Numerous clustering algorithms are valuable in pattern recognition in forest vegetation,with new ones continually being proposed.While some are well-known,others are underutilized in vegetation science.This study comp...Numerous clustering algorithms are valuable in pattern recognition in forest vegetation,with new ones continually being proposed.While some are well-known,others are underutilized in vegetation science.This study compares the performance of practical iterative reallocation algorithms with model-based clustering algorithms.The data is from forest vegetation in Virginia(United States),the Hyrcanian Forest(Asia),and European beech forests.Practical iterative reallocation algorithms were applied as non-hierarchical methods and Finite Gaussian mixture modeling was used as a model-based clustering method.Due to limitations on dimensionality in model-based clustering,principal coordinates analysis was employed to reduce the dataset’s dimensions.A log transformation was applied to achieve a normal distribution for the pseudo-species data before calculating the Bray-Curtis dissimilarity.The findings indicate that the reallocation of misclassified objects based on silhouette width(OPTSIL)with Flexible-β(-0.25)had the highest mean among the tested clustering algorithms with Silhouette width 1(REMOS1)with Flexible-β(-0.25)second.However,model-based clustering performed poorly.Based on these results,it is recommended using OPTSIL with Flexible-β(-0.25)and REMOS1 with Flexible-β(-0.25)for forest vegetation classification instead of model-based clustering particularly for heterogeneous datasets common in forest vegetation community data.展开更多
Unlike traditional propeller-driven underwater vehicles,blended-wing-body underwater gliders(BWBUGs)achieve zigzag gliding through periodic adjustments of their net buoyancy,enhancing their cruising capabilities while...Unlike traditional propeller-driven underwater vehicles,blended-wing-body underwater gliders(BWBUGs)achieve zigzag gliding through periodic adjustments of their net buoyancy,enhancing their cruising capabilities while mini-mizing energy consumption.However,enhancing gliding performance is challenging due to the complex system design and limited design experience.To address this challenge,this paper introduces a model-based,multidisciplinary system design optimization method for BWBUGs at the conceptual design stage.First,a model-based,multidisciplinary co-simulation design framework is established to evaluate both system-level and disciplinary indices of BWBUG performance.A data-driven,many-objective multidisciplinary optimization is subsequently employed to explore the design space,yielding 32 Pareto optimal solutions.Finally,a model-based physical system simulation,which represents the design with the largest hyper-volume contribution among the 32 final designs,is established.Its gliding perfor-mance,validated by component behavior,lays the groundwork for constructing the entire system’s digital prototype.In conclusion,this model-based,multidisciplinary design optimization method effectively generates design schemes for innovative underwater vehicles,facilitating the development of digital prototypes.展开更多
有许多软件可以帮助分子生物学工作者解决一些他们日常实验室工作中遇到的问题。Vector NTI Su ite是一种高度集成、功能齐全的分子生物学应用软件,它可以对核酸、蛋白质等分子进行大量的操作和分析,以及建立和管理生物数据库。重点对Ve...有许多软件可以帮助分子生物学工作者解决一些他们日常实验室工作中遇到的问题。Vector NTI Su ite是一种高度集成、功能齐全的分子生物学应用软件,它可以对核酸、蛋白质等分子进行大量的操作和分析,以及建立和管理生物数据库。重点对Vector NTI Su ite软件的概况、应用现状及其在分子生物学领域的应用进行综述与探讨。展开更多
A tablet consisting of direct-acting antiviral agents,ledipasvir（a NS5 A protein inhibitor） and sofosbuvir（a NS5 B polymerase inhibitor）,is the first fixed-dose preparation used in the antiviral therapy of hepatit...A tablet consisting of direct-acting antiviral agents,ledipasvir（a NS5 A protein inhibitor） and sofosbuvir（a NS5 B polymerase inhibitor）,is the first fixed-dose preparation used in the antiviral therapy of hepatitis C.A model-based meta-analysis of ledipasvir and GS331007,the primary metabolite of sofosbuvir,enabled the integration of pharmacokinetic（PK） information from separate clinical trials and the quantitative characterization of the population pharmacokinetics of these two drugs.A systematic publication search was conducted for the clinical studies of ledipasvir and sofosbuvir.A total of 401 arm-level aggregate concentrations of GS331007 and 188 concentrations of ledipasvir were used for PK modeling.A two-compartment disposition model was used for both ledipasvir and GS331007.Zero-order absorption was applied for ledipasvir PK modeling,and a combined zero- and first-order absorption was used for the modeling of GS331007.Absorption lag was observed in concentration-time profiles of both ledipasvir and GS331007.To aid the development of direct-acting antiviral drugs,our established PK models provided a basis for the further PK-viral kinetic studies of ledipasvir and sofosbuvir.展开更多
