One of the key challenges for underground rock reservoirs is ensuring prevention of the unwanted fluid leakage through rock fracture networks during their service life.Microbial-induced calcium carbonate precipitation...One of the key challenges for underground rock reservoirs is ensuring prevention of the unwanted fluid leakage through rock fracture networks during their service life.Microbial-induced calcium carbonate precipitation(MICP)technology has emerged as a promising bio-healing method for rock fractures with small apertures.In this study,a new“three-stage”injection strategy-based MICP(TS-MICP)bio-healing method was proposed,aiming to achieve a“three-high”performance that includes high bridging rate,high mechanical strength,and high homogeneity.A series of meter-scale rock fracture models were prepared to conduct TS-MICP grouting tests.Compared with the traditional injection strategy-based biohealing methods,the TS-MICP method significantly improved the bridging rate(32.1%e89.5%),mechanical properties(0.138e1.023 MPa),and homogeneity of CaCO_(3)precipitation(334.4%).Additionally,it achieved a higher material utilization rate(1.72 times higher),reducing the consumption of cementation solution(CS)by 258.8%,thereby demonstrating greater potential for field applications.The underlying mechanism for achieving high bridging rate and high homogeneity in CaCO_(3)precipitation can be attributed to the synergistic effects of the coupling injection strategy,which optimizes the advantages at each stage.In stage I,under the influence of gravity,the rapid flocculation and hydrogen bonding interactions of organic matter lead to formation of the dense and high-strength CaCO_(3)precipitation at the bottom using a low-concentration bacterial suspension(BS).This process establishes bridging steps along the wall sides for subsequent uniform CaCO_(3)precipitation.In stage II,concentrated BS is utilized to produce looser CaCO_(3)flocculation,which precipitates uniformly on the pre-existing bridging steps.In stage III,a two-step injection strategy was employed to reinforce the loose CaCO_(3)crystals formed in stages I and II,and finally forms a strong bridging effect with“three-high”performance.展开更多
Inorganic materials can solve transportable and on-site hydrolytic hydrogen generation issues.CaH_(2)/(Al/Si)composites are preferable due to their notable chemical properties.However,these composites require pretreat...Inorganic materials can solve transportable and on-site hydrolytic hydrogen generation issues.CaH_(2)/(Al/Si)composites are preferable due to their notable chemical properties.However,these composites require pretreatments,an inert environment,and long hours of physical ball milling for high homogeneity and synergistic effects.CaH_(2)also inhibits the hydrolysis reaction by forming its products on the Al/Si surface,which hinders the direct utilization of composites.This work represents the first investigation of NaH-CaH_(2)(Al/Si)fuel composites,which greatly overcome these limitations and can be directly used for on-site hydrogen generation and proton exchange membrane(PEM)fuel cells.The NaH-CaH_(2)(Al/Si)fuel composites were prepared by using a straightforward mixing method with variable composition ratios,showing high H_(2)yield and fuel cell(FC)performance.NaH addition provides the bridge effect,which opens up a new way to enable efficient hydrolysis and greatly enhances the hydrolysis activity of CaH_(2)/(Al/Si)composites.The novel fuel composites(NaH-CaH_(2)/Al)have extraordinary FC performance and a 0.42 W/cm2 peak power density greater than commercial hydrogen generators.It provides high H_(2)yield 84.4%for NaH-CaH_(2)/Al and 82%for NaH-CaH_(2)/Si compared to NaOH-CaH_(2)(Al/Si),NaCl-CaH_(2)(Al/Si),and KCl-CaH_(2)(Al/Si)composites.The NaH bridge effect hinders the direct water contact and stops the formation of Ca(OH)2 around Al/Si,which provides adequate pathways for the CaH_(2)(Al/Si)hydrolysis.The impressive capabilities of novel fuel composites are anticipated to offer practical uses in fuel cells,automobile applications,and portable/on-board H_(2)generation.展开更多
As Thailand and China mark the 50th anniversary of their diplomatic ties this year,most headlines will naturally focus on trade deals,railways,and strategic partnerships.But tucked behind the golden spires of Bangkok...As Thailand and China mark the 50th anniversary of their diplomatic ties this year,most headlines will naturally focus on trade deals,railways,and strategic partnerships.But tucked behind the golden spires of Bangkok’s Wat Po temple lies a quieter,gentler form of diplomacy—one that happens through kneading hands,respectful bows,and an ancient art passed down across generations.At the Wat Po Thai Traditional Medical School,headmaster Serat Tangtrongchitr sees Thai massage not only as a healing craft,but as a cultural bridge—one that connects people across borders,languages,and belief systems.“We don’t just teach massage,”Serat said,his voice calm but assured.“We teach a way of life.And when people from other cultures learn this with us—Chinese students included—they come to understand not just the techniques,but the heart of Thai culture.”展开更多
In this paper, we aim to use an innovative model to integrate applied work on a fast-acting mind-body intervention, Mind-Body Bridging (MBB), with theoretical work based on psychology and neuroscience. In an affect-ob...In this paper, we aim to use an innovative model to integrate applied work on a fast-acting mind-body intervention, Mind-Body Bridging (MBB), with theoretical work based on psychology and neuroscience. In an affect-object generative inference and regulation (AGIR) model, we propose that functional dynamics between two systems, the affect-object thought generation system and the cognitive control system, can guide an individual to achieve homeostasis within self and harmonious relationships with others. We used Neurosynth (www.neurosynth.org), an automated meta-analysis database, to identify potential brain substrates underlying the key components in the AGIR model. Based on the findings, some brain regions are implicated as the key cortical substrates in this model, corroborating our central hypothesis that a hallmark of mind-body wellbeing can be characterized as a low-frequency anti-correlantion between 1) the cognitive control system including the dorsal anterior/middle cingulate cortex, and 2) the affect-object thought generation system including the ventromedial prefrontal cortex and posterior cingulate cortex. MBB provides an efficient strategy for responding to and dissolving a fundamental problem that impairs mind-body wellbeing, i.e., unrealistic identity-grasping consisting of self-centered embodied expectations of self and others. We demonstrated how theoretical and applied work could be integrated by drawing evidence from the neuroscience literature to support the AGIR model, and then we applied the AGIR model to elucidate how MBB might work.展开更多
