Objective:To compare the clinical efficacy and safety of intravitreal injection of faricimab and conbercept in the treatment of diabetic macular edema(DME).Methods:A total of 50 patients diagnosed with DME in our hosp...Objective:To compare the clinical efficacy and safety of intravitreal injection of faricimab and conbercept in the treatment of diabetic macular edema(DME).Methods:A total of 50 patients diagnosed with DME in our hospital from January 2023 to May 2025 were selected and randomly divided into an observation group and a control group,with 25 cases in each group,using a random number table method.The observation group received intravitreal injection of faricimab,while the control group received intravitreal injection of conbercept.Both groups adopted a loading phase plus maintenance phase treatment regimen.The best-corrected visual acuity(BCVA,expressed in logMAR)and central subfield thickness(CST)of the two groups were compared before treatment and at 1,3,and 6 months after treatment,and the incidence of adverse events during treatment was recorded.Results:The logMAR BCVA in the observation group was lower than that in the control group at 3 and 6 months after treatment(both p<0.05).The CST in the observation group was smaller than that in the control group at 1,3,and 6 months after treatment(all p<0.05).There was no statistically significant difference in the overall incidence of adverse events between the two groups(χ^(2)=0.189,p=0.663).Conclusion:Both intravitreal injections of faricimab and conbercept are effective in improving visual acuity and reducing macular edema in patients with DME,with good safety profiles.However,faricimab demonstrates superior efficacy in the medium to long term(3 and 6 months)compared to conbercept,making it more suitable for long-term treatment of patients with DME.展开更多
Objective:To investigate the clinical efficacy of electrophysiological therapy under different parameter modes in chronic pelvic pain syndrome(CPPS).Methods:A total of 95patients with CPPS from the Department of Urolo...Objective:To investigate the clinical efficacy of electrophysiological therapy under different parameter modes in chronic pelvic pain syndrome(CPPS).Methods:A total of 95patients with CPPS from the Department of Urology,First Affiliated Hospital of Jinan University,were selected and treated with electrophysiological therapy.They were randomly divided into three groups:the fixed-parameter AA7 treatment group,the P2+P4 treatment group,and the precision treatment group(individualized parameter treatment).Pain scores of patients in each group were compared before and after treatment,with a pain score of 0 indicating cure.The cure rate of each group was observed.Results:The average ages of the AA7 group,P2+P4 group,and precision treatment group were 34±14.17 years,35.58±12.57 years,and 35.5±11.27 years,respectively.There was no significant difference in age among the three groups(p>0.05).Before treatment,the pain scores of the AA7 group,P2+P4 group,and precision treatment group were 4.14±1.74,4.64±1.72,and 3.50±1.89,respectively,with no significant differences among the groups(p>0.05).After treatment,the pain scores were 0.71±0.99 for the AA7 group(cure rate:57%),0.49±0.79 for the P2+P4 group(cure rate:67%),and 0.50±0.77 for the precision treatment group(cure rate:64%),with no significant differences among the groups(p>0.05).The cure rates for different pain locations were as follows:83%for lower abdominal pain,74%for perineal pain,62%for dysuria,49%for testicular pain,and 75%for inguinal pain.Conclusion:The pathogenesis of CPPS is complex and diverse,with numerous treatment options and uncertain efficacy,posing significant challenges to clinical practice.This study showed that electrophysiological therapy under different parameter modes significantly reduced pain scores before and after treatment,indicating significant therapeutic effects on CPPS.All three modes demonstrated good cure rates.Individualized precision treatment and fixed-mode P2+P4 or AA7 treatment were safe and effective in CPPS treatment and are worth promoting.Fixed-mode P2+P4 and AA7,due to their easier standardization of parameters and patch modes,reduced the learning curve and had better potential for widespread application.展开更多
Chemotherapy-induced diarrhea(CID)is a major concern for cancer patients and is associated with significant morbidity and mortality.Currently,the clinical management of CID is limited.The utilization of antidiarrheal ...Chemotherapy-induced diarrhea(CID)is a major concern for cancer patients and is associated with significant morbidity and mortality.Currently,the clinical management of CID is limited.The utilization of antidiarrheal medications,such as loperamide and octreotide,is relatively limited because of their unsatisfactory efficacy and adverse effects.In recent years,traditional Chinese medicine(TCM)has attracted great interest because of its beneficial effect in treating CID,which has multitarget and low-toxicity therapeutic characteristics.TCM exhibits remarkable therapeutic potential in the prevention and treatment of CID.It can alleviate and treat CID by regulating chemical drug