Objective:To investigate the dynamic trajectory,predictors,and underlying adaptation mechanisms of family resilience(FR)among Chinese families with preterm infants(PIs)from birth to six months.Methods:Guided by Ecolog...Objective:To investigate the dynamic trajectory,predictors,and underlying adaptation mechanisms of family resilience(FR)among Chinese families with preterm infants(PIs)from birth to six months.Methods:Guided by Ecological Systems Theory,a convergent parallel mixed-methods study was conducted in the Neonatal Intensive Care Unit(NICU)of a tertiary hospital in Fujian Province,China,from June 2023 to June 2024.Quantitative data were collected from 202 caregivers selected by convenience sampling at four time points:at birth(T0),42 days postpartum(T1),3 months postpartum(T2),and 6 months postpartum(T3).Generalized Estimating Equations(GEE)was used to analyze scale score differences across time points and explore factors influencing FR.Qualitative data were collected through semi-structured interviews with 14 caregivers recruited by maximum variation purposive sampling and analyzed using Colaizzi’s phenomenological approach.After conducting separate data analyses,the findings were integrated through side-by-side comparison and joint display.Results:Quantitative results revealed a non-linear,“V”-shaped trajectory of FR,significantly influenced by educational level,conception via assisted reproduction,farming occupation,coping style,psychological resilience,family functioning,and social support.Qualitative findings identified four themes:initial uncertainty and emotional distress,post-discharge anxiety,gradual adaptation,and eventual stabilization.Integrated mixed-methods findings revealed that the initial confusion phase demands a comprehensive response to family needs(T0);the post-discharge bottleneck requires addressing the care capability-needs gap(T1);the role adaptation phase is pivotal for enhancing internal family resources(T2);and the family-work transition necessitates enhanced work-family facilitation(T3).Conclusions:This study systematically identifies the unique“V”-shaped trajectory of FR in Chinese families with PIs and its key influencing factors,and accurately analyzes their dynamic experiences and adaptation across four stages.These findings provide an empirical basis for stage-specific targeted interventions,strongly support the practical advancement of the family-centered care model,and deliver critical guidance for enhancing FR.展开更多
Cohort studies are important epidemiological methods to investigate associations between environmental factors,individual characteristics,and disease or other health outcomes.As a paradigm of cohort studies,the Framin...Cohort studies are important epidemiological methods to investigate associations between environmental factors,individual characteristics,and disease or other health outcomes.As a paradigm of cohort studies,the Framingham Heart Study(FHS)is the longest-running cardiovascular epidemiological study,starting in 1948.展开更多
Using comparative molecular field analysis approach, the interaction of 17 tetrahydroprotdederines to D1 reccptor and15 ones to D2 reccptor have ben studied by 3D-QsAR. respectively. The results indicated that the int...Using comparative molecular field analysis approach, the interaction of 17 tetrahydroprotdederines to D1 reccptor and15 ones to D2 reccptor have ben studied by 3D-QsAR. respectively. The results indicated that the interactions of THPBs withdopamine receplors were primarily clectrostatic interactions. with more positive charge in lignnd and more negative in receptor.展开更多
Functional linguistics has exerted an increasing impact on modern linguistic studies.Functional approaches,especially metafunctions have undergone a process of development and improvement.The affirmation of the metafu...Functional linguistics has exerted an increasing impact on modern linguistic studies.Functional approaches,especially metafunctions have undergone a process of development and improvement.The affirmation of the metafunctions of language has aroused more and more scholars'concern on the"functional"facet of language,especially in Translation studies.The formation and improvement of functional approaches are introduced separately.展开更多
Increasing yield is one of the most important goals in crop breeding. Soybean （Glycine max L. Merr.）, one of the most economically important leguminous seed crops, provides the majority of plant proteins, and more t...Increasing yield is one of the most important goals in crop breeding. Soybean （Glycine max L. Merr.）, one of the most economically important leguminous seed crops, provides the majority of plant proteins, and more than a quarter of the world＇s food and animal feed （Graham and Vance, 2003）. The yield of soybean is finally determined by the number of seeds per unit area, which affected by many characters, such as height, branching number, photosynthesis, seed size, seed number. The number of seeds per pod is taken for one of the critical components that related to yield （You et al., 1995）.展开更多