Lost circulation of drilling fluid is one of the most common and costly problems in drilling operations.This highlights the importance of wellbore strengthening treatment sthat can utilize lost circulation materials(L...Lost circulation of drilling fluid is one of the most common and costly problems in drilling operations.This highlights the importance of wellbore strengthening treatment sthat can utilize lost circulation materials(LCMs)to seal fractures associated with the wellbore.In this work,a numerical model accounting for the deformation of surrounding rock,fluid flow in the fracture,fracture propagation,and the transport of LCMs is presented to investigate the wellbore strengthening,from the fracture initiation to the fracture arrest,due to plugs formed by LCMs.The equations governing the rock deformation and fluid flow are solved by the dual boundary element method and the finite volume method,respectively.The transport of LCMs is solved based on an empirical constitutive model in suspension flow,and several characteristic quantities are derived by dimensional analysis.It is found that two dimensionless parameters,dimensionless toughness and normalized initial particle concentration,control the migration of LCM particles.The numerical results show that the dimensionless toughness influences the entrance and bridging of LCMs while the initial concentration controls the location of the particle bridging.When the initial concentration is larger than 0.8,the particle bridging tends to occur near the fracture entry.Conversely,when the initial concentration is less than 0.8,the particle bridging occurs near the fracture tip.This work provides an effective tool to predict the LCM transport and plugging in the wellbore strengthening process.展开更多
BACKGROUND Patients diagnosed with esophageal mucosal bridges often experience symptoms such as chest pain and dysphagia,which pose considerable challenges for endo-scopic surgical interventions.CASE SUMMARY We presen...BACKGROUND Patients diagnosed with esophageal mucosal bridges often experience symptoms such as chest pain and dysphagia,which pose considerable challenges for endo-scopic surgical interventions.CASE SUMMARY We present a case involving early-stage esophageal cancer discovered in a resting room,notable for the rare manifestation of esophageal mucosal bridging.Following a comprehensive multidisciplinary discussion and the development of a treatment strategy,we proceeded with endoscopic submucosal dissection for the patient.During the procedure,we encountered operational challenges due to the presence of a diverticulum and a partial absence of the muscularis propria.To facilitate the retraction of a portion of the resected specimen,we utilized dental floss.Ultimately,we successfully excised the entire lesion.After a three-day period of fasting with a water-only diet,subsequent iodine water cholan-giography did not indicate any perforations,and the patient was advised to transition to a liquid diet.The patient was discharged five days post-operation.A follow-up endoscopy conducted three months later revealed scar-like changes in the mid-esophagus,with the patient reporting no significant discomfort.CONCLUSION In summary,although esophageal mucosal bridges are rarely documented,they should be considered in the differential diagnosis of mechanical dysphagia.Furthermore,endoscopic therapy represents a feasible approach for their mana-gement.展开更多
The energy release of energetic composites is severely limited by the inert alumina(Al_(2)O_(3))layer on the surface of aluminum(Al).Polytetrafluoroethylene(PTFE)could eliminate Al_(2)O_(3)layer due to its highly elec...The energy release of energetic composites is severely limited by the inert alumina(Al_(2)O_(3))layer on the surface of aluminum(Al).Polytetrafluoroethylene(PTFE)could eliminate Al_(2)O_(3)layer due to its highly electronegativity and oxidability of fluorine.However,adding PTFE particles would weaken interfacial interactions resulted in poor mechanical properties and interfacial exothermic reaction.Herein,a bridging Al-PTFE as fuel and interfacial reinforcing agent was added and used to prepare LLM-105/AlPTFE microspheres,achieving both high energy output and excellent mechanical properties.The energy release and combustion reaction performance of LLM-105/Al-PTFE microspheres are significantly improved due to high reaction heat and increased interfacial reaction area of Al-PTFE.The maximum pressure and pressurization rate of LLM-105/Al-PTFE microspheres are 164.06 kPa and 29.88 kPa/s,respectively,which are 40.11%and 16.67%higher than those of physical mixed samples.Furthermore,the tensile strength and compressive strength of LLM-105/Al-PTFE microspheres are 100.40%and 26.47%higher than those of LLM-105/Al.This work provides a new approach to improve the energy release and mechanical properties for energetic composites.展开更多
Biocatalysis with nicotinamide adenine dinucleotide phosphate(NADP)-dependent oxidoreductases faces a challenge in improving the efficiency of the costly cofactor utilization.Although enzyme fusion can offer cofactor ...Biocatalysis with nicotinamide adenine dinucleotide phosphate(NADP)-dependent oxidoreductases faces a challenge in improving the efficiency of the costly cofactor utilization.Although enzyme fusion can offer cofactor regeneration,the high-volume input and limited cofactor recyclability still make the enzymatic processes unsustainable.Therefore,it is of great significance to reduce cofactor input in a fusion enzyme(FuE)system,but no successful practice has been reported.Herein,we design a decapeptide bridge,RRRQRRRARR(R10),with high affinity for NADPH to construct fusion oxidoreductases(phenylacetone monooxygenase and phosphite dehydrogenase)for ester synthesis and NADP recycling.The peptide bridge enables electrostatic cofactor channeling that transports NADPH/NADP^(+)across the peptide between the enzymes’NADP-binding pockets,so the fusion enzyme(FuE-R10)presents 2.1-folds and 2.0-folds higher conversions than mixed free enzymes and a flexible linker(GGGGSGGGGS)-fused enzyme,respectively,at NADPH/FuE of 0.1.The fusion enzyme,FuE-R5,bridged by a half-shortened linker,is proved more effective in facilitating cofactor channeling;compared to the mixed free enzymes,FuE-R5 exhibits two orders of magnitude reduction of NADPH input in ester synthesis.The work has thus demonstrated the potential of the cofactor bridging strategy in the development of sustainable cofactor-dependent cascade biocatalysis.展开更多
The Emerging Markets and Developing Countries Forum on Bridging the AI Divide and Opening Ceremony of AIM Global CoE were held on July 27 in Minhang district,Shanghai.The event was hosted by AIM Global CoE,and co-orga...The Emerging Markets and Developing Countries Forum on Bridging the AI Divide and Opening Ceremony of AIM Global CoE were held on July 27 in Minhang district,Shanghai.The event was hosted by AIM Global CoE,and co-organized by Shanghai Artificial Intelligence Research Institute(SAIRI),Shanghai Technology Innovation Center,Shanghai Grand Neobay Investment Development Group,and Organizing Committee of AI Journey Conference.Asian Association of Business Incubation(AABI)and SAIRI served as the international partners.展开更多
Traditional Chinese medicine (TCM) with its millenniaold wisdom rooted in the principles of holistic Yin-Yang balance and “Bianzheng Lunzhi”[辨证论治, Zhenghou(证候) differentiation and treatment], has long offered ...Traditional Chinese medicine (TCM) with its millenniaold wisdom rooted in the principles of holistic Yin-Yang balance and “Bianzheng Lunzhi”[辨证论治, Zhenghou(证候) differentiation and treatment], has long offered a unique lens to understand human health and disease.However, the modern scientific interpretation of TCM remains at the stage of “knowing that it works, but not knowing why it works”.展开更多