metabolism,improving the integrity of the intestinal barrier,stimulating proliferation while suppressing the apoptosis of intestinal epithelial cells,ameliorating oxidative stress and inflammation and regulating bile acids and aquaporins.However,large-scale,randomized,double-blind clinical trials of TCM for the treatment of CID are lacking,and most preclinical experiments have not been translated to clinical trials.Accordingly,this review highlights the clinical efficacy and molecular mechanisms of TCM against CID via PubMed,Web of Science and China National Knowledge Infrastructure and proposes that future research on TCM against CID should focus on strengthening the connection from bench to bed,which may help to comprehensively evaluate the therapeutic potential of TCM against CID.展开更多
Objective:To retrospectively evaluate the diagnostic efficacy of traditional MRI and T2 Mapping quantitative imaging technology for knee joint cartilage injury,clarify the differences in diagnostic value of the two im...Objective:To retrospectively evaluate the diagnostic efficacy of traditional MRI and T2 Mapping quantitative imaging technology for knee joint cartilage injury,clarify the differences in diagnostic value of the two imaging methods in different injury grades and different cartilage subregions,and provide evidence-based basis for the accurate diagnosis of clinical cartilage injury.Methods:Clinical and imaging data of 286 patients with knee joint lesions admitted to the Affiliated Hospital of Xiangtan Medicine and Health Vocational College from January 2020 to June 2023 were collected retrospectively.All patients underwent both traditional MRI sequences and T2 Mapping sequences.The knee joint cartilage was divided into 14 subregions.Two senior radiologists independently diagnosed the images of the two imaging technologies using a blind method and recorded the cartilage injury grades.The sensitivity,specificity,accuracy,positive predictive value,negative predictive value,and area under the receiver operating characteristic curve(AUC)of the two technologies for diagnosing cartilage injury were calculated and compared,and the differences in their diagnostic efficacy in different injury grades and different subregions were analyzed.Results:A total of 4004 cartilage subregions from 286 patients were included in the analysis,including 1836 injured subregions and 2168 normal subregions.The overall sensitivity(89.7%),accuracy(91.2%),and AUC(0.946)of T2 Mapping quantitative imaging for diagnosing cartilage injury were significantly higher than those of traditional MRI(76.3%,82.5%,and 0.852 respectively),with statistically significant differences(p<0.001);there was no significant difference in specificity between the two(93.5%vs 90.8%,p=0.062).Subgroup analysis showed that T2 Mapping had the most significant diagnostic advantage in early cartilage injury(Grade 1),with sensitivity(78.5%)33.2%higher than that of traditional MRI(45.3%)(p<0.001).Conclusion:The diagnostic efficacy of T2 Mapping quantitative imaging for knee joint cartilage injury is significantly superior to that of traditional MRI,especially in the detection of early cartilage injury and accurate evaluation of weight-bearing area injury.Data verify its clinical applicability and reliability.It can be used as an important supplementary method to traditional MRI,and is recommended for the early diagnosis,grading evaluation,and clinical follow-up of cartilage injury.展开更多
Objective: To evaluate the efficacy of noninvasive positive pressure ventilation (NIPPV) in respiratory support for severe pneumonia. Methods: Data were analyzed from 74 patients with severe pneumonia undergoing respi...Objective: To evaluate the efficacy of noninvasive positive pressure ventilation (NIPPV) in respiratory support for severe pneumonia. Methods: Data were analyzed from 74 patients with severe pneumonia undergoing respiratory support at our hospital between May 2024 and April 2025. Patients were randomly assigned using a random number table to two groups (n = 37 each): the experimental group received NIPPV, while the control group underwent conventional invasive mechanical ventilation. Intergroup differences were compared. Results: Compared with the control group, the experimental group demonstrated significantly higher PaO2 and oxygenation index, significantly lower PaCO2, significantly reduced levels of WBC, CRP, and PCT, significantly higher overall efficacy rate, and significantly lower incidence of adverse reactions after treatment (p < 0.05). Pre-treatment PaO2, oxygenation index, PaCO2, WBC, CRP, and PCT levels showed no significant differences between groups (p > 0.05). Conclusion: Non-invasive positive pressure ventilation demonstrates favorable outcomes in respiratory support for severe pneumonia.展开更多
