77% and 94.33%, while the traditional treatment group was 15.09% and 77.35% (x211.999,p0.020). The results were different. (2) After treatment, TNF-a and IL-6 in nasal hormone group were 1.87±0.21 (ng.l-1), 26.15±3.29(ng.L-1), 3.26±0.36 (ng.l-1) and 35.64±4.32(ng.L-1) in traditional treatment group, respectively. The results were different. Conclusion: the therapeutic effect of mometasone acetate nasal spray for secretory otitis media in children is excellent and can be popularized.
