BACKGROUND Mixed-phenotype acute leukemia(MPAL)is characterized by acute undifferentiated leukemia with blasts co-expressing myeloid and lymphoid antigens.However,consensus regarding the ideal management strategy for ...BACKGROUND Mixed-phenotype acute leukemia(MPAL)is characterized by acute undifferentiated leukemia with blasts co-expressing myeloid and lymphoid antigens.However,consensus regarding the ideal management strategy for MPAL is yet to be established,owing to its rarity.CASE SUMMARY A 55-year-old male was diagnosed with T/myeloid MPAL.Vincristine,prednisolone,daunorubicin,and L-asparaginase were administered as induction chemotherapy.Septic shock occurred 10 days after induction,and bone marrow examination following recovery from sepsis revealed refractory disease.Venetoclax and decitabine were administered as chemotherapy-free induction therapy to reduce the infection risk.There were no serious infections,including febrile neutropenia,at the end of the treatment.After receiving two additional cycles of venetoclax/decitabine,the patient underwent haploidentical peripheral blood stem-cell transplantation and achieved complete response(CR)to treatment.CONCLUSION CR was maintained in a patient with MPAL who underwent haploidentical peripheral blood stem-cell transplantation after additional venetoclax/decitabine cycles.展开更多
Background:Mixed-phenotype acute leukemia is a rare,high-risk subtype of acute leukemia.Myeloid sarcoma is a localized tumor formed by the proliferation and infiltration of primitive or immature myeloid cells outside ...Background:Mixed-phenotype acute leukemia is a rare,high-risk subtype of acute leukemia.Myeloid sarcoma is a localized tumor formed by the proliferation and infiltration of primitive or immature myeloid cells outside the bone marrow.It is often an extramedullary man-ifestation of acute myeloid leukemia,and imaging lacks specificity,leading to potential misdiagnosis.Case Presentation:A female patient diagnosed with mixed-phenotype acute leukemia achieved complete remission after chemother-apy and allogeneic hematopoietic stem cell transplantation.However,a relapse occurred in the breast after transplantation.The patient achieved local control through mastectomy and removal of the axillary lymph nodes on the affected side.Unfortunately,during the subse-quent course of chemotherapy,the patient died of a severe pulmonary infection caused by coronavirus disease 2019.Conclusion:Continuous treatment and monitoring of mixed-phenotype acute leukemia patients are essential,especially for those with extramedullary manifestations(such as breast involvement).展开更多
文摘BACKGROUND Mixed-phenotype acute leukemia(MPAL)is characterized by acute undifferentiated leukemia with blasts co-expressing myeloid and lymphoid antigens.However,consensus regarding the ideal management strategy for MPAL is yet to be established,owing to its rarity.CASE SUMMARY A 55-year-old male was diagnosed with T/myeloid MPAL.Vincristine,prednisolone,daunorubicin,and L-asparaginase were administered as induction chemotherapy.Septic shock occurred 10 days after induction,and bone marrow examination following recovery from sepsis revealed refractory disease.Venetoclax and decitabine were administered as chemotherapy-free induction therapy to reduce the infection risk.There were no serious infections,including febrile neutropenia,at the end of the treatment.After receiving two additional cycles of venetoclax/decitabine,the patient underwent haploidentical peripheral blood stem-cell transplantation and achieved complete response(CR)to treatment.CONCLUSION CR was maintained in a patient with MPAL who underwent haploidentical peripheral blood stem-cell transplantation after additional venetoclax/decitabine cycles.
文摘Background:Mixed-phenotype acute leukemia is a rare,high-risk subtype of acute leukemia.Myeloid sarcoma is a localized tumor formed by the proliferation and infiltration of primitive or immature myeloid cells outside the bone marrow.It is often an extramedullary man-ifestation of acute myeloid leukemia,and imaging lacks specificity,leading to potential misdiagnosis.Case Presentation:A female patient diagnosed with mixed-phenotype acute leukemia achieved complete remission after chemother-apy and allogeneic hematopoietic stem cell transplantation.However,a relapse occurred in the breast after transplantation.The patient achieved local control through mastectomy and removal of the axillary lymph nodes on the affected side.Unfortunately,during the subse-quent course of chemotherapy,the patient died of a severe pulmonary infection caused by coronavirus disease 2019.Conclusion:Continuous treatment and monitoring of mixed-phenotype acute leukemia patients are essential,especially for those with extramedullary manifestations(such as breast involvement).
