1教学目标:1.1知识目标:(1)多数学生能够在语境中听说理解句子:Where do you live?(2)所有学生能够理解文本内容。1.2能力目标:(1)多数学生能够正确模仿朗读文本对话。(2)所有学生能够运用'Where do you live?'结构来介绍自己,...1教学目标:1.1知识目标:(1)多数学生能够在语境中听说理解句子:Where do you live?(2)所有学生能够理解文本内容。1.2能力目标:(1)多数学生能够正确模仿朗读文本对话。(2)所有学生能够运用'Where do you live?'结构来介绍自己,了解朋友。1.3情感态度目标:感知英语的实用性。展开更多
Chemotherapy remains one of the most prevailing strategies for cancer treatment.However,its treatment effect is hampered by drug resistance,nonspecific tumor targeting,and severe toxic side effects.Combination chemoth...Chemotherapy remains one of the most prevailing strategies for cancer treatment.However,its treatment effect is hampered by drug resistance,nonspecific tumor targeting,and severe toxic side effects.Combination chemotherapy with synergistic effect has become an attractive tumor therapy.N6-methyladenosine(m6A)regulators determine the fate of m6A-modified transcripts and play vital roles in cancer development and drug resistance.Gene therapy such as small interfering RNA(siRNA)is a promising strategy to reduce the abnormal gene expression of m6A regulators.However,its poor selectivity and high systemic toxicity necessitate the use of delivery vectors to target specific cells and tissues.Here,we constructed a dual-functional targeted nanodrug platform for the synergetic m6A-associated epigenetic regulation and chemotherapy of ovarian cancer.We encapsulated siRNA targeting the m6A reader YT521-B homology(YTH)N6-methyladenosine RNA-binding protein 1(YTHDF1)and docetaxel(DTX),the first-line chemotherapeutic agent of ovarian cancer,into mesenchymal stem cell-derived small extracellular vesicles(MsEVs).This nanosystem exhibits significant tumor targeting and endo/lysosomal escape of siYTHDF1.It effectively depletes YTHDF1 and suppresses the protein translation of eukaryotic translation initiation factor 3 subunit C(EIF3C)in an m6A-dependent manner.The combination of YTHDF1-targeting epigenetic regulation significantly enhances the anti-tumor effect of DTX and effectively inhibits ovarian cancer progression without causing significant systemic toxicity.This co-delivery nanoplatform offers a promising approach for combinational cancer treatment,showing improved anti-tumor efficacy through the synergistic effects of epigenetic regulation and chemotherapeutic inhibition.展开更多
本模块知识网络词汇短语园地1. accommodate vt.容纳(乘客等)The hotel can accommodate 500 tourists.这家旅馆可住五百名观光客。The cottage could accommodate up to five people.这间小屋最多能容纳五个人。
词汇短语园地1. acquaintancen.相识的人;泛泛之交Mr Smith is one of my acquaintances.我认识史密斯先生。短语make an acquaintance of sb结识某人;接近某人I made an acquaintance of Jenny through his introduction.通过他的介绍...词汇短语园地1. acquaintancen.相识的人;泛泛之交Mr Smith is one of my acquaintances.我认识史密斯先生。短语make an acquaintance of sb结识某人;接近某人I made an acquaintance of Jenny through his introduction.通过他的介绍,我认识了珍妮。展开更多
文摘1教学目标:1.1知识目标:(1)多数学生能够在语境中听说理解句子:Where do you live?(2)所有学生能够理解文本内容。1.2能力目标:(1)多数学生能够正确模仿朗读文本对话。(2)所有学生能够运用'Where do you live?'结构来介绍自己,了解朋友。1.3情感态度目标:感知英语的实用性。
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000)the National Key Research and Development Program of China(No.2021YFA1201504)the National Natural Science Foundation of China(Nos.21721002 and 31971295)。
文摘Chemotherapy remains one of the most prevailing strategies for cancer treatment.However,its treatment effect is hampered by drug resistance,nonspecific tumor targeting,and severe toxic side effects.Combination chemotherapy with synergistic effect has become an attractive tumor therapy.N6-methyladenosine(m6A)regulators determine the fate of m6A-modified transcripts and play vital roles in cancer development and drug resistance.Gene therapy such as small interfering RNA(siRNA)is a promising strategy to reduce the abnormal gene expression of m6A regulators.However,its poor selectivity and high systemic toxicity necessitate the use of delivery vectors to target specific cells and tissues.Here,we constructed a dual-functional targeted nanodrug platform for the synergetic m6A-associated epigenetic regulation and chemotherapy of ovarian cancer.We encapsulated siRNA targeting the m6A reader YT521-B homology(YTH)N6-methyladenosine RNA-binding protein 1(YTHDF1)and docetaxel(DTX),the first-line chemotherapeutic agent of ovarian cancer,into mesenchymal stem cell-derived small extracellular vesicles(MsEVs).This nanosystem exhibits significant tumor targeting and endo/lysosomal escape of siYTHDF1.It effectively depletes YTHDF1 and suppresses the protein translation of eukaryotic translation initiation factor 3 subunit C(EIF3C)in an m6A-dependent manner.The combination of YTHDF1-targeting epigenetic regulation significantly enhances the anti-tumor effect of DTX and effectively inhibits ovarian cancer progression without causing significant systemic toxicity.This co-delivery nanoplatform offers a promising approach for combinational cancer treatment,showing improved anti-tumor efficacy through the synergistic effects of epigenetic regulation and chemotherapeutic inhibition.
文摘本模块知识网络词汇短语园地1. accommodate vt.容纳(乘客等)The hotel can accommodate 500 tourists.这家旅馆可住五百名观光客。The cottage could accommodate up to five people.这间小屋最多能容纳五个人。
文摘词汇短语园地1. acquaintancen.相识的人;泛泛之交Mr Smith is one of my acquaintances.我认识史密斯先生。短语make an acquaintance of sb结识某人;接近某人I made an acquaintance of Jenny through his introduction.通过他的介绍,我认识了珍妮。