To ensure the compatibility between rolling stock and infrastructure when dynamically assessing railway bridges under high-speed traffic,the damping properties considered in the calculation model significantly influen...To ensure the compatibility between rolling stock and infrastructure when dynamically assessing railway bridges under high-speed traffic,the damping properties considered in the calculation model significantly influence the predicted acceleration amplitude at resonance.However,due to the normative specifications of EN 1991-2,which are considered to be overly conservative,damping factors that are far below the actual damping have to be used when predicting vibrations of railway bridges,which means that accelerations at resonance tend to be overestimated to an uneconomical extent.Comparisons between damping factors prescribed by the standard and those identified based on in situ structure measurements always reveal a large discrepancy between reality and regulation.Given this background,this contribution presents a novel approach for defining the damping factor of railway bridges with ballasted tracks,where the damping factor for bridges is mathematically determined based on three different two-dimensional mechanical models.The basic principle of the approach for mathematically determining the damping factor is to separately define and superimpose the dissipative contributions of the supporting structure(including the substructure)and the superstructure.Using the results of a measurement campaign on 15 existing steel railway bridges in the Austrian rail network,the presented mechanical models are calibrated,and by analysing the energy dissipation in the ballasted track,guiding principles for practical application are defined.This guideline is intended to establish an alternative to the currently valid specifications of EN 1991-2,enabling the damping factor of railway bridges to be assessed in a realistic range by mathematical calculation and thus without the need for extensive in situ measurements on the individual structure.In this way,the existing potential of the infrastructure with regard to the damping properties of bridges can be utilised.This contribution focuses on steel bridges,but the mathematical approach for determining the damping factor applies equally to other bridge types(concrete,composite,or filler beam).展开更多
Blinatumomab has demonstrated efficacy in B-cell acute lymphoblastic leukemia(B-ALL),achieving a measurable residual disease(MRD)negativity rate of 78%(1).Its addition to consolidation chemotherapy or administration p...Blinatumomab has demonstrated efficacy in B-cell acute lymphoblastic leukemia(B-ALL),achieving a measurable residual disease(MRD)negativity rate of 78%(1).Its addition to consolidation chemotherapy or administration prior to allogeneic hematopoietic stem cell transplantation(allo-HSCT)has been shown to significantly improve overall survival(OS)and relapse-free survival(RFS)in adult B-ALL patients(2,3).展开更多
In the Kigongo area of Mwanza Region,northwest Tanzania,fishmonger Neema Aisha remembers how the morning’s fresh catch would sour while she queued for the ferry,putting her business at risk.
To examine stress redistribution phenomena in bridges subjected to varying operational conditions,this study conducts a comprehensive analysis of three years of monitoring data from a 153-m double-deck road–rail stee...To examine stress redistribution phenomena in bridges subjected to varying operational conditions,this study conducts a comprehensive analysis of three years of monitoring data from a 153-m double-deck road–rail steel arch bridge.An initial statistical comparison of sensor data distributions reveals clear temporal variations in stress redistribution patterns.XGBoost(eXtreme Gradient Boosting),a gradient-boosting machine learning(ML)algorithm,was employed not only for predictive modeling but also to uncover the underlying mechanisms of stress evolution.Unlike traditional numerical models that rely on extensive assumptions and idealizations,XGBoost effectively captures nonlinear and time-varying relationships between stress states and operational/environmental factors,such as temperature,traffic load,and structural geometry.This approach allows for the identification of critical periods and conditions under which stress redistribution becomes significant.Results indicate a clear shift of stress concentrations frombeamends toward mid-span regions following the commencement of metro operations,reflecting both structural adaptation and localized overstress near arch ribs.Furthermore,the model generates robust predictions of stress evolution,demonstrating potential applications in early warning systems and fatigue risk assessment.This work represents the first application of interpretable gradient-boosting techniques to stress redistribution modeling in double-deck bridges.In addition,a Stress Redistribution Index(SRI)is proposed,derived from this monitoring study and finite-element-based transverse load distributions,to quantify temporal stress shifts between midspan and edge beams.The results provide both theoretical contributions and practical guidance for the design,inspection,and maintenance of complex bridge structures.展开更多
This study proposes a new post-tensioned precast bridge column(PT-PBC)with a socket connection.Compared to conventional PBCs connected by PT tendons,the combination of the PT tendons with the socket connection can avo...This study proposes a new post-tensioned precast bridge column(PT-PBC)with a socket connection.Compared to conventional PBCs connected by PT tendons,the combination of the PT tendons with the socket connection can avoid tensioning the PT tendons on site,which further accelerates construction speed while improving construction quality and safety.In addition,compared to conventional PBCs with a socket connection,a rocking interface can avoid the formation of a plastic hinge in a column,which greatly alleviates seismic damage to that area.One specimen for quasi-static testing is used to validate the feasibility of this connection type.Subsequently,finite element models(FEM)are established to systematically predict the responses of the proposed columns under lateral cyclic loading.The accuracy of the FEM is verified through quasistatic testing.Next,the influences of the key design parameters of the PT-PBC,including the area ratio and prestress level of the PT tendons,the area ratio of energy dissipation(ED)steel rebars,and the total axial compression ratio on the seismic performances of PT-PBC are systematically investigated.The use of shape memory alloy(SMA)rods as energy dissipation devices and their performances also are investigated.The results show that increasing the area ratio and prestress level of PT tendons has an overall positive impact on the self-centering capacity of the column.The prestress level of PT tendons should be kept between 35%and 55%,depending on different conditions.The total compression axial ratio of the columns should be maintained between 0.3 and 0.4.Both ED steel rebars and SMA rods can boost the column’s energy dissipation capacity,while SMA rods can reduce residual deformation due to their inherent mechanical properties.展开更多
