To optimize the temperature coefficient of reactivity(TCR)for a graphite-moderated and liquid-fueled molten salt reactor,the effects of fuel salt composition on the fuel salt temperature coefficient of reactivity(FSTC...To optimize the temperature coefficient of reactivity(TCR)for a graphite-moderated and liquid-fueled molten salt reactor,the effects of fuel salt composition on the fuel salt temperature coefficient of reactivity(FSTC)were investigated in our earlier work.In this study,we aim to provide a more comprehensive analysis of the TCR by considering the effects of the graphite-moderator temperature coefficient of reactivity(MTC).The effects of^235U enrichment and heavy metal(HM)proportion in the salt mixture on the MTC are investigated from the perspective of the six-factor formula based on a full-core model.For the MTC(labeled“αTM”),the temperature coefficient of the fast fission factors(αTM(ε))is positive,while those of the resonance escape probability(αTM(p)),the thermal reproduction factor(αTM(η)),the thermal utilization factor(αTM(f)),and the total non-leakage probability(αTM(A))are negative.The results reveal that the magnitudes ofαTM(ε)andαTM(p)for the MTC are similar.Thus,variations in the MTC with^235U enrichment for different HM proportions are mainly dependent onαTM(η),αTM(A),andαTM(f),but especially on the former two.To obtain a more negative MTC,a lower HM proportion and/or a lower 235U enrichment is recommended.Together with our previous studies on the FSTC,a relatively soft neutron spectrum could strengthen the TCR with a sufficiently negative MTC.展开更多
Calculation of moderator analogues for 14 MeV neutrons as source were made at a IBM/PC AT computer using TAMAKER-ANISN program and 46 groups (25 neutron groups, 21 photon groups) UW cross section data. The intensifyin...Calculation of moderator analogues for 14 MeV neutrons as source were made at a IBM/PC AT computer using TAMAKER-ANISN program and 46 groups (25 neutron groups, 21 photon groups) UW cross section data. The intensifying effect of lead and natural uranium for moderating 14 MeV neutrons is confirmed. Adopting proper structure of the moderator, the intensifying factor M (times) may be larger than 3. Using lead and natural uranium in sub-critical assemblies (or call boosters),with 14 MeV neutrons as source, with the same dimension as that of above, the intensifying effect is also condrmed. With a proper structure of sub-critical assembly,the intensifying factor M may be close to or eved larger than (1 - k)-1 where k isthe effective multiplication factor.展开更多
Objective This study aims to explore the complex relationship between social engagement and depressive symptoms among older adults in China,focusing particularly on the moderating role of marital status.Methods This s...Objective This study aims to explore the complex relationship between social engagement and depressive symptoms among older adults in China,focusing particularly on the moderating role of marital status.Methods This study used data from the latest Chinese Longitudinal Healthy Longevity Survey(CLHLS).The analysis used the latent class analysis to delineate personality clusters and hierarchical linear regression,supplemented by the PROCESS macro,to investigate the effects of social engagement and marital status on depressive symptoms.Results The analysis encompassed 7,789 respondents(mean age:82.53[s=11.20]years),with 54%female.The personality analysis categorized participants into four clusters,with the majority(77.60%)classified as Confident Idealists,who exhibited the lowest levels of depressive symptoms.Hierarchical linear regression analysis yielded several significant findings:Higher levels of social engagement were significantly associated with fewer depressive symptoms(t=-7.932,P<0.001,B=-0.463).Marital status was a significant factor;married individuals reported fewer depressive symptoms compared to their unmarried counterparts(t=-6.368,P<0.001,B=-0.750).There was a significant moderating effect of marital status on the relationship between social engagement and depressive symptoms(t=-2.092,P=0.037,B=-0.217).Conclusion This study demonstrates that,among Chinese older adults,both social engagement and marital status significantly influence depressive symptoms.Higher social engagement,particularly in other activities like doing household chores,gardening,reading newspapers or books,and playing cards or Mahjong,is associated with fewer depressive symptoms,especially among married individuals.展开更多
Delusional disorder(DD)has been traditionally considered a relatively rare and treatment-resistant psychotic disorder.In the last decade,increasing attention has focused on therapeutic outcomes of individuals affected...Delusional disorder(DD)has been traditionally considered a relatively rare and treatment-resistant psychotic disorder.In the last decade,increasing attention has focused on therapeutic outcomes of individuals affected by this disorder.The aim of this paper is to provide a synthesis of the literature addressing two very important questions arising from DD research:(1)For which patients with DD do antipsychotic medications work best(the moderators of response);and(2)What variables best explain the relationship between such treatments and their effectiveness(the mediators of response).We searched PubMed and Google Scholar databases for English,German,French and Spanish language papers published since 2000.We also included a few classic earlier papers addressing this topic.Variables potentially moderating antipsychotic response in DD are gender,reproductive status,age,duration of illness,the presence of comorbidity(especially psychiatric comorbidity)and its treatment,brain structure,and genetics of neurochemical receptors and drug metabolizing enzymes.Antipsychotic and hormonal blood levels during treatment,as well as functional brain changes,are potential mediating variables.Some,but not all,patients with DD benefit from antipsychotic treatment.Understanding the circumstances under which treatment works best can serve to guide optimal management.展开更多
Korea Atomic Energy Research Institute (KAERI) has been carrying out a scaled-down moderator test program to simulate the CANDU-6 moderator circulation phenomena during steady state operation and accident conditions. ...Korea Atomic Energy Research Institute (KAERI) has been carrying out a scaled-down moderator test program to simulate the CANDU-6 moderator circulation phenomena during steady state operation and accident conditions. The Moderator Circulation Test (MCT) facility was designed and constructed as 1/4 scale of the prototype of CANDU-6 reactor. In the present work spatial distribution of two-dimensional velocity in the MCT facility under isothermal condition was measured using planar Particle Image Velocimetry (PIV) system which consists of double pulsed laser, synchronizer, and high speed camera. TSI’s Insight TM 4G software was used to perform PIV image capturing, PIV calculation and post processing. 10 μm sized silver-coated hollow sphere particles were used as flow tracer particles. Multiple experiments were conducted to cover large area of the MCT facility with limited field of view of a single camera. Instantaneous and averaged velocity field were analyzed for each spatial position and flow rate. This research is capable of offering validation data for self-reliant CFD tools to predict moderator subcooling margin in CANDU-6 reactor.展开更多
