A new kind of multiple metal （Cu, Mg, Ce） doped Ni based mixed oxide catalyst, synthesized by the co-precipitation method, was used for efficient production of hydrogen from bio-oil reforming at 250-500℃. Two refor...A new kind of multiple metal （Cu, Mg, Ce） doped Ni based mixed oxide catalyst, synthesized by the co-precipitation method, was used for efficient production of hydrogen from bio-oil reforming at 250-500℃. Two reforming processes, the conventional steam reforming （CSR） and the electrochemical catalytic reforming （ECR）, were performed for the bio-oil reforming. The catalyst with an atomic mol ratio of Ni：Cu：Mg：Ce：AI=5.6：1.1：1.9：1.0：9.9 exhibited very high reforming activity both in CSR and ECR processes, reaching 82.8% hydrogen yield at 500℃ in the CSR, yield of 91.1% at 400℃ and 3.1 A in the ECR, respectively. The influences of reforming temperature and the current through the catalyst in the ECR were investigated. It was observed that the reforming and decomposition of the bio-oil were significantly enhanced by the current. The promoting effects of current on the decomposition and reforming processes of bio-oil were further studied by using the model compounds of bio- oil （acetic acid and ethanol） under 101 kPa or low pressure （0.1 Pa） through the time of flight analysis. The catalyst also shows high water gas shift activity in the range of 300-600 ℃. The catalyst features and alterations in the bio-oil reforming were characterized by the ICP, XRD, XPS and BET measurements. The mechanism of bio-oil reforming was discussed based on the study of the elemental reactions and catalyst characterizations. The research catalyst, potentially, may be a practical catalyst for high efficient production of hydrogen from reforming of bio-oil at mild-temperature.展开更多
Effective mild-temperature photothermal therapy(MTPTT) requires photothermal agents with high photothermal conversion efficiency(PCE) and balanced fluorescence quantum yield to enable efficient tumor treatment while m...Effective mild-temperature photothermal therapy(MTPTT) requires photothermal agents with high photothermal conversion efficiency(PCE) and balanced fluorescence quantum yield to enable efficient tumor treatment while minimizing damage to surrounding healthy tissues. In this study, we designed donor–acceptor–donor structured dyes, 4,4'-((6,7-di(thiophen-2-yl)-[1,2,5]thiadiazolo[3,4-g]quinoxaline-4,9-diyl)bis(thiophene-5,2-diyl))bis(N,N-bis(4-methoxyphenyl)aniline)(IT-STPA) and4,4'-((6,7-di(furan-2-yl)-[1,2,5]thiadiazolo[3,4-g]quinoxaline-4,9-diyl)bis(thiophene-5,2-diyl))bis(N,N-bis(4-methoxyphenyl)aniline)(IT-OTPA), featuring furan-modified thiadiazoloquinoxaline for near-infrared–Ⅱ(NIR-Ⅱ) fluorescence imaging and enhanced PCE. The furan and thiophene modifications promoted aggregation-induced emission, resulting in strong fluorescence emission(1 000–1 400 nm) while maintaining a high PCE of 48.5%. IT-OTPA was encapsulated into nanoparticles for improved aqueous dispersion and combined with the HSP70 inhibitor apoptozole(APZ) to form OTAPZ nanoparticles. The efficacy of this combination was evaluated both in vitro and in vivo, showing efficient tumor targeting and effective MTPTT under NIR laser irradiation. This study presents a promising approach for enhancing MTPTT through balanced photothermal and fluorescence properties, offering new possibilities for cancer treatment.展开更多
Single-atom nanozymes(SAzymes)hold significant potential for tumor catalytic therapy,but their effectiveness is often compromised by low catalytic efficiency within tumor microenvironment.This efficiency is mainly inf...Single-atom nanozymes(SAzymes)hold significant potential for tumor catalytic therapy,but their effectiveness is often compromised by low catalytic efficiency within tumor microenvironment.This efficiency is mainly influenced by key factors including hydrogen peroxide(H_(2)O_(2))availability,acidity,and temperature.Simultaneous optimization of these key factors presents a significant challenge for tumor catalytic therapy.In this study,we developed a comprehensive strategy to refine single-atom catalytic kinetics for enhancing tumor catalytic therapy through dual-enzyme-driven cascade reactions.Iridium(Ir)SAzymes with high