Objectives:This study aimed to generate a theoretical framework based on empirical data to explain the behavioral patterns closely related to young and middle-aged patients with lymphoma throughout the disease.Methods...Objectives:This study aimed to generate a theoretical framework based on empirical data to explain the behavioral patterns closely related to young and middle-aged patients with lymphoma throughout the disease.Methods:This study followed the classic grounded theory methodology,involving procedures such as theoretical sampling,substantive coding,theoretical coding,constant comparison,and memo writing and sorting.Multiple data types were used based on the principle of“all is data,”including 34 participants providing interview data along with observation notes and 40 relevant secondary texts from the“Lymphoma House”network platform and the“Lymphoma House 086”public account.Two autobiographical books written by lymphoma patients were also selected as data resources.Data collection and analysis were conducted in an iterative process until theoretical saturation was reached.The COREQ checklist was followed to report this study.Results:The main concern of middle-aged and young patients with lymphoma was identifiedas restoring normality,while managing uncertainty was the main behavioral pattern for restoring normality.Uncertainty consists of two interrelated types:inherent uncertainty of illness and perceived uncertainty of patients.Four strategies are used to manage uncertainty:reconstructing certainty,adaptive coping,defensive buffering,and compensatory changing.Managing uncertainty is influenced by disease characteristics and perceptions,social resources,and cultural concepts.The consequence of managing uncertainty is reaching a new normality.Conclusions:Pervasive uncertainty significantly affects the daily lives of young and middle-aged patients with lymphoma.Consequently,strategies for managing disease-related uncertainty to sustain normality are commonly observed in this population.This theoretical framework for addressing uncertainty can serve as a foundation for understanding and developing tailored interventions to manage uncertainty.Future research should focus on managing uncertainty to help patients restore normality.展开更多
BACKGROUND Breast cancer(BC)is the second most common malignancy globally.Young and middle-aged patients face more pressures from diagnosis,treatment,costs,and psychological issues like self-image concerns,social barr...BACKGROUND Breast cancer(BC)is the second most common malignancy globally.Young and middle-aged patients face more pressures from diagnosis,treatment,costs,and psychological issues like self-image concerns,social barriers,and professional challenges.Compared to other age groups,they have higher recurrence rates,lower survival rates,and increased risk of depression.Research is lacking on factors influencing depressive symptoms and predictive models for this age group.AIM To analyze factors influencing depressive symptoms in young/middle-aged BC patients and construct a depression risk predictive model.METHODS A total of 360 patients undergoing BC treatment at two tertiary hospitals in Jiangsu Province,China from November 2023 to April 2024 were included in the study.Participants were surveyed using a general information questionnaire,the patient health questionnaire depression scale,the visual analog scale for pain,the revised family support scale,and the long form of the international physical activity questionnaire.Univariate and multivariate analyses were conducted to identify the factors affecting depression in middle-aged and young BC patients,and a predictive model for depression risk was developed based on these findings.RESULTS Among the 360 middle-aged and young BC patients,the incidence rate of depressive symptoms was 38.61%(139/360).Multivariate analysis revealed that tumor grade,patient’s monthly income,pain score,family support score,and physical activity score were factors influencing depression in this patient group(P<0.05).The risk prediction model constructed based on these factors yielded an area under the receiver operating characteristic curve of 0.852,with a maximum Youden index of 0.973,sensitivity of 86.80%,specificity of 89.50%,and a diagnostic odds ratio of 0.552.The Hosmer-Lemeshow test for goodness of fit indicated an adequate model fit(χ^(2)=0.360,P=0.981).CONCLUSION The constructed predictive model demonstrates good predictive performance and can serve as a reference for medical professionals to early identify high-risk patients and implement corresponding preventive measures to decrease the incidence of depressive symptoms in this population.展开更多
AIM:To evaluate the prevalence of early post-traumatic stress disorder(PTSD)among young and middle-aged patients who have suffered open globe injuries,and to identify the psychosocial factors influencing PTSD in these...AIM:To evaluate the prevalence of early post-traumatic stress disorder(PTSD)among young and middle-aged patients who have suffered open globe injuries,and to identify the psychosocial factors influencing PTSD in these patients.METHODS:A total of 280 patients who underwent ocular trauma surgery between January 2023 and January 2024 were selected through convenience sampling.Data were collected using a custom-designed demographic questionnaire,the Connor-Davidson Resilience Scale(CDRISC),the Cognitive Emotion Regulation Questionnaire(C-ERRI),and the PTSD Checklist-Civilian Version(PCL-C).Univariate analysis and stepwise multiple linear regression analysis were performed to determine the factors affecting PTSD in these patients.RESULTS:The average PTSD score for the patients was 33.22±13.48.The scores for individual PTSD dimensions,ranked from highest to lowest,were recurrent traumatic experiences,heightened arousal,avoidance reactions,and social dysfunction.Positive PTSD symptoms were observed in 85 patients(30.36%).Univariate analysis indicated that gender,postoperative vision,marital status,psychological resilience,and rumination were significant factors affecting PTSD symptoms(χ^(2)/t=6.53,17.88,8.83,2.17,and 14.1,respectively;all P<0.05).Pearson correlation analysis showed a positive correlation between rumination and PTSD symptoms(r=0.73,P<0.01)and a negative correlation between psychological resilience and PTSD symptoms(r=-0.14,P<0.05).Stepwise multiple linear regression analysis identified postoperative vision(notably eye removal),rumination levels,and psychological resilience(optimism)as major factors influencing PTSD in these patients(R^(2)=0.57,P<0.001).CONCLUSION:Young and middle-aged patients with open globe injuries have a high incidence of PTSD.Significant risk factors for early PTSD include primary enucleation,high levels of rumination,and low psychological resilience(optimism).Conversely,patients with good postoperative vision recovery,low rumination levels,and high levels of optimism are less likely to develop PTSD.Healthcare providers should pay special attention to patients who undergo primary enucleation,strive to reduce their rumination levels,and enhance their psychological resilience,thereby promoting a positive and optimistic attitude towards their condition and reducing the incidence of PTSD.展开更多
[Objectives]To systematically evaluate the impact of interventions based on the Common Sense Model of Self-Regulation(CSM)on the psychosocial adaptation of young and middle-aged patients with acute coronary syndrome(A...[Objectives]To systematically evaluate the impact of interventions based on the Common Sense Model of Self-Regulation(CSM)on the psychosocial adaptation of young and middle-aged patients with acute coronary syndrome(ACS),providing evidence-based support for clinical practice.[Methods]A systematic review was conducted using a literature search method,systematically searching through Chinese and English databases such as PubMed,Embase,Cochrane Library,CINAHL,China National Knowledge Infrastructure(CNKI),Wanfang Database,and VIP Database,from the database inception to December 31,2024.The search focused on studies related to the impact of the CSM on the psychosocial adaptation of young and middle-aged ACS patients.Two researchers independently performed literature screening,quality assessment,and data extraction.[Results]A total of 18 studies were included,comprising 12 randomized controlled trials,4 quasi-experimental studies,and 2 cohort studies,involving 2847 young and middle-aged ACS patients.Interventions based on the CSM significantly improved patients disease perception,emotional regulation,self-efficacy,and quality of life.Patients in the intervention group showed significant reductions in anxiety and depression levels,cardiac-related fear,and improvements in disease perception accuracy,treatment adherence,and social function recovery.[Conclusions]Interventions based on the CSM can effectively promote the psychosocial adaptation of young and middle-aged ACS patients,improve their disease perception and emotional state,and enhance their quality of life.It is recommended that this model be widely applied in the clinical care of young and middle-aged ACS patients.展开更多