Sarcopenia in the elderly is a syndrome characterized by age-related progressive loss of muscle mass, decline in muscle strength, and deterioration of muscle function. Its high incidence significantly increases the ri...Sarcopenia in the elderly is a syndrome characterized by age-related progressive loss of muscle mass, decline in muscle strength, and deterioration of muscle function. Its high incidence significantly increases the risk of falls, fractures, disability, and mortality among the elderly, posing a global public health challenge for geriatric health. Insulin-like growth factor-1 (IGF-1), a key cytokine regulating muscle growth, repair, and metabolism, exhibits a progressive decline in serum levels with aging and is closely associated with the onset and progression of sarcopenia in the elderly. This study reviews the research progress of IGF-1 in the diagnosis and efficacy prediction of sarcopenia in the elderly, providing theoretical references for precise diagnosis, treatment, and prognosis assessment of sarcopenia in the elderly.展开更多
Objective:To evaluate the clinical efficacy of blood-letting cupping combined with manual lymphatic drainage in treating breast cancer-related lymphedema(BCRL)and explore its mechanism of action from both traditional ...Objective:To evaluate the clinical efficacy of blood-letting cupping combined with manual lymphatic drainage in treating breast cancer-related lymphedema(BCRL)and explore its mechanism of action from both traditional Chinese medicine and modern medical perspectives,providing a scientific basis and novel therapeutic approaches for clinical management of BCRL.Methods:Patients with BCRL admitted to the outpatient and inpatient departments of Hebei University Affiliated Hospital were enrolled.A prospective randomized controlled trial design was adopted,with eligible patients randomly assigned to a treatment group and a control group.The control group received manual lymphatic drainage alone,while the treatment group received manual lymphtic drainage combined with blood-letting cupping therapy.Posttreatment comparisons evaluated upper limb circumference reduction,edema severity grading,and upper limb functional scores.Vital signs and adverse reactions during treatment were recorded for both groups.Statistical software analyzed the data.Results:The treatment group demonstrated significantly greater reduction in upper limb circumference,improvement in edema severity,and higher upper limb function scores compared to the control group(P<0.05).Vital signs remained stable throughout treatment in both groups.No severe adverse reactions occurred in the treatment group;only isolated cases of mild skin itching were reported,which resolved after symptomatic management.Conclusion:The combination of bloodletting cupping and manual lymphatic drainage demonstrates reliable efficacy in treating BCRL,effectively alleviating edema symptoms and improving upper limb function with high safety.Its mechanism may relate to traditional Chinese medicine principles of“unblocking meridians,promoting blood circulation,and resolving stasis”and modern medical concepts of“enhancing local blood circulation,facilitating lymphatic drainage,and reducing inflammatory responses”.展开更多
Chronic atrophic gastritis(CAG)is an important stage of precancerous lesions of gastric cancer.Effective treatment and regulation of CAG are essential to prevent its progression to malignancy.Traditional Chinese medic...Chronic atrophic gastritis(CAG)is an important stage of precancerous lesions of gastric cancer.Effective treatment and regulation of CAG are essential to prevent its progression to malignancy.Traditional Chinese medicine(TCM)has shown multi-targeted efficacy in CAG treatment,with advantages in enhancing gastric mucosal barrier defense,improving microcirculation,modulating inflammatory and immune responses,and promoting lesion healing,etc.Clinical studies and meta-analyses indicate that TCM provides significant benefits,with specific Chinese herbal compounds and monomers demonstrating protective effects on the gastric mucosa through mechanisms including anti-inflammation,antioxidation,and regulation of cellular proliferation and apoptosis,etc.Finally,it is pointed out that the efficacy of TCM in the treatment of CAG requires standardized research and unified standards,and constantly clarifies and improves the evaluation criteria of each dimension of gastric mucosal barrier function.展开更多
BACKGROUND Gastric cancer is a leading global cause of cancer mortality,with poor survival in locally advanced stages.While immune checkpoint inhibitors(ICIs)like sintilimab have improved outcomes in advanced disease,...BACKGROUND Gastric cancer is a leading global cause of cancer mortality,with poor survival in locally advanced stages.While immune checkpoint inhibitors(ICIs)like sintilimab have improved outcomes in advanced disease,their role as neoadjuvant therapy remains understudied.This study investigates sintilimab combined with nabpaclitaxel/S-1 as preoperative treatment for locally advanced gastric cancer(LAGC),addressing an unmet need for effective neoadjuvant strategies.AIM To explore the efficacy and safety of combination treatment with sintilimab and nab-paclitaxel plus S-1 as neoadjuvant therapy for LAGC.METHODS Clinical data from 82 patients diagnosed with LAGC,who underwent preoperative treatment and surgery between April 2020 and December 2022,were included.Patients were divided into 2 groups according to treatment regimen:ICI(sintilimab+nab-paclitaxel+S-1);and