Objective: to analyze the influence of prenatal and postpartum nursing method on breast milk secretion and feeding. Methods: choose our obstetrics and gynecology in April 2020-2021 between 120 cases of maternal, rando...Objective: to analyze the influence of prenatal and postpartum nursing method on breast milk secretion and feeding. Methods: choose our obstetrics and gynecology in April 2020-2021 between 120 cases of maternal, randomized observation group maternal prenatal postpartum nursing intervention, control group maternal routine nursing intervention, statistical two groups of maternal postpartum lactation and other clinical indicators, summarizes the effect of prenatal postpartum nursing model in maternal nursing intervention. Methods: to compare the postpartum lactation situation between the two maternal groups, the proportion of adequate maternal milk volume in the observed group was significantly higher than that in the control group. The data varied significantly between the groups (P <0.05);comparison of postpartum infant feeding data between the two maternal groups, the proportion of breastfeeding in the observation group was significantly higher than that in the control group (P <0.05);comparing the postpartum lactation time between the two maternal groups, the postpartum lactation time was earlier than the control group, and the data varied significantly between the groups (P <0.05);comparison of maternal postpartum feeding-related knowledge scores between the two groups, maternal breastfeeding skills, self-care methods, and health behavior management scores were significantly higher than those in the control group, and the data varied significantly (P <0.05). Conclusion: in the current obstetric clinical nursing work, the active prenatal and postpartum nursing intervention method can further promote the secretion of breast milk, improve the level and enthusiasm of breastfeeding, and is worth promoting.展开更多
BACKGROUND Human milk oligosaccharides(HMOs)are bioactive components of breast milk with diverse health benefits,including shaping the gut microbiota,modulating the immune system,and protecting against infections.HMOs...BACKGROUND Human milk oligosaccharides(HMOs)are bioactive components of breast milk with diverse health benefits,including shaping the gut microbiota,modulating the immune system,and protecting against infections.HMOs exhibit dynamic secretion patterns during lactation,influenced by maternal genetics and environ-mental factors.Their direct and indirect antimicrobial properties have garnered significant research interest.However,a comprehensive understanding of the secretion dynamics of HMOs and their correlation with antimicrobial efficacy remains underexplored.AIM To synthesize current evidence on the secretion dynamics of HMOs during lactation and evaluate their antimicrobial roles against bacterial,viral,and protozoal pathogens.METHODS A systematic search of PubMed,Scopus,Web of Science,and Cochrane Library focused on studies investigating natural and synthetic HMOs,their secretion dynamics,and antimicrobial properties.Studies involving human,animal,and in vitro models were included.Data on HMO composition,temporal secretion patterns,and mechanisms of antimicrobial action were extracted.Quality assess-ment was performed using validated tools appropriate for study design.RESULTS A total of 44 studies were included,encompassing human,animal,and in vitro research.HMOs exhibited dynamic secretion patterns,with 2′-fucosyllactose(2′-FL)and lacto-N-tetraose peaking in early lactation and declining over time,while 3-fucosyllactose(3-FL)increased during later stages.HMOs demonstrated significant antimicrobial properties through pathogen adhesion inhibition,biofilm disruption,and enzymatic activity impairment.Synthetic HMOs,including bioengineered 2′-FL and 3-FL,were structurally and functionally comparable to natural HMOs,effectively inhibiting pathogens such as Pseudomonas aeruginosa,Escherichia coli,and Campylobacter jejuni.Additionally,HMOs exhibited synergistic effects with antibiotics,enhancing their efficacy against resistant pathogens.CONCLUSION HMOs are vital in antimicrobial defense,supporting infant health by targeting various pathogens.Both natural and synthetic HMOs hold significant potential for therapeutic applications,particularly in infant nutrition and as adjuncts to antibiotics.Further research,including clinical trials,is essential to address gaps in knowledge,validate findings,and explore the broader applicability of HMOs in improving maternal and neonatal health.展开更多
文摘Objective: to analyze the influence of prenatal and postpartum nursing method on breast milk secretion and feeding. Methods: choose our obstetrics and gynecology in April 2020-2021 between 120 cases of maternal, randomized observation group maternal prenatal postpartum nursing intervention, control group maternal routine nursing intervention, statistical two groups of maternal postpartum lactation and other clinical indicators, summarizes the effect of prenatal postpartum nursing model in maternal nursing intervention. Methods: to compare the postpartum lactation situation between the two maternal groups, the proportion of adequate maternal milk volume in the observed group was significantly higher than that in the control group. The data varied significantly between the groups (P <0.05);comparison of postpartum infant feeding data between the two maternal groups, the proportion of breastfeeding in the observation group was significantly higher than that in the control group (P <0.05);comparing the postpartum lactation time between the two maternal groups, the postpartum lactation time was earlier than the control group, and the data varied significantly between the groups (P <0.05);comparison of maternal postpartum feeding-related knowledge scores between the two groups, maternal breastfeeding skills, self-care methods, and health behavior management scores were significantly higher than those in the control group, and the data varied significantly (P <0.05). Conclusion: in the current obstetric clinical nursing work, the active prenatal and postpartum nursing intervention method can further promote the secretion of breast milk, improve the level and enthusiasm of breastfeeding, and is worth promoting.
文摘BACKGROUND Human milk oligosaccharides(HMOs)are bioactive components of breast milk with diverse health benefits,including shaping the gut microbiota,modulating the immune system,and protecting against infections.HMOs exhibit dynamic secretion patterns during lactation,influenced by maternal genetics and environ-mental factors.Their direct and indirect antimicrobial properties have garnered significant research interest.However,a comprehensive understanding of the secretion dynamics of HMOs and their correlation with antimicrobial efficacy remains underexplored.AIM To synthesize current evidence on the secretion dynamics of HMOs during lactation and evaluate their antimicrobial roles against bacterial,viral,and protozoal pathogens.METHODS A systematic search of PubMed,Scopus,Web of Science,and Cochrane Library focused on studies investigating natural and synthetic HMOs,their secretion dynamics,and antimicrobial properties.Studies involving human,animal,and in vitro models were included.Data on HMO composition,temporal secretion patterns,and mechanisms of antimicrobial action were extracted.Quality assess-ment was performed using validated tools appropriate for study design.RESULTS A total of 44 studies were included,encompassing human,animal,and in vitro research.HMOs exhibited dynamic secretion patterns,with 2′-fucosyllactose(2′-FL)and lacto-N-tetraose peaking in early lactation and declining over time,while 3-fucosyllactose(3-FL)increased during later stages.HMOs demonstrated significant antimicrobial properties through pathogen adhesion inhibition,biofilm disruption,and enzymatic activity impairment.Synthetic HMOs,including bioengineered 2′-FL and 3-FL,were structurally and functionally comparable to natural HMOs,effectively inhibiting pathogens such as Pseudomonas aeruginosa,Escherichia coli,and Campylobacter jejuni.Additionally,HMOs exhibited synergistic effects with antibiotics,enhancing their efficacy against resistant pathogens.CONCLUSION HMOs are vital in antimicrobial defense,supporting infant health by targeting various pathogens.Both natural and synthetic HMOs hold significant potential for therapeutic applications,particularly in infant nutrition and as adjuncts to antibiotics.Further research,including clinical trials,is essential to address gaps in knowledge,validate findings,and explore the broader applicability of HMOs in improving maternal and neonatal health.