Objective: To explore the association between cardiometabolic multimorbidity and frailty among middle- aged and older adults in China. Methods: Data were derived from the 2013 wave of the China Longitudinal Healthy Lo...Objective: To explore the association between cardiometabolic multimorbidity and frailty among middle- aged and older adults in China. Methods: Data were derived from the 2013 wave of the China Longitudinal Healthy Longevity Survey, including a total of 6,179 individuals aged 45 years and above with complete follow-up records. Basic demographic information was collected, and frailty status was assessed using a physical frailty scale. Generalized linear models were employed to analyze the association between the number and combinations of cardiometabolic conditions- such as hypertension, diabetes, heart disease, and stroke-and frailty. Results: The prevalence of cardiometabolic multimorbidity among middle-aged and older adults was 14.23%. After adjusting for sociodemographic covariates, individuals with cardiometabolic multimorbidity had a significantly increased risk of frailty compared to those without such conditions (OR = 1.78, 95% CI: 1.45-2.19), along with higher frailty scale scores (β = 0.26, 95% CI: 0.19-0.34). Compared to individuals without cardiometabolic diseases, those with both hypertension and stroke (OR = 1.18, 95% CI: 1.06-1.31) and those with hypertension, heart disease, and stroke (OR = 1.46, 95% CI: 1.24-1.73) exhibited notably higher frailty risks. Conclusion: There is a significant association between cardiometabolic multimorbidity and frailty in middle- aged and older adults in China, particularly for comorbidity patterns involving hypertension. These findings provide evidence for developing targeted health interventions for aging populations.展开更多
This article reviews the characteristics of psychological disorders in young and middle-aged acute coronary syndrome(ACS)patients,the mechanisms and effects of various psychological intervention strategies,factors inf...This article reviews the characteristics of psychological disorders in young and middle-aged acute coronary syndrome(ACS)patients,the mechanisms and effects of various psychological intervention strategies,factors influencing return to work,and current research problems and development trends,to provide scientific evidence for psychological rehabilitation and social function recovery of young and middle-aged ACS patients.展开更多
Objective:To explore the application effect of the hospital-community-family model-based combined rehabilitation exercise intervention on middle-aged and elderly patients with chronic kidney disease.Methods:Using the ...Objective:To explore the application effect of the hospital-community-family model-based combined rehabilitation exercise intervention on middle-aged and elderly patients with chronic kidney disease.Methods:Using the convenience sampling method,80 patients in the stable stage of CKD who were treated in the nephrology department of a tertiary hospital from May 2022 to June 2023 were selected as the research subjects.They were divided into the experimental group(40 cases)and the control group(40 cases)by random number table method.The control group received conventional exercise intervention plus telephone follow-up,while the experimental group received combined hospital-community-family modelbased exercise intervention in addition to the control group,using remote medical guidance and monitoring of the application effect of exercise rehabilitation on middle-aged and elderly patients with chronic kidney disease.The glomerular filtration rate,6-minute walking distance,fatigue and social support scores of the two groups of patients were measured before the intervention,4 weeks after the intervention,and 12 weeks after the intervention.Results:Before the intervention,there were no statistically significant differences in glomerular filtration rate,6-minute walking distance,fatigue and social support scores between the two groups(p>0.05).After 12 weeks of intervention,the glomerular filtration rate,6-minute walking distance and social support scores of the experimental group were higher than those of the control group;the differences were statistically significant(p<0.05).The behavioral,emotional,sensory and cognitive scores of the Piper-Fatigue Revised Scale of the experimental group were lower than those of the control group,and the differences were statistically significant(p<0.05).Conclusion:Based on the hospital-community-family model combined rehabilitation exercise,using remote medical guidance for the continuous care of middle-aged and elderly patients in the stable stage of chronic kidney disease can effectively improve the exercise endurance and social support level of patients,improve the fatigue condition,and the implementation effect is positively correlated with the intervention time.展开更多
Objective:To analyze the impact and mechanism of the SOC model intervention on improving health literacy and reducing disease uncertainty among young and middle-aged patients with coronary heart disease.Methods:A hund...Objective:To analyze the impact and mechanism of the SOC model intervention on improving health literacy and reducing disease uncertainty among young and middle-aged patients with coronary heart disease.Methods:A hundred young and middle-aged patients with coronary heart disease from our hospital between March and October 2024 were randomly divided into an observation group and a control group,with 50 patients in each group.Both groups received routine nursing intervention,while the observation group also received intervention based on the Stages of Change(SOC)model.The intervention period was 30 days.Changes in self-efficacy,health literacy,and disease uncertainty were compared between the two groups before and after the intervention.Results:After the intervention,the self-efficacy scores of both groups increased significantly,and the observation group had higher self-efficacy scores than the control group,with a significant difference(P<0.05).Additionally,the observation group showed significantly higher levels of health literacy than the control group(P<0.001).Furthermore,the observation group had significantly lower scores for disease uncertainty compared to the control group(P<0.001).Conclusion:The SOC model,in addition to routine nursing,significantly affects self-efficacy,disease uncertainty,and health literacy among young and middle-aged patients with coronary heart disease.It helps to enhance patients’knowledge of coronary heart disease,improve health literacy levels,and reduce disease uncertainty,making it worthy of clinical promotion and application.展开更多
Objective:To explore the current status of social alienation and its influencing factors among young and middle-aged stroke patients in Dali.Methods:A convenience sampling method was used to survey 385 young and middl...Objective:To explore the current status of social alienation and its influencing factors among young and middle-aged stroke patients in Dali.Methods:A convenience sampling method was used to survey 385 young and middle-aged stroke patients in a tertiary hospital in Dali from December 2024 to July 2025.Questionnaires including general demographic information,the General Alienation Scale,the Athens insomnia scale,and others were administered.Results:The social alienation score of young and middle-aged stroke patients in Dali was(35.67±3.46).Univariate analysis showed that general demographic factors[education level,monthly household income,whether it was the first onset,presence of sequelae,disease duration,activities of daily living(ADL,Barthel Index)],social support,stigma,self-perceived burden,anxiety and depression,and sleep status were influencing factors of social alienation(P<0.05).Regression analysis indicated that social support,anxiety and depression,disease duration,stigma,presence of sequelae,and self-care ability were significant influencing factors of social alienation(P<0.01),explaining 65.3%of the total variance.Conclusion:The level of social alienation among young and middle-aged stroke patients in Dali is relatively low.Special attention should be paid to patients with a disease duration of<7 days,those with sequelae,moderate-to-severe dependence in self-care,low social support,high stigma,and high levels of anxiety and depression,to effectively reduce their social alienation.展开更多
BACKGROUND Psychological problems affect economic development.However,there is a huge gap between mental health service resources and mental health service needs.Existing mental health service technology and platforms...BACKGROUND Psychological problems affect economic development.However,there is a huge gap between mental health service resources and mental health service needs.Existing mental health service technology and platforms cannot meet all the diverse mental health needs of people.Smart medicine is a new medical system based online that can effectively improve the quality and efficiency of medical services and make mental health services accessible.AIM To explore the level of intelligent medical use among young and middle-aged people and its correlation with psychological factors.METHODS Convenience sampling was used to select 200 young and middle-aged patients with medical experience at the Third People's Hospital of Chengdu between January 2022 and January 2023 as the research subjects.The general condition Questionnaire,Eysenck Personality Questionnaire,Symptom Checklist-90,General Health Questionnaire,and Smart Medical Service Use Intention Questionnaire were used to collect data.Pearson’s correlation was used to analyze the correlation between the participants’willingness to use smart medical services and their personality characteristics,psychological symptoms,and mental health.RESULTS The results revealed that the mental health of young and middle-aged people was poor,and some had psycho-logical problems such as anxiety,depression,and physical discomfort.Familiarity,acceptance,and usage of smart healthcare in this population are at a medium level,and these levels correlate with psychological characteristics.Acceptance was positively correlated with E,and negatively correlated with P,anxiety,fear,anxiety/insomnia,and social dysfunction.The degree of use was negatively correlated with P,obsessive-compulsive symptoms,depression,anxiety,hostility,paranoia,and somatic symptoms.CONCLUSION The familiarity,acceptance,and usage of smart medical services among the middle-aged and young groups are related to various psychological characteristics.展开更多