Annual arrhythmic sudden cardiac death ranges from 0.6%to 4%in ischemic cardiomyopathy(ICM),1%to 2%in non-ischemic cardiomyopathy(NICM),and 1%in hypertrophic cardiomyopathy(HCM).Towards a more effective arrhythmic ris...Annual arrhythmic sudden cardiac death ranges from 0.6%to 4%in ischemic cardiomyopathy(ICM),1%to 2%in non-ischemic cardiomyopathy(NICM),and 1%in hypertrophic cardiomyopathy(HCM).Towards a more effective arrhythmic risk stratification(ARS)we hereby present a two-step ARS with the usage of seven non-invasive risk factors:Late potentials presence(≥2/3 positive criteria),premature ventricular contractions(≥30/h),non-sustained ventricular tachycardia(≥1episode/24 h),abnormal heart rate turbulence(onset≥0%and slope≤2.5 ms)and reduced deceleration capacity(≤4.5 ms),abnormal T wave alternans(≥65μV),decreased heart rate variability(SDNN<70ms),and prolonged QT_(c)interval(>440 ms in males and>450 ms in females)which reflect the arrhythmogenic mechanisms for the selection of the intermediate arrhythmic risk patients in the first step.In the second step,these intermediate-risk patients undergo a programmed ventricular stimulation(PVS)for the detection of inducible,truly high-risk ICM and NICM patients,who will benefit from an implantable cardioverter defibrillator.For HCM patients,we also suggest the incorporation of the PVS either for the low HCM Risk-score patients or for the patients with one traditional risk factor in order to improve the inadequate sensitivity of the former and the low specificity of the latter.展开更多
Global change research and sustainable development need to be addressed at larger scales in the light of small scale process studies. Much remains to be done before the small scale, process level understanding of ecos...Global change research and sustainable development need to be addressed at larger scales in the light of small scale process studies. Much remains to be done before the small scale, process level understanding of ecosystem responses to global change can be reliably translated to larger scales. The paper reviews the status of scaling issues and tries to find how to extrapolate our observations and our findings at site scale up to regional scale and provide ecological information and interpretations at the regional scale. An integrated approach to scaling-up from site to region is proposed combining hierarchical theory, landscape ecology, remote sensing, geographical information system (GIS) with process/mechanistic modeling. Remote sensing and GIS will play key roles in spatial analysis, integration as well as cross scale modeling.展开更多
The study of green compression strength of a green sand mould using statistical approach has been undertaken. Empirically generated data in National Metallurgical Development Centre, Jos Sand Testing Laboratory were u...The study of green compression strength of a green sand mould using statistical approach has been undertaken. Empirically generated data in National Metallurgical Development Centre, Jos Sand Testing Laboratory were used for the study. Coefficient of correlation, coefficients of determination and coefficient of multiple determinations were used to explain the relationship existing between the two independent variables of clay and moisture content and green compression strength, the dependent variable. The study showed that the coefficient of determination for Ys: X1 was 0.88 while the coefficient of correlation was 0.94, coefficient of determination for Ys: X2 was 0.90 while the coefficient of correlation was 0.95 and the coefficient of multiple determination was 0.72;these coefficients assisted tremendously in the study of green compression strength. A mathematical model was developed for the prediction of green compression strength;it was tested and proved to be a good estimation tool for estimating green compression strength values on the foundry shop floor. The study has clearly shown that statistical approach is a good tool for studying green compression strength of green sand moulds.展开更多