non-ICI(nab-paclitaxel+S-1).Imaging and pathological efficacy,intra-and postoperative conditions,molecular subtypes,short-term survival outcomes,and safety were compared between the 2 groups.RESULTS Imaging evaluation of therapeutic efficacy revealed that the inclusion of ICI yielded a significantly higher complete response rate(13.2%vs 0.0%;P=0.048),and objective response rate(69.8%vs 31.0%,P=0.001)compared with non-ICI treatment.Pathological evaluation revealed that the ICI group exhibited a significantly higher pathological complete response rate(13.2%vs 0.0%;P=0.048)and major pathological response rate(35.8%vs 13.8%;P=0.041)than those in the non-ICI group.The two-year disease-free survival rate in the ICI group was greater than that in the non-ICI group(83.0%vs 55.2%;P=0.043).The use of ICI did not increase the incidence of adverse reactions(47.2%vs 41.4%;P=0.614)or perioperative adverse events(18.9%vs 13.8%;P=0.761).CONCLUSION The combination of sintilimab with nab-paclitaxel+S-1 for neoadjuvant treatment of LAGC improved efficacy in patients without increasing adverse drug reactions and perioperative adverse events,suggesting that this treatment regimen is safe and feasible.展开更多
Peptic ulcer(PU)is characterized by inflammation,necrosis,and erosion of the gastrointestinal mucosa caused by various pathogenic factors,leading to ulcer formation.The stomach and duodenum are the most commonly affec...Peptic ulcer(PU)is characterized by inflammation,necrosis,and erosion of the gastrointestinal mucosa caused by various pathogenic factors,leading to ulcer formation.The stomach and duodenum are the most commonly affected sites.Bletilla striata,a traditional Chinese medicinal herb,contains diverse chemical constituents and exhibits multiple pharmacological effects.As a key component in various traditional Chinese medicine compound formulations,it has demonstrated notable clinical efficacy.Moreover,it has a solid research foundation and broad application prospects in the treatment of gastrointestinal diseases.This paper systematically elaborates on the clinical efficacy and mechanisms of action of Bletilla striata in the treatment of PUs,drawing from ancient medical literature and traditional formula applications to provide support for clinical use.展开更多
Objective:To investigate the potential efficacy and safety of Lutai Danshen Baishao granules(LDBG)for treating female melasma associated with kidney deficiency and blood stasis patterns.Methods:A randomized,double-bli...Objective:To investigate the potential efficacy and safety of Lutai Danshen Baishao granules(LDBG)for treating female melasma associated with kidney deficiency and blood stasis patterns.Methods:A randomized,double-blind,placebo-controlled trial was conducted at the Third Central Hospital of Tianjin,China from March to December 2023.A total of 110 female patients with melasma linked to kidney deficiency and blood stasis were enrolled and treated with either LDBG or a placebo twice daily for 60 days.Efficacy was assessed through measures such as the total melasma area,reduced melasma area,reduction rate of melasma area,melasma color score,Melasma Area and Severity Index(MASI)score,and traditional Chinese medicine(TCM)symptom score scale.Safety assessments included routine blood and biochemical tests.Results:Participants in both groups were aged 52-63 years,with no significant differences.After the 2-month intervention,the total melasma area decreased in both groups;however,a greater reduction was observed in the test group[462.50 mm^(2)(12.81%)vs.100.00 mm2(3.11%),P<.001].Moreover,LDBG treatment significantly reduced the MASI and melasma color scores in the test group(P<.05).The total TCM symptom evaluation score significantly decreased(test group:6.00 vs.placebo group:7.00,P=.001),with significant relief in symptoms such as improvement in dark lips,nails,and waist soreness in the test group,compared with that in the placebo group(P<.05).Within-group comparisons revealed that TCM syndrome was significantly alleviated in the test group(P<.05).Conclusion:LDBG intervention shows promising effectiveness in reducing female melasma and alleviating TCM syndromes.展开更多
Yttrium-90(Y-90)microsphere therapy,known as radioembolization,has emerged as a pivotal treatment modality for hepatocellular carcinoma(HCC),delivering targeted radiation with minimal collateral damage to healthy live...Yttrium-90(Y-90)microsphere therapy,known as radioembolization,has emerged as a pivotal treatment modality for hepatocellular carcinoma(HCC),delivering targeted radiation with minimal collateral damage to healthy liver tissues.This review meticulously synthesizes current evidence regarding the clinical efficacy,underlying therapeutic mechanisms,patient selection criteria,and comparative advantages of Y-90 therapy.Clinical studies consistently demonstrate significant improvements in overall survival and progression-free survival,coupled with robust tumor response rates and manageable adverse events.The therapy’s efficacy is substantially enhanced by advanced dosimetric techniques,enabling precise radiation delivery tailored to individual tumor profiles.Comparative analyses reveal that Y-90 therapy provides superior local tumor control and a preferable safety profile compared to conventional treatments such as transarterial chemoembolization and external beam radiation therapy.Additionally,its clinical outcomes are comparable to those achieved with contemporary systemic therapies.Ongoing research into combination treatments incorporating Y-90 with systemic therapies,including targeted agents and immune checkpoint inhibitors,suggests promising advancements in comprehensive HCC management.Future directions highlight the necessity for continued refinement of dosimetry and patient stratification approaches,aiming to further optimize therapeutic outcomes.展开更多
