This paper examines theπ/4QPSK modulation communication transmission system,analyzing the performance advantages and disadvantages ofπ/4QPSK in comparison to QPSK.It also presents a comprehensive FPGA implementation...This paper examines theπ/4QPSK modulation communication transmission system,analyzing the performance advantages and disadvantages ofπ/4QPSK in comparison to QPSK.It also presents a comprehensive FPGA implementation scheme for a modulation communication transmission system,integrating RS channel coding,framing,frequency conversion,and other modules.This design is based on practical research and development requirements.The Xilinx Spartan6 chip board was used for board-level verification.Theπ/4QPSK modulated signal was transmitted via D/A conversion and radio frequency,with the transmitted waveform was looped back for reception.After A/D processing,the correctness of the designed modulation transmission scheme was verified.展开更多
Motivated by the widespread applications of nanofluids,a nanofluid model is proposed which focuses on uniform magnetohydrodynamic(MHD)boundary layer flow over a non-linear stretching sheet,incorporating the Casson mod...Motivated by the widespread applications of nanofluids,a nanofluid model is proposed which focuses on uniform magnetohydrodynamic(MHD)boundary layer flow over a non-linear stretching sheet,incorporating the Casson model for blood-based nanofluid while accounting for viscous and Ohmic dissipation effects under the cases of Constant Surface Temperature(CST)and Prescribed Surface Temperature(PST).The study employs a two-phase model for the nanofluid,coupled with thermophoresis and Brownian motion,to analyze the effects of key fluid parameters such as thermophoresis,Brownian motion,slip velocity,Schmidt number,Eckert number,magnetic parameter,and non-linear stretching parameter on the velocity,concentration,and temperature profiles of the nanofluid.The proposed model is novel as it simultaneously considers the impact of thermophoresis and Brownian motion,along with Ohmic and viscous dissipation effects,in both CST and PST scenarios for blood-based Casson nanofluid.The numerical technique built into MATLAB’s bvp4c module is utilized to solve the governing system of coupled differential equations,revealing that the concentration of nanoparticles decreases with increasing thermophoresis and Brownian motion parameters while the temperature of the nanofluid increases.Additionally,a higher Eckert number is found to reduce the nanofluid temperature.A comparative analysis between CST and PST scenarios is also undertaken,which highlights the significant influence of these factors on the fluid’s characteristics.The findings have potential applications in biomedical processes to enhance fluid velocity and heat transfer rates,ultimately improving patient outcomes.展开更多
Bone tissue engineering may be hindered by underlying osteoporosis because of a decreased osteogenic ability of autologous seed cells and an unfavorably changed microenvironment in these patients. Epigenetic regulatio...Bone tissue engineering may be hindered by underlying osteoporosis because of a decreased osteogenic ability of autologous seed cells and an unfavorably changed microenvironment in these patients. Epigenetic regulation plays an important role in the developmental origins of osteoporosis; however, few studies have investigated the potential of epigenetic therapy to improve or rescue the osteogenic ability of bone marrow mesenchymal stem cells(BMMSCs) under osteoporotic conditions. Here, we investigated pargyline, an inhibitor of lysine-specific demethylase 1(LSD1), which mainly catalyzes the demethylation of the di- and mono-methylation of H3K4. We demonstrated that 1.5 mmol·Lpargyline was the optimal concentration for the osteogenic differentiation of human BMMSCs. Pargyline rescued the osteogenic differentiation ability of mouse BMMSCs under osteoporotic conditions by enhancing the dimethylation level of H3K4 at the promoter regions of osteogenesis-related genes. Moreover, pargyline partially rescued or prevented the osteoporotic conditions in aged or ovariectomized mouse models, respectively. By introducing the concept of epigenetic therapy into the field of osteoporosis, this study demonstrated that LSD1 inhibitors could improve the clinical practice of MSC-based bone tissue engineering and proposes their novel use to treat osteoporosis.展开更多
Objective In this study, the pharmacological kinetics of Buthus martensi Karsch （BmK） AS, a specific modulator of voltage-gated sodium channel site 4, was investigated on Nav1.3 expressed in Xenopus oocytes. Methods...Objective In this study, the pharmacological kinetics of Buthus martensi Karsch （BmK） AS, a specific modulator of voltage-gated sodium channel site 4, was investigated on Nav1.3 expressed in Xenopus oocytes. Methods Two-electrode voltage clamp was used to record the whole-cell sodium current. Results The peak currents of Nav1.3 were depressed by BmK AS over a wide range of concentrations （10, 100, and 500 nmol/L）. Most remarkably, BmK AS at 100 nmol/L hyperpolarized the voltage-dependence and increased the voltage-sensitivity of steady-state activation/inactivation. In addition, BmK AS was capable of hyperpolarizing not only the fast inactivation but also the slow inactivation, with a greater preference for the latter. Moreover, BmK AS accelerated the time constant and increased the ratio of recovery in Nav1.3 at all concentrations. Conclusion This study provides direct evidence that BmK AS facilitates steady-state activation and inhibits slow inactivation by stabilizing both the closed and open states of the Nav1.3 channel, which might result from an integrative binding to two receptor sites on the voltage-gated sodium channels. These results may shed light on therapeutics against Nav1.3-targeted pathology.展开更多