This research provides an exploration of a biomimetic approach in the process of designing a candelabra model using linear shaped leaves of a Bell flower.The design process described in this research contains two step...This research provides an exploration of a biomimetic approach in the process of designing a candelabra model using linear shaped leaves of a Bell flower.The design process described in this research contains two steps:biological and geometrical.In the first biological step,a proper model for the creation of an urban element was found from nature in a Bell flower(Campanula persicifolia L.).The upper leaves of the selected plant,which are small with a linear spear and sharpening at the top,were chosen for the modeling process.The second step included applying two geometrical methods,i.e.,Voronoi diagrams and Delaunay triangulation.A geometrical leaf form of the selected plant species and the modeling process were obtained using aparametric modeling software,Blender.Using different Blender plug-ins and modifiers,Delaunay triangulation and Voronoi diagram were implemented by marking the starting points on the leaf form in the image data source,adjusting the Delaunay triangulation parameters,and creating Voronoi diagrams in which the Voronoi points were located at the shortest distance from the edges of the Voronoi polygon.Consequently,a three dimensional model of a candelabra was developed through this study.展开更多
The average variational principle was employed in this paper to study the evolution of large-scale and slowly varying Rossby wave packet with basic flow both in barotropic and baroclinic atmospheres. The evolution of ...The average variational principle was employed in this paper to study the evolution of large-scale and slowly varying Rossby wave packet with basic flow both in barotropic and baroclinic atmospheres. The evolution of the structure of Rossby wave packet with both time and space was studied. The results obtained in this paper are similar to the results of by WKBJ method. In addition, the dispersive process of the wave packet was analysed by taking Gaussian type wave packet as an initial disturbance. The valid time scale for application of wave packet theory in the atmosphere was obtained.展开更多
Based on a case study of TESOL approaches applied in several Australian institutions,this paper gives critical analysis of the approaches by comparing them with the one encountered in the situation in which the author...Based on a case study of TESOL approaches applied in several Australian institutions,this paper gives critical analysis of the approaches by comparing them with the one encountered in the situation in which the author has been working.A further implication of those approaches is also examined.展开更多
Objective To design a paramedian supracerebelalr infratentorial keyhole approach by applying the keyhole conception and explore its feasibility. The keyhole approach is imitated and microanatomical structures are obse...Objective To design a paramedian supracerebelalr infratentorial keyhole approach by applying the keyhole conception and explore its feasibility. The keyhole approach is imitated and microanatomical structures are observed,which could be reference of this approach in clinical use. Methods The paramedian展开更多
The U.S.Food and Drug Administration(FDA)'s program documents regarding the animal-free approach for the efficacy,pharmacokinetics,and safety evaluation of new drug preclinical studies have been rolled out gradual...The U.S.Food and Drug Administration(FDA)'s program documents regarding the animal-free approach for the efficacy,pharmacokinetics,and safety evaluation of new drug preclinical studies have been rolled out gradually.This process has taken the FDA seven years.Starting from the reduction of funding for animal of data from organ-on-a-chip solely for pharmacodynamic studies[[1],[2],[3]],to the explicit proposal of the animal-free approach for pharmacodynamic studies in the FDA Modernization Act in Reference[4],and to the indication in 2025 that safety studies should also prioritize safety research data from in vitro microphysiological systems[5],this demonstrates the FDAs determination to gradually achieve the animal-free approach and also signals a profound paradigm shift in the field of drug research and development.This policy direction not only addresses the requirements of ethics and technological advancement but may also reshape the entire new drug development industrial chain.展开更多
We theoretically explore a non-Hermitian superfluid model with complex-valued interaction, inspired by two-body loss stemming from inelastic scattering observed in ultracold atomic experiments. Utilizing both the righ...We theoretically explore a non-Hermitian superfluid model with complex-valued interaction, inspired by two-body loss stemming from inelastic scattering observed in ultracold atomic experiments. Utilizing both the right-eigenstate-based mean-field theory and its biorthogonal counterpart, we study the properties of the system. Notably, the right-eigenstate-based framework produces smooth and continuous solutions, in stark contrast to the absence of nontrivial solutions and the abrupt discontinuities observed in the biorthogonal-eigenstatebased framework under moderate dissipation. In addition, the lower condensation energy obtained in the former framework suggests its superior suitability for describing this system. Furthermore, we explore the impact of backscattering, a crucial factor in realistic systems. Our analysis reveals that, facilitated by two-body loss, even moderate backscattering destabilizes the superfluid state. Sufficiently strong backscattering completely destroys it, highlighting a key mechanism for the fragility of this non-Hermitian quantum phase.展开更多