BACKGROUND Cirrhosis-related upper gastrointestinal bleeding(UGIB)poses a fatal risk,and endoscopic ligation as a sole intervention shows inadequate effectiveness.AIM To evaluate the therapeutic efficacy of endoscopic...BACKGROUND Cirrhosis-related upper gastrointestinal bleeding(UGIB)poses a fatal risk,and endoscopic ligation as a sole intervention shows inadequate effectiveness.AIM To evaluate the therapeutic efficacy of endoscopic variceal ligation(EVL)plus pro-pranolol vs EVL monotherapy in patients with cirrhosis complicated with acute UGIB and identify predictors for clinical outcomes.METHODS This study enrolled 99 consecutive patients with cirrhosis presenting with acute UGIB between January 2024 and January 2025.Participants were allocated to either the control group(n=49)receiving EVL alone or(2)the research group(n=50)receiving EVL plus propranolol.Primary outcomes included treatment efficacy,venous blood flow[portal venous flow(PVF)/splenic venous flow(SVF)],and postoperative outcomes(hemostasis time,length of hospital stay,and rebleeding rates).Univariate and multivariate regression analyses were conducted to determine independent predictors of treatment response.RESULTS Compared with the control group,the research group demonstrated significantly better outcomes,including higher overall treatment efficacy,greater reductions in PVF and SVF,shorter hemostasis time and hospital stay,and lower rebleeding rates.Univariate analysis demonstrated significant associations between treatment efficacy and age,cirrhosis duration,Child-Pugh grade,bleeding duration,and treatment approach in patients with cirrhosis complicated with acute UGIB.Multivariate logistic regression identified three independent risk factors for poor outcomes,namely,advanced age(>55 years),prolonged cirrhosis duration(≥4 years),and delayed bleeding intervention(>24 hours).CONCLUSION The EVL plus propranolol regimen demonstrates significant efficacy in treating UGIB in cirrhosis,outperforming EVL alone in improving hemodynamics(PVF/SVF),shortening hemostasis and hospitalization duration,and reducing rebleeding rates.Moreover,advanced age,prolonged disease duration,and longer bleeding times are independent risk factors for poor therapeutic outcomes.展开更多
This paper thoroughly explores the multifaceted factors influencing the efficacy of Chinese medicinals and categorizes them into three main groups:medicinal related factors,patient related factors,and practitioner rel...This paper thoroughly explores the multifaceted factors influencing the efficacy of Chinese medicinals and categorizes them into three main groups:medicinal related factors,patient related factors,and practitioner related factors.Regarding medicinal related factors,the place of origin,growing environment,harvesting time,storage conditions,quality control,dosage form selection,compatibility of medicinals,precise dosing,decoction methods,and administration routes all significantly impact efficacy.The place of origin determines the authenticity of medicinals,the growing environment affects their composition,harvesting time influences potency,improper storage leads to deterioration,quality control forms the foundation of efficacy,dosage forms and compatibility of medicinals affect absorption,dosing and decoction methods require precision,and administration routes should be tailored to individuals.Patient related factors include psychological state,individual differences,background,and disease condition.Psychological state affects treatment compliance,individual differences determine medicine responses,background influences patients’understanding of Chinese medicinals,and disease condition directly reflects efficacy.Practitioner related factors encompass theoretical knowledge,clinical experience,inherited practices,psychological state,and professional ethics.Theoretical knowledge guides medication use,clinical experience enhances efficacy,inherited practices influence prescribing styles,psychological state affects doctor–patient communication,and professional ethics ensure medical quality.These interrelated factors collectively influence the efficacy of Chinese medicinals,emphasizing the need for comprehensive consideration in clinical applications to achieve optimal therapeutic outcomes.展开更多