Following the previous relevant works [1]-[3], a scaling analysis is performed to derive a set of scaling criteria which were thought to be suitable for reproducing the major thermal-hydraulic phenomena in a scaled-do...Following the previous relevant works [1]-[3], a scaling analysis is performed to derive a set of scaling criteria which were thought to be suitable for reproducing the major thermal-hydraulic phenomena in a scaled-down CANDU moderator tank similar to that in a prototype power plant during a full power steady state condition. The objective of building a scaled-down moderator tank is to generate the experimental data necessary to validate the computer codes which are used to analyze the accident analysis of CANDU-6 plants. The major variables of interests in this paper are moderator flow velocity and temperature of the moderator which is D2O inside the moderator tank during a steady state and transient conditions. The reason is that the local subcooling of the moderator is found to be a critical parameter determining whether the stable film boiling can sustain on the outer surface of the calandria tube if the contact of overheated pressure tube and cold calandria tube should occur due to pressure tube ballooning during LBLOCA with ECC injection failure [4]. The key phenomena involved include the inlet jet development and impingement, buoyancy force driven by the moderator temperature gradient caused by non-uniform direct heating of the moderator, and the pressure drop due to viscous friction of the flow across the calandria tube array. In this paper, the previous researches are reviewed, some concerns or potential problems associated with them implied by comparing CFD analyses results between the CANDU-6 moderator tank and 1/4 scaled-down test facility are described, and as a way to examine the assumption of the scaling analysis is true an order-of-magnitude analyses are performed. Based on the results of these analyses the assumption of neglecting ?and ?terms cannot be justified for the power of 0.5 MW and 1.566 MW for the 1/4 scaled-down facility. Further investigation is thought to be necessary to confirm this result, i.e. if the scaling of the previous work1 is justifiable by some other independent analyses.展开更多
An important limitation of the research literatures which study the effect on the export of the real effective exchange rates is the lack of application of interaction or moderator effect among the independent variabl...An important limitation of the research literatures which study the effect on the export of the real effective exchange rates is the lack of application of interaction or moderator effect among the independent variables. To remedy this lacuna, the authors developed a model in which real effective exchange rate moderated the effect of import and utilization of foreign capital on export. The sample comprised 11 years＇ data in Guangdong China. The result showed that real effective exchange rate of RMB affected the export by interacting with utilization of foreign capital. Moreover, to some degree, the real effective exchange rate can also act as moderator between import and export.展开更多
Middle school serves as a pivotal juncture in career development,where adolescents grapple with adaptability challenges during transitional phases such as entrance exams and the selection of elective majors.Simultaneo...Middle school serves as a pivotal juncture in career development,where adolescents grapple with adaptability challenges during transitional phases such as entrance exams and the selection of elective majors.Simultaneously,they embark on integrating their ongoing learning tasks with their ideal aspirations to lay the groundwork for future career development.Against this backdrop,the significance of career exploration and understanding future developmental directions becomes particularly pronounced.To investigate the intricate relationship between career exploration and the clarity of one’s future work-self,along with the moderating role of proactive personality,this study employed the career exploration scale,proactive personality scale,and clarity of future work-self scale.Data from 457 high school students were collected,revealing a substantial positive correlation between career exploration and both future work self-clarity and proactive personality.Adjusting for gender and age highlighted proactive personality as a regulatory factor influencing the relationship between career exploration and future work self-clarity.Furthermore,the results underscored the crucial moderating role of proactive personality in shaping the connection between career exploration and the clarity of future work-self.In-depth analysis revealed noteworthy interactions,particularly with the environmental exploration dimension(standard coefficient of 0.849,p<0.001).Similarly,interactions with self-exploration,goal-system exploration,and information quantity dimensions were also significant,featuring standard coefficients of 0.905(p=0.002),0.935(p<0.001),and 0.854(p<0.001),respectively.In essence,these findings illuminate the nuanced dynamics at play,emphasizing the amplified connection between career exploration and the clarity of future work-self in the presence of higher proactive personality levels.This insight holds implications for educators,counselors,and researchers invested in fostering comprehensive career development strategies for adolescents.展开更多
Subcritical reactors(SCRs)or subcritical assemblies(SCAs)are the main infrastructure for designing power reactors.These reactors are widely used for training and research because of their high level of inherent safety...Subcritical reactors(SCRs)or subcritical assemblies(SCAs)are the main infrastructure for designing power reactors.These reactors are widely used for training and research because of their high level of inherent safety.The objective of this study is to design a subcritical reactor using a pressurized water reactor(PWR)conventional fuel following two safety points.In the first approach,deeply placed SCR cores with an infinite multiplication factor(k_(∞))of less than unity were identified using the DRAGON lattice code.In the second approach,subcritical reactor cores with an effective multiplication factor(k_(eff))of less than unity were determined by coupling the cell calculations of the DRAGON lattice code and core calculations of the DONJON code.For the deeply subcritical reactor design,it was found that the reactor would remain inherently subcritical while using fuel rods with ^(235)U enrichment of up to 0.9%,regardless of the pitch of the fuel rods.In the second approach,the optimal pitches(1.3 to 2.3 cm)were determined for different fuel enrichment values from 1 to 5%.Subsequently,the k_(eff) was obtained for a fuel rod arrangement of 8×8 to 80×80,and the states in which the reactor would be subcritical were determined for different fuel enrichments at the corresponding optimal pitch.To validate the models used in the DRAGON and DONJON codes,the k_(eff) of the Isfahan Light Water Subcritical Reactor(LWSCR)was experimentally measured and compared with the results of the calculations.Finally,the effects of fuel and moderator temperature changes were investigated to ensure that the designed assemblies remained in the subcritical state at all operational temperatures.展开更多