Objective:To investigate the interrelationship between cardiovascular health awareness,risk perception,behavioural intention,and INTERHEART risk stratification in a middle-aged adult population in Malaysia.Methods:A c...Objective:To investigate the interrelationship between cardiovascular health awareness,risk perception,behavioural intention,and INTERHEART risk stratification in a middle-aged adult population in Malaysia.Methods:A cross-sectional survey with convenience sampling was conducted during November 2022 and January 2023.Participants completed validated questionnaires assessing cardiovascular health awareness,risk perception of cardiovascular diseases,behavioural intention towards adopting healthy habits,and INTERHEART risk stratification score(IHRS)based on established risk factors.A total of 602 respondents were included in the final analysis.Data were analysed with independent t-test/one-way ANOVA or Mann-Whitney/Kruskal-Wallis to test the differences,Pearson correlation or linear regression test to analyze the association of independent and dependent variables.Results:There was a significant positive correlation between medical knowledge related to cardiovascular disease(CVD)and knowledge related to CVD risk prevention,risk perception,behavioural intention and IHRS(P<0.05,Pearson correlation).Notably,individuals with higher IHRS tended to have lower knowledge related to CVD and CVD risk prevention,risk perception,and behavioural intention.Males,laborers,active/former smokers,individuals with lower household income and educational levels,those involved in occupations not related to the healthcare sector,and those who did not receive the CVD health brochure or are unaware of health self-assessment tools are likely to have lower levels of knowledge,risk perception,and poorer behavioural intention regarding cardiovascular health(P<0.05,one-way ANOVA).While educational level,smoking status,awareness about CVD poster,self-assessment tools were repeatedly significantly associated with knowledge related to CVD and CVD risk prevention,risk perception,behavioral intention and/or IHRS(P<0.05,linear regression).Conclusions:These findings underscore the importance of promoting cardiovascular health awareness and risk perception among middle-aged adults to foster positive BI and reduce CVD risk.Tailored interventions targeting specific risk factors identified by INTERHEART may enhance risk stratification accuracy and facilitate targeted preventive strategies.展开更多
BACKGROUND Arthritis is a prevalent and debilitating condition that affects a significant proportion of middle-aged and older adults worldwide.Characterized by chronic pain,inflammation,and joint dysfunction,arthritis...BACKGROUND Arthritis is a prevalent and debilitating condition that affects a significant proportion of middle-aged and older adults worldwide.Characterized by chronic pain,inflammation,and joint dysfunction,arthritis can severely impact physical function,quality of life,and mental health.The overall burden of arthritis is further compounded in this population due to its frequent association with depression.As the global population both the prevalence and severity of arthritis are anticipated to increase.AIM To investigate depressive symptoms in the middle-aged and elderly arthritic population in China,a risk prediction model was constructed,and its effectiveness was validated.METHODS Using the China Health and Retirement Longitudinal Study 2018 data on middleaged and elderly arthritic individuals,the population was randomly divided into a training set(n=4349)and a validation set(n=1862)at a 7:3 ratio.Based on 10-fold cross-validation,least absolute shrinkage and selection regression was used to screen the model for the best predictor variables.Logistic regression was used to construct the nomogram model.Subject receiver operating characteristic and calibration curves were used to determine model differentiation and accuracy.Decision curve analysis was used to assess the net clinical benefit.RESULTS The prevalence of depressive symptoms in the middle-aged and elderly arthritis population in China was 47.1%,multifactorial logistic regression analyses revealed that gender,age,number of chronic diseases,number of pain sites,nighttime sleep time,education,audiological status,health status,and place of residence were all predictors of depressive symptoms.The area under the curve values for the training and validation sets were 0.740(95%confidence interval:0.726-0.755)and 0.731(95%confidence interval:0.709-0.754),respectively,indicating good model differentiation.The calibration curves demonstrated good prediction accuracy,and the decision curve analysis curves demonstrated good clinical utility.CONCLUSION The risk prediction model developed in this study has strong predictive performance and is useful for screening and assessing depression symptoms in middle-aged and elderly arthritis patients.展开更多
Background:The prevalence of multimorbidity is increasing,with a notable shift towards younger age groups.Methods:Convenience sampling was employed to select 15,988 young and middle-aged adults in Chongqing as the stu...Background:The prevalence of multimorbidity is increasing,with a notable shift towards younger age groups.Methods:Convenience sampling was employed to select 15,988 young and middle-aged adults in Chongqing as the study population.The Apriori algorithm was used to identify the multimorbidity patterns within this population,while an unordered binary logistic regression model was applied to assess the association between sleep,diet and the risk of multimorbidity.Results:The study population had an average age of 39.2±10.1 years.Apriori association rules revealed that the most prevalent binary chronic disease multimorbidity pattern was dyslipidaemia+hypertension(14.78%),while the most common ternary chronic disease multimorbidity pattern was diabetes+dyslipidaemia+hypertension(9.66%).The logistic regression analysis revealed that a lower rating of sleep quality was associated with an elevated risk of multimorbidity(odds ratio(OR)=1.17,95%confidence interval(CI):1.01,1.36).Individuals who adhere to a meat-based diet(OR=1.45,95%CI:1.25,1.68)and those with elevated salt intake(OR=1.22,95%CI:1.01,1.47)were also observed to have an increased risk of multimorbidity.Additionally,a greater likelihood of multimorbidity was observed among those following a spicy diet(OR=1.3,95%CI:1.11,1.52)and consuming more oil(OR=1.16,95%CI:1.01,1.33).Conclusion:A poor sleep quality and a dietary preference for meat-based,salt,spicy and oils were found to be associated with an increased risk of multimorbidity progression among young and middle-aged populations.It is recommended that young and middle-aged adults should pay attention not only to sleep duration but also to sleep quality and improve dietary habits to reduce the likelihood of multimorbidity.展开更多
This study used Arksey and O’Malley’s scoping review methodology as a framework and searched the following databases:PubMed,Embase,EBSCO,CINAHL,Web of Science,Cochrane Library,Scopus,CNKI,Wanfang,VIP,and the Chinese...This study used Arksey and O’Malley’s scoping review methodology as a framework and searched the following databases:PubMed,Embase,EBSCO,CINAHL,Web of Science,Cochrane Library,Scopus,CNKI,Wanfang,VIP,and the Chinese Biomedical Literature Database.The database is open to December 20,2023,and documents related to the fear of dementia among the elderly in the community are described and analyzed to provide a reference for future research in this field.At the same time,we screened,extracted,and summarized relevant information from 21 included documents(16 in English and 5 in Chinese),which consisted of 16 cross-sectional studies,2 quasi-experimental studies,2 randomized controlled studies,and 1 longitudinal study.Sixteen of the included documents mentioned the incidence or level of dementia fear among the elderly in the community,2 addressed the adverse effects of dementia fear,and 4 reported prevention and intervention measures for dementia fear.In total,there are 8 assessment tools,and the influencing factors are categorized into sociodemographic characteristics,psychological and behavioral characteristics,sociocultural background factors,and health and dementia-related factors.The final conclusion is that the fear of dementia is common among the elderly in the community.In the future,the application of research tools should be expanded among middle-aged individuals,with considerations for other types of dementia in mind.It is recommended to conduct large-scale,multi-center randomized controlled trials while confirming the intervention’s effect on different types of middle-aged and elderly individuals,focusing on the long-term impact of these intervention measures to promote healthy aging.展开更多