The soothing efficacy of baby moisturizer was evaluated by analyzing the changes of inflammatory cytokines in vitro and human efficacy tests.RAW264.7 cells were induced by Lipopolysaccharide(LPS) to establish a cell i...The soothing efficacy of baby moisturizer was evaluated by analyzing the changes of inflammatory cytokines in vitro and human efficacy tests.RAW264.7 cells were induced by Lipopolysaccharide(LPS) to establish a cell inflammation model in vitro,and the inflammatory cytokines of Interleukin-6 (IL-6) and NO were detected to observe the inhibitory effect of baby moisturizer in vitro.The non-toxic concentration of baby moisturizer was detected by MTT assay,the level of IL-6 in RAW264.7 cells supernatant was detected by ELISA kits,and the level of NO in RAW 264.7 cells supernatant was detected by Griess reagent.Dexamethasone was used as the positive control.At the same time,the hydration of the stratum corneum,transepidermal water loss (TEWL),erythema index,the redness of skin (a^(*) value) and the proportion of redness area in facial cheekbones were detected after using the baby moisturizer for 28 days.The experiment results showed that the baby moisturizer at a non-toxic concentration of 0.3 mg/mL,could significantly reduce IL-6 and NO in RAW264.7 cells supernatant,meanwhile it could significantly enhance the hydration of the stratum corneum,and reduce the TEWL,erythema index,the redness of skin (a^(*) value) and the proportion of redness area.In conclusion,the baby moisturizer (0.3 mg/mL) can restrain inflammatory cytokines in vitro and can also significantly improve human facial skin irritation,which can be considered to have soothing efficacy.展开更多
An acute skin injury model using continuous tape tearing was established,and studies the application of this model in the evaluation of soothing effects through instrument evaluation.30 healthy adult subjects were sel...An acute skin injury model using continuous tape tearing was established,and studies the application of this model in the evaluation of soothing effects through instrument evaluation.30 healthy adult subjects were selected as the research subjects,and an acute skin model was established on the forearm flexion side of the subjects.The skin color a^(*)value and transdermal water loss rate(TEWL)value of the blank and experimental groups were tested using instruments.The results showed that at 15 and 30 minutes after using the sample,the growth values of a^(*)value and TEWL value in the experimental group were significantly lower than those in the blank group(P<0.05),the acute skin lesion model can effectively evaluate the soothing effect of cosmetics.展开更多
BACKGROUND Schizophrenia,a complex group of mental disorders,is primarily managed with antipsychotic medications.The safety and efficacy of different initial doses of lurasidone for acute schizophrenia remain uncertai...BACKGROUND Schizophrenia,a complex group of mental disorders,is primarily managed with antipsychotic medications.The safety and efficacy of different initial doses of lurasidone for acute schizophrenia remain uncertain,particularly concerning discontinuation rates due to adverse events(AEs).AIM To compare the safety of two initial doses of lurasidone for the treatment of acute schizophrenia in Chinese patients.METHODS This 6-week,randomized,open-label,multicenter trial allocated participants to receive either 40 mg/day or 80 mg/day lurasidone initially,with dose adjustment allowed after a one-week fixed-dose period.Safety assessments included the primary endpoint of discontinuation due to AEs,as well as evaluations of AEs,weight changes,and laboratory parameters.Efficacy assessments included responder rates and changes in scores on the Positive and Negative Syndrome Scale(PANSS),Clinical Global Impression-Severity scale,and Calgary Depression Scale for Schizophrenia.RESULTS Among 197 participants,no significant difference was found in discontinuation rate due to AEs between groups(3.03% vs 5.10%,P=0.707).Treatment-emergent AEs were reported in 64.6%and 71.4%of participants in the 40 mg/day and 80 mg/day initiation groups,respectively.Response rates at weeks 1 and 2 showed no statistically significant differences.Both groups demonstrated significant improvements in PANSS total,Clinical Global Impression-Severity,and Calgary Depression Scale for Schizophrenia scores from baseline(all P<0.01).Notably,the 80 mg/day initiation group showed greater improvement in the PANSS positive subscale score at visits 1 and 2 compared to the 40 mg/day initiation group(P<0.05).CONCLUSION Initial doses of 40 mg/day and 80 mg/day lurasidone are safe and effective for acute schizophrenia,with no significant increase in AEs-related discontinuation rate at the higher dose.展开更多