AIMTo describe the development and validation of a novel neuronavigation-based method, which allows the quan-tification of the anatomical features that define anapproach, as well as real-time visualization of the surg...AIMTo describe the development and validation of a novel neuronavigation-based method, which allows the quan-tification of the anatomical features that define anapproach, as well as real-time visualization of the surgicapyramid. METHODSThe method was initially developed with commercially-available hardware for coordinate collection （a digitizerand a frameless navigation system） and software forvolume rendering; dedicated neuronavigation software （ApproachViewer, part of GTx-UHN） was then developed. The accuracy of measurements and the possibility of volumetric rendering of surgical approaches simulated in a phantom were compared among three different methods and commercially-available radiological software. In the anatomy laboratory, ApproachViewer was applied to the comparative quantitative analysis of multiple neurosurgical approaches and was used by many surgeons who were untrained for the research method.RESULTSThe accuracy of ApproachViewer is comparable to com-mercially-available radiological software. In the anatomy laboratory, the method appears versatile. The system can be easily used after brief training. ApproachViewer allows for real-time evaluation and comparison of surgical approaches, as well as post-dissection analyses of collected data. The accuracy of the method depends on the navigation registration： with a 1-2 mm registration error, it is adequate for evaluation and comparison of most neurosurgical approaches.CONCLUSIONThis new research method and software allows semi-automated visualization, quantifcation, and comparison of neurosurgical approaches in the anatomy laboratory.展开更多
This study compares the subject matter appeared on traditional Thai textbooks and Japanese textbooks and analyzes how extension and integration sequence on Japanese textbooks evokes students＇ mathematical creativity....This study compares the subject matter appeared on traditional Thai textbooks and Japanese textbooks and analyzes how extension and integration sequence on Japanese textbooks evokes students＇ mathematical creativity. The data were collected from the series of four lessons in the fifth grade by teaching experiment methodology conducted following the professional development project implemented lesson study and open approach in Thailand. The results show that extension and integration sequence is an appropriate subject matter to generate lesson for problem-solving classroom. The sequence of lesson leads students to excitement, curiosity, confidence and intimacy in mathematics that are powerful effects of mathematical creativity. Students can produce the different and various ways to solve problems that indicate their divergent thinking.展开更多
Grain size plays a significant role in rice,starting from affecting yield to consumer preference,which is the driving force for deep investigation and improvement of grain size characters.Quantitative inheritance make...Grain size plays a significant role in rice,starting from affecting yield to consumer preference,which is the driving force for deep investigation and improvement of grain size characters.Quantitative inheritance makes these traits complex to breed on account of several alleles contributing to the complete trait expression.We employed genome-wide association study in an association panel of 88 rice genotypes using 142 new candidate gene based SSR(cgSSR)markers,derived from yield-related candidate genes,with the efficient mixed-model association coupled mixed linear model for dissecting complete genetic control of grain size traits.A total of 10 significant associations were identified for four grain size-related characters(grain weight,grain length,grain width,and length-width ratio).Among the identified associations,seven marker trait associations explain more than 10%of the phenotypic variation,indicating major putative QTLs for respective traits.The allelic variations at genes OsBC1L4,SHO1 and OsD2 showed association between 1000-grain weight and grain width,1000-grain weight and grain length,and grain width and length-width ratio,respectively.The cgSSR markers,associated with corresponding traits,can be utilized for direct allelic selection,while other significantly associated cgSSRs may be utilized for allelic accumulation in the breeding programs or grain size improvement.The new cgSSR markers associated with grain size related characters have a significant impact on practical plant breeding to increase the number of causative alleles for these traits through marker aided rice breeding programs.展开更多