Objective:To explore the potential categories and influencing factors of self-advocacy in young and middle-aged patients with breast cancer and to provide a theoretical basis for personalized intervention.Methods:From...Objective:To explore the potential categories and influencing factors of self-advocacy in young and middle-aged patients with breast cancer and to provide a theoretical basis for personalized intervention.Methods:From September 2023 to March 2024,314 young and middle-aged breast cancer patients were studied.Female cancer patients were surveyed using the self-advocacy scale,social support rating scale,and chronic health literacy scale.Latent profile analysis was used to investigate the heterogeneity and influencing factors of self-advocacy.Results:Self-advocacy among young and middle-aged breast cancer patients were classified into two potential categories:low advocacy-lack of support(51.7%)and high advocacy-effective communication(48.3%).Binary logistic regression analysis indicated that educational level,per capita monthly income,social support,and health literacy were significant influencing factors of these categories(P<0.05).Conclusion:Self-advocacy in young and middle-aged breast cancer patients demonstrates categorical heterogeneity.Identifying self-advocacy characteristics and implementing targeted intervention strategies—focused on self-efficacy and improving health literacy—can enhance self-advocacy in these patients.展开更多
Objective:To examine insomnia in the modern young and middle-aged population and explore nursing intervention strategies using traditional Chinese and Western medicine.Methods:A total of 255 inpatients and outpatients...Objective:To examine insomnia in the modern young and middle-aged population and explore nursing intervention strategies using traditional Chinese and Western medicine.Methods:A total of 255 inpatients and outpatients were sampled from Shenzhen Hospital of Traditional Chinese Medicine.The Sleep Questionnaire for Young and Middle-aged People was used to assess insomnia,and a linear regression model was applied for data analysis.Results:A total of 251 valid questionnaires were collected.Correlation analysis revealed a high incidence of insomnia among respondents.Linear correlation analysis indicated that mental illness or other underlying diseases leading to pain had a significantly positive effect on symptom improvement through Chinese and Western medicine treatments(B=0.763,P<0.01).Conversely,work or life pressures(emotional or financial issues)had a significantly negative impact on treatment effectiveness(B=-0.503,P<0.01).Cross-analysis identified high life or work pressure as the primary cause of insomnia(70.1%).Conclusion:Insomnia is prevalent among the young and middle-aged in modern times,with high work or life pressure being the leading factor.展开更多
In order to promote the growth of mid-aged Pinus elliottii plantation, the effects of different fertilizing amounts of formula fertilizer were studied on the growth, the soil and cost-benefit of 9 year-old Pinus el/io...In order to promote the growth of mid-aged Pinus elliottii plantation, the effects of different fertilizing amounts of formula fertilizer were studied on the growth, the soil and cost-benefit of 9 year-old Pinus el/iottii plantations in the north- ern part of Hunan, China. Three years after fertilization, the results showed that the increments of DBH, height, individual volume and stock volume of stand, and the fertilizer benefit of the different fertilization treatments were higher than the control to varying degrees, and among them, 700 g/tree was the best for promoting the growth of Pinus elliottii. Two years fertilization, the soil nutrients were improved compared with before, pH values of different layers decreased, organic matter and rapid available K contents increased, and rapid available N content increased dra- matically with the upper layer having an increase higher than the lower one; rapid available P decreased at different levels with the upper layer having a decrease lower than the lower one; and proper application of fertilizer could promote the growth of Pisolithus tinctofius, and 7 months after fertilization, the number of Pisolithus fruiting body generally increased with the increase of the fertilizer within 100-800 g/tree. The yield and benefit per unit area could be increased by fertiliza- tion for 1 time in middle-aged Pinus elliottii plantations, and the best fertilizing amount was N-P-K fertilizer 700 g/tree.展开更多
This study sought to investigate late-onset hypogonadism （LOH） in old and middle-aged males in Shanghai communities, using symptom score evaluation systems and measurements of sex hormone levels. One thousand cases ...This study sought to investigate late-onset hypogonadism （LOH） in old and middle-aged males in Shanghai communities, using symptom score evaluation systems and measurements of sex hormone levels. One thousand cases of males aged 40-70 years were investigated. The aging male symptoms （AMS） scale and androgen deficiency in aging males （ADAM） questionnaire were used at the beginning of the investigation, followed by measurement of the sex hormone-related factors （total testosterone （TT）, free testosterone （fT）, sex hormone-binding globulin （SHBG） and bioavailability of testosterone （Bio-T））. There were 977 valid questionnaires. The LOH-positive rates shown by AMS and ADAM were 59.88% and 84.65%, respectively; values increased with the age of the patients. There were 946 results related to sex hormone measurements, which showed the following results： TT was not related to aging （P〉O.05）; levels of SHBG increased with age; and fT and Bio-T decreased with age. There was a significant difference in fT between LOH-positive and LOH-negative patients, as shown by the ADAM. In summary, TT levels were not related to aging, even though SHBG did increase while fT and Bio-T decreased with aging. Clinically, the diagnosis of LOH cannot be based on serum TT level.展开更多
This study aimed to propose an operational definition of late-onset hypogonadism(LOH)that incorporates both clinical symptoms and serum testosterone measurements to evaluate the prevalence of LOH in aging males in Chi...This study aimed to propose an operational definition of late-onset hypogonadism(LOH)that incorporates both clinical symptoms and serum testosterone measurements to evaluate the prevalence of LOH in aging males in China.A population-based sample of 6296 men aged 40 years-79 years old was enrolled from six representative provinces in China.Serum total testosterone(TT),sex hormone-binding globulin(SHBG),and luteinizing hormone(LH)were measured and free testosterone(cFT)was calculated.The Aging Males’Symptoms(AMS)scale was used to evaluate the LOH symptoms.Finally,5078 men were included in this analysis.The TT levels did not decrease with age(P=0.59),and had no relationship with AMS symptoms(P=0.87 for AMS total score,P=0.74 for≥3 sexual symptoms).The cFT levels decreased significantly with age(P<0.01)and showed a negative association with the presence of≥3 sexual symptoms(P=0.03).The overall estimated prevalence of LOH was 7.8%(395/5078)if a cFT level<210 pmol l−1 combined with the presence of≥3 sexual symptoms was used as the criterion of LOH.Among them,26.1%(103/395)and 73.9%(292/395)had primary and secondary hypogonadism,respectively.After adjustment for confounding factors,primary and secondary hypogonadism was positively related to age and comorbidities.Body mass index was an independent risk factor for secondary hypogonadism.The results suggest that the AMS total score is not an appropriate indicator for decreased testosterone,and that the cFT level is more reliable than TT for LOH diagnosis.Secondary hypogonadism is the most common form of LOH.展开更多
In this study, we investigated the essential criteria for late-onset hypogonadism （LOH） syndrome based on the presence of symptoms associated with low testosterone levels in Han Chinese men. Blood tests for total te...In this study, we investigated the essential criteria for late-onset hypogonadism （LOH） syndrome based on the presence of symptoms associated with low testosterone levels in Han Chinese men. Blood tests for total testosterone （TT） and sex hormone-binding globulin （SHBG） were performed, and the aging male symptoms （AMS） questionnaire was conducted in a randomly selected cohort composed of 944 Chinese men aged 40 to 79 years from nine urban communities. Three sexual symptoms （decreased ability/frequency of sexual activity, decreased number of morning erections, and decreased libido） were confirmed to be related to the total and free testosterone levels. The thresholds for TT were approximately 12.55 nmol l^-1 for a decreased ability/frequency to perform sex, 12.55 nmol l^-1 for decreased frequency of morning erections, and 14.35 nmol l^-1 for decreased sexual desire. The calculated free testosterone （CFT） thresholds for these three sexual symptoms were 281.14, 264.90, and 287.21 pmol l^-1, respectively. TT 〈13.21 nmol l^-1 （OR =1.4, 95%Ch 1.0-1.9, P= 0.037） or CFT 〈268.89 pmol l^-1 （OR - 1.5, 95%Ch 1.1-20, P=0.020） was associated with an increase in the aforementioned three sexual symptoms. The prevalence of LOH was 9.1% under the criteria, including all three sexual symptoms with TT levels 〈13.21 nmol l^-1 and CFT levels 〈268.89 pmol l^-1. Our results may improve the diagnostic accuracy of LOH in older men.展开更多