In boron neutron capture therapy （BNCT）, the ratio of the fast neutron flux to the neutron flux in the tumor （RFNT） must be less than 3% If a D-T neutron generator is used in BNCT, the 14 MeV neutron moderator mus...In boron neutron capture therapy （BNCT）, the ratio of the fast neutron flux to the neutron flux in the tumor （RFNT） must be less than 3% If a D-T neutron generator is used in BNCT, the 14 MeV neutron moderator must be optimized to reduce the RFNT. Based on the neutron moderation theory and the simulation results, tungsten, lead and diamond were used to moderate the 14 MeV neutrons. Satisfying RFNT of less than 3%, the maximum neutron flux in the tumor was achieved with a three-layer moderator comprised of a 3 cm thick tungsten layer, a 14 cm thick lead layer and a 21 cm thick diamond layer.展开更多
Conflicting results from previous research relating information technology （IT） investments and firm performance suggest that there is no direct relationship between IT investments and firm performance. The resource...Conflicting results from previous research relating information technology （IT） investments and firm performance suggest that there is no direct relationship between IT investments and firm performance. The resource-based view （RBV） of the firm is introduced as a research tool to examine how IT resources and capabilities affect firm performance. A theoretical rationale model is then used to investigate the relationship between IT investment and firm performance. The IT capability is assumed to be an important moderator variable rather than a mediator variable linking IT investments to firm performance, while the time period, the firm size, and the industry type, all recognized as factors influencing performance, are treated as control variables. The model and hypotheses are verified by sample data from leading IT firms in China. The data confirms the moderating effect of the IT capability.展开更多
This study employed integrated metabolomic and transcriptomic analyses to investigate the impacts of moderate withering(approximately 30%weight loss)on organic acid and flavonoid accumulation in blueberries and the re...This study employed integrated metabolomic and transcriptomic analyses to investigate the impacts of moderate withering(approximately 30%weight loss)on organic acid and flavonoid accumulation in blueberries and the resultant blueberry wines.Moderate withering led to decreases in aliphatic organic acids but increases in phenolic acids and flavonoids in blueberries.The decrease in malate could be linked to the downregulated VcMDH and VcDTC,and the decrease in citrate and 2-oxoglutarate could be a consequence of y-aminobutyric acid shunt activation.The increases of phenolic acids were associated with upregulated VcCAD and VcPOD in withered blueberries.Additionally,moderate withering upregulated the expression of VcLAR and VcUFGT,promoting flavonoid accumulation.In blueberry wines,moderate withering decreased total aliphatic organic acid content but increased anthocyanin content,consistent with the findings in blueberries.Overall,this study provided references for applying moderate withering in blueberry winemaking,contributing to modulating acidity and enriching phenolic substances.展开更多
In the evolving global economy,China’s Outward Foreign Direct Investment(OFDI)holds increasing significance,specially within the context of the Belt and Road Initiative(BRI).Despite earlier studies have acknowledged ...In the evolving global economy,China’s Outward Foreign Direct Investment(OFDI)holds increasing significance,specially within the context of the Belt and Road Initiative(BRI).Despite earlier studies have acknowledged the role of governance quality in at-tracting Chinese OFDI,their explanatory capacity regarding human development has not received sufficient attention.This study ad-dresses this gap,investigating the relationship between Chinese OFDI and human development,emphasizing the governance quality’s moderating role.Using data from 122 BRI countries from 2004 to 2021,we employed the Panel Corrected Standard Error model through Prais-Winsten regression,complimented by robustness check via the Spatial Durbin Model.Our analysis revealed a significant positive relationship between Chinese OFDI and human development in BRI countries,indicating that Chinese investments act as cata-lysts for improved well-being.More importantly,governance quality plays a vital role in shaping this relationship,revealing that effect-ive governance enhanced the human development outcomes of OFDI.Post-hoc analysis of governance indicators,both as a composite index and individual dimensions,supported this finding.Regional heterogeneity analysis further showed that Chinese OFDI has stronger effects on Human Development Index(HDI)in Asia and Africa compared to Europe,Latin America,and Oceania.However,the moder-ating effect of governance quality seemed more prominent in Oceania and Latin America,indicating its role in fostering the benefits of Chinese investments in these regions.These findings hold implications for academia and policy,emphasizing the need for transparent,accountable,and effective governance to drive sustainable and inclusive human development within the BRI framework.展开更多
Background:Depression is prevalent among female college students,with eating behavior potentially related to this issue.This study examines the relationship between eating behavior and depression,focusing on the role ...Background:Depression is prevalent among female college students,with eating behavior potentially related to this issue.This study examines the relationship between eating behavior and depression,focusing on the role of social appearance anxiety and physical activity.Methods:We recruited 2161 female college students from nine universities in China via convenience sampling.Data was collected via an online questionnaire.Eating behavior was assessed via the Eating Behavior Scale short form(EBS-SF),depression was measured via the Center for Epidemiological Studies Depression Scale(CES-D),social appearance anxiety was evaluated via the Social Appearance Anxiety Scale,and physical activity was assessed via a single-item question.Descriptive statistics were analyzed via SPSS 26.0,and moderated mediation analysis was conducted via PROCESS version 3.5.Results:Unhealthy eating behavior was significantly associated with higher levels of depression(β=0.285,p<0.001).Social appearance anxiety mediated this relationship,accounting for 46%of the total effect(β=0.132,95%CI=[0.108,0.158]).The interaction effect between eating behavior and physical activity was significantly and negatively correlated with depression(β=−0.052,p<0.01).The association between eating behavior and depression was stronger under conditions of low physical activity(β=0.210,p<0.001)than under conditions of high physical activity(β=0.105,p<0.001).Conclusions:Integrating nutritional guidance,body image acceptance training,and exercise promotion into campus mental health programs is crucial for addressing depression in female college students.Future research should use longitudinal designs and broader participant ranges to increase the general applicability of the findings.展开更多