The goal of this paper is to investigate the long-time dynamics of solutions to a Kirchhoff type suspension bridge equation with nonlinear damping and memory term.For this problem we establish the well-posedness and e...The goal of this paper is to investigate the long-time dynamics of solutions to a Kirchhoff type suspension bridge equation with nonlinear damping and memory term.For this problem we establish the well-posedness and existence of uniform attractor under some suitable assumptions on the nonlinear term g(u),the nonlinear damping f(u_(t))and the external force h(x,t).Specifically,the asymptotic compactness of the semigroup is verified by the energy reconstruction method.展开更多
The main cable is the primary load-bearing component of a suspension bridge,continuously exposed to harsh environmental conditions,such as wind and rain,throughout the year.These adverse conditions contribute to varyi...The main cable is the primary load-bearing component of a suspension bridge,continuously exposed to harsh environmental conditions,such as wind and rain,throughout the year.These adverse conditions contribute to varying degrees of degradation and damage to the main cable,necessitating regular inspections to prevent catastrophic failures.Traditional manual inspection methods not only suffer from low efficiency but also pose significant safety risks to personnel.To address these challenges and ensure the safe and effective inspection of suspension bridge main cables,this study introduces a novel cooperative climbing robot,designated as Main Cable Robot Version II(CCRobot-M-II),inspired by the locomotion of the inchworm.The robot employs an alternating opening and closing mechanism of four gripper sets,mimicking the inchworm's movement to achieve efficient crawling along the suspension bridge handrails.This paper provides a comprehensive analysis of the structural design,key components,and motion mechanisms of CCRobot-M-II.A detailed force analysis of the robot's crawling process is also presented,followed by the design of the control system and the development of an efficient motion control algorithm.Laboratory experiments demonstrate that the robot achieves a positional error of 00.64%during crawling,with a maximum average crawling speed of 7.6 m/min.Furthermore,the biomimetic design enables the robot to overcome obstacles up to 30 mm in height and possess the capability to handle suspension bridge cables with spans ranging from 740 to 1100 mm.Finally,CCRobot-M-II successfully conducted an inspection of the main cable on a suspension bridge,marking the world's first successful deployment of a climbing robot for main cable inspection on a suspension bridge.展开更多
The spatial offset of bridge has a significant impact on the safety,comfort,and durability of high-speed railway(HSR)operations,so it is crucial to rapidly and effectively detect the spatial offset of operational HSR ...The spatial offset of bridge has a significant impact on the safety,comfort,and durability of high-speed railway(HSR)operations,so it is crucial to rapidly and effectively detect the spatial offset of operational HSR bridges.Drive-by monitoring of bridge uneven settlement demonstrates significant potential due to its practicality,cost-effectiveness,and efficiency.However,existing drive-by methods for detecting bridge offset have limitations such as reliance on a single data source,low detection accuracy,and the inability to identify lateral deformations of bridges.This paper proposes a novel drive-by inspection method for spatial offset of HSR bridge based on multi-source data fusion of comprehensive inspection train.Firstly,dung beetle optimizer-variational mode decomposition was employed to achieve adaptive decomposition of non-stationary dynamic signals,and explore the hidden temporal relationships in the data.Subsequently,a long short-term memory neural network was developed to achieve feature fusion of multi-source signal and accurate prediction of spatial settlement of HSR bridge.A dataset of track irregularities and CRH380A high-speed train responses was generated using a 3D train-track-bridge interaction model,and the accuracy and effectiveness of the proposed hybrid deep learning model were numerically validated.Finally,the reliability of the proposed drive-by inspection method was further validated by analyzing the actual measurement data obtained from comprehensive inspection train.The research findings indicate that the proposed approach enables rapid and accurate detection of spatial offset in HSR bridge,ensuring the long-term operational safety of HSR bridges.展开更多
Designing a heterogeneous interface to improve the kinetics of electrocatalysts represents an effective yet challenging approach for enhancing the oxygen reduction reaction(ORR)and oxygen evolution reaction(OER).Herei...Designing a heterogeneous interface to improve the kinetics of electrocatalysts represents an effective yet challenging approach for enhancing the oxygen reduction reaction(ORR)and oxygen evolution reaction(OER).Herein,a simple MOF-assisted etching-pyrolysis strategy is proposed to fabricate an advanced Mott-Schottky(M–S)electrocatalyst composed of Co/CeO_(2)hetero-nanoparticles embedded within N-doped hollow carbon nanoboxes(H-Co/CeO_(2)@NCBs).Notably,the interfacial Co–O–Ce bond bridging productively facilitates the electron transfer and modulates the charge distribution of the active center,thereby contributing to the ORR/OER kinetics.As expected,the optimal M–S H-Co/CeO_(2)@NCBs catalyst exhibits promising bifunctional electrocatalytic activity with a small potential discrepancy of 0.65 V.Theoretical calculations reveal that the built-in electric field in the M–S heterojunction promotes electron transfer in oxygen electrocatalysis and the interfacial bridge-induced electron redistribution optimizes the adsorption/desorption of the oxygen intermediates,leading to reduced activation energy for the bifunctional ORR/OER reactions.Importantly,H-Co/CeO_(2)@NCBs-assembled Zn-air battery(ZAB)delivers high power density(179.8 mW cm^(−2))and long-term stability(400 h).Furthermore,the assembled flexible solid-state ZAB with H-Co/CeO_(2)@NCBs cathode also exhibits excellent charge–discharge reversibility and flexibility at various bending angles.This work provides a novel perspective on developing efficient and stable M–S bifunctional oxygen electrocatalysts.展开更多
A monolithic integrated full-wave bridge rectifier consisted of horizontal Schottky-barrier diodes(SBD)is prepared based on 100 nm ultra-thin β-Ga_(2)O_(3)and demonstrated the solar-blind UV(SUV)light-modulated chara...A monolithic integrated full-wave bridge rectifier consisted of horizontal Schottky-barrier diodes(SBD)is prepared based on 100 nm ultra-thin β-Ga_(2)O_(3)and demonstrated the solar-blind UV(SUV)light-modulated characteristics.Under SUV light illumination,the rectifier has the excellent full-wave rectification characteristics for the AC input signals of 5,12,and 24 V with different frequencies.Further,experimental results confirmed the feasibility of continuously tuning the rectified output through SUV light-encoding.This work provides valuable insights for the development of optically programmable Ga_(2)O_(3)ACDC converters.展开更多
基金supported by the National Key Research and Development Program of China(Grant No.2023YFC3007102)the National Natural Science Foundation of China(Grant Nos.42477188 and 41925012).
