[Objectives]To investigate the therapeutic effects of combined treatment on children diagnosed with pseudomyopia,based on the theoretical framework that the liver is associated with eye health in traditional Chinese m...[Objectives]To investigate the therapeutic effects of combined treatment on children diagnosed with pseudomyopia,based on the theoretical framework that the liver is associated with eye health in traditional Chinese medicine.[Methods]A multicenter randomized controlled trial was conducted involving 100 children,with the treatment group consisting of 50 participants receiving a combined treatment,while the control group,also comprising 50 participants,received conventional tuina.In the treatment group,the Yizhichan Pushing Manipulation was applied at a frequency of 120 times/min and a strength of 0.5-1.0 kg,targeting acupoints such as Ganyu and Guangming.The alterations in naked eye visual acuity,diopter measurements,and ciliary muscle regulation function were compared between the two groups of children both prior to and following treatment,and the clinical efficacy was assessed.[Results]The treatment group demonstrated a statistically significant enhancement in visual acuity(1.74±0.49 lines vs.1.02±0.52 lines),diopter improvement(0.91±0.29 D vs.0.46±0.25 D),and overall efficiency(96%vs.78%)when compared to the control group(all P<0.01).[Conclusions]This combined treatment exerts a therapeutic effect through a dual mechanism that involves the regulation of liver meridian qi and blood,as well as the enhancement of ciliary muscle function.This approach merits further dissemination and application in the prevention and management of myopia in children.展开更多
OBJECTIVE: To study the effect of Erzhi Mingmu Decoction in the treatment of non-exudative age-related macular degeneration. METHODS: A total of 100 patients with non-exudative age-related macular degeneration admitte...OBJECTIVE: To study the effect of Erzhi Mingmu Decoction in the treatment of non-exudative age-related macular degeneration. METHODS: A total of 100 patients with non-exudative age-related macular degeneration admitted to our hospital from May 2017 to May 2018 were selected. They were randomly divided into the study group and the control group. The control group was treated with oral vitamin C and vitamin E while study group was treated with Erzhi Mingmu Decoction based on the same treatment of the control group. Both groups were continuously treated for 1 month, the visual improvement, fundus changes, and changes of serum VEGF and CRP levels were compared before and after treatment. RESULTS: The number of patients with visual improvement was higher in the study group than that in the control group(P < 0.05). The number of patients with fundus improvement in the study group was more than that of the control group(P < 0.05). Serum VEGF levels were decreased in the 2 groups after treatment, and they were decreased more in the study group than those in control group(all P < 0.05). Serum CRP levels were decreased in the 2 groups after treatment, and the serum CRP levels were decreased more in the study group than those in control group(all P < 0.05). CONCLUSION: The treatment of non-exudative age-related macular degeneration with Erzhimingmu Decoction can significantly improve the vision of patients, improve the condition of the fundus, and reduce the levels of serum VEGF and CRP, which is worthy of clinical promotion and application.展开更多
Objective:To investigate the inhibitory effects and underlying mechanisms of Qideng Mingmu Capsule(QD)on retinal neovascularization(RNV).Methods:Seven-day-old C57BL/6J mice were assigned to the following groups:contro...Objective:To investigate the inhibitory effects and underlying mechanisms of Qideng Mingmu Capsule(QD)on retinal neovascularization(RNV).Methods:Seven-day-old C57BL/6J mice were assigned to the following groups:control,oxygen-induced retinopathy(OIR),low-,medium-,high-dose QD(225,450,and 900 mg/g daily),and angiopoietin 1(Ang1),20 mice in each group.Except for the control group,an OIR model was induced by exposing mice to a hyperoxic environment for 5 d(postnatal days 7-12),followed by a normoxic environment for 5 d(postnatal days 12-17).From day 12,the treatment groups received QD orally or Ang1 via binocular intravitreal injection.On day 17,hematoxylin and eosin staining and fluorescein isothiocyanate-dextran staining were performed to evaluate RNV growth.Immunofluorescence staining,immunohistochemistry,and Western blotting were used to analyze the expressions of Ang/tyrosine kinase with immunoglobulin and epidermal growth factor homology domain-2(Tie2)signaling pathway,hypoxia-inducible factor-1α(HIF-1α),and retinal vascular maturation markers.In addition,the effects of QD on the viability of rat retinal microvascular endothelial cells(r RMECs)was assessed.Results:QD significantly inhibited RNV formation,reduced RNV density,increased the expressions of Ang1,Tie2,and phosphorylated protein kinase B,and decreased the expression of Ang2(P<0.05 or P<0.01).QD also enhanced retinal vascular pericyte coverage,reduced HIF-1αexpression,and increased vascular endothelial cadherin levels(P<0.05 or P<0.01).Furthermore,no adverse effects were observed on the viability of r RMECs after QD intervention.Conclusions:QD effectively inhibited RNV formation,promoted neovascular maturation and remodeling,and protected retinal function by modulating the Ang/Tie2 signaling pathway.Therefore,QD may serve as a promising therapeutic option for retinal neovascular diseases.展开更多
Objective: To evaluate the clinical effect of Shezhu Mingmu Powder (SZMMP) in treatment of early senile cataract. Methods: A comparison was made between the treatment group, 162 eyes of 92 cases of early senile catara...Objective: To evaluate the clinical effect of Shezhu Mingmu Powder (SZMMP) in treatment of early senile cataract. Methods: A comparison was made between the treatment group, 162 eyes of 92 cases of early senile cataract treated by SZMMP, and the control group, 57 eyes of 30 cases treated by drops baineitini.The treatment periods were one to three months. Results: The total effective rate for the treatment group was79. 01 % and the rate of obvious improvement was 25. 31 %. In the treatment group both rateswere clearly higher than the rates (36. 84 % and 7. 02 % ) of the control group. After 4 to 8 months' following up, treatment of 42 cases showed that most of them reached the best curative effect within 1 to 3 months. Conclusion: SZMMP is obviously effective in improving visual acuity of early senile cataract, but the lens opacity was not changed.展开更多
基金Supported by Hospital-level Project of Shiyan Taihe Hospital(2018JJXM093).