Physical activity,moderate aerobic or resistance exercise are well established to offer health benefits and promote healthy aging and longevity.^(1)In contrast,lack of exercise contributes to adverse events,especially...Physical activity,moderate aerobic or resistance exercise are well established to offer health benefits and promote healthy aging and longevity.^(1)In contrast,lack of exercise contributes to adverse events,especially in some patients with organ failure.^(2)Therefore,“exercise pills”and“exercise mimetics”have attracted growing interest because of their potential to induce exercise-related health effects despite physical exercise not being performed.^(3)Robust studies over the past decade have identified many natural biomacromolecules,such as peptide,non-coding Ribonucleic Acid(RNAs),and lipids,that are induced by exercise.^(4-6)These molecules trigger physiological adaptations,including promotion of cardiomyocyte proliferation,anti-apoptotic capacity,and healthy tissue growth.7However,identifying or designing an exercise pill that mimics the extensive benefits of exercise is still challenging.展开更多
Cotton is an important global cash crops that serve as the primary source of natural fiber for textiles.A thorough understand-ing of the long-term variations in cotton cultivation is vital for optimizing cotton cultiv...Cotton is an important global cash crops that serve as the primary source of natural fiber for textiles.A thorough understand-ing of the long-term variations in cotton cultivation is vital for optimizing cotton cultivation management and promoting the sustainable development of the cotton industry.Xinjiang is the primary cotton-producing region in China.However,long-term data of cotton cultiv-ation areas with high spatial resolution are unavailable for Xinjiang,China.Therefore,this study aimed to identify and map an accurate 30-m cotton cultivation area dataset in Xinjiang from 2000 to 2020 by applying a Random Forest(RF)-based method that integrates Landsat and Moderate Resolution Imaging Spectroradiometer(MODIS)images,and validated the applicability and accuracy of dataset at a large spatial scale.Then,this study analyzed the spatiotemporal variations and influencing factors of cotton cultivation in the study period.The results showed that a high classification accuracy was achieved(overall accuracy>85%,F1>0.80),strongly agreeing with county-level agricultural statistical yearbook data(R2>0.72).Significant spatiotemporal variation in the cotton cultivation areas was found in Xinjiang,with a total increase of 1131.26 kha from 2000 to 2020.Notably,cotton cultivation area in southern Xinjiang expan-ded substantially,with that in Aksu increasing from 20.10%in 2000 to 28.17%in 2020,representing an expansion of 374.29 kha.In northern Xinjiang,the cotton areas in the Tacheng region also exhibited significant increased by almost ten percentage points in the same period.In contrast,cotton cultivation in eastern Xinjiang declined,decreasing from 2.22%in 2000 to merely 0.24%in 2020.Standard deviation ellipse analysis revealed a‘northeast-southwest’spatial distribution,with the centroid consistently located in Aksu and shifting 102.96 km over the 20-yr period.Pearson correlation analysis indicated that socioeconomic factors had a stronger influence on cotton cultivation than climatic factors,with effective irrigation area(r=0.963,P<0.05)and total agricultural machinery power(r=0.823)showing significant positive correlations,whereas climatic variables exhibiting weak associations(r<0.200).These results provide valuable scientific data for informed agricultural management,sustainable development,and policymaking.展开更多
In this paper,large deviations principle(LDP)and moderate deviations principle(MDP)of record numbers in random walks are studied under certain conditions.The results show that the rate functions of LDP and MDP are dif...In this paper,large deviations principle(LDP)and moderate deviations principle(MDP)of record numbers in random walks are studied under certain conditions.The results show that the rate functions of LDP and MDP are different from those of weak record numbers,which are interesting complements of the conclusions by Li and Yao[1].展开更多
This article comprehensively reviews research progress in prostate cancer radiation therapy.It provides an overview of fundamental principles,encompassing the disease’s epidemiology,pathological mechanisms,and radiat...This article comprehensively reviews research progress in prostate cancer radiation therapy.It provides an overview of fundamental principles,encompassing the disease’s epidemiology,pathological mechanisms,and radiation sensitivity,alongside technological advancements.The clinical application,technological progress,and efficacy evaluation of moderate hypofractionated radiation therapy and ultra hypofractionated radiation therapy are discussed.Diagnostic and monitoring techniques specific to radiation therapy are analyzed,alongside prevailing controversies and challenges.Finally,the review outlines future prospects,including novel radiotherapy techniques,multidisciplinary collaboration trends,and the evolving role of radiation within comprehensive treatment.The findings demonstrate continuous technological and clinical evolution in prostate cancer radiotherapy,yet emphasize the need for further exploration to optimize treatments and improve patient survival and quality of life.展开更多
Background Higher accelerometer-assessed volume and intensity of physical activity(PA)have been associated with a longer life expectancy but can be difficult to translate into recommended doses of PA.We aimed to:(a)im...Background Higher accelerometer-assessed volume and intensity of physical activity(PA)have been associated with a longer life expectancy but can be difficult to translate into recommended doses of PA.We aimed to:(a)improve interpretability by producing UK Biobank age-referenced centiles for PA volume and intensity;(b)inform public-health messaging by examining how adding recommended quantities of moderate and vigorous PA affect PA volume and intensity.Methods 92,480 UK Biobank participants aged 43-80 years with wrist-worn accelerometer data were included.Average acceleration and intensity gradient were derived as proxies for PA volume and intensity.We generated sex-specific centile curves using Generalized Additive Models for Location Scale and Shape(GAMLSS)and modeled the effect of adding moderate(walking)or vigorous(running)activity on the combined change in the volume and intensity centiles(change in PA profile).Results In men,volume was lower as age increased while intensity was lower after age 55;in women,both volume and intensity were lower as age increased.Adding 150 min of moderate PA weekly(5×30 min walking)increased the PA profile by 4 percentage points.Defining moderate PA as brisk walking approximately doubled the increase(9 percentage points)while 75 min of vigorous PA weekly(5×15 min running)trebled the increase(13 percentage points).Conclusion These UK Biobank reference centiles provide a benchmark for interpretation of accelerometer data.Application of our translational methods demonstrate that meeting PA guidelines through shorter duration vigorous activity is more beneficial to the PA profile(volume and intensity)than longer duration moderate activity.展开更多