Vehicle sounds are important factors of customer satisfaction and have a decisive influence on the product automobile andits quality impression. It becomes more and more important to connect customer requirements and ...Vehicle sounds are important factors of customer satisfaction and have a decisive influence on the product automobile andits quality impression. It becomes more and more important to connect customer requirements and technical specifications to developa vehicle sound with high quality. The turn indicator sound can be described as one sound, which gives the customer an importantfeedback of correct function performance and can be seen as one of the sounds, which play a role in the customer＇s perception ofvehicle quality. In a laboratory experimental study, the question was investigated, how a turn indicator sound must be designed to beperceived as pleasant and high-quality. A multidimensional approach was chosen to combine subjective customer assessments,objective psychophysiological responses of the study participants and physical parameters of the sounds. In total, 15 different tumindicator sounds were assessed by 48 subjects. The study shows how the connection of subjective and objective parameters cansupport product development. The multi-dimensional approach helps to derive recommendations for action to improve the soundquality of the product automobile. Also, the study shows a possibility to involve the human factor in a highly technical environment.展开更多
文摘Objective:To investigate the dynamic trajectory,predictors,and underlying adaptation mechanisms of family resilience(FR)among Chinese families with preterm infants(PIs)from birth to six months.Methods:Guided by Ecological Systems Theory,a convergent parallel mixed-methods study was conducted in the Neonatal Intensive Care Unit(NICU)of a tertiary hospital in Fujian Province,China,from June 2023 to June 2024.Quantitative data were collected from 202 caregivers selected by convenience sampling at four time points:at birth(T0),42 days postpartum(T1),3 months postpartum(T2),and 6 months postpartum(T3).Generalized Estimating Equations(GEE)was used to analyze scale score differences across time points and explore factors influencing FR.Qualitative data were collected through semi-structured interviews with 14 caregivers recruited by maximum variation purposive sampling and analyzed using Colaizzi’s phenomenological approach.After conducting separate data analyses,the findings were integrated through side-by-side comparison and joint display.Results:Quantitative results revealed a non-linear,“V”-shaped trajectory of FR,significantly influenced by educational level,conception via assisted reproduction,farming occupation,coping style,psychological resilience,family functioning,and social support.Qualitative findings identified four themes:initial uncertainty and emotional distress,post-discharge anxiety,gradual adaptation,and eventual stabilization.Integrated mixed-methods findings revealed that the initial confusion phase demands a comprehensive response to family needs(T0);the post-discharge bottleneck requires addressing the care capability-needs gap(T1);the role adaptation phase is pivotal for enhancing internal family resources(T2);and the family-work transition necessitates enhanced work-family facilitation(T3).Conclusions:This study systematically identifies the unique“V”-shaped trajectory of FR in Chinese families with PIs and its key influencing factors,and accurately analyzes their dynamic experiences and adaptation across four stages.These findings provide an empirical basis for stage-specific targeted interventions,strongly support the practical advancement of the family-centered care model,and deliver critical guidance for enhancing FR.
文摘Cohort studies are important epidemiological methods to investigate associations between environmental factors,individual characteristics,and disease or other health outcomes.As a paradigm of cohort studies,the Framingham Heart Study(FHS)is the longest-running cardiovascular epidemiological study,starting in 1948.
文摘Using comparative molecular field analysis approach, the interaction of 17 tetrahydroprotdederines to D1 reccptor and15 ones to D2 reccptor have ben studied by 3D-QsAR. respectively. The results indicated that the interactions of THPBs withdopamine receplors were primarily clectrostatic interactions. with more positive charge in lignnd and more negative in receptor.
文摘Functional linguistics has exerted an increasing impact on modern linguistic studies.Functional approaches,especially metafunctions have undergone a process of development and improvement.The affirmation of the metafunctions of language has aroused more and more scholars'concern on the"functional"facet of language,especially in Translation studies.The formation and improvement of functional approaches are introduced separately.