文摘[Objectives]To investigate the therapeutic effects of combined treatment on children diagnosed with pseudomyopia,based on the theoretical framework that the liver is associated with eye health in traditional Chinese medicine.[Methods]A multicenter randomized controlled trial was conducted involving 100 children,with the treatment group consisting of 50 participants receiving a combined treatment,while the control group,also comprising 50 participants,received conventional tuina.In the treatment group,the Yizhichan Pushing Manipulation was applied at a frequency of 120 times/min and a strength of 0.5-1.0 kg,targeting acupoints such as Ganyu and Guangming.The alterations in naked eye visual acuity,diopter measurements,and ciliary muscle regulation function were compared between the two groups of children both prior to and following treatment,and the clinical efficacy was assessed.[Results]The treatment group demonstrated a statistically significant enhancement in visual acuity(1.74±0.49 lines vs.1.02±0.52 lines),diopter improvement(0.91±0.29 D vs.0.46±0.25 D),and overall efficiency(96%vs.78%)when compared to the control group(all P<0.01).[Conclusions]This combined treatment exerts a therapeutic effect through a dual mechanism that involves the regulation of liver meridian qi and blood,as well as the enhancement of ciliary muscle function.This approach merits further dissemination and application in the prevention and management of myopia in children.
基金funded by the Natural Science Foundation of Liaoning Province (Project No.:20170520009)
文摘OBJECTIVE: To study the effect of Erzhi Mingmu Decoction in the treatment of non-exudative age-related macular degeneration. METHODS: A total of 100 patients with non-exudative age-related macular degeneration admitted to our hospital from May 2017 to May 2018 were selected. They were randomly divided into the study group and the control group. The control group was treated with oral vitamin C and vitamin E while study group was treated with Erzhi Mingmu Decoction based on the same treatment of the control group. Both groups were continuously treated for 1 month, the visual improvement, fundus changes, and changes of serum VEGF and CRP levels were compared before and after treatment. RESULTS: The number of patients with visual improvement was higher in the study group than that in the control group(P < 0.05). The number of patients with fundus improvement in the study group was more than that of the control group(P < 0.05). Serum VEGF levels were decreased in the 2 groups after treatment, and they were decreased more in the study group than those in control group(all P < 0.05). Serum CRP levels were decreased in the 2 groups after treatment, and the serum CRP levels were decreased more in the study group than those in control group(all P < 0.05). CONCLUSION: The treatment of non-exudative age-related macular degeneration with Erzhimingmu Decoction can significantly improve the vision of patients, improve the condition of the fundus, and reduce the levels of serum VEGF and CRP, which is worthy of clinical promotion and application.
基金Supported by the Natural Science Project of Sichuan Province(No.2023NSFSC0690)。
文摘Objective:To investigate the inhibitory effects and underlying mechanisms of Qideng Mingmu Capsule(QD)on retinal neovascularization(RNV).Methods:Seven-day-old C57BL/6J mice were assigned to the following groups:control,oxygen-induced retinopathy(OIR),low-,medium-,high-dose QD(225,450,and 900 mg/g daily),and angiopoietin 1(Ang1),20 mice in each group.Except for the control group,an OIR model was induced by exposing mice to a hyperoxic environment for 5 d(postnatal days 7-12),followed by a normoxic environment for 5 d(postnatal days 12-17).From day 12,the treatment groups received QD orally or Ang1 via binocular intravitreal injection.On day 17,hematoxylin and eosin staining and fluorescein isothiocyanate-dextran staining were performed to evaluate RNV growth.Immunofluorescence staining,immunohistochemistry,and Western blotting were used to analyze the expressions of Ang/tyrosine kinase with immunoglobulin and epidermal growth factor homology domain-2(Tie2)signaling pathway,hypoxia-inducible factor-1α(HIF-1α),and retinal vascular maturation markers.In addition,the effects of QD on the viability of rat retinal microvascular endothelial cells(r RMECs)was assessed.Results:QD significantly inhibited RNV formation,reduced RNV density,increased the expressions of Ang1,Tie2,and phosphorylated protein kinase B,and decreased the expression of Ang2(P<0.05 or P<0.01).QD also enhanced retinal vascular pericyte coverage,reduced HIF-1αexpression,and increased vascular endothelial cadherin levels(P<0.05 or P<0.01).Furthermore,no adverse effects were observed on the viability of r RMECs after QD intervention.Conclusions:QD effectively inhibited RNV formation,promoted neovascular maturation and remodeling,and protected retinal function by modulating the Ang/Tie2 signaling pathway.Therefore,QD may serve as a promising therapeutic option for retinal neovascular diseases.
文摘Objective: To evaluate the clinical effect of Shezhu Mingmu Powder (SZMMP) in treatment of early senile cataract. Methods: A comparison was made between the treatment group, 162 eyes of 92 cases of early senile cataract treated by SZMMP, and the control group, 57 eyes of 30 cases treated by drops baineitini.The treatment periods were one to three months. Results: The total effective rate for the treatment group was79. 01 % and the rate of obvious improvement was 25. 31 %. In the treatment group both rateswere clearly higher than the rates (36. 84 % and 7. 02 % ) of the control group. After 4 to 8 months' following up, treatment of 42 cases showed that most of them reached the best curative effect within 1 to 3 months. Conclusion: SZMMP is obviously effective in improving visual acuity of early senile cataract, but the lens opacity was not changed.