catalytic activity and natural enzyme glucose oxidase(GOx)were utilized to construct the cascade reaction system.GOx was loaded by Ir SAzymes due to its large surface area.Then,the dual-enzyme-driven cascade reaction system was modified by cancer cell membranes for improving biocompatibility and achieving tumor homologous targeting ability.GOx catalysis reaction could produce abundant H2O2 and lower the local p H,thereby optimizing key reaction-limiting factors.Additionally,upon laser irradiation,Ir SAzymes could raise local temperature,further enhancing the catalytic efficiency of dual-enzyme system.This comprehensive optimization maximized the performance of Ir SAzymes,significantly improving the efficiency of catalytic therapy.Our findings present a strategy of refining single-atom catalytic kinetics for tumor homologous-targeted catalytic therapy.展开更多
Under laser irradiation,photothermal therapy(PTT)effectively ablates tumors above 50℃.However,hyperthermia can cause additional damage due to the inevitable heat spread to surrounding healthy tissue.Herein,nanopartic...Under laser irradiation,photothermal therapy(PTT)effectively ablates tumors above 50℃.However,hyperthermia can cause additional damage due to the inevitable heat spread to surrounding healthy tissue.Herein,nanoparticles named as GI@P NPs were designed for enhanced PTT with heat shock protein 90(HSP90)inhibition at temperatures below 50℃to achieve optimal cancer therapy and avoid surrounding damage.GI@P NPs were done by co-loading Garcinia cambogia acid(GA)and photosensitizer IR783 in polymer PLG-g-mPEG to form a nanomedicine,where IR783 with excellent photoacoustic(PA)signal acted as an excellent photothermal therapeutic agent that converted the laser energy into heat to kill tumor cells,GA was used as antitumor drug for chemotherapy and an inhibitor of HSP90 to overcome the heat resistance of tumors for efficient cryo-photothermal therapy,and PLG-g-mPEG can encapsulate IR783 and GA to increase biocompatibility and accumulate effectively in the tumor.After GI@P NPs were injected into the mice,we could observe that the PA signals gradually increased in the tumor region and showed the strongest PA signals at 12 h.Under laser irradiation,the tumor temperature of the mice could raise to about 43.5℃,and the tumor was significantly inhibited after long-term monitoring by PA imaging.As a result,gentle PTT produced by GI@P NPs exhibited good antitumor effects at relatively low temperature and minimized nonspecific thermal damage to normal tissues.The GI@P NPs as nanomedicine enriched our understanding of various applications of polymeric carriers,especially in the biomedical field.展开更多
文摘A new kind of multiple metal （Cu, Mg, Ce） doped Ni based mixed oxide catalyst, synthesized by the co-precipitation method, was used for efficient production of hydrogen from bio-oil reforming at 250-500℃. Two reforming processes, the conventional steam reforming （CSR） and the electrochemical catalytic reforming （ECR）, were performed for the bio-oil reforming. The catalyst with an atomic mol ratio of Ni：Cu：Mg：Ce：AI=5.6：1.1：1.9：1.0：9.9 exhibited very high reforming activity both in CSR and ECR processes, reaching 82.8% hydrogen yield at 500℃ in the CSR, yield of 91.1% at 400℃ and 3.1 A in the ECR, respectively. The influences of reforming temperature and the current through the catalyst in the ECR were investigated. It was observed that the reforming and decomposition of the bio-oil were significantly enhanced by the current. The promoting effects of current on the decomposition and reforming processes of bio-oil were further studied by using the model compounds of bio- oil （acetic acid and ethanol） under 101 kPa or low pressure （0.1 Pa） through the time of flight analysis. The catalyst also shows high water gas shift activity in the range of 300-600 ℃. The catalyst features and alterations in the bio-oil reforming were characterized by the ICP, XRD, XPS and BET measurements. The mechanism of bio-oil reforming was discussed based on the study of the elemental reactions and catalyst characterizations. The research catalyst, potentially, may be a practical catalyst for high efficient production of hydrogen from reforming of bio-oil at mild-temperature.