文摘One of the key challenges for underground rock reservoirs is ensuring prevention of the unwanted fluid leakage through rock fracture networks during their service life.Microbial-induced calcium carbonate precipitation(MICP)technology has emerged as a promising bio-healing method for rock fractures with small apertures.In this study,a new“three-stage”injection strategy-based MICP(TS-MICP)bio-healing method was proposed,aiming to achieve a“three-high”performance that includes high bridging rate,high mechanical strength,and high homogeneity.A series of meter-scale rock fracture models were prepared to conduct TS-MICP grouting tests.Compared with the traditional injection strategy-based biohealing methods,the TS-MICP method significantly improved the bridging rate(32.1%e89.5%),mechanical properties(0.138e1.023 MPa),and homogeneity of CaCO_(3)precipitation(334.4%).Additionally,it achieved a higher material utilization rate(1.72 times higher),reducing the consumption of cementation solution(CS)by 258.8%,thereby demonstrating greater potential for field applications.The underlying mechanism for achieving high bridging rate and high homogeneity in CaCO_(3)precipitation can be attributed to the synergistic effects of the coupling injection strategy,which optimizes the advantages at each stage.In stage I,under the influence of gravity,the rapid flocculation and hydrogen bonding interactions of organic matter lead to formation of the dense and high-strength CaCO_(3)precipitation at the bottom using a low-concentration bacterial suspension(BS).This process establishes bridging steps along the wall sides for subsequent uniform CaCO_(3)precipitation.In stage II,concentrated BS is utilized to produce looser CaCO_(3)flocculation,which precipitates uniformly on the pre-existing bridging steps.In stage III,a two-step injection strategy was employed to reinforce the loose CaCO_(3)crystals formed in stages I and II,and finally forms a strong bridging effect with“three-high”performance.
基金financial support granted by the National Natural Science Foundation of China (No. 22402225)the Gusu Innovation and Entrepreneurship Leading Talent Plan(No. ZXL2023193)+2 种基金the Sinano Talents Plan (No. 2022000175)the Guangdong Basic and Applied Basic Research Foundation (No.2023A1515111133)the ANSO Scholarship for Young Talents
文摘Inorganic materials can solve transportable and on-site hydrolytic hydrogen generation issues.CaH_(2)/(Al/Si)composites are preferable due to their notable chemical properties.However,these composites require pretreatments,an inert environment,and long hours of physical ball milling for high homogeneity and synergistic effects.CaH_(2)also inhibits the hydrolysis reaction by forming its products on the Al/Si surface,which hinders the direct utilization of composites.This work represents the first investigation of NaH-CaH_(2)(Al/Si)fuel composites,which greatly overcome these limitations and can be directly used for on-site hydrogen generation and proton exchange membrane(PEM)fuel cells.The NaH-CaH_(2)(Al/Si)fuel composites were prepared by using a straightforward mixing method with variable composition ratios,showing high H_(2)yield and fuel cell(FC)performance.NaH addition provides the bridge effect,which opens up a new way to enable efficient hydrolysis and greatly enhances the hydrolysis activity of CaH_(2)/(Al/Si)composites.The novel fuel composites(NaH-CaH_(2)/Al)have extraordinary FC performance and a 0.42 W/cm2 peak power density greater than commercial hydrogen generators.It provides high H_(2)yield 84.4%for NaH-CaH_(2)/Al and 82%for NaH-CaH_(2)/Si compared to NaOH-CaH_(2)(Al/Si),NaCl-CaH_(2)(Al/Si),and KCl-CaH_(2)(Al/Si)composites.The NaH bridge effect hinders the direct water contact and stops the formation of Ca(OH)2 around Al/Si,which provides adequate pathways for the CaH_(2)(Al/Si)hydrolysis.The impressive capabilities of novel fuel composites are anticipated to offer practical uses in fuel cells,automobile applications,and portable/on-board H_(2)generation.
文摘As Thailand and China mark the 50th anniversary of their diplomatic ties this year,most headlines will naturally focus on trade deals,railways,and strategic partnerships.But tucked behind the golden spires of Bangkok’s Wat Po temple lies a quieter,gentler form of diplomacy—one that happens through kneading hands,respectful bows,and an ancient art passed down across generations.At the Wat Po Thai Traditional Medical School,headmaster Serat Tangtrongchitr sees Thai massage not only as a healing craft,but as a cultural bridge—one that connects people across borders,languages,and belief systems.“We don’t just teach massage,”Serat said,his voice calm but assured.“We teach a way of life.And when people from other cultures learn this with us—Chinese students included—they come to understand not just the techniques,but the heart of Thai culture.”
文摘In this paper, we aim to use an innovative model to integrate applied work on a fast-acting mind-body intervention, Mind-Body Bridging (MBB), with theoretical work based on psychology and neuroscience. In an affect-object generative inference and regulation (AGIR) model, we propose that functional dynamics between two systems, the affect-object thought generation system and the cognitive control system, can guide an individual to achieve homeostasis within self and harmonious relationships with others. We used Neurosynth (www.neurosynth.org), an automated meta-analysis database, to identify potential brain substrates underlying the key components in the AGIR model. Based on the findings, some brain regions are implicated as the key cortical substrates in this model, corroborating our central hypothesis that a hallmark of mind-body wellbeing can be characterized as a low-frequency anti-correlantion between 1) the cognitive control system including the dorsal anterior/middle cingulate cortex, and 2) the affect-object thought generation system including the ventromedial prefrontal cortex and posterior cingulate cortex. MBB provides an efficient strategy for responding to and dissolving a fundamental problem that impairs mind-body wellbeing, i.e., unrealistic identity-grasping consisting of self-centered embodied expectations of self and others. We demonstrated how theoretical and applied work could be integrated by drawing evidence from the neuroscience literature to support the AGIR model, and then we applied the AGIR model to elucidate how MBB might work.