基金supported by the Postgraduate Supervision Fund within the School of Nursing at Fujian Medical University(No.110013)。
文摘Objectives:This study aimed to generate a theoretical framework based on empirical data to explain the behavioral patterns closely related to young and middle-aged patients with lymphoma throughout the disease.Methods:This study followed the classic grounded theory methodology,involving procedures such as theoretical sampling,substantive coding,theoretical coding,constant comparison,and memo writing and sorting.Multiple data types were used based on the principle of“all is data,”including 34 participants providing interview data along with observation notes and 40 relevant secondary texts from the“Lymphoma House”network platform and the“Lymphoma House 086”public account.Two autobiographical books written by lymphoma patients were also selected as data resources.Data collection and analysis were conducted in an iterative process until theoretical saturation was reached.The COREQ checklist was followed to report this study.Results:The main concern of middle-aged and young patients with lymphoma was identifiedas restoring normality,while managing uncertainty was the main behavioral pattern for restoring normality.Uncertainty consists of two interrelated types:inherent uncertainty of illness and perceived uncertainty of patients.Four strategies are used to manage uncertainty:reconstructing certainty,adaptive coping,defensive buffering,and compensatory changing.Managing uncertainty is influenced by disease characteristics and perceptions,social resources,and cultural concepts.The consequence of managing uncertainty is reaching a new normality.Conclusions:Pervasive uncertainty significantly affects the daily lives of young and middle-aged patients with lymphoma.Consequently,strategies for managing disease-related uncertainty to sustain normality are commonly observed in this population.This theoretical framework for addressing uncertainty can serve as a foundation for understanding and developing tailored interventions to manage uncertainty.Future research should focus on managing uncertainty to help patients restore normality.
基金Supported by Jiangsu Provincial Cadre Healthcare Scientific Research Grant Project,No.BJ23019Jiangsu Provincial Association of Maternal and Child Healthcare Scientific Research Grant Project,No.FYX202350+2 种基金Special Fund for the Project of Enhancing Academic Capability of Integrative Nursing,No.ZXYJHHL-K-2023-M20Jiangsu Provincial Graduate Student Practice and Innovation Program Project,No.SJCX24_0833the Training Project for Backbone Talents in Traditional Chinese Medicine Nursing in Nanjing Region,No.Ningwei Zhongyi[2023]No.8.
文摘BACKGROUND Breast cancer(BC)is the second most common malignancy globally.Young and middle-aged patients face more pressures from diagnosis,treatment,costs,and psychological issues like self-image concerns,social barriers,and professional challenges.Compared to other age groups,they have higher recurrence rates,lower survival rates,and increased risk of depression.Research is lacking on factors influencing depressive symptoms and predictive models for this age group.AIM To analyze factors influencing depressive symptoms in young/middle-aged BC patients and construct a depression risk predictive model.METHODS A total of 360 patients undergoing BC treatment at two tertiary hospitals in Jiangsu Province,China from November 2023 to April 2024 were included in the study.Participants were surveyed using a general information questionnaire,the patient health questionnaire depression scale,the visual analog scale for pain,the revised family support scale,and the long form of the international physical activity questionnaire.Univariate and multivariate analyses were conducted to identify the factors affecting depression in middle-aged and young BC patients,and a predictive model for depression risk was developed based on these findings.RESULTS Among the 360 middle-aged and young BC patients,the incidence rate of depressive symptoms was 38.61%(139/360).Multivariate analysis revealed that tumor grade,patient’s monthly income,pain score,family support score,and physical activity score were factors influencing depression in this patient group(P<0.05).The risk prediction model constructed based on these factors yielded an area under the receiver operating characteristic curve of 0.852,with a maximum Youden index of 0.973,sensitivity of 86.80%,specificity of 89.50%,and a diagnostic odds ratio of 0.552.The Hosmer-Lemeshow test for goodness of fit indicated an adequate model fit(χ^(2)=0.360,P=0.981).CONCLUSION The constructed predictive model demonstrates good predictive performance and can serve as a reference for medical professionals to early identify high-risk patients and implement corresponding preventive measures to decrease the incidence of depressive symptoms in this population.
文摘AIM:To evaluate the prevalence of early post-traumatic stress disorder(PTSD)among young and middle-aged patients who have suffered open globe injuries,and to identify the psychosocial factors influencing PTSD in these patients.METHODS:A total of 280 patients who underwent ocular trauma surgery between January 2023 and January 2024 were selected through convenience sampling.Data were collected using a custom-designed demographic questionnaire,the Connor-Davidson Resilience Scale(CDRISC),the Cognitive Emotion Regulation Questionnaire(C-ERRI),and the PTSD Checklist-Civilian Version(PCL-C).Univariate analysis and stepwise multiple linear regression analysis were performed to determine the factors affecting PTSD in these patients.RESULTS:The average PTSD score for the patients was 33.22±13.48.The scores for individual PTSD dimensions,ranked from highest to lowest,were recurrent traumatic experiences,heightened arousal,avoidance reactions,and social dysfunction.Positive PTSD symptoms were observed in 85 patients(30.36%).Univariate analysis indicated that gender,postoperative vision,marital status,psychological resilience,and rumination were significant factors affecting PTSD symptoms(χ^(2)/t=6.53,17.88,8.83,2.17,and 14.1,respectively;all P<0.05).Pearson correlation analysis showed a positive correlation between rumination and PTSD symptoms(r=0.73,P<0.01)and a negative correlation between psychological resilience and PTSD symptoms(r=-0.14,P<0.05).Stepwise multiple linear regression analysis identified postoperative vision(notably eye removal),rumination levels,and psychological resilience(optimism)as major factors influencing PTSD in these patients(R^(2)=0.57,P<0.001).CONCLUSION:Young and middle-aged patients with open globe injuries have a high incidence of PTSD.Significant risk factors for early PTSD include primary enucleation,high levels of rumination,and low psychological resilience(optimism).Conversely,patients with good postoperative vision recovery,low rumination levels,and high levels of optimism are less likely to develop PTSD.Healthcare providers should pay special attention to patients who undergo primary enucleation,strive to reduce their rumination levels,and enhance their psychological resilience,thereby promoting a positive and optimistic attitude towards their condition and reducing the incidence of PTSD.
基金Supported by Philosophy and Social Sciences Research Project of Hubei Provincial Department of Education(22Q149,19Y090).
文摘[Objectives]To systematically evaluate the impact of interventions based on the Common Sense Model of Self-Regulation(CSM)on the psychosocial adaptation of young and middle-aged patients with acute coronary syndrome(ACS),providing evidence-based support for clinical practice.[Methods]A systematic review was conducted using a literature search method,systematically searching through Chinese and English databases such as PubMed,Embase,Cochrane Library,CINAHL,China National Knowledge Infrastructure(CNKI),Wanfang Database,and VIP Database,from the database inception to December 31,2024.The search focused on studies related to the impact of the CSM on the psychosocial adaptation of young and middle-aged ACS patients.Two researchers independently performed literature screening,quality assessment,and data extraction.[Results]A total of 18 studies were included,comprising 12 randomized controlled trials,4 quasi-experimental studies,and 2 cohort studies,involving 2847 young and middle-aged ACS patients.Interventions based on the CSM significantly improved patients disease perception,emotional regulation,self-efficacy,and quality of life.Patients in the intervention group showed significant reductions in anxiety and depression levels,cardiac-related fear,and improvements in disease perception accuracy,treatment adherence,and social function recovery.[Conclusions]Interventions based on the CSM can effectively promote the psychosocial adaptation of young and middle-aged ACS patients,improve their disease perception and emotional state,and enhance their quality of life.It is recommended that this model be widely applied in the clinical care of young and middle-aged ACS patients.
