Objectives:Due to systematic side effects,there is a growing interest in nanoparticle formulation of anticancer drugs.Here,we aimed to synthesize poly(styrene-alt-maleic anhydride)cross-linked by melamine(PSMA/Me)and ...Objectives:Due to systematic side effects,there is a growing interest in nanoparticle formulation of anticancer drugs.Here,we aimed to synthesize poly(styrene-alt-maleic anhydride)cross-linked by melamine(PSMA/Me)and coated with magnetite nanoparticles(MNPs)PSMA/Me/Fe_(3)O_(4).In addition,we aimed to load paclitaxel(PTX)into PSMA/Me/Fe_(3)O_(4)for drug delivery and anticancer investigations.Methods:Novel PSMA/Me was synthesized via free radical copolymerization,coated with Fe_(3)O_(4),and then used as a transporter for PTX delivery.Fabricated copolymer was characterized using SEM,TGA,and XRD techniques.Drug release rate and loading efficiency were investigated.Human ovarian cancer cells(Skov-3)and breast cancer cells(MCF-7 cells)were incubated with the serial concentration of either free PTX or PSMA/Me/Fe_(3)O_(4)/PTX for cell viability and IC_(50)analysis for 24 and 48 h.Results:Characterization methods confirmed PSMA/Me copolymer formation.The results showed a significant encapsulation efficiency of 83%.The drug release analysis exhibited that PSMA/Me/Fe_(3)O_(4)/PTX may be considered pH-sensitive nanocarriers.PSMA/Me/Fe_(3)O_(4)/PTX reduced cell viability both dose and time-dependently(p<0.05).IC50 values of PSMA/Me/Fe_(3)O_(4)/PTX were low when compared to free PTX either 24 or 48 h post-treatment.Conclusions:Our results indicated that PSMA/Me/Fe_(3)O_(4)/PTX was more cytotoxic than PTX in both cancer cells.Findings indicated the potential of PSMA/Me/Fe_(3)O_(4)/PTX as an anticancer nanocarrier system.展开更多
Although advanced anode materials for the lithium-ion battery have been investigated for decades,a reliable,high-capacity,and durable material that can enable a fast charge remains elusive.Herein,we report that a meta...Although advanced anode materials for the lithium-ion battery have been investigated for decades,a reliable,high-capacity,and durable material that can enable a fast charge remains elusive.Herein,we report that a metal phosphorous trichalcogenide of MnPS_(3)(manganese phosphorus trisulfide),endowed with a unique and layered van der Waals structure,is highly beneficial for the fast insertion/extraction of alkali metal ions and can facilitate changes in the buffer volume during cycles with robust structural stability.The few-layered MnPS_(3)anodes displayed the desirable specific capacity and excellent rate chargeability owing to their good electronic and ionic conductivities.When assembled as a half-cell lithium-ion battery,a high reversible capacity of 380 mA h g^(−1)was maintained by the MnPS_(3)after 3000 cycles at a high current density of 4 A g^(−1),with a capacity retention of close to or above 100%.In full-cell testing,a reversible capacity of 450 mA h g^(−1)after 200 cycles was maintained as well.The results of in-situ TEM revealed that MnPS_(3)nanoflakes maintained a high structural integrity without exhibiting any pulverization after undergoing large volumetric expansion for the insertion of a large number of lithium ions.Their kinetics of lithium-ion diffusion,stable structure,and high pseudocapacitance contributed to their comprehensive performance,for example,a high specific capacity,rapid charge-discharge,and long cyclability.MnPS_(3)is thus an efficient anode for the next generation of batteries with a fast charge/discharge capability.展开更多
The intercalation of 4-methyl pyridine （4-picoline） into layered semiconductive material （MnPS3） and the stability of the resulting materials in corrosive environments （water, HCI and open atmosphere） were inves...The intercalation of 4-methyl pyridine （4-picoline） into layered semiconductive material （MnPS3） and the stability of the resulting materials in corrosive environments （water, HCI and open atmosphere） were investigated. Powder X-ray diffraction （XRD） indicated that the presence of water and hydrochloric acid greatly influenced the existing form of intercalation and its orientation in the interlayer of the host. Atmospheric environment （open air） affected the vip orientation in the interlayer of the host material. Phase transformation occurred and the material was stable. The intercalated compounds could be indexed in the trigonal unit cell. The XRD patterns exhibited sharp hkl reflections of the intercalated compounds, which formed in water and HCI, confirming that the materials were well crystalline and stable in corrosive environments.展开更多
With the rapid improvements in nanomaterials and imaging technology,great progresses have been made in diagnosis and treatment of diseases during the pastdecades.Fe_(3)O_(4) magnetic nanoparticles(MNPs)with good bioco...With the rapid improvements in nanomaterials and imaging technology,great progresses have been made in diagnosis and treatment of diseases during the pastdecades.Fe_(3)O_(4) magnetic nanoparticles(MNPs)with good biocompatibility and super-paramagnetic property are usually used as contrast agent for diagnosis of diseases inmagnetic resonance imaging(MRI).Currently,the combination of multiple imagingtechnologies has been considered as new tendency in diagnosis and treatment ofdiseases,which could enhance the accuracy and reliability of disease diagnosis andprovide new strategies for disease treatment.Therefore,novel contrast agents used formultifunctional imaging are urgently needed.Fe_(3)O_(4) MNPs are believed to be a potentialcandidate for construction of multifunctional platform in diagnosis and treatment ofdiseases.In recent years,there are a plethora of studies concerning the construction ofmultifunctional platform presented based on Fe_(3)O_(4) MNPs.In this review,we introducefabrication methods and modification strategies of Fe_(3)O_(4) MNPs,expecting greatimprovements for diagnosis and treatment of diseases in the future.展开更多