基金support of the National Natural Science Foundation of China(Grant No.52371279)the Program for International Exchange and Cooperation in Education by the Ministry of Education of the People's Republic of China(Grant No.57220500123).
文摘Lost circulation of drilling fluid is one of the most common and costly problems in drilling operations.This highlights the importance of wellbore strengthening treatment sthat can utilize lost circulation materials(LCMs)to seal fractures associated with the wellbore.In this work,a numerical model accounting for the deformation of surrounding rock,fluid flow in the fracture,fracture propagation,and the transport of LCMs is presented to investigate the wellbore strengthening,from the fracture initiation to the fracture arrest,due to plugs formed by LCMs.The equations governing the rock deformation and fluid flow are solved by the dual boundary element method and the finite volume method,respectively.The transport of LCMs is solved based on an empirical constitutive model in suspension flow,and several characteristic quantities are derived by dimensional analysis.It is found that two dimensionless parameters,dimensionless toughness and normalized initial particle concentration,control the migration of LCM particles.The numerical results show that the dimensionless toughness influences the entrance and bridging of LCMs while the initial concentration controls the location of the particle bridging.When the initial concentration is larger than 0.8,the particle bridging tends to occur near the fracture entry.Conversely,when the initial concentration is less than 0.8,the particle bridging occurs near the fracture tip.This work provides an effective tool to predict the LCM transport and plugging in the wellbore strengthening process.
基金Supported by the Research Project of the Chinese Digestive Early Cancer Physicians’Joint Growth Program,No.GTCZ-2021-AH-34-0012.
文摘BACKGROUND Patients diagnosed with esophageal mucosal bridges often experience symptoms such as chest pain and dysphagia,which pose considerable challenges for endo-scopic surgical interventions.CASE SUMMARY We present a case involving early-stage esophageal cancer discovered in a resting room,notable for the rare manifestation of esophageal mucosal bridging.Following a comprehensive multidisciplinary discussion and the development of a treatment strategy,we proceeded with endoscopic submucosal dissection for the patient.During the procedure,we encountered operational challenges due to the presence of a diverticulum and a partial absence of the muscularis propria.To facilitate the retraction of a portion of the resected specimen,we utilized dental floss.Ultimately,we successfully excised the entire lesion.After a three-day period of fasting with a water-only diet,subsequent iodine water cholan-giography did not indicate any perforations,and the patient was advised to transition to a liquid diet.The patient was discharged five days post-operation.A follow-up endoscopy conducted three months later revealed scar-like changes in the mid-esophagus,with the patient reporting no significant discomfort.CONCLUSION In summary,although esophageal mucosal bridges are rarely documented,they should be considered in the differential diagnosis of mechanical dysphagia.Furthermore,endoscopic therapy represents a feasible approach for their mana-gement.
基金supported by the National Natural Science Foundation of China(Grant Nos.T2222027 and 12202416)。
文摘The energy release of energetic composites is severely limited by the inert alumina(Al_(2)O_(3))layer on the surface of aluminum(Al).Polytetrafluoroethylene(PTFE)could eliminate Al_(2)O_(3)layer due to its highly electronegativity and oxidability of fluorine.However,adding PTFE particles would weaken interfacial interactions resulted in poor mechanical properties and interfacial exothermic reaction.Herein,a bridging Al-PTFE as fuel and interfacial reinforcing agent was added and used to prepare LLM-105/AlPTFE microspheres,achieving both high energy output and excellent mechanical properties.The energy release and combustion reaction performance of LLM-105/Al-PTFE microspheres are significantly improved due to high reaction heat and increased interfacial reaction area of Al-PTFE.The maximum pressure and pressurization rate of LLM-105/Al-PTFE microspheres are 164.06 kPa and 29.88 kPa/s,respectively,which are 40.11%and 16.67%higher than those of physical mixed samples.Furthermore,the tensile strength and compressive strength of LLM-105/Al-PTFE microspheres are 100.40%and 26.47%higher than those of LLM-105/Al.This work provides a new approach to improve the energy release and mechanical properties for energetic composites.
文摘Biocatalysis with nicotinamide adenine dinucleotide phosphate(NADP)-dependent oxidoreductases faces a challenge in improving the efficiency of the costly cofactor utilization.Although enzyme fusion can offer cofactor regeneration,the high-volume input and limited cofactor recyclability still make the enzymatic processes unsustainable.Therefore,it is of great significance to reduce cofactor input in a fusion enzyme(FuE)system,but no successful practice has been reported.Herein,we design a decapeptide bridge,RRRQRRRARR(R10),with high affinity for NADPH to construct fusion oxidoreductases(phenylacetone monooxygenase and phosphite dehydrogenase)for ester synthesis and NADP recycling.The peptide bridge enables electrostatic cofactor channeling that transports NADPH/NADP^(+)across the peptide between the enzymes’NADP-binding pockets,so the fusion enzyme(FuE-R10)presents 2.1-folds and 2.0-folds higher conversions than mixed free enzymes and a flexible linker(GGGGSGGGGS)-fused enzyme,respectively,at NADPH/FuE of 0.1.The fusion enzyme,FuE-R5,bridged by a half-shortened linker,is proved more effective in facilitating cofactor channeling;compared to the mixed free enzymes,FuE-R5 exhibits two orders of magnitude reduction of NADPH input in ester synthesis.The work has thus demonstrated the potential of the cofactor bridging strategy in the development of sustainable cofactor-dependent cascade biocatalysis.
文摘The Emerging Markets and Developing Countries Forum on Bridging the AI Divide and Opening Ceremony of AIM Global CoE were held on July 27 in Minhang district,Shanghai.The event was hosted by AIM Global CoE,and co-organized by Shanghai Artificial Intelligence Research Institute(SAIRI),Shanghai Technology Innovation Center,Shanghai Grand Neobay Investment Development Group,and Organizing Committee of AI Journey Conference.Asian Association of Business Incubation(AABI)and SAIRI served as the international partners.