文摘Objective: To explore the association between cardiometabolic multimorbidity and frailty among middle- aged and older adults in China. Methods: Data were derived from the 2013 wave of the China Longitudinal Healthy Longevity Survey, including a total of 6,179 individuals aged 45 years and above with complete follow-up records. Basic demographic information was collected, and frailty status was assessed using a physical frailty scale. Generalized linear models were employed to analyze the association between the number and combinations of cardiometabolic conditions- such as hypertension, diabetes, heart disease, and stroke-and frailty. Results: The prevalence of cardiometabolic multimorbidity among middle-aged and older adults was 14.23%. After adjusting for sociodemographic covariates, individuals with cardiometabolic multimorbidity had a significantly increased risk of frailty compared to those without such conditions (OR = 1.78, 95% CI: 1.45-2.19), along with higher frailty scale scores (β = 0.26, 95% CI: 0.19-0.34). Compared to individuals without cardiometabolic diseases, those with both hypertension and stroke (OR = 1.18, 95% CI: 1.06-1.31) and those with hypertension, heart disease, and stroke (OR = 1.46, 95% CI: 1.24-1.73) exhibited notably higher frailty risks. Conclusion: There is a significant association between cardiometabolic multimorbidity and frailty in middle- aged and older adults in China, particularly for comorbidity patterns involving hypertension. These findings provide evidence for developing targeted health interventions for aging populations.
基金Supported by Humanities and Social Sciences Project of Hubei Provincial Department of Education(22Q149&19Y090).
文摘This article reviews the characteristics of psychological disorders in young and middle-aged acute coronary syndrome(ACS)patients,the mechanisms and effects of various psychological intervention strategies,factors influencing return to work,and current research problems and development trends,to provide scientific evidence for psychological rehabilitation and social function recovery of young and middle-aged ACS patients.
基金2024 Annual Medical Science Research Project of Hebei Province,Research on the Rehabilitation Effect of Joint Exercise Intervention Based on Hospital-Community-Family Model for Elderly Patients with Chronic Diseases(Project No.:20240083)。
文摘Objective:To explore the application effect of the hospital-community-family model-based combined rehabilitation exercise intervention on middle-aged and elderly patients with chronic kidney disease.Methods:Using the convenience sampling method,80 patients in the stable stage of CKD who were treated in the nephrology department of a tertiary hospital from May 2022 to June 2023 were selected as the research subjects.They were divided into the experimental group(40 cases)and the control group(40 cases)by random number table method.The control group received conventional exercise intervention plus telephone follow-up,while the experimental group received combined hospital-community-family modelbased exercise intervention in addition to the control group,using remote medical guidance and monitoring of the application effect of exercise rehabilitation on middle-aged and elderly patients with chronic kidney disease.The glomerular filtration rate,6-minute walking distance,fatigue and social support scores of the two groups of patients were measured before the intervention,4 weeks after the intervention,and 12 weeks after the intervention.Results:Before the intervention,there were no statistically significant differences in glomerular filtration rate,6-minute walking distance,fatigue and social support scores between the two groups(p>0.05).After 12 weeks of intervention,the glomerular filtration rate,6-minute walking distance and social support scores of the experimental group were higher than those of the control group;the differences were statistically significant(p<0.05).The behavioral,emotional,sensory and cognitive scores of the Piper-Fatigue Revised Scale of the experimental group were lower than those of the control group,and the differences were statistically significant(p<0.05).Conclusion:Based on the hospital-community-family model combined rehabilitation exercise,using remote medical guidance for the continuous care of middle-aged and elderly patients in the stable stage of chronic kidney disease can effectively improve the exercise endurance and social support level of patients,improve the fatigue condition,and the implementation effect is positively correlated with the intervention time.
基金Handan City Science and Technology Research and Development Program Project Application(Project No.:23422083096ZC)。
文摘Objective:To analyze the impact and mechanism of the SOC model intervention on improving health literacy and reducing disease uncertainty among young and middle-aged patients with coronary heart disease.Methods:A hundred young and middle-aged patients with coronary heart disease from our hospital between March and October 2024 were randomly divided into an observation group and a control group,with 50 patients in each group.Both groups received routine nursing intervention,while the observation group also received intervention based on the Stages of Change(SOC)model.The intervention period was 30 days.Changes in self-efficacy,health literacy,and disease uncertainty were compared between the two groups before and after the intervention.Results:After the intervention,the self-efficacy scores of both groups increased significantly,and the observation group had higher self-efficacy scores than the control group,with a significant difference(P<0.05).Additionally,the observation group showed significantly higher levels of health literacy than the control group(P<0.001).Furthermore,the observation group had significantly lower scores for disease uncertainty compared to the control group(P<0.001).Conclusion:The SOC model,in addition to routine nursing,significantly affects self-efficacy,disease uncertainty,and health literacy among young and middle-aged patients with coronary heart disease.It helps to enhance patients’knowledge of coronary heart disease,improve health literacy levels,and reduce disease uncertainty,making it worthy of clinical promotion and application.
基金Scientific Research Fund Project of Yunnan Provincial Education Department(Project No.:2024J0832)。
文摘Objective:To explore the current status of social alienation and its influencing factors among young and middle-aged stroke patients in Dali.Methods:A convenience sampling method was used to survey 385 young and middle-aged stroke patients in a tertiary hospital in Dali from December 2024 to July 2025.Questionnaires including general demographic information,the General Alienation Scale,the Athens insomnia scale,and others were administered.Results:The social alienation score of young and middle-aged stroke patients in Dali was(35.67±3.46).Univariate analysis showed that general demographic factors[education level,monthly household income,whether it was the first onset,presence of sequelae,disease duration,activities of daily living(ADL,Barthel Index)],social support,stigma,self-perceived burden,anxiety and depression,and sleep status were influencing factors of social alienation(P<0.05).Regression analysis indicated that social support,anxiety and depression,disease duration,stigma,presence of sequelae,and self-care ability were significant influencing factors of social alienation(P<0.01),explaining 65.3%of the total variance.Conclusion:The level of social alienation among young and middle-aged stroke patients in Dali is relatively low.Special attention should be paid to patients with a disease duration of<7 days,those with sequelae,moderate-to-severe dependence in self-care,low social support,high stigma,and high levels of anxiety and depression,to effectively reduce their social alienation.
基金Project of Chengdu Municipal Health Commission,No.2022179.