本刊讯5月22日，CA宣布推出新版本的AllFusion Modeling Suite建模工具，在功能强大的AllFusion Erwin Data Modeler内嵌具有专利的通用的数据建模引擎。通过简化复杂数据库应用的设计、实施和分析，AllFusion Modeling Suite r7将帮助I...本刊讯5月22日，CA宣布推出新版本的AllFusion Modeling Suite建模工具，在功能强大的AllFusion Erwin Data Modeler内嵌具有专利的通用的数据建模引擎。通过简化复杂数据库应用的设计、实施和分析，AllFusion Modeling Suite r7将帮助IT部门加快应用交付、提升员工生产力及控制数据库的拥有成本。同时，它还可提供全面的数据库及数据仓库变化的审计记录，促进公司遵从法规并迅速发现问题。展开更多
The condition of rotor system must be assessed in order to develop condition-based maintenance for rotating machinery. It is determined by multiple variables such as unbalance degree, misalignment degree, the amount o...The condition of rotor system must be assessed in order to develop condition-based maintenance for rotating machinery. It is determined by multiple variables such as unbalance degree, misalignment degree, the amount of bending deformation of the shaft, occurrence of shaft crack of rotor system and so on. The estimation of the degrees of unbalance and misalignment in flexible coupling-rotor system is discussed. The model-based approach is employed to solve this problem. The models of the equivalent external loads for unbalance and misalignment are derived and analyzed. Then, the degrees of unbalance and misalignment are estimated by analyzing the components of the equivalent external loads of which the frequencies are equal to the 1 and 2 times running frequency respectively. The equivalent external loads are calculated according to the dynamic equation of the original rotor system and the differences between the dynamical responses in normal case and the vibrations when the degree of unbalance or misalignment or both changes. The denoise method based on bandpass filter is used to decrease the effect of noise on the estimation accuracy. The numerical examples are given to show that the proposed approach can estimate the degrees of unbalance and misalignment of the flexible coupling-rotor system accurately.展开更多
This paper focuses on the use of models for increasing the precision of estimators in large-area forest surveys. It is motivated by the increasing availability of remotely sensed data, which facilitates the developmen...This paper focuses on the use of models for increasing the precision of estimators in large-area forest surveys. It is motivated by the increasing availability of remotely sensed data, which facilitates the development of models predicting the variables of interest in forest surveys. We present, review and compare three different estimation frameworks where models play a core role： model-assisted, model-based, and hybrid estimation. The first two are well known, whereas the third has only recently been introduced in forest surveys. Hybrid inference mixes design- based and model-based inference, since it relies on a probability sample of auxiliary data and a model predicting the target variable from the auxiliary data.We review studies on large-area forest surveys based on model-assisted, model- based, and hybrid estimation, and discuss advantages and disadvantages of the approaches. We conclude that no general recommendations can be made about whether model-assisted, model-based, or hybrid estimation should be preferred. The choice depends on the objective of the survey and the possibilities to acquire appropriate field and remotely sensed data. We also conclude that modelling approaches can only be successfully applied for estimating target variables such as growing stock volume or biomass, which are adequately related to commonly available remotely sensed data, and thus purely field based surveys remain important for several important forest parameters.展开更多
In previous researches on a model-based diagnostic system, the components are assumed mutually independent. Howerver , the assumption is not always the case because the information about whether a component is faulty ...In previous researches on a model-based diagnostic system, the components are assumed mutually independent. Howerver , the assumption is not always the case because the information about whether a component is faulty or not usually influences our knowledge about other components. Some experts may draw such a conclusion that 'if component m 1 is faulty, then component m 2 may be faulty too'. How can we use this experts' knowledge to aid the diagnosis? Based on Kohlas's probabilistic assumption-based reasoning method, we use Bayes networks to solve this problem. We calculate the posterior fault probability of the components in the observation state. The result is reasonable and reflects the effectiveness of the experts' knowledge.展开更多