On March 14,2025,the Centre for China and Globalisation(CCG)held its first VIP Luncheon of the year at the Beijing International Club.The event was moderated by CCG President Wang Huiyao and brought together over 50 C...On March 14,2025,the Centre for China and Globalisation(CCG)held its first VIP Luncheon of the year at the Beijing International Club.The event was moderated by CCG President Wang Huiyao and brought together over 50 Chinese and international vips,including ambassadors from 17 countries,senior diplomats from 8 countries,as well as representatives from international organisations and chambers of commerce,corporate executives,and prominent media professionals.展开更多
基金supported by the Chinese TMSR Strategic Pioneer Science and Technology Project(No.XDA02010000)the Frontier Science Key Program of the Chinese Academy of Sciences(No.QYZDY-SSW-JSC016)
文摘To optimize the temperature coefficient of reactivity(TCR)for a graphite-moderated and liquid-fueled molten salt reactor,the effects of fuel salt composition on the fuel salt temperature coefficient of reactivity(FSTC)were investigated in our earlier work.In this study,we aim to provide a more comprehensive analysis of the TCR by considering the effects of the graphite-moderator temperature coefficient of reactivity(MTC).The effects of^235U enrichment and heavy metal(HM)proportion in the salt mixture on the MTC are investigated from the perspective of the six-factor formula based on a full-core model.For the MTC(labeled“αTM”),the temperature coefficient of the fast fission factors(αTM(ε))is positive,while those of the resonance escape probability(αTM(p)),the thermal reproduction factor(αTM(η)),the thermal utilization factor(αTM(f)),and the total non-leakage probability(αTM(A))are negative.The results reveal that the magnitudes ofαTM(ε)andαTM(p)for the MTC are similar.Thus,variations in the MTC with^235U enrichment for different HM proportions are mainly dependent onαTM(η),αTM(A),andαTM(f),but especially on the former two.To obtain a more negative MTC,a lower HM proportion and/or a lower 235U enrichment is recommended.Together with our previous studies on the FSTC,a relatively soft neutron spectrum could strengthen the TCR with a sufficiently negative MTC.
文摘Calculation of moderator analogues for 14 MeV neutrons as source were made at a IBM/PC AT computer using TAMAKER-ANISN program and 46 groups (25 neutron groups, 21 photon groups) UW cross section data. The intensifying effect of lead and natural uranium for moderating 14 MeV neutrons is confirmed. Adopting proper structure of the moderator, the intensifying factor M (times) may be larger than 3. Using lead and natural uranium in sub-critical assemblies (or call boosters),with 14 MeV neutrons as source, with the same dimension as that of above, the intensifying effect is also condrmed. With a proper structure of sub-critical assembly,the intensifying factor M may be close to or eved larger than (1 - k)-1 where k isthe effective multiplication factor.
基金supported by National Natural Science Foundation of China[72174183].
文摘Objective This study aims to explore the complex relationship between social engagement and depressive symptoms among older adults in China,focusing particularly on the moderating role of marital status.Methods This study used data from the latest Chinese Longitudinal Healthy Longevity Survey(CLHLS).The analysis used the latent class analysis to delineate personality clusters and hierarchical linear regression,supplemented by the PROCESS macro,to investigate the effects of social engagement and marital status on depressive symptoms.Results The analysis encompassed 7,789 respondents(mean age:82.53[s=11.20]years),with 54%female.The personality analysis categorized participants into four clusters,with the majority(77.60%)classified as Confident Idealists,who exhibited the lowest levels of depressive symptoms.Hierarchical linear regression analysis yielded several significant findings:Higher levels of social engagement were significantly associated with fewer depressive symptoms(t=-7.932,P<0.001,B=-0.463).Marital status was a significant factor;married individuals reported fewer depressive symptoms compared to their unmarried counterparts(t=-6.368,P<0.001,B=-0.750).There was a significant moderating effect of marital status on the relationship between social engagement and depressive symptoms(t=-2.092,P=0.037,B=-0.217).Conclusion This study demonstrates that,among Chinese older adults,both social engagement and marital status significantly influence depressive symptoms.Higher social engagement,particularly in other activities like doing household chores,gardening,reading newspapers or books,and playing cards or Mahjong,is associated with fewer depressive symptoms,especially among married individuals.
基金Supported by Intensification of the Research Activity Grant from the Health Department of the Generalitat de Catalunya,No.SLT006/17/00012 to Labad J.
文摘Delusional disorder(DD)has been traditionally considered a relatively rare and treatment-resistant psychotic disorder.In the last decade,increasing attention has focused on therapeutic outcomes of individuals affected by this disorder.The aim of this paper is to provide a synthesis of the literature addressing two very important questions arising from DD research:(1)For which patients with DD do antipsychotic medications work best(the moderators of response);and(2)What variables best explain the relationship between such treatments and their effectiveness(the mediators of response).We searched PubMed and Google Scholar databases for English,German,French and Spanish language papers published since 2000.We also included a few classic earlier papers addressing this topic.Variables potentially moderating antipsychotic response in DD are gender,reproductive status,age,duration of illness,the presence of comorbidity(especially psychiatric comorbidity)and its treatment,brain structure,and genetics of neurochemical receptors and drug metabolizing enzymes.Antipsychotic and hormonal blood levels during treatment,as well as functional brain changes,are potential mediating variables.Some,but not all,patients with DD benefit from antipsychotic treatment.Understanding the circumstances under which treatment works best can serve to guide optimal management.