For new submarine pipeline maintenance lifting equipment,a specialized analysis model is constructed in this study.A pipeline can be divided into the lifted portion and the touch-down portion that lies on the seabed,a...For new submarine pipeline maintenance lifting equipment,a specialized analysis model is constructed in this study.A pipeline can be divided into the lifted portion and the touch-down portion that lies on the seabed,and each of these portions can be analyzed separately by converting the continuity conditions at the touch-down points to boundary conditions.The typical two-point sequence secant iterative technique is used to obtain the unknown lifted length and determine pipeline lifting confgurations.The BVP4C module in MATLAB software is used to solve this multiple-point boundary value problem issued from frst-order diferential equations.Also,the triple-point lifting mode of truncated maintenance and the two-point lifting mode of online maintenance are discussed.When the lifted heights at truss positions are shown,the lifting deformation,lifting forces,bending moment distribution,and axial force distribution can be analyzed using a dedicated analysis program.Numerical results can then be used to design a lifting strategy to protect the pipeline.展开更多
A one-dimensional fluid/Monte-Carlo（MC）hybrid model is developed to describe capacitively coupled SiH_4/Ar discharge,in which the lower electrode is applied by a RF source and pulse modulated by a square-wave,to inv...A one-dimensional fluid/Monte-Carlo（MC）hybrid model is developed to describe capacitively coupled SiH_4/Ar discharge,in which the lower electrode is applied by a RF source and pulse modulated by a square-wave,to investigate the modulation effects of the pulse duty cycle on the discharge mechanism.An electron Monte Carlo simulation is used to calculate the electron energy distribution as a function of position and time phase.Rate coefficients in chemical reactions can then be obtained and transferred to the fluid model for the calculation of electron temperature and densities of different species,such as electrons,ions,and radicals.The simulation results show that,the electron energy distribution f（ε）is modulated evidently within a pulse cycle,with its tail extending to higher energies during the power-on period,while shrinking back promptly in the afterglow period.Thus,the rate coefficients could be controlled during the discharge,resulting in modulation of the species composition on the substrate compared with continuous excitation.Meanwhile,more negative ions,like Si H_3^-and Si H_2^-,may escape to the electrodes owing to the collapse of ambipolar electric fields,which is beneficial to films deposition.Pulse modulation is thus expected to provide additional methods to customize the plasma densities and components.展开更多
Three-level Neutral-Point-Clamped(NPC)voltage source inverters(VSIs)have been widely used in application of medium-voltage high-power induction motor drives.Due to the limitation of a switching frequency of several hu...Three-level Neutral-Point-Clamped(NPC)voltage source inverters(VSIs)have been widely used in application of medium-voltage high-power induction motor drives.Due to the limitation of a switching frequency of several hundred Hz in the high-power drive application,a 4-segment synchronized SVPWM scheme is adopted to reduce output current ripple.However,in the overmodulation region,the 4-segment synchronized SVPWM scheme shows high computation complexity and high current THD.Thus,this paper presents an optimized 4-segment synchronized overmodulation scheme with the advantages of low current harmonics and simple digital realization.Optimized and conventional 4-segment synchronized SVPWM schemes are compared and verified in experimental tests.Experimental results prove the proposed scheme can achieve lower current harmonics and computational burden in the overmodulation region,compared with traditional schemes.展开更多
文摘This paper examines theπ/4QPSK modulation communication transmission system,analyzing the performance advantages and disadvantages ofπ/4QPSK in comparison to QPSK.It also presents a comprehensive FPGA implementation scheme for a modulation communication transmission system,integrating RS channel coding,framing,frequency conversion,and other modules.This design is based on practical research and development requirements.The Xilinx Spartan6 chip board was used for board-level verification.Theπ/4QPSK modulated signal was transmitted via D/A conversion and radio frequency,with the transmitted waveform was looped back for reception.After A/D processing,the correctness of the designed modulation transmission scheme was verified.