基金financially supported by the vice chancellor for research and technology of Urmia University
文摘Numerous clustering algorithms are valuable in pattern recognition in forest vegetation,with new ones continually being proposed.While some are well-known,others are underutilized in vegetation science.This study compares the performance of practical iterative reallocation algorithms with model-based clustering algorithms.The data is from forest vegetation in Virginia(United States),the Hyrcanian Forest(Asia),and European beech forests.Practical iterative reallocation algorithms were applied as non-hierarchical methods and Finite Gaussian mixture modeling was used as a model-based clustering method.Due to limitations on dimensionality in model-based clustering,principal coordinates analysis was employed to reduce the dataset’s dimensions.A log transformation was applied to achieve a normal distribution for the pseudo-species data before calculating the Bray-Curtis dissimilarity.The findings indicate that the reallocation of misclassified objects based on silhouette width(OPTSIL)with Flexible-β(-0.25)had the highest mean among the tested clustering algorithms with Silhouette width 1(REMOS1)with Flexible-β(-0.25)second.However,model-based clustering performed poorly.Based on these results,it is recommended using OPTSIL with Flexible-β(-0.25)and REMOS1 with Flexible-β(-0.25)for forest vegetation classification instead of model-based clustering particularly for heterogeneous datasets common in forest vegetation community data.
基金supported by the Postdoctoral Fellowship Program of CPSF(Grant No.GZC20242194)the National Natural Science Foundation of China(Grant Nos.52175251 and 52205268)+1 种基金the Industry Key Technology Research Fund Project of Northwestern Polytechnical University(Grant No.HYGJXM202318)the National Basic Scientific Research Program(Grant No.JCKY2021206B005).
文摘Unlike traditional propeller-driven underwater vehicles,blended-wing-body underwater gliders(BWBUGs)achieve zigzag gliding through periodic adjustments of their net buoyancy,enhancing their cruising capabilities while mini-mizing energy consumption.However,enhancing gliding performance is challenging due to the complex system design and limited design experience.To address this challenge,this paper introduces a model-based,multidisciplinary system design optimization method for BWBUGs at the conceptual design stage.First,a model-based,multidisciplinary co-simulation design framework is established to evaluate both system-level and disciplinary indices of BWBUG performance.A data-driven,many-objective multidisciplinary optimization is subsequently employed to explore the design space,yielding 32 Pareto optimal solutions.Finally,a model-based physical system simulation,which represents the design with the largest hyper-volume contribution among the 32 final designs,is established.Its gliding perfor-mance,validated by component behavior,lays the groundwork for constructing the entire system’s digital prototype.In conclusion,this model-based,multidisciplinary design optimization method effectively generates design schemes for innovative underwater vehicles,facilitating the development of digital prototypes.
文摘有许多软件可以帮助分子生物学工作者解决一些他们日常实验室工作中遇到的问题。Vector NTI Su ite是一种高度集成、功能齐全的分子生物学应用软件,它可以对核酸、蛋白质等分子进行大量的操作和分析,以及建立和管理生物数据库。重点对Vector NTI Su ite软件的概况、应用现状及其在分子生物学领域的应用进行综述与探讨。
基金Janssen Research & DevelopmentChina，Pfizer Scholarship for Pharmacometrics during this project
文摘A tablet consisting of direct-acting antiviral agents,ledipasvir（a NS5 A protein inhibitor） and sofosbuvir（a NS5 B polymerase inhibitor）,is the first fixed-dose preparation used in the antiviral therapy of hepatitis C.A model-based meta-analysis of ledipasvir and GS331007,the primary metabolite of sofosbuvir,enabled the integration of pharmacokinetic（PK） information from separate clinical trials and the quantitative characterization of the population pharmacokinetics of these two drugs.A systematic publication search was conducted for the clinical studies of ledipasvir and sofosbuvir.A total of 401 arm-level aggregate concentrations of GS331007 and 188 concentrations of ledipasvir were used for PK modeling.A two-compartment disposition model was used for both ledipasvir and GS331007.Zero-order absorption was applied for ledipasvir PK modeling,and a combined zero- and first-order absorption was used for the modeling of GS331007.Absorption lag was observed in concentration-time profiles of both ledipasvir and GS331007.To aid the development of direct-acting antiviral drugs,our established PK models provided a basis for the further PK-viral kinetic studies of ledipasvir and sofosbuvir.