文摘Traditional Chinese medicine (TCM) with its millenniaold wisdom rooted in the principles of holistic Yin-Yang balance and “Bianzheng Lunzhi”[辨证论治, Zhenghou(证候) differentiation and treatment], has long offered a unique lens to understand human health and disease.However, the modern scientific interpretation of TCM remains at the stage of “knowing that it works, but not knowing why it works”.
基金funded by the Austrian Federal Railways(ÖBB Infrastruktur AG)in the context of the research project‘VeMoDiss’(acronym)。
文摘To ensure the compatibility between rolling stock and infrastructure when dynamically assessing railway bridges under high-speed traffic,the damping properties considered in the calculation model significantly influence the predicted acceleration amplitude at resonance.However,due to the normative specifications of EN 1991-2,which are considered to be overly conservative,damping factors that are far below the actual damping have to be used when predicting vibrations of railway bridges,which means that accelerations at resonance tend to be overestimated to an uneconomical extent.Comparisons between damping factors prescribed by the standard and those identified based on in situ structure measurements always reveal a large discrepancy between reality and regulation.Given this background,this contribution presents a novel approach for defining the damping factor of railway bridges with ballasted tracks,where the damping factor for bridges is mathematically determined based on three different two-dimensional mechanical models.The basic principle of the approach for mathematically determining the damping factor is to separately define and superimpose the dissipative contributions of the supporting structure(including the substructure)and the superstructure.Using the results of a measurement campaign on 15 existing steel railway bridges in the Austrian rail network,the presented mechanical models are calibrated,and by analysing the energy dissipation in the ballasted track,guiding principles for practical application are defined.This guideline is intended to establish an alternative to the currently valid specifications of EN 1991-2,enabling the damping factor of railway bridges to be assessed in a realistic range by mathematical calculation and thus without the need for extensive in situ measurements on the individual structure.In this way,the existing potential of the infrastructure with regard to the damping properties of bridges can be utilised.This contribution focuses on steel bridges,but the mathematical approach for determining the damping factor applies equally to other bridge types(concrete,composite,or filler beam).
基金supported by the National Natural Science Foundation of China(No.82170206 and No.82470213)Project of Disciplines of Excellence(No.20234Z0002)。
文摘Blinatumomab has demonstrated efficacy in B-cell acute lymphoblastic leukemia(B-ALL),achieving a measurable residual disease(MRD)negativity rate of 78%(1).Its addition to consolidation chemotherapy or administration prior to allogeneic hematopoietic stem cell transplantation(allo-HSCT)has been shown to significantly improve overall survival(OS)and relapse-free survival(RFS)in adult B-ALL patients(2,3).
文摘In the Kigongo area of Mwanza Region,northwest Tanzania,fishmonger Neema Aisha remembers how the morning’s fresh catch would sour while she queued for the ferry,putting her business at risk.
基金supported by the Key Technologies Research and Development Program under Grant 2021YFB1600300.
文摘To examine stress redistribution phenomena in bridges subjected to varying operational conditions,this study conducts a comprehensive analysis of three years of monitoring data from a 153-m double-deck road–rail steel arch bridge.An initial statistical comparison of sensor data distributions reveals clear temporal variations in stress redistribution patterns.XGBoost(eXtreme Gradient Boosting),a gradient-boosting machine learning(ML)algorithm,was employed not only for predictive modeling but also to uncover the underlying mechanisms of stress evolution.Unlike traditional numerical models that rely on extensive assumptions and idealizations,XGBoost effectively captures nonlinear and time-varying relationships between stress states and operational/environmental factors,such as temperature,traffic load,and structural geometry.This approach allows for the identification of critical periods and conditions under which stress redistribution becomes significant.Results indicate a clear shift of stress concentrations frombeamends toward mid-span regions following the commencement of metro operations,reflecting both structural adaptation and localized overstress near arch ribs.Furthermore,the model generates robust predictions of stress evolution,demonstrating potential applications in early warning systems and fatigue risk assessment.This work represents the first application of interpretable gradient-boosting techniques to stress redistribution modeling in double-deck bridges.In addition,a Stress Redistribution Index(SRI)is proposed,derived from this monitoring study and finite-element-based transverse load distributions,to quantify temporal stress shifts between midspan and edge beams.The results provide both theoretical contributions and practical guidance for the design,inspection,and maintenance of complex bridge structures.
基金Natural Science Foundation of China under Grant No.52178449,the Beijing Natural Science Foundation under Grant No.8234060the Innovation Center of Beijing Association for Science and Technology。
文摘This study proposes a new post-tensioned precast bridge column(PT-PBC)with a socket connection.Compared to conventional PBCs connected by PT tendons,the combination of the PT tendons with the socket connection can avoid tensioning the PT tendons on site,which further accelerates construction speed while improving construction quality and safety.In addition,compared to conventional PBCs with a socket connection,a rocking interface can avoid the formation of a plastic hinge in a column,which greatly alleviates seismic damage to that area.One specimen for quasi-static testing is used to validate the feasibility of this connection type.Subsequently,finite element models(FEM)are established to systematically predict the responses of the proposed columns under lateral cyclic loading.The accuracy of the FEM is verified through quasistatic testing.Next,the influences of the key design parameters of the PT-PBC,including the area ratio and prestress level of the PT tendons,the area ratio of energy dissipation(ED)steel rebars,and the total axial compression ratio on the seismic performances of PT-PBC are systematically investigated.The use of shape memory alloy(SMA)rods as energy dissipation devices and their performances also are investigated.The results show that increasing the area ratio and prestress level of PT tendons has an overall positive impact on the self-centering capacity of the column.The prestress level of PT tendons should be kept between 35%and 55%,depending on different conditions.The total compression axial ratio of the columns should be maintained between 0.3 and 0.4.Both ED steel rebars and SMA rods can boost the column’s energy dissipation capacity,while SMA rods can reduce residual deformation due to their inherent mechanical properties.
基金Supported by the National Natural Science Foundation of China(Grant Nos.11961059,1210502)the University Innovation Project of Gansu Province(Grant No.2023B-062)the Gansu Province Basic Research Innovation Group Project(Grant No.23JRRA684).
文摘The goal of this paper is to investigate the long-time dynamics of solutions to a Kirchhoff type suspension bridge equation with nonlinear damping and memory term.For this problem we establish the well-posedness and existence of uniform attractor under some suitable assumptions on the nonlinear term g(u),the nonlinear damping f(u_(t))and the external force h(x,t).Specifically,the asymptotic compactness of the semigroup is verified by the energy reconstruction method.
