To study the functional changes of immunological survcillsnce after vasectomy,we hzve dynamically obscrved the influence of vasectonly on the functions of T lymphocytes and macrophages of peripheral blood from vasecto...To study the functional changes of immunological survcillsnce after vasectomy,we hzve dynamically obscrved the influence of vasectonly on the functions of T lymphocytes and macrophages of peripheral blood from vasectomized animals as the exPerimental model. The results showed that: (1) PHA and Con-A induced mitogenesis of T lymphocytes from the rabbits vasectomized for eight months was significantly inhibited (P<0.01) and recovered in rabbits vasectoomized for 12, 18 and 22 months respectively, (2) The IL -2 secretion from peripheral blood mononuclcar cells (PBMCs) in the rabbits vasectomized for 8 months was reduced remarkably (P<0.01) and reached the normal level in the rabbits vasectomlied for 12 months; (3) A significant correlation was found betwecn Con-A induced mitogenesis of T lymphocytes and the IL-2 secrcted from PBMCs (r=0.661, P<0.01); (4) The IL- 1 secrction form periPhoal blood macrophsges induced by LPS significantly increased in the rabbits vasectonlized for S months (P<0.02) and returned to the normal level in the rabbits vasectomized for 12, 18 and 22 months respectively, (5) The levl of plasma lysozyme increased significantly in the rabbits vasectomized for 8 months (P<0.05) and returned to the normal in the rabbits vasectomized for 12 months, (6) The level of IL- 1 secreted by the macrophages and the level of plasma lysozyme were closely. Correlated (r=0.576, P<0.001). The present results may provide an expeimantal evidence for the evaluating the functional changes of immunological surveillance in vasectomized animals.展开更多
文摘To study the functional changes of immunological survcillsnce after vasectomy,we hzve dynamically obscrved the influence of vasectonly on the functions of T lymphocytes and macrophages of peripheral blood from vasectomized animals as the exPerimental model. The results showed that: (1) PHA and Con-A induced mitogenesis of T lymphocytes from the rabbits vasectomized for eight months was significantly inhibited (P<0.01) and recovered in rabbits vasectoomized for 12, 18 and 22 months respectively, (2) The IL -2 secretion from peripheral blood mononuclcar cells (PBMCs) in the rabbits vasectomized for 8 months was reduced remarkably (P<0.01) and reached the normal level in the rabbits vasectomlied for 12 months; (3) A significant correlation was found betwecn Con-A induced mitogenesis of T lymphocytes and the IL-2 secrcted from PBMCs (r=0.661, P<0.01); (4) The IL- 1 secrction form periPhoal blood macrophsges induced by LPS significantly increased in the rabbits vasectonlized for S months (P<0.02) and returned to the normal level in the rabbits vasectomized for 12, 18 and 22 months respectively, (5) The levl of plasma lysozyme increased significantly in the rabbits vasectomized for 8 months (P<0.05) and returned to the normal in the rabbits vasectomized for 12 months, (6) The level of IL- 1 secreted by the macrophages and the level of plasma lysozyme were closely. Correlated (r=0.576, P<0.001). The present results may provide an expeimantal evidence for the evaluating the functional changes of immunological surveillance in vasectomized animals.
