Selectivity-control has long been a central pursuit in organic chemistry.Most recent advances have focused on achieving individual forms of selectivity,such as chemo-,regio-,E/Z-,diastereo-,or enantioselectivity.Tradi...Selectivity-control has long been a central pursuit in organic chemistry.Most recent advances have focused on achieving individual forms of selectivity,such as chemo-,regio-,E/Z-,diastereo-,or enantioselectivity.Traditionally,multi-selectivities have been realized through one-dimensional linear synthetic routes,in which distinct sites are modified sequentially across multiple reaction steps.展开更多
By precisely controlling both active sites and their surrounding microenvironments,enzymes catalyze complex transformations with remarkable efficiency and selectivity.This intricate interplay of structure and function...By precisely controlling both active sites and their surrounding microenvironments,enzymes catalyze complex transformations with remarkable efficiency and selectivity.This intricate interplay of structure and function in natural enzymes has inspired the emerging field of precision catalysis,which seeks to similarly modify active site architecture and local environments to enhance catalytic activity and selectivity in nonenzymaticsystems.Precision catalysis aims to enhance activity and selectivity,rivaling natural enzymes while achieving greater atom economy in catalyst design.Among various material platforms,metal-organic frame-works(MOFs)are uniquely positioned to advance precision catalysis due to their modular construction,structural regularity,and synthetic tunability.MOFs are porous crystalline molecular materials built from metal clusters and organic linkers.Their reticular nature enables the rational synthesis of hundreds of thousands of MOFs with diverse topologies and compositions.2 Unlike conventional homogeneous or heterogeneous catalysts,MOFs allow for atomic-level spatial control over the placement of catalytic sites.展开更多
文摘Selectivity-control has long been a central pursuit in organic chemistry.Most recent advances have focused on achieving individual forms of selectivity,such as chemo-,regio-,E/Z-,diastereo-,or enantioselectivity.Traditionally,multi-selectivities have been realized through one-dimensional linear synthetic routes,in which distinct sites are modified sequentially across multiple reaction steps.
文摘By precisely controlling both active sites and their surrounding microenvironments,enzymes catalyze complex transformations with remarkable efficiency and selectivity.This intricate interplay of structure and function in natural enzymes has inspired the emerging field of precision catalysis,which seeks to similarly modify active site architecture and local environments to enhance catalytic activity and selectivity in nonenzymaticsystems.Precision catalysis aims to enhance activity and selectivity,rivaling natural enzymes while achieving greater atom economy in catalyst design.Among various material platforms,metal-organic frame-works(MOFs)are uniquely positioned to advance precision catalysis due to their modular construction,structural regularity,and synthetic tunability.MOFs are porous crystalline molecular materials built from metal clusters and organic linkers.Their reticular nature enables the rational synthesis of hundreds of thousands of MOFs with diverse topologies and compositions.2 Unlike conventional homogeneous or heterogeneous catalysts,MOFs allow for atomic-level spatial control over the placement of catalytic sites.