基金the National Natural Science Foundation of China (No. 82172835)the Doctoral Scientific Research Foundation of Xinxiang Medical University (No. 505541)。
文摘Effective mild-temperature photothermal therapy(MTPTT) requires photothermal agents with high photothermal conversion efficiency(PCE) and balanced fluorescence quantum yield to enable efficient tumor treatment while minimizing damage to surrounding healthy tissues. In this study, we designed donor–acceptor–donor structured dyes, 4,4'-((6,7-di(thiophen-2-yl)-[1,2,5]thiadiazolo[3,4-g]quinoxaline-4,9-diyl)bis(thiophene-5,2-diyl))bis(N,N-bis(4-methoxyphenyl)aniline)(IT-STPA) and4,4'-((6,7-di(furan-2-yl)-[1,2,5]thiadiazolo[3,4-g]quinoxaline-4,9-diyl)bis(thiophene-5,2-diyl))bis(N,N-bis(4-methoxyphenyl)aniline)(IT-OTPA), featuring furan-modified thiadiazoloquinoxaline for near-infrared–Ⅱ(NIR-Ⅱ) fluorescence imaging and enhanced PCE. The furan and thiophene modifications promoted aggregation-induced emission, resulting in strong fluorescence emission(1 000–1 400 nm) while maintaining a high PCE of 48.5%. IT-OTPA was encapsulated into nanoparticles for improved aqueous dispersion and combined with the HSP70 inhibitor apoptozole(APZ) to form OTAPZ nanoparticles. The efficacy of this combination was evaluated both in vitro and in vivo, showing efficient tumor targeting and effective MTPTT under NIR laser irradiation. This study presents a promising approach for enhancing MTPTT through balanced photothermal and fluorescence properties, offering new possibilities for cancer treatment.
基金financially supported by National Natural Science Foundation of China(U23A2097,82372116,22474079,22104094,82302362)Shenzhen Medical Research Fund(B2302047)+3 种基金Basic Research Program of Shenzhen(KQTD20190929172538530,JCYJ20220818095806014,JCYJ20240813142810014)Natural Science Foundation of Guangdong Province(2024A1515012677)Research Team Cultivation Program of Shenzhen University(2023QNT017,2023QNT019)Shenzhen University 2035 Program for Excellent Research(2024C004)。
文摘Single-atom nanozymes(SAzymes)hold significant potential for tumor catalytic therapy,but their effectiveness is often compromised by low catalytic efficiency within tumor microenvironment.This efficiency is mainly influenced by key factors including hydrogen peroxide(H_(2)O_(2))availability,acidity,and temperature.Simultaneous optimization of these key factors presents a significant challenge for tumor catalytic therapy.In this study,we developed a comprehensive strategy to refine single-atom catalytic kinetics for enhancing tumor catalytic therapy through dual-enzyme-driven cascade reactions.Iridium(Ir)SAzymes with high catalytic activity and natural enzyme glucose oxidase(GOx)were utilized to construct the cascade reaction system.GOx was loaded by Ir SAzymes due to its large surface area.Then,the dual-enzyme-driven cascade reaction system was modified by cancer cell membranes for improving biocompatibility and achieving tumor homologous targeting ability.GOx catalysis reaction could produce abundant H2O2 and lower the local p H,thereby optimizing key reaction-limiting factors.Additionally,upon laser irradiation,Ir SAzymes could raise local temperature,further enhancing the catalytic efficiency of dual-enzyme system.This comprehensive optimization maximized the performance of Ir SAzymes,significantly improving the efficiency of catalytic therapy.Our findings present a strategy of refining single-atom catalytic kinetics for tumor homologous-targeted catalytic therapy.
基金the National Natural Science Foundation of China(Nos.52173115,52073278,51925305 and 51873208)Jilin province science and technology development program(No.20200201103JC)Foundation of Department of Education of Jilin Province of China(No.JJKH20210828KJ).
文摘Under laser irradiation,photothermal therapy(PTT)effectively ablates tumors above 50℃.However,hyperthermia can cause additional damage due to the inevitable heat spread to surrounding healthy tissue.Herein,nanoparticles named as GI@P NPs were designed for enhanced PTT with heat shock protein 90(HSP90)inhibition at temperatures below 50℃to achieve optimal cancer therapy and avoid surrounding damage.GI@P NPs were done by co-loading Garcinia cambogia acid(GA)and photosensitizer IR783 in polymer PLG-g-mPEG to form a nanomedicine,where IR783 with excellent photoacoustic(PA)signal acted as an excellent photothermal therapeutic agent that converted the laser energy into heat to kill tumor cells,GA was used as antitumor drug for chemotherapy and an inhibitor of HSP90 to overcome the heat resistance of tumors for efficient cryo-photothermal therapy,and PLG-g-mPEG can encapsulate IR783 and GA to increase biocompatibility and accumulate effectively in the tumor.After GI@P NPs were injected into the mice,we could observe that the PA signals gradually increased in the tumor region and showed the strongest PA signals at 12 h.Under laser irradiation,the tumor temperature of the mice could raise to about 43.5℃,and the tumor was significantly inhibited after long-term monitoring by PA imaging.As a result,gentle PTT produced by GI@P NPs exhibited good antitumor effects at relatively low temperature and minimized nonspecific thermal damage to normal tissues.The GI@P NPs as nanomedicine enriched our understanding of various applications of polymeric carriers,especially in the biomedical field.