To verify the inhibitory ability of the combination on the biofilm production of Propionibacterium acnes and its ameliorative effect on facial acne problems.The ability of the combination to inhibit the biofilm format...To verify the inhibitory ability of the combination on the biofilm production of Propionibacterium acnes and its ameliorative effect on facial acne problems.The ability of the combination to inhibit the biofilm formation of Propionibacterium acnes was verified by suspension quantification and crystal violet staining,and then 60 effective volunteers were selected for the efficacy measurement of topical acne elimination combinations+bases for 4 consecutive weeks,which were measured by a professional instrument,and the volunteers’facial acne lesion areas and acne lesion colours were evaluated respectively.In vitro tests verified that the combination can inhibit the formation of P.acnes biofilm and will not completely kill P.acnes and will not disrupt the micro-ecological balance of the skin;3%and 5%acne combinations can reduce the biofilm of P.acnes by 61.3%and 61.6%respectively;after 4 weeks of continuous use,the area of acne lesions of the samples with 5%acne combinations decreased by 54.61%and the colour of acne lesions decreased by 54.61%compared with the area of acne lesions before the use of the combination.54.61%,acne lesion colour a^(*)decreased by 13.74%,and the subjects’self-assessment of the mildness and non-irritation of the samples in the test group had a 100%agreement rate.The acne combination can improve acne problems by inhibiting the biofilm formation of Propionibacterium acnes,and has a mild and effective acne elimination effect.展开更多
BACKGROUND Surgery is the first choice of treatment for patients with colorectal cancer.Traditional open surgery imparts great damage to the body of the patient and can easily cause adverse stress reactions.With the c...BACKGROUND Surgery is the first choice of treatment for patients with colorectal cancer.Traditional open surgery imparts great damage to the body of the patient and can easily cause adverse stress reactions.With the continuous development of medical technology,laparoscopic minimally invasive surgery has shown great advantages for the treatment of patients with celiac disease.AIM To investigate the short-term efficacy of laparoscopic radical surgery and traditional laparotomy for the treatment of colorectal cancer,and the differences in the risk analysis of unplanned reoperation after operation.METHODS As the research subjects,this study selected 100 patients with colorectal cancer who received surgical treatment at the Yulin First Hospital from January 2018 to January 2022.Among them,50 patients who underwent laparoscopic radical resection were selected as the research group and 50 patients who underwent traditional laparotomy were selected as the control group.Data pertaining to clinical indexes,gastrointestinal hormones,nutrition indexes,the levels of inflammatory factors,quality of life,Visual Analog Scale score,and the postoperative complications of the two groups of patients before and after treatment were collected,and the therapeutic effects in the two groups were analyzed and compared.RESULTS Compared with the control group,perioperative bleeding,peristalsis recovery time,and hospital stays were significantly shorter in the research group.After surgery,the levels of gastrin(GAS)and motilin(MTL)were decreased in both groups,and the fluctuation range of GAS and MTL observed in the research group was significantly lower than that recorded in the control group.The hemoglobin(Hb)levels increased after surgery,and the level of Hb in the research group was significantly higher compared with the control group.After the operation,the expression levels of tumor necrosis factor-α,interleukin-6,and C-reactive protein and the total incidence of complications were significantly lower in the research group compared with the control group.One year after the operation,the quality of life of the two groups was greatly improved,with the quality of life in the research group being significantly better.CONCLUSION Laparoscopy was effective for colorectal surgery by reducing the occurrence of complications and inflammatory stress reaction;moreover,the quality of life of patients was significantly improved,which warrants further promotion.展开更多
BACKGROUND Gastrointestinal angiodysplasias(GIAD)causes recurrent bleeding,and current treatments have limitations.Sirolimus,a mammalian target of rapamycin inhibi-tor,shows promise in inhibiting abnormal angiogenesis...BACKGROUND Gastrointestinal angiodysplasias(GIAD)causes recurrent bleeding,and current treatments have limitations.Sirolimus,a mammalian target of rapamycin inhibi-tor,shows promise in inhibiting abnormal angiogenesis.AIM To evaluate the efficacy and safety of sirolimus in reducing bleeding episodes and improving clinical outcomes in patients with GIAD.METHODS We conducted a self-controlled study with 11 patients taking oral sirolimus.Retrospective data were collected prior to treatment,and prospective data were gathered during the study.Efficacy was assessed primarily by comparing blee-ding episodes before and after sirolimus,with measurements at 3 and 6 months post-administration.The initial dose was 0.8 mg/m^(2)once daily,adjusted to main-tain trough blood concentrations between 5-10 ng/mL.Secondary outcomes included hemoglobin(Hb)levels,blood transfusion volume,and vascular lesions.Safety was monitored by tracking adverse reactions.RESULTS The average number of bleeding episodes decreased significantly from 2.09±1.04 to 1.00±0.75 in the 3 months preceding treatment,and from 3.80±1.93 to 2.00±1.63 in the 6 months preceding treatment.Sirolimus also increased Hb levels,reduced the need for transfusions,and decreased vascular lesions,improving clinical outcomes.All adverse effects were mild and resolved or improved within 1 week to 1 month without stopping sirolimus or needing lipid-lowering treatment.CONCLUSION Sirolimus reduced bleeding and transfusion needs while improving Hb levels in GIAD patients.Although these findings are encouraging,the limited sample size and lack of a control group warrant caution.Future controlled trials with larger populations are needed to validate sirolimus’s potential in GIAD.展开更多