文摘Korea Atomic Energy Research Institute (KAERI) has been carrying out a scaled-down moderator test program to simulate the CANDU-6 moderator circulation phenomena during steady state operation and accident conditions. The Moderator Circulation Test (MCT) facility was designed and constructed as 1/4 scale of the prototype of CANDU-6 reactor. In the present work spatial distribution of two-dimensional velocity in the MCT facility under isothermal condition was measured using planar Particle Image Velocimetry (PIV) system which consists of double pulsed laser, synchronizer, and high speed camera. TSI’s Insight TM 4G software was used to perform PIV image capturing, PIV calculation and post processing. 10 μm sized silver-coated hollow sphere particles were used as flow tracer particles. Multiple experiments were conducted to cover large area of the MCT facility with limited field of view of a single camera. Instantaneous and averaged velocity field were analyzed for each spatial position and flow rate. This research is capable of offering validation data for self-reliant CFD tools to predict moderator subcooling margin in CANDU-6 reactor.
文摘Following the previous relevant works [1]-[3], a scaling analysis is performed to derive a set of scaling criteria which were thought to be suitable for reproducing the major thermal-hydraulic phenomena in a scaled-down CANDU moderator tank similar to that in a prototype power plant during a full power steady state condition. The objective of building a scaled-down moderator tank is to generate the experimental data necessary to validate the computer codes which are used to analyze the accident analysis of CANDU-6 plants. The major variables of interests in this paper are moderator flow velocity and temperature of the moderator which is D2O inside the moderator tank during a steady state and transient conditions. The reason is that the local subcooling of the moderator is found to be a critical parameter determining whether the stable film boiling can sustain on the outer surface of the calandria tube if the contact of overheated pressure tube and cold calandria tube should occur due to pressure tube ballooning during LBLOCA with ECC injection failure [4]. The key phenomena involved include the inlet jet development and impingement, buoyancy force driven by the moderator temperature gradient caused by non-uniform direct heating of the moderator, and the pressure drop due to viscous friction of the flow across the calandria tube array. In this paper, the previous researches are reviewed, some concerns or potential problems associated with them implied by comparing CFD analyses results between the CANDU-6 moderator tank and 1/4 scaled-down test facility are described, and as a way to examine the assumption of the scaling analysis is true an order-of-magnitude analyses are performed. Based on the results of these analyses the assumption of neglecting ?and ?terms cannot be justified for the power of 0.5 MW and 1.566 MW for the 1/4 scaled-down facility. Further investigation is thought to be necessary to confirm this result, i.e. if the scaling of the previous work1 is justifiable by some other independent analyses.
文摘An important limitation of the research literatures which study the effect on the export of the real effective exchange rates is the lack of application of interaction or moderator effect among the independent variables. To remedy this lacuna, the authors developed a model in which real effective exchange rate moderated the effect of import and utilization of foreign capital on export. The sample comprised 11 years＇ data in Guangdong China. The result showed that real effective exchange rate of RMB affected the export by interacting with utilization of foreign capital. Moreover, to some degree, the real effective exchange rate can also act as moderator between import and export.
基金Collaborative education project of industry university cooperation of the Ministry of Education of China:Research on practice teaching of the competency of future mental health teachers based on virtual reality(No.202102080005).
文摘Middle school serves as a pivotal juncture in career development,where adolescents grapple with adaptability challenges during transitional phases such as entrance exams and the selection of elective majors.Simultaneously,they embark on integrating their ongoing learning tasks with their ideal aspirations to lay the groundwork for future career development.Against this backdrop,the significance of career exploration and understanding future developmental directions becomes particularly pronounced.To investigate the intricate relationship between career exploration and the clarity of one’s future work-self,along with the moderating role of proactive personality,this study employed the career exploration scale,proactive personality scale,and clarity of future work-self scale.Data from 457 high school students were collected,revealing a substantial positive correlation between career exploration and both future work self-clarity and proactive personality.Adjusting for gender and age highlighted proactive personality as a regulatory factor influencing the relationship between career exploration and future work self-clarity.Furthermore,the results underscored the crucial moderating role of proactive personality in shaping the connection between career exploration and the clarity of future work-self.In-depth analysis revealed noteworthy interactions,particularly with the environmental exploration dimension(standard coefficient of 0.849,p<0.001).Similarly,interactions with self-exploration,goal-system exploration,and information quantity dimensions were also significant,featuring standard coefficients of 0.905(p=0.002),0.935(p<0.001),and 0.854(p<0.001),respectively.In essence,these findings illuminate the nuanced dynamics at play,emphasizing the amplified connection between career exploration and the clarity of future work-self in the presence of higher proactive personality levels.This insight holds implications for educators,counselors,and researchers invested in fostering comprehensive career development strategies for adolescents.
文摘Subcritical reactors(SCRs)or subcritical assemblies(SCAs)are the main infrastructure for designing power reactors.These reactors are widely used for training and research because of their high level of inherent safety.The objective of this study is to design a subcritical reactor using a pressurized water reactor(PWR)conventional fuel following two safety points.In the first approach,deeply placed SCR cores with an infinite multiplication factor(k_(∞))of less than unity were identified using the DRAGON lattice code.In the second approach,subcritical reactor cores with an effective multiplication factor(k_(eff))of less than unity were determined by coupling the cell calculations of the DRAGON lattice code and core calculations of the DONJON code.For the deeply subcritical reactor design,it was found that the reactor would remain inherently subcritical while using fuel rods with ^(235)U enrichment of up to 0.9%,regardless of the pitch of the fuel rods.In the second approach,the optimal pitches(1.3 to 2.3 cm)were determined for different fuel enrichment values from 1 to 5%.Subsequently,the k_(eff) was obtained for a fuel rod arrangement of 8×8 to 80×80,and the states in which the reactor would be subcritical were determined for different fuel enrichments at the corresponding optimal pitch.To validate the models used in the DRAGON and DONJON codes,the k_(eff) of the Isfahan Light Water Subcritical Reactor(LWSCR)was experimentally measured and compared with the results of the calculations.Finally,the effects of fuel and moderator temperature changes were investigated to ensure that the designed assemblies remained in the subcritical state at all operational temperatures.