基金supported by the National Natural Science Foundation of China(Grant Nos.31271297 and 31222042) "One-hundred talents" Startup Funds from Chinese Academy of SciencesNational Key Basic Research Program(No. 2009CB 118402)
文摘Increasing yield is one of the most important goals in crop breeding. Soybean （Glycine max L. Merr.）, one of the most economically important leguminous seed crops, provides the majority of plant proteins, and more than a quarter of the world＇s food and animal feed （Graham and Vance, 2003）. The yield of soybean is finally determined by the number of seeds per unit area, which affected by many characters, such as height, branching number, photosynthesis, seed size, seed number. The number of seeds per pod is taken for one of the critical components that related to yield （You et al., 1995）.
文摘Annual arrhythmic sudden cardiac death ranges from 0.6%to 4%in ischemic cardiomyopathy(ICM),1%to 2%in non-ischemic cardiomyopathy(NICM),and 1%in hypertrophic cardiomyopathy(HCM).Towards a more effective arrhythmic risk stratification(ARS)we hereby present a two-step ARS with the usage of seven non-invasive risk factors:Late potentials presence(≥2/3 positive criteria),premature ventricular contractions(≥30/h),non-sustained ventricular tachycardia(≥1episode/24 h),abnormal heart rate turbulence(onset≥0%and slope≤2.5 ms)and reduced deceleration capacity(≤4.5 ms),abnormal T wave alternans(≥65μV),decreased heart rate variability(SDNN<70ms),and prolonged QT_(c)interval(>440 ms in males and>450 ms in females)which reflect the arrhythmogenic mechanisms for the selection of the intermediate arrhythmic risk patients in the first step.In the second step,these intermediate-risk patients undergo a programmed ventricular stimulation(PVS)for the detection of inducible,truly high-risk ICM and NICM patients,who will benefit from an implantable cardioverter defibrillator.For HCM patients,we also suggest the incorporation of the PVS either for the low HCM Risk-score patients or for the patients with one traditional risk factor in order to improve the inadequate sensitivity of the former and the low specificity of the latter.
基金the Important Directional Project of Knowledge Innovation of the Chinese Academy of Sciences (No: KZCX2-308-4).
文摘Global change research and sustainable development need to be addressed at larger scales in the light of small scale process studies. Much remains to be done before the small scale, process level understanding of ecosystem responses to global change can be reliably translated to larger scales. The paper reviews the status of scaling issues and tries to find how to extrapolate our observations and our findings at site scale up to regional scale and provide ecological information and interpretations at the regional scale. An integrated approach to scaling-up from site to region is proposed combining hierarchical theory, landscape ecology, remote sensing, geographical information system (GIS) with process/mechanistic modeling. Remote sensing and GIS will play key roles in spatial analysis, integration as well as cross scale modeling.
文摘The study of green compression strength of a green sand mould using statistical approach has been undertaken. Empirically generated data in National Metallurgical Development Centre, Jos Sand Testing Laboratory were used for the study. Coefficient of correlation, coefficients of determination and coefficient of multiple determinations were used to explain the relationship existing between the two independent variables of clay and moisture content and green compression strength, the dependent variable. The study showed that the coefficient of determination for Ys: X1 was 0.88 while the coefficient of correlation was 0.94, coefficient of determination for Ys: X2 was 0.90 while the coefficient of correlation was 0.95 and the coefficient of multiple determination was 0.72;these coefficients assisted tremendously in the study of green compression strength. A mathematical model was developed for the prediction of green compression strength;it was tested and proved to be a good estimation tool for estimating green compression strength values on the foundry shop floor. The study has clearly shown that statistical approach is a good tool for studying green compression strength of green sand moulds.
基金The Ministry of Education,Science and Technological Development of the Republic of Serbia,No.TP 36008(451–02-68/2020/14/2000169).