基金funded by Universiti Teknikal Malaysia Melaka and Ministry of Higher Education(MoHE)Malaysia,grant number FRGS/1/2024/FTKM/F00586.
文摘Motivated by the widespread applications of nanofluids,a nanofluid model is proposed which focuses on uniform magnetohydrodynamic(MHD)boundary layer flow over a non-linear stretching sheet,incorporating the Casson model for blood-based nanofluid while accounting for viscous and Ohmic dissipation effects under the cases of Constant Surface Temperature(CST)and Prescribed Surface Temperature(PST).The study employs a two-phase model for the nanofluid,coupled with thermophoresis and Brownian motion,to analyze the effects of key fluid parameters such as thermophoresis,Brownian motion,slip velocity,Schmidt number,Eckert number,magnetic parameter,and non-linear stretching parameter on the velocity,concentration,and temperature profiles of the nanofluid.The proposed model is novel as it simultaneously considers the impact of thermophoresis and Brownian motion,along with Ohmic and viscous dissipation effects,in both CST and PST scenarios for blood-based Casson nanofluid.The numerical technique built into MATLAB’s bvp4c module is utilized to solve the governing system of coupled differential equations,revealing that the concentration of nanoparticles decreases with increasing thermophoresis and Brownian motion parameters while the temperature of the nanofluid increases.Additionally,a higher Eckert number is found to reduce the nanofluid temperature.A comparative analysis between CST and PST scenarios is also undertaken,which highlights the significant influence of these factors on the fluid’s characteristics.The findings have potential applications in biomedical processes to enhance fluid velocity and heat transfer rates,ultimately improving patient outcomes.
基金supported by grants from the National Natural Science Foundation of China(81200763 to WG and 81070809 to YZ)the Program for New Century Excellent Talents(NCET)at the University from Ministry of Education of China(NCET-11-0026)+1 种基金the PKU School of Stomatology for Talented Young Investigators(PKUSS20150107)the Construction Program for the National Key Clinical Specialty from the National Health and Family Planning Commission of China(2011)
文摘Bone tissue engineering may be hindered by underlying osteoporosis because of a decreased osteogenic ability of autologous seed cells and an unfavorably changed microenvironment in these patients. Epigenetic regulation plays an important role in the developmental origins of osteoporosis; however, few studies have investigated the potential of epigenetic therapy to improve or rescue the osteogenic ability of bone marrow mesenchymal stem cells(BMMSCs) under osteoporotic conditions. Here, we investigated pargyline, an inhibitor of lysine-specific demethylase 1(LSD1), which mainly catalyzes the demethylation of the di- and mono-methylation of H3K4. We demonstrated that 1.5 mmol·Lpargyline was the optimal concentration for the osteogenic differentiation of human BMMSCs. Pargyline rescued the osteogenic differentiation ability of mouse BMMSCs under osteoporotic conditions by enhancing the dimethylation level of H3K4 at the promoter regions of osteogenesis-related genes. Moreover, pargyline partially rescued or prevented the osteoporotic conditions in aged or ovariectomized mouse models, respectively. By introducing the concept of epigenetic therapy into the field of osteoporosis, this study demonstrated that LSD1 inhibitors could improve the clinical practice of MSC-based bone tissue engineering and proposes their novel use to treat osteoporosis.