基金Shenzhen Science and Technology Program(Grant No.20220817171811004)(Grant No.RCBS20231211090816033)+4 种基金the Major Key Project of PCL,China under Grant PCL2025A13Longgang District,Shenzhen's"Ten-Action Plan"for Supporting Innovation Projects(Grant No.LGKCSDPT2024002,LGKCSDPT2024003,LGKCSDPT2024004)the"Zhiguo"Action of Guangxi Science and Technology Program(Grant No.ZG2503980003)Guangdong S&T Program under(Grant No.2025B0909040003)Guangdong Provincial Leading Talent Program(Grant No.2024TX08Z319).
文摘The main cable is the primary load-bearing component of a suspension bridge,continuously exposed to harsh environmental conditions,such as wind and rain,throughout the year.These adverse conditions contribute to varying degrees of degradation and damage to the main cable,necessitating regular inspections to prevent catastrophic failures.Traditional manual inspection methods not only suffer from low efficiency but also pose significant safety risks to personnel.To address these challenges and ensure the safe and effective inspection of suspension bridge main cables,this study introduces a novel cooperative climbing robot,designated as Main Cable Robot Version II(CCRobot-M-II),inspired by the locomotion of the inchworm.The robot employs an alternating opening and closing mechanism of four gripper sets,mimicking the inchworm's movement to achieve efficient crawling along the suspension bridge handrails.This paper provides a comprehensive analysis of the structural design,key components,and motion mechanisms of CCRobot-M-II.A detailed force analysis of the robot's crawling process is also presented,followed by the design of the control system and the development of an efficient motion control algorithm.Laboratory experiments demonstrate that the robot achieves a positional error of 00.64%during crawling,with a maximum average crawling speed of 7.6 m/min.Furthermore,the biomimetic design enables the robot to overcome obstacles up to 30 mm in height and possess the capability to handle suspension bridge cables with spans ranging from 740 to 1100 mm.Finally,CCRobot-M-II successfully conducted an inspection of the main cable on a suspension bridge,marking the world's first successful deployment of a climbing robot for main cable inspection on a suspension bridge.
基金sponsored by the National Natural Science Foundation of China(Grant No.52178100).
文摘The spatial offset of bridge has a significant impact on the safety,comfort,and durability of high-speed railway(HSR)operations,so it is crucial to rapidly and effectively detect the spatial offset of operational HSR bridges.Drive-by monitoring of bridge uneven settlement demonstrates significant potential due to its practicality,cost-effectiveness,and efficiency.However,existing drive-by methods for detecting bridge offset have limitations such as reliance on a single data source,low detection accuracy,and the inability to identify lateral deformations of bridges.This paper proposes a novel drive-by inspection method for spatial offset of HSR bridge based on multi-source data fusion of comprehensive inspection train.Firstly,dung beetle optimizer-variational mode decomposition was employed to achieve adaptive decomposition of non-stationary dynamic signals,and explore the hidden temporal relationships in the data.Subsequently,a long short-term memory neural network was developed to achieve feature fusion of multi-source signal and accurate prediction of spatial settlement of HSR bridge.A dataset of track irregularities and CRH380A high-speed train responses was generated using a 3D train-track-bridge interaction model,and the accuracy and effectiveness of the proposed hybrid deep learning model were numerically validated.Finally,the reliability of the proposed drive-by inspection method was further validated by analyzing the actual measurement data obtained from comprehensive inspection train.The research findings indicate that the proposed approach enables rapid and accurate detection of spatial offset in HSR bridge,ensuring the long-term operational safety of HSR bridges.
基金supported by the National Natural Science Foundation of China(U24A20550,52273264 and 52470073)the Key Project of the Heilongjiang Provincial Natural Science Foundation(ZD2024B001)Outstanding Youth Fund of Heilongjiang Province(JQ2022E005).
文摘Designing a heterogeneous interface to improve the kinetics of electrocatalysts represents an effective yet challenging approach for enhancing the oxygen reduction reaction(ORR)and oxygen evolution reaction(OER).Herein,a simple MOF-assisted etching-pyrolysis strategy is proposed to fabricate an advanced Mott-Schottky(M–S)electrocatalyst composed of Co/CeO_(2)hetero-nanoparticles embedded within N-doped hollow carbon nanoboxes(H-Co/CeO_(2)@NCBs).Notably,the interfacial Co–O–Ce bond bridging productively facilitates the electron transfer and modulates the charge distribution of the active center,thereby contributing to the ORR/OER kinetics.As expected,the optimal M–S H-Co/CeO_(2)@NCBs catalyst exhibits promising bifunctional electrocatalytic activity with a small potential discrepancy of 0.65 V.Theoretical calculations reveal that the built-in electric field in the M–S heterojunction promotes electron transfer in oxygen electrocatalysis and the interfacial bridge-induced electron redistribution optimizes the adsorption/desorption of the oxygen intermediates,leading to reduced activation energy for the bifunctional ORR/OER reactions.Importantly,H-Co/CeO_(2)@NCBs-assembled Zn-air battery(ZAB)delivers high power density(179.8 mW cm^(−2))and long-term stability(400 h).Furthermore,the assembled flexible solid-state ZAB with H-Co/CeO_(2)@NCBs cathode also exhibits excellent charge–discharge reversibility and flexibility at various bending angles.This work provides a novel perspective on developing efficient and stable M–S bifunctional oxygen electrocatalysts.
基金supported by Natural Science Basic Research Program of Shaanxi Province of China(Grant No.2023JCYB574)National Natural Science Foundation of China(Grant No.62204203)。
文摘A monolithic integrated full-wave bridge rectifier consisted of horizontal Schottky-barrier diodes(SBD)is prepared based on 100 nm ultra-thin β-Ga_(2)O_(3)and demonstrated the solar-blind UV(SUV)light-modulated characteristics.Under SUV light illumination,the rectifier has the excellent full-wave rectification characteristics for the AC input signals of 5,12,and 24 V with different frequencies.Further,experimental results confirmed the feasibility of continuously tuning the rectified output through SUV light-encoding.This work provides valuable insights for the development of optically programmable Ga_(2)O_(3)ACDC converters.