文摘本刊讯5月22日，CA宣布推出新版本的AllFusion Modeling Suite建模工具，在功能强大的AllFusion Erwin Data Modeler内嵌具有专利的通用的数据建模引擎。通过简化复杂数据库应用的设计、实施和分析，AllFusion Modeling Suite r7将帮助IT部门加快应用交付、提升员工生产力及控制数据库的拥有成本。同时，它还可提供全面的数据库及数据仓库变化的审计记录，促进公司遵从法规并迅速发现问题。
基金supported by National Natural Science Foundation of China(Grant No. 10772061)Heilongjiang Provincial Natural Science Foundation of China(Grant No. ZJG0704)
文摘The condition of rotor system must be assessed in order to develop condition-based maintenance for rotating machinery. It is determined by multiple variables such as unbalance degree, misalignment degree, the amount of bending deformation of the shaft, occurrence of shaft crack of rotor system and so on. The estimation of the degrees of unbalance and misalignment in flexible coupling-rotor system is discussed. The model-based approach is employed to solve this problem. The models of the equivalent external loads for unbalance and misalignment are derived and analyzed. Then, the degrees of unbalance and misalignment are estimated by analyzing the components of the equivalent external loads of which the frequencies are equal to the 1 and 2 times running frequency respectively. The equivalent external loads are calculated according to the dynamic equation of the original rotor system and the differences between the dynamical responses in normal case and the vibrations when the degree of unbalance or misalignment or both changes. The denoise method based on bandpass filter is used to decrease the effect of noise on the estimation accuracy. The numerical examples are given to show that the proposed approach can estimate the degrees of unbalance and misalignment of the flexible coupling-rotor system accurately.
文摘This paper focuses on the use of models for increasing the precision of estimators in large-area forest surveys. It is motivated by the increasing availability of remotely sensed data, which facilitates the development of models predicting the variables of interest in forest surveys. We present, review and compare three different estimation frameworks where models play a core role： model-assisted, model-based, and hybrid estimation. The first two are well known, whereas the third has only recently been introduced in forest surveys. Hybrid inference mixes design- based and model-based inference, since it relies on a probability sample of auxiliary data and a model predicting the target variable from the auxiliary data.We review studies on large-area forest surveys based on model-assisted, model- based, and hybrid estimation, and discuss advantages and disadvantages of the approaches. We conclude that no general recommendations can be made about whether model-assisted, model-based, or hybrid estimation should be preferred. The choice depends on the objective of the survey and the possibilities to acquire appropriate field and remotely sensed data. We also conclude that modelling approaches can only be successfully applied for estimating target variables such as growing stock volume or biomass, which are adequately related to commonly available remotely sensed data, and thus purely field based surveys remain important for several important forest parameters.
文摘In previous researches on a model-based diagnostic system, the components are assumed mutually independent. Howerver , the assumption is not always the case because the information about whether a component is faulty or not usually influences our knowledge about other components. Some experts may draw such a conclusion that 'if component m 1 is faulty, then component m 2 may be faulty too'. How can we use this experts' knowledge to aid the diagnosis? Based on Kohlas's probabilistic assumption-based reasoning method, we use Bayes networks to solve this problem. We calculate the posterior fault probability of the components in the observation state. The result is reasonable and reflects the effectiveness of the experts' knowledge.
