The molar absorption coefficients of each of 14 kinds of amino acids were determined by the spectrophotometric method, and the mean molar absorption coefficients of 37 different mixtures of each with amino acid compos...The molar absorption coefficients of each of 14 kinds of amino acids were determined by the spectrophotometric method, and the mean molar absorption coefficients of 37 different mixtures of each with amino acid composition exactly equivalent to that of the peptide chain of the corresponding lipopeptide were determined based on calculation or experimental. The significance of the results is that the mean molar absorption coefficients strongly demonstrate the regular patterns, though different amino acids bear quite different molar absorption coefficients.展开更多
Aggregation-induced emission(AIE)molecules have attracted widespread attention due to their remarkable fluorescence properties in the aggregated state.However,the highly twisted structures of AIE molecules significant...Aggregation-induced emission(AIE)molecules have attracted widespread attention due to their remarkable fluorescence properties in the aggregated state.However,the highly twisted structures of AIE molecules significantly disrupt theπ-conjugations,thus resulting in weak absorption abilities(i.e.,small molar absorption coefficientsε).To overcome this problem,herein we have proposed an efficient molecular design strategy:π-bridged dimer of AIE molecules.Accordingly,two series of AIE dimer molecules,TPE-BTO-Dimer 1-6 and DTPE-BTO-Dimer 1-6 with variousπ-bridged moieties,have been newly synthesized.In comparison to the corresponding AIE monomer molecules TPE-BTO and DTPE-BTO,the dimer molecules retain the AIE character while exhibit largely improved absorption abilities(theεvalues are increased by 2.3-3.7 times to 6.01-9.54×10^(4) M^(-1) cm^(-1))as well as significantly redshifted absorption maxima.The theoretical calculations have revealed that theπ-bridged dimer strategy dramatically increases the oscillator strength of electron transition from the ground state to an excited state and thus results in a largeε.In the transient absorption studies,the local excited state components of dimer molecules are obviously higher than those ofmonomer molecules,which further confirms the effectiveness ofπ-bridged dimer strategy.Moreover,one of the AIE dimer molecules DTPE-BTO-Dimer 6 with near-infrared(NIR)emission has been applied in NIR fluorescence imaging-guided photothermal therapy.The very strong absorption ability has enabled its nanoparticles to exhibit a high photothermal conversion efficiency of 73%under the 655 nm laser irradiation and thus display a desired photothermal therapy performance.展开更多
基金This work was supported by the National Natural Science Foundation of China(No.50374038,50574040)Specialized Research Fund for the Doctoral Program of Higher Education(20030251002)+1 种基金Key Project of the Ministry of Education(03071)by the Department of Science and Technology Shanghai(045407017).
文摘The molar absorption coefficients of each of 14 kinds of amino acids were determined by the spectrophotometric method, and the mean molar absorption coefficients of 37 different mixtures of each with amino acid composition exactly equivalent to that of the peptide chain of the corresponding lipopeptide were determined based on calculation or experimental. The significance of the results is that the mean molar absorption coefficients strongly demonstrate the regular patterns, though different amino acids bear quite different molar absorption coefficients.
基金supported by the National Key R&D Program of China(No.2023YFB3208301)the National Natural Science Foundation of China(Nos.62475098,61975200)Jilin Province Science and Technology Research Project(No.YDZJ202501ZYTS292).
文摘Aggregation-induced emission(AIE)molecules have attracted widespread attention due to their remarkable fluorescence properties in the aggregated state.However,the highly twisted structures of AIE molecules significantly disrupt theπ-conjugations,thus resulting in weak absorption abilities(i.e.,small molar absorption coefficientsε).To overcome this problem,herein we have proposed an efficient molecular design strategy:π-bridged dimer of AIE molecules.Accordingly,two series of AIE dimer molecules,TPE-BTO-Dimer 1-6 and DTPE-BTO-Dimer 1-6 with variousπ-bridged moieties,have been newly synthesized.In comparison to the corresponding AIE monomer molecules TPE-BTO and DTPE-BTO,the dimer molecules retain the AIE character while exhibit largely improved absorption abilities(theεvalues are increased by 2.3-3.7 times to 6.01-9.54×10^(4) M^(-1) cm^(-1))as well as significantly redshifted absorption maxima.The theoretical calculations have revealed that theπ-bridged dimer strategy dramatically increases the oscillator strength of electron transition from the ground state to an excited state and thus results in a largeε.In the transient absorption studies,the local excited state components of dimer molecules are obviously higher than those ofmonomer molecules,which further confirms the effectiveness ofπ-bridged dimer strategy.Moreover,one of the AIE dimer molecules DTPE-BTO-Dimer 6 with near-infrared(NIR)emission has been applied in NIR fluorescence imaging-guided photothermal therapy.The very strong absorption ability has enabled its nanoparticles to exhibit a high photothermal conversion efficiency of 73%under the 655 nm laser irradiation and thus display a desired photothermal therapy performance.