文摘This research provides an exploration of a biomimetic approach in the process of designing a candelabra model using linear shaped leaves of a Bell flower.The design process described in this research contains two steps:biological and geometrical.In the first biological step,a proper model for the creation of an urban element was found from nature in a Bell flower(Campanula persicifolia L.).The upper leaves of the selected plant,which are small with a linear spear and sharpening at the top,were chosen for the modeling process.The second step included applying two geometrical methods,i.e.,Voronoi diagrams and Delaunay triangulation.A geometrical leaf form of the selected plant species and the modeling process were obtained using aparametric modeling software,Blender.Using different Blender plug-ins and modifiers,Delaunay triangulation and Voronoi diagram were implemented by marking the starting points on the leaf form in the image data source,adjusting the Delaunay triangulation parameters,and creating Voronoi diagrams in which the Voronoi points were located at the shortest distance from the edges of the Voronoi polygon.Consequently,a three dimensional model of a candelabra was developed through this study.
文摘The average variational principle was employed in this paper to study the evolution of large-scale and slowly varying Rossby wave packet with basic flow both in barotropic and baroclinic atmospheres. The evolution of the structure of Rossby wave packet with both time and space was studied. The results obtained in this paper are similar to the results of by WKBJ method. In addition, the dispersive process of the wave packet was analysed by taking Gaussian type wave packet as an initial disturbance. The valid time scale for application of wave packet theory in the atmosphere was obtained.
文摘Based on a case study of TESOL approaches applied in several Australian institutions,this paper gives critical analysis of the approaches by comparing them with the one encountered in the situation in which the author has been working.A further implication of those approaches is also examined.
文摘Objective To design a paramedian supracerebelalr infratentorial keyhole approach by applying the keyhole conception and explore its feasibility. The keyhole approach is imitated and microanatomical structures are observed,which could be reference of this approach in clinical use. Methods The paramedian
文摘The U.S.Food and Drug Administration(FDA)'s program documents regarding the animal-free approach for the efficacy,pharmacokinetics,and safety evaluation of new drug preclinical studies have been rolled out gradually.This process has taken the FDA seven years.Starting from the reduction of funding for animal of data from organ-on-a-chip solely for pharmacodynamic studies[[1],[2],[3]],to the explicit proposal of the animal-free approach for pharmacodynamic studies in the FDA Modernization Act in Reference[4],and to the indication in 2025 that safety studies should also prioritize safety research data from in vitro microphysiological systems[5],this demonstrates the FDAs determination to gradually achieve the animal-free approach and also signals a profound paradigm shift in the field of drug research and development.This policy direction not only addresses the requirements of ethics and technological advancement but may also reshape the entire new drug development industrial chain.
基金financially supported by the National Key Research and Development Program of China (Grant No.2024YFA1409001)the National Natural Science Foundation of China (Grants Nos.12374037 and 12204044)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No.XDB28000000)the Fundamental Research Funds for the Central Universities。
文摘We theoretically explore a non-Hermitian superfluid model with complex-valued interaction, inspired by two-body loss stemming from inelastic scattering observed in ultracold atomic experiments. Utilizing both the right-eigenstate-based mean-field theory and its biorthogonal counterpart, we study the properties of the system. Notably, the right-eigenstate-based framework produces smooth and continuous solutions, in stark contrast to the absence of nontrivial solutions and the abrupt discontinuities observed in the biorthogonal-eigenstatebased framework under moderate dissipation. In addition, the lower condensation energy obtained in the former framework suggests its superior suitability for describing this system. Furthermore, we explore the impact of backscattering, a crucial factor in realistic systems. Our analysis reveals that, facilitated by two-body loss, even moderate backscattering destabilizes the superfluid state. Sufficiently strong backscattering completely destroys it, highlighting a key mechanism for the fragility of this non-Hermitian quantum phase.