基金Supported by National Natural Science Foundation of China (10105003)
文摘In boron neutron capture therapy （BNCT）, the ratio of the fast neutron flux to the neutron flux in the tumor （RFNT） must be less than 3% If a D-T neutron generator is used in BNCT, the 14 MeV neutron moderator must be optimized to reduce the RFNT. Based on the neutron moderation theory and the simulation results, tungsten, lead and diamond were used to moderate the 14 MeV neutrons. Satisfying RFNT of less than 3%, the maximum neutron flux in the tumor was achieved with a three-layer moderator comprised of a 3 cm thick tungsten layer, a 14 cm thick lead layer and a 21 cm thick diamond layer.
文摘Conflicting results from previous research relating information technology （IT） investments and firm performance suggest that there is no direct relationship between IT investments and firm performance. The resource-based view （RBV） of the firm is introduced as a research tool to examine how IT resources and capabilities affect firm performance. A theoretical rationale model is then used to investigate the relationship between IT investment and firm performance. The IT capability is assumed to be an important moderator variable rather than a mediator variable linking IT investments to firm performance, while the time period, the firm size, and the industry type, all recognized as factors influencing performance, are treated as control variables. The model and hypotheses are verified by sample data from leading IT firms in China. The data confirms the moderating effect of the IT capability.
基金supported by the Anhui Agricultural University Foundation for Stability and Introduction of Talent(rc352111)the Natural Science Research Project in Anhui Universities(2023AH051046)+2 种基金the Anhui Provincial Natural Science Foundation(2108085MC118)the Special Fund for Anhui Provincial Academic and Technological Leader(2021D297)the Special Fund for Anhui Agriculture Research System(AHCYJSTX-NCPJG)。
文摘This study employed integrated metabolomic and transcriptomic analyses to investigate the impacts of moderate withering(approximately 30%weight loss)on organic acid and flavonoid accumulation in blueberries and the resultant blueberry wines.Moderate withering led to decreases in aliphatic organic acids but increases in phenolic acids and flavonoids in blueberries.The decrease in malate could be linked to the downregulated VcMDH and VcDTC,and the decrease in citrate and 2-oxoglutarate could be a consequence of y-aminobutyric acid shunt activation.The increases of phenolic acids were associated with upregulated VcCAD and VcPOD in withered blueberries.Additionally,moderate withering upregulated the expression of VcLAR and VcUFGT,promoting flavonoid accumulation.In blueberry wines,moderate withering decreased total aliphatic organic acid content but increased anthocyanin content,consistent with the findings in blueberries.Overall,this study provided references for applying moderate withering in blueberry winemaking,contributing to modulating acidity and enriching phenolic substances.
基金Under the auspices of Fundamental Research Funds for the Central Universities,Zhongnan University of Economics and Law,China(No.2722021EG001)。
文摘In the evolving global economy,China’s Outward Foreign Direct Investment(OFDI)holds increasing significance,specially within the context of the Belt and Road Initiative(BRI).Despite earlier studies have acknowledged the role of governance quality in at-tracting Chinese OFDI,their explanatory capacity regarding human development has not received sufficient attention.This study ad-dresses this gap,investigating the relationship between Chinese OFDI and human development,emphasizing the governance quality’s moderating role.Using data from 122 BRI countries from 2004 to 2021,we employed the Panel Corrected Standard Error model through Prais-Winsten regression,complimented by robustness check via the Spatial Durbin Model.Our analysis revealed a significant positive relationship between Chinese OFDI and human development in BRI countries,indicating that Chinese investments act as cata-lysts for improved well-being.More importantly,governance quality plays a vital role in shaping this relationship,revealing that effect-ive governance enhanced the human development outcomes of OFDI.Post-hoc analysis of governance indicators,both as a composite index and individual dimensions,supported this finding.Regional heterogeneity analysis further showed that Chinese OFDI has stronger effects on Human Development Index(HDI)in Asia and Africa compared to Europe,Latin America,and Oceania.However,the moder-ating effect of governance quality seemed more prominent in Oceania and Latin America,indicating its role in fostering the benefits of Chinese investments in these regions.These findings hold implications for academia and policy,emphasizing the need for transparent,accountable,and effective governance to drive sustainable and inclusive human development within the BRI framework.
文摘Background:Depression is prevalent among female college students,with eating behavior potentially related to this issue.This study examines the relationship between eating behavior and depression,focusing on the role of social appearance anxiety and physical activity.Methods:We recruited 2161 female college students from nine universities in China via convenience sampling.Data was collected via an online questionnaire.Eating behavior was assessed via the Eating Behavior Scale short form(EBS-SF),depression was measured via the Center for Epidemiological Studies Depression Scale(CES-D),social appearance anxiety was evaluated via the Social Appearance Anxiety Scale,and physical activity was assessed via a single-item question.Descriptive statistics were analyzed via SPSS 26.0,and moderated mediation analysis was conducted via PROCESS version 3.5.Results:Unhealthy eating behavior was significantly associated with higher levels of depression(β=0.285,p<0.001).Social appearance anxiety mediated this relationship,accounting for 46%of the total effect(β=0.132,95%CI=[0.108,0.158]).The interaction effect between eating behavior and physical activity was significantly and negatively correlated with depression(β=−0.052,p<0.01).The association between eating behavior and depression was stronger under conditions of low physical activity(β=0.210,p<0.001)than under conditions of high physical activity(β=0.105,p<0.001).Conclusions:Integrating nutritional guidance,body image acceptance training,and exercise promotion into campus mental health programs is crucial for addressing depression in female college students.Future research should use longitudinal designs and broader participant ranges to increase the general applicability of the findings.
基金supported by the National Key Research and Development Project(2022YFA1104500 to JX)the National Natural Science Foundation of China(82020108002 and82225005 to JX and 82370277 to HW)+1 种基金the Science and Technology Commission of Shanghai Municipality(23ZR1422900 to HW and 23410750100 to JX)supported by a Biotechnology and Biological Sciences Research Council(BBSRC)International Partnering Award。
文摘Physical activity,moderate aerobic or resistance exercise are well established to offer health benefits and promote healthy aging and longevity.^(1)In contrast,lack of exercise contributes to adverse events,especially in some patients with organ failure.^(2)Therefore,“exercise pills”and“exercise mimetics”have attracted growing interest because of their potential to induce exercise-related health effects despite physical exercise not being performed.^(3)Robust studies over the past decade have identified many natural biomacromolecules,such as peptide,non-coding Ribonucleic Acid(RNAs),and lipids,that are induced by exercise.^(4-6)These molecules trigger physiological adaptations,including promotion of cardiomyocyte proliferation,anti-apoptotic capacity,and healthy tissue growth.7However,identifying or designing an exercise pill that mimics the extensive benefits of exercise is still challenging.