文摘BACKGROUND Psychological problems affect economic development.However,there is a huge gap between mental health service resources and mental health service needs.Existing mental health service technology and platforms cannot meet all the diverse mental health needs of people.Smart medicine is a new medical system based online that can effectively improve the quality and efficiency of medical services and make mental health services accessible.AIM To explore the level of intelligent medical use among young and middle-aged people and its correlation with psychological factors.METHODS Convenience sampling was used to select 200 young and middle-aged patients with medical experience at the Third People's Hospital of Chengdu between January 2022 and January 2023 as the research subjects.The general condition Questionnaire,Eysenck Personality Questionnaire,Symptom Checklist-90,General Health Questionnaire,and Smart Medical Service Use Intention Questionnaire were used to collect data.Pearson’s correlation was used to analyze the correlation between the participants’willingness to use smart medical services and their personality characteristics,psychological symptoms,and mental health.RESULTS The results revealed that the mental health of young and middle-aged people was poor,and some had psycho-logical problems such as anxiety,depression,and physical discomfort.Familiarity,acceptance,and usage of smart healthcare in this population are at a medium level,and these levels correlate with psychological characteristics.Acceptance was positively correlated with E,and negatively correlated with P,anxiety,fear,anxiety/insomnia,and social dysfunction.The degree of use was negatively correlated with P,obsessive-compulsive symptoms,depression,anxiety,hostility,paranoia,and somatic symptoms.CONCLUSION The familiarity,acceptance,and usage of smart medical services among the middle-aged and young groups are related to various psychological characteristics.
基金This work was supported by the Ministry of Higher Education(MOHE),Malaysia,through Fundamental Research Grant Scheme(FRGS/1/2022/SKK10/UTAR/02/1)Universiti Tunku Abdul Rahman,Malaysia,through UTAR-Research Grant(IPSR/RMC/UTARRF/2021-C2/L08)MBBS Community Health Project(2022/2023),UTAR.
文摘Objective:To investigate the interrelationship between cardiovascular health awareness,risk perception,behavioural intention,and INTERHEART risk stratification in a middle-aged adult population in Malaysia.Methods:A cross-sectional survey with convenience sampling was conducted during November 2022 and January 2023.Participants completed validated questionnaires assessing cardiovascular health awareness,risk perception of cardiovascular diseases,behavioural intention towards adopting healthy habits,and INTERHEART risk stratification score(IHRS)based on established risk factors.A total of 602 respondents were included in the final analysis.Data were analysed with independent t-test/one-way ANOVA or Mann-Whitney/Kruskal-Wallis to test the differences,Pearson correlation or linear regression test to analyze the association of independent and dependent variables.Results:There was a significant positive correlation between medical knowledge related to cardiovascular disease(CVD)and knowledge related to CVD risk prevention,risk perception,behavioural intention and IHRS(P<0.05,Pearson correlation).Notably,individuals with higher IHRS tended to have lower knowledge related to CVD and CVD risk prevention,risk perception,and behavioural intention.Males,laborers,active/former smokers,individuals with lower household income and educational levels,those involved in occupations not related to the healthcare sector,and those who did not receive the CVD health brochure or are unaware of health self-assessment tools are likely to have lower levels of knowledge,risk perception,and poorer behavioural intention regarding cardiovascular health(P<0.05,one-way ANOVA).While educational level,smoking status,awareness about CVD poster,self-assessment tools were repeatedly significantly associated with knowledge related to CVD and CVD risk prevention,risk perception,behavioral intention and/or IHRS(P<0.05,linear regression).Conclusions:These findings underscore the importance of promoting cardiovascular health awareness and risk perception among middle-aged adults to foster positive BI and reduce CVD risk.Tailored interventions targeting specific risk factors identified by INTERHEART may enhance risk stratification accuracy and facilitate targeted preventive strategies.
基金Supported by the Changning District Health Committee Excellent Innovation Talent Training Project,No.RCJD2022S01.
文摘BACKGROUND Arthritis is a prevalent and debilitating condition that affects a significant proportion of middle-aged and older adults worldwide.Characterized by chronic pain,inflammation,and joint dysfunction,arthritis can severely impact physical function,quality of life,and mental health.The overall burden of arthritis is further compounded in this population due to its frequent association with depression.As the global population both the prevalence and severity of arthritis are anticipated to increase.AIM To investigate depressive symptoms in the middle-aged and elderly arthritic population in China,a risk prediction model was constructed,and its effectiveness was validated.METHODS Using the China Health and Retirement Longitudinal Study 2018 data on middleaged and elderly arthritic individuals,the population was randomly divided into a training set(n=4349)and a validation set(n=1862)at a 7:3 ratio.Based on 10-fold cross-validation,least absolute shrinkage and selection regression was used to screen the model for the best predictor variables.Logistic regression was used to construct the nomogram model.Subject receiver operating characteristic and calibration curves were used to determine model differentiation and accuracy.Decision curve analysis was used to assess the net clinical benefit.RESULTS The prevalence of depressive symptoms in the middle-aged and elderly arthritis population in China was 47.1%,multifactorial logistic regression analyses revealed that gender,age,number of chronic diseases,number of pain sites,nighttime sleep time,education,audiological status,health status,and place of residence were all predictors of depressive symptoms.The area under the curve values for the training and validation sets were 0.740(95%confidence interval:0.726-0.755)and 0.731(95%confidence interval:0.709-0.754),respectively,indicating good model differentiation.The calibration curves demonstrated good prediction accuracy,and the decision curve analysis curves demonstrated good clinical utility.CONCLUSION The risk prediction model developed in this study has strong predictive performance and is useful for screening and assessing depression symptoms in middle-aged and elderly arthritis patients.
基金supported by Chongqing Natural Science Foundation General Project(cstc2021jcyi msxmX0069)Chongqing Social Science Planning Project(2022NDYB196).
文摘Background:The prevalence of multimorbidity is increasing,with a notable shift towards younger age groups.Methods:Convenience sampling was employed to select 15,988 young and middle-aged adults in Chongqing as the study population.The Apriori algorithm was used to identify the multimorbidity patterns within this population,while an unordered binary logistic regression model was applied to assess the association between sleep,diet and the risk of multimorbidity.Results:The study population had an average age of 39.2±10.1 years.Apriori association rules revealed that the most prevalent binary chronic disease multimorbidity pattern was dyslipidaemia+hypertension(14.78%),while the most common ternary chronic disease multimorbidity pattern was diabetes+dyslipidaemia+hypertension(9.66%).The logistic regression analysis revealed that a lower rating of sleep quality was associated with an elevated risk of multimorbidity(odds ratio(OR)=1.17,95%confidence interval(CI):1.01,1.36).Individuals who adhere to a meat-based diet(OR=1.45,95%CI:1.25,1.68)and those with elevated salt intake(OR=1.22,95%CI:1.01,1.47)were also observed to have an increased risk of multimorbidity.Additionally,a greater likelihood of multimorbidity was observed among those following a spicy diet(OR=1.3,95%CI:1.11,1.52)and consuming more oil(OR=1.16,95%CI:1.01,1.33).Conclusion:A poor sleep quality and a dietary preference for meat-based,salt,spicy and oils were found to be associated with an increased risk of multimorbidity progression among young and middle-aged populations.It is recommended that young and middle-aged adults should pay attention not only to sleep duration but also to sleep quality and improve dietary habits to reduce the likelihood of multimorbidity.
文摘This study used Arksey and O’Malley’s scoping review methodology as a framework and searched the following databases:PubMed,Embase,EBSCO,CINAHL,Web of Science,Cochrane Library,Scopus,CNKI,Wanfang,VIP,and the Chinese Biomedical Literature Database.The database is open to December 20,2023,and documents related to the fear of dementia among the elderly in the community are described and analyzed to provide a reference for future research in this field.At the same time,we screened,extracted,and summarized relevant information from 21 included documents(16 in English and 5 in Chinese),which consisted of 16 cross-sectional studies,2 quasi-experimental studies,2 randomized controlled studies,and 1 longitudinal study.Sixteen of the included documents mentioned the incidence or level of dementia fear among the elderly in the community,2 addressed the adverse effects of dementia fear,and 4 reported prevention and intervention measures for dementia fear.In total,there are 8 assessment tools,and the influencing factors are categorized into sociodemographic characteristics,psychological and behavioral characteristics,sociocultural background factors,and health and dementia-related factors.The final conclusion is that the fear of dementia is common among the elderly in the community.In the future,the application of research tools should be expanded among middle-aged individuals,with considerations for other types of dementia in mind.It is recommended to conduct large-scale,multi-center randomized controlled trials while confirming the intervention’s effect on different types of middle-aged and elderly individuals,focusing on the long-term impact of these intervention measures to promote healthy aging.