基金Supported by Fondazione"Giuseppe Alazio",via Torquato Tasso,22,90144 Palermo,Italy(to Doglietto F)
文摘AIMTo describe the development and validation of a novel neuronavigation-based method, which allows the quan-tification of the anatomical features that define anapproach, as well as real-time visualization of the surgicapyramid. METHODSThe method was initially developed with commercially-available hardware for coordinate collection （a digitizerand a frameless navigation system） and software forvolume rendering; dedicated neuronavigation software （ApproachViewer, part of GTx-UHN） was then developed. The accuracy of measurements and the possibility of volumetric rendering of surgical approaches simulated in a phantom were compared among three different methods and commercially-available radiological software. In the anatomy laboratory, ApproachViewer was applied to the comparative quantitative analysis of multiple neurosurgical approaches and was used by many surgeons who were untrained for the research method.RESULTSThe accuracy of ApproachViewer is comparable to com-mercially-available radiological software. In the anatomy laboratory, the method appears versatile. The system can be easily used after brief training. ApproachViewer allows for real-time evaluation and comparison of surgical approaches, as well as post-dissection analyses of collected data. The accuracy of the method depends on the navigation registration： with a 1-2 mm registration error, it is adequate for evaluation and comparison of most neurosurgical approaches.CONCLUSIONThis new research method and software allows semi-automated visualization, quantifcation, and comparison of neurosurgical approaches in the anatomy laboratory.
文摘This study compares the subject matter appeared on traditional Thai textbooks and Japanese textbooks and analyzes how extension and integration sequence on Japanese textbooks evokes students＇ mathematical creativity. The data were collected from the series of four lessons in the fifth grade by teaching experiment methodology conducted following the professional development project implemented lesson study and open approach in Thailand. The results show that extension and integration sequence is an appropriate subject matter to generate lesson for problem-solving classroom. The sequence of lesson leads students to excitement, curiosity, confidence and intimacy in mathematics that are powerful effects of mathematical creativity. Students can produce the different and various ways to solve problems that indicate their divergent thinking.
基金ICAR-National Rice Research Institute for financial support
文摘Grain size plays a significant role in rice,starting from affecting yield to consumer preference,which is the driving force for deep investigation and improvement of grain size characters.Quantitative inheritance makes these traits complex to breed on account of several alleles contributing to the complete trait expression.We employed genome-wide association study in an association panel of 88 rice genotypes using 142 new candidate gene based SSR(cgSSR)markers,derived from yield-related candidate genes,with the efficient mixed-model association coupled mixed linear model for dissecting complete genetic control of grain size traits.A total of 10 significant associations were identified for four grain size-related characters(grain weight,grain length,grain width,and length-width ratio).Among the identified associations,seven marker trait associations explain more than 10%of the phenotypic variation,indicating major putative QTLs for respective traits.The allelic variations at genes OsBC1L4,SHO1 and OsD2 showed association between 1000-grain weight and grain width,1000-grain weight and grain length,and grain width and length-width ratio,respectively.The cgSSR markers,associated with corresponding traits,can be utilized for direct allelic selection,while other significantly associated cgSSRs may be utilized for allelic accumulation in the breeding programs or grain size improvement.The new cgSSR markers associated with grain size related characters have a significant impact on practical plant breeding to increase the number of causative alleles for these traits through marker aided rice breeding programs.
文摘Vehicle sounds are important factors of customer satisfaction and have a decisive influence on the product automobile andits quality impression. It becomes more and more important to connect customer requirements and technical specifications to developa vehicle sound with high quality. The turn indicator sound can be described as one sound, which gives the customer an importantfeedback of correct function performance and can be seen as one of the sounds, which play a role in the customer＇s perception ofvehicle quality. In a laboratory experimental study, the question was investigated, how a turn indicator sound must be designed to beperceived as pleasant and high-quality. A multidimensional approach was chosen to combine subjective customer assessments,objective psychophysiological responses of the study participants and physical parameters of the sounds. In total, 15 different tumindicator sounds were assessed by 48 subjects. The study shows how the connection of subjective and objective parameters cansupport product development. The multi-dimensional approach helps to derive recommendations for action to improve the soundquality of the product automobile. Also, the study shows a possibility to involve the human factor in a highly technical environment.