基金Under the auspices of the National Natural Science Foundation of China(No.42101342,U2243205)the Third Comprehensive Scientific Expedition to Xinjiang(No.2021XJKK1403)。
文摘Cotton is an important global cash crops that serve as the primary source of natural fiber for textiles.A thorough understand-ing of the long-term variations in cotton cultivation is vital for optimizing cotton cultivation management and promoting the sustainable development of the cotton industry.Xinjiang is the primary cotton-producing region in China.However,long-term data of cotton cultiv-ation areas with high spatial resolution are unavailable for Xinjiang,China.Therefore,this study aimed to identify and map an accurate 30-m cotton cultivation area dataset in Xinjiang from 2000 to 2020 by applying a Random Forest(RF)-based method that integrates Landsat and Moderate Resolution Imaging Spectroradiometer(MODIS)images,and validated the applicability and accuracy of dataset at a large spatial scale.Then,this study analyzed the spatiotemporal variations and influencing factors of cotton cultivation in the study period.The results showed that a high classification accuracy was achieved(overall accuracy>85%,F1>0.80),strongly agreeing with county-level agricultural statistical yearbook data(R2>0.72).Significant spatiotemporal variation in the cotton cultivation areas was found in Xinjiang,with a total increase of 1131.26 kha from 2000 to 2020.Notably,cotton cultivation area in southern Xinjiang expan-ded substantially,with that in Aksu increasing from 20.10%in 2000 to 28.17%in 2020,representing an expansion of 374.29 kha.In northern Xinjiang,the cotton areas in the Tacheng region also exhibited significant increased by almost ten percentage points in the same period.In contrast,cotton cultivation in eastern Xinjiang declined,decreasing from 2.22%in 2000 to merely 0.24%in 2020.Standard deviation ellipse analysis revealed a‘northeast-southwest’spatial distribution,with the centroid consistently located in Aksu and shifting 102.96 km over the 20-yr period.Pearson correlation analysis indicated that socioeconomic factors had a stronger influence on cotton cultivation than climatic factors,with effective irrigation area(r=0.963,P<0.05)and total agricultural machinery power(r=0.823)showing significant positive correlations,whereas climatic variables exhibiting weak associations(r<0.200).These results provide valuable scientific data for informed agricultural management,sustainable development,and policymaking.
基金supported by the National Natural Science Foundation of China(Grant No.11671145)the Science and Technology Commission of Shanghai Municipality(Grant No.18dz2271000).
文摘In this paper,large deviations principle(LDP)and moderate deviations principle(MDP)of record numbers in random walks are studied under certain conditions.The results show that the rate functions of LDP and MDP are different from those of weak record numbers,which are interesting complements of the conclusions by Li and Yao[1].
文摘This article comprehensively reviews research progress in prostate cancer radiation therapy.It provides an overview of fundamental principles,encompassing the disease’s epidemiology,pathological mechanisms,and radiation sensitivity,alongside technological advancements.The clinical application,technological progress,and efficacy evaluation of moderate hypofractionated radiation therapy and ultra hypofractionated radiation therapy are discussed.Diagnostic and monitoring techniques specific to radiation therapy are analyzed,alongside prevailing controversies and challenges.Finally,the review outlines future prospects,including novel radiotherapy techniques,multidisciplinary collaboration trends,and the evolving role of radiation within comprehensive treatment.The findings demonstrate continuous technological and clinical evolution in prostate cancer radiotherapy,yet emphasize the need for further exploration to optimize treatments and improve patient survival and quality of life.
基金supported by the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre and NIHR Applied Research Collaboration East Midlands (ARC EM, (IS-BRC-1215-20010))funded by the National Institute for Health and Care Research Bristol Biomedical Research Centre (IS-BRC-1215-20011)supported by a UKRI research grant (EP/X042464/1)。
文摘Background Higher accelerometer-assessed volume and intensity of physical activity(PA)have been associated with a longer life expectancy but can be difficult to translate into recommended doses of PA.We aimed to:(a)improve interpretability by producing UK Biobank age-referenced centiles for PA volume and intensity;(b)inform public-health messaging by examining how adding recommended quantities of moderate and vigorous PA affect PA volume and intensity.Methods 92,480 UK Biobank participants aged 43-80 years with wrist-worn accelerometer data were included.Average acceleration and intensity gradient were derived as proxies for PA volume and intensity.We generated sex-specific centile curves using Generalized Additive Models for Location Scale and Shape(GAMLSS)and modeled the effect of adding moderate(walking)or vigorous(running)activity on the combined change in the volume and intensity centiles(change in PA profile).Results In men,volume was lower as age increased while intensity was lower after age 55;in women,both volume and intensity were lower as age increased.Adding 150 min of moderate PA weekly(5×30 min walking)increased the PA profile by 4 percentage points.Defining moderate PA as brisk walking approximately doubled the increase(9 percentage points)while 75 min of vigorous PA weekly(5×15 min running)trebled the increase(13 percentage points).Conclusion These UK Biobank reference centiles provide a benchmark for interpretation of accelerometer data.Application of our translational methods demonstrate that meeting PA guidelines through shorter duration vigorous activity is more beneficial to the PA profile(volume and intensity)than longer duration moderate activity.
文摘On March 14,2025,the Centre for China and Globalisation(CCG)held its first VIP Luncheon of the year at the Beijing International Club.The event was moderated by CCG President Wang Huiyao and brought together over 50 Chinese and international vips,including ambassadors from 17 countries,senior diplomats from 8 countries,as well as representatives from international organisations and chambers of commerce,corporate executives,and prominent media professionals.