文摘Objectives:Due to systematic side effects,there is a growing interest in nanoparticle formulation of anticancer drugs.Here,we aimed to synthesize poly(styrene-alt-maleic anhydride)cross-linked by melamine(PSMA/Me)and coated with magnetite nanoparticles(MNPs)PSMA/Me/Fe_(3)O_(4).In addition,we aimed to load paclitaxel(PTX)into PSMA/Me/Fe_(3)O_(4)for drug delivery and anticancer investigations.Methods:Novel PSMA/Me was synthesized via free radical copolymerization,coated with Fe_(3)O_(4),and then used as a transporter for PTX delivery.Fabricated copolymer was characterized using SEM,TGA,and XRD techniques.Drug release rate and loading efficiency were investigated.Human ovarian cancer cells(Skov-3)and breast cancer cells(MCF-7 cells)were incubated with the serial concentration of either free PTX or PSMA/Me/Fe_(3)O_(4)/PTX for cell viability and IC_(50)analysis for 24 and 48 h.Results:Characterization methods confirmed PSMA/Me copolymer formation.The results showed a significant encapsulation efficiency of 83%.The drug release analysis exhibited that PSMA/Me/Fe_(3)O_(4)/PTX may be considered pH-sensitive nanocarriers.PSMA/Me/Fe_(3)O_(4)/PTX reduced cell viability both dose and time-dependently(p<0.05).IC50 values of PSMA/Me/Fe_(3)O_(4)/PTX were low when compared to free PTX either 24 or 48 h post-treatment.Conclusions:Our results indicated that PSMA/Me/Fe_(3)O_(4)/PTX was more cytotoxic than PTX in both cancer cells.Findings indicated the potential of PSMA/Me/Fe_(3)O_(4)/PTX as an anticancer nanocarrier system.
基金National Natural Science Foundation of China,Grant/Award Numbers:11902185,11972219,U21A2086National Key Research and Development Program of China,Grant/Award Number:2020YFB0704503+1 种基金Young Elite Scientist Sponsorship Program by CAST,Grant/Award Number:2019QNRC001Shanghai Sailing Program,Grant/Award Number:19YF1415100。
文摘Although advanced anode materials for the lithium-ion battery have been investigated for decades,a reliable,high-capacity,and durable material that can enable a fast charge remains elusive.Herein,we report that a metal phosphorous trichalcogenide of MnPS_(3)(manganese phosphorus trisulfide),endowed with a unique and layered van der Waals structure,is highly beneficial for the fast insertion/extraction of alkali metal ions and can facilitate changes in the buffer volume during cycles with robust structural stability.The few-layered MnPS_(3)anodes displayed the desirable specific capacity and excellent rate chargeability owing to their good electronic and ionic conductivities.When assembled as a half-cell lithium-ion battery,a high reversible capacity of 380 mA h g^(−1)was maintained by the MnPS_(3)after 3000 cycles at a high current density of 4 A g^(−1),with a capacity retention of close to or above 100%.In full-cell testing,a reversible capacity of 450 mA h g^(−1)after 200 cycles was maintained as well.The results of in-situ TEM revealed that MnPS_(3)nanoflakes maintained a high structural integrity without exhibiting any pulverization after undergoing large volumetric expansion for the insertion of a large number of lithium ions.Their kinetics of lithium-ion diffusion,stable structure,and high pseudocapacitance contributed to their comprehensive performance,for example,a high specific capacity,rapid charge-discharge,and long cyclability.MnPS_(3)is thus an efficient anode for the next generation of batteries with a fast charge/discharge capability.
文摘The intercalation of 4-methyl pyridine （4-picoline） into layered semiconductive material （MnPS3） and the stability of the resulting materials in corrosive environments （water, HCI and open atmosphere） were investigated. Powder X-ray diffraction （XRD） indicated that the presence of water and hydrochloric acid greatly influenced the existing form of intercalation and its orientation in the interlayer of the host. Atmospheric environment （open air） affected the vip orientation in the interlayer of the host material. Phase transformation occurred and the material was stable. The intercalated compounds could be indexed in the trigonal unit cell. The XRD patterns exhibited sharp hkl reflections of the intercalated compounds, which formed in water and HCI, confirming that the materials were well crystalline and stable in corrosive environments.
基金supported by the National Natural Science Foundation of China(Grant Nos.11502158,11632013 and 11802197)The support of the Shanxi Provincial Key Research and Development Project,China(Grant Nos.201803D421060,201903D421064 and 201803D421076)+1 种基金the Natural Science Foundation of Shanxi Province,China(201901D111078 and 201901D111077)the Shanxi ScholarshipCouncil of China(No.HGKY2019037)are also acknowledged withgratitude.
文摘With the rapid improvements in nanomaterials and imaging technology,great progresses have been made in diagnosis and treatment of diseases during the pastdecades.Fe_(3)O_(4) magnetic nanoparticles(MNPs)with good biocompatibility and super-paramagnetic property are usually used as contrast agent for diagnosis of diseases inmagnetic resonance imaging(MRI).Currently,the combination of multiple imagingtechnologies has been considered as new tendency in diagnosis and treatment ofdiseases,which could enhance the accuracy and reliability of disease diagnosis andprovide new strategies for disease treatment.Therefore,novel contrast agents used formultifunctional imaging are urgently needed.Fe_(3)O_(4) MNPs are believed to be a potentialcandidate for construction of multifunctional platform in diagnosis and treatment ofdiseases.In recent years,there are a plethora of studies concerning the construction ofmultifunctional platform presented based on Fe_(3)O_(4) MNPs.In this review,we introducefabrication methods and modification strategies of Fe_(3)O_(4) MNPs,expecting greatimprovements for diagnosis and treatment of diseases in the future.