文摘Objective:To explore the potential categories and influencing factors of self-advocacy in young and middle-aged patients with breast cancer and to provide a theoretical basis for personalized intervention.Methods:From September 2023 to March 2024,314 young and middle-aged breast cancer patients were studied.Female cancer patients were surveyed using the self-advocacy scale,social support rating scale,and chronic health literacy scale.Latent profile analysis was used to investigate the heterogeneity and influencing factors of self-advocacy.Results:Self-advocacy among young and middle-aged breast cancer patients were classified into two potential categories:low advocacy-lack of support(51.7%)and high advocacy-effective communication(48.3%).Binary logistic regression analysis indicated that educational level,per capita monthly income,social support,and health literacy were significant influencing factors of these categories(P<0.05).Conclusion:Self-advocacy in young and middle-aged breast cancer patients demonstrates categorical heterogeneity.Identifying self-advocacy characteristics and implementing targeted intervention strategies—focused on self-efficacy and improving health literacy—can enhance self-advocacy in these patients.
基金2024 China Mainland-Hong Kong-Macao University Teachers and Students Exchange Program(Project No.202311060001)。
文摘Objective:To examine insomnia in the modern young and middle-aged population and explore nursing intervention strategies using traditional Chinese and Western medicine.Methods:A total of 255 inpatients and outpatients were sampled from Shenzhen Hospital of Traditional Chinese Medicine.The Sleep Questionnaire for Young and Middle-aged People was used to assess insomnia,and a linear regression model was applied for data analysis.Results:A total of 251 valid questionnaires were collected.Correlation analysis revealed a high incidence of insomnia among respondents.Linear correlation analysis indicated that mental illness or other underlying diseases leading to pain had a significantly positive effect on symptom improvement through Chinese and Western medicine treatments(B=0.763,P<0.01).Conversely,work or life pressures(emotional or financial issues)had a significantly negative impact on treatment effectiveness(B=-0.503,P<0.01).Cross-analysis identified high life or work pressure as the primary cause of insomnia(70.1%).Conclusion:Insomnia is prevalent among the young and middle-aged in modern times,with high work or life pressure being the leading factor.
基金Supported by Basic Scientific Research Business Expense Project for Public-interest Scientific Institute of Sichuan Province(ZL2014-13)~~
文摘In order to promote the growth of mid-aged Pinus elliottii plantation, the effects of different fertilizing amounts of formula fertilizer were studied on the growth, the soil and cost-benefit of 9 year-old Pinus el/iottii plantations in the north- ern part of Hunan, China. Three years after fertilization, the results showed that the increments of DBH, height, individual volume and stock volume of stand, and the fertilizer benefit of the different fertilization treatments were higher than the control to varying degrees, and among them, 700 g/tree was the best for promoting the growth of Pinus elliottii. Two years fertilization, the soil nutrients were improved compared with before, pH values of different layers decreased, organic matter and rapid available K contents increased, and rapid available N content increased dra- matically with the upper layer having an increase higher than the lower one; rapid available P decreased at different levels with the upper layer having a decrease lower than the lower one; and proper application of fertilizer could promote the growth of Pisolithus tinctofius, and 7 months after fertilization, the number of Pisolithus fruiting body generally increased with the increase of the fertilizer within 100-800 g/tree. The yield and benefit per unit area could be increased by fertiliza- tion for 1 time in middle-aged Pinus elliottii plantations, and the best fertilizing amount was N-P-K fertilizer 700 g/tree.
文摘This study sought to investigate late-onset hypogonadism （LOH） in old and middle-aged males in Shanghai communities, using symptom score evaluation systems and measurements of sex hormone levels. One thousand cases of males aged 40-70 years were investigated. The aging male symptoms （AMS） scale and androgen deficiency in aging males （ADAM） questionnaire were used at the beginning of the investigation, followed by measurement of the sex hormone-related factors （total testosterone （TT）, free testosterone （fT）, sex hormone-binding globulin （SHBG） and bioavailability of testosterone （Bio-T））. There were 977 valid questionnaires. The LOH-positive rates shown by AMS and ADAM were 59.88% and 84.65%, respectively; values increased with the age of the patients. There were 946 results related to sex hormone measurements, which showed the following results： TT was not related to aging （P〉O.05）; levels of SHBG increased with age; and fT and Bio-T decreased with age. There was a significant difference in fT between LOH-positive and LOH-negative patients, as shown by the ADAM. In summary, TT levels were not related to aging, even though SHBG did increase while fT and Bio-T decreased with aging. Clinically, the diagnosis of LOH cannot be based on serum TT level.
文摘This study aimed to propose an operational definition of late-onset hypogonadism(LOH)that incorporates both clinical symptoms and serum testosterone measurements to evaluate the prevalence of LOH in aging males in China.A population-based sample of 6296 men aged 40 years-79 years old was enrolled from six representative provinces in China.Serum total testosterone(TT),sex hormone-binding globulin(SHBG),and luteinizing hormone(LH)were measured and free testosterone(cFT)was calculated.The Aging Males’Symptoms(AMS)scale was used to evaluate the LOH symptoms.Finally,5078 men were included in this analysis.The TT levels did not decrease with age(P=0.59),and had no relationship with AMS symptoms(P=0.87 for AMS total score,P=0.74 for≥3 sexual symptoms).The cFT levels decreased significantly with age(P<0.01)and showed a negative association with the presence of≥3 sexual symptoms(P=0.03).The overall estimated prevalence of LOH was 7.8%(395/5078)if a cFT level<210 pmol l−1 combined with the presence of≥3 sexual symptoms was used as the criterion of LOH.Among them,26.1%(103/395)and 73.9%(292/395)had primary and secondary hypogonadism,respectively.After adjustment for confounding factors,primary and secondary hypogonadism was positively related to age and comorbidities.Body mass index was an independent risk factor for secondary hypogonadism.The results suggest that the AMS total score is not an appropriate indicator for decreased testosterone,and that the cFT level is more reliable than TT for LOH diagnosis.Secondary hypogonadism is the most common form of LOH.
文摘In this study, we investigated the essential criteria for late-onset hypogonadism （LOH） syndrome based on the presence of symptoms associated with low testosterone levels in Han Chinese men. Blood tests for total testosterone （TT） and sex hormone-binding globulin （SHBG） were performed, and the aging male symptoms （AMS） questionnaire was conducted in a randomly selected cohort composed of 944 Chinese men aged 40 to 79 years from nine urban communities. Three sexual symptoms （decreased ability/frequency of sexual activity, decreased number of morning erections, and decreased libido） were confirmed to be related to the total and free testosterone levels. The thresholds for TT were approximately 12.55 nmol l^-1 for a decreased ability/frequency to perform sex, 12.55 nmol l^-1 for decreased frequency of morning erections, and 14.35 nmol l^-1 for decreased sexual desire. The calculated free testosterone （CFT） thresholds for these three sexual symptoms were 281.14, 264.90, and 287.21 pmol l^-1, respectively. TT 〈13.21 nmol l^-1 （OR =1.4, 95%Ch 1.0-1.9, P= 0.037） or CFT 〈268.89 pmol l^-1 （OR - 1.5, 95%Ch 1.1-20, P=0.020） was associated with an increase in the aforementioned three sexual symptoms. The prevalence of LOH was 9.1% under the criteria, including all three sexual symptoms with TT levels 〈13.21 nmol l^-1 and CFT levels 〈268.89 pmol l^-1. Our results may improve the diagnostic accuracy of LOH in older men.