基金supported by grants from the National Basic Research Development Program of China (2010CB529806)the National Natural Science Foundation of China (31171064)+1 种基金the Key Research Program of Science and Technology Commissions of Shanghai Municipality (11JC1404300)the Leading Academic Discipline Project of Shanghai Municipal Education Commission (J50108)
文摘Objective In this study, the pharmacological kinetics of Buthus martensi Karsch （BmK） AS, a specific modulator of voltage-gated sodium channel site 4, was investigated on Nav1.3 expressed in Xenopus oocytes. Methods Two-electrode voltage clamp was used to record the whole-cell sodium current. Results The peak currents of Nav1.3 were depressed by BmK AS over a wide range of concentrations （10, 100, and 500 nmol/L）. Most remarkably, BmK AS at 100 nmol/L hyperpolarized the voltage-dependence and increased the voltage-sensitivity of steady-state activation/inactivation. In addition, BmK AS was capable of hyperpolarizing not only the fast inactivation but also the slow inactivation, with a greater preference for the latter. Moreover, BmK AS accelerated the time constant and increased the ratio of recovery in Nav1.3 at all concentrations. Conclusion This study provides direct evidence that BmK AS facilitates steady-state activation and inhibits slow inactivation by stabilizing both the closed and open states of the Nav1.3 channel, which might result from an integrative binding to two receptor sites on the voltage-gated sodium channels. These results may shed light on therapeutics against Nav1.3-targeted pathology.
基金This paper was financially supported by the National Natural Science Foundation of China(Grant No.51679251)the authors would like to express their sincere thanks.
文摘For new submarine pipeline maintenance lifting equipment,a specialized analysis model is constructed in this study.A pipeline can be divided into the lifted portion and the touch-down portion that lies on the seabed,and each of these portions can be analyzed separately by converting the continuity conditions at the touch-down points to boundary conditions.The typical two-point sequence secant iterative technique is used to obtain the unknown lifted length and determine pipeline lifting confgurations.The BVP4C module in MATLAB software is used to solve this multiple-point boundary value problem issued from frst-order diferential equations.Also,the triple-point lifting mode of truncated maintenance and the two-point lifting mode of online maintenance are discussed.When the lifted heights at truss positions are shown,the lifting deformation,lifting forces,bending moment distribution,and axial force distribution can be analyzed using a dedicated analysis program.Numerical results can then be used to design a lifting strategy to protect the pipeline.
基金supported by National Natural Science Foundation of China(No.11275038)
文摘A one-dimensional fluid/Monte-Carlo（MC）hybrid model is developed to describe capacitively coupled SiH_4/Ar discharge,in which the lower electrode is applied by a RF source and pulse modulated by a square-wave,to investigate the modulation effects of the pulse duty cycle on the discharge mechanism.An electron Monte Carlo simulation is used to calculate the electron energy distribution as a function of position and time phase.Rate coefficients in chemical reactions can then be obtained and transferred to the fluid model for the calculation of electron temperature and densities of different species,such as electrons,ions,and radicals.The simulation results show that,the electron energy distribution f（ε）is modulated evidently within a pulse cycle,with its tail extending to higher energies during the power-on period,while shrinking back promptly in the afterglow period.Thus,the rate coefficients could be controlled during the discharge,resulting in modulation of the species composition on the substrate compared with continuous excitation.Meanwhile,more negative ions,like Si H_3^-and Si H_2^-,may escape to the electrodes owing to the collapse of ambipolar electric fields,which is beneficial to films deposition.Pulse modulation is thus expected to provide additional methods to customize the plasma densities and components.
文摘Three-level Neutral-Point-Clamped(NPC)voltage source inverters(VSIs)have been widely used in application of medium-voltage high-power induction motor drives.Due to the limitation of a switching frequency of several hundred Hz in the high-power drive application,a 4-segment synchronized SVPWM scheme is adopted to reduce output current ripple.However,in the overmodulation region,the 4-segment synchronized SVPWM scheme shows high computation complexity and high current THD.Thus,this paper presents an optimized 4-segment synchronized overmodulation scheme with the advantages of low current harmonics and simple digital realization.Optimized and conventional 4-segment synchronized SVPWM schemes are compared and verified in experimental tests.Experimental results prove the proposed scheme can achieve lower current harmonics and computational burden in the overmodulation region,compared with traditional schemes.