文摘Objective:To compare the clinical efficacy and safety of intravitreal injection of faricimab and conbercept in the treatment of diabetic macular edema(DME).Methods:A total of 50 patients diagnosed with DME in our hospital from January 2023 to May 2025 were selected and randomly divided into an observation group and a control group,with 25 cases in each group,using a random number table method.The observation group received intravitreal injection of faricimab,while the control group received intravitreal injection of conbercept.Both groups adopted a loading phase plus maintenance phase treatment regimen.The best-corrected visual acuity(BCVA,expressed in logMAR)and central subfield thickness(CST)of the two groups were compared before treatment and at 1,3,and 6 months after treatment,and the incidence of adverse events during treatment was recorded.Results:The logMAR BCVA in the observation group was lower than that in the control group at 3 and 6 months after treatment(both p<0.05).The CST in the observation group was smaller than that in the control group at 1,3,and 6 months after treatment(all p<0.05).There was no statistically significant difference in the overall incidence of adverse events between the two groups(χ^(2)=0.189,p=0.663).Conclusion:Both intravitreal injections of faricimab and conbercept are effective in improving visual acuity and reducing macular edema in patients with DME,with good safety profiles.However,faricimab demonstrates superior efficacy in the medium to long term(3 and 6 months)compared to conbercept,making it more suitable for long-term treatment of patients with DME.
文摘Objective:To investigate the clinical efficacy of electrophysiological therapy under different parameter modes in chronic pelvic pain syndrome(CPPS).Methods:A total of 95patients with CPPS from the Department of Urology,First Affiliated Hospital of Jinan University,were selected and treated with electrophysiological therapy.They were randomly divided into three groups:the fixed-parameter AA7 treatment group,the P2+P4 treatment group,and the precision treatment group(individualized parameter treatment).Pain scores of patients in each group were compared before and after treatment,with a pain score of 0 indicating cure.The cure rate of each group was observed.Results:The average ages of the AA7 group,P2+P4 group,and precision treatment group were 34±14.17 years,35.58±12.57 years,and 35.5±11.27 years,respectively.There was no significant difference in age among the three groups(p>0.05).Before treatment,the pain scores of the AA7 group,P2+P4 group,and precision treatment group were 4.14±1.74,4.64±1.72,and 3.50±1.89,respectively,with no significant differences among the groups(p>0.05).After treatment,the pain scores were 0.71±0.99 for the AA7 group(cure rate:57%),0.49±0.79 for the P2+P4 group(cure rate:67%),and 0.50±0.77 for the precision treatment group(cure rate:64%),with no significant differences among the groups(p>0.05).The cure rates for different pain locations were as follows:83%for lower abdominal pain,74%for perineal pain,62%for dysuria,49%for testicular pain,and 75%for inguinal pain.Conclusion:The pathogenesis of CPPS is complex and diverse,with numerous treatment options and uncertain efficacy,posing significant challenges to clinical practice.This study showed that electrophysiological therapy under different parameter modes significantly reduced pain scores before and after treatment,indicating significant therapeutic effects on CPPS.All three modes demonstrated good cure rates.Individualized precision treatment and fixed-mode P2+P4 or AA7 treatment were safe and effective in CPPS treatment and are worth promoting.Fixed-mode P2+P4 and AA7,due to their easier standardization of parameters and patch modes,reduced the learning curve and had better potential for widespread application.
基金supported by the Innovative Team Project of Ordinary Universities in Guangdong Province(No.2022KCXTD016).
文摘Chemotherapy-induced diarrhea(CID)is a major concern for cancer patients and is associated with significant morbidity and mortality.Currently,the clinical management of CID is limited.The utilization of antidiarrheal medications,such as loperamide and octreotide,is relatively limited because of their unsatisfactory efficacy and adverse effects.In recent years,traditional Chinese medicine(TCM)has attracted great interest because of its beneficial effect in treating CID,which has multitarget and low-toxicity therapeutic characteristics.TCM exhibits remarkable therapeutic potential in the prevention and treatment of CID.It can alleviate and treat CID by regulating chemical drug metabolism,improving the integrity of the intestinal barrier,stimulating proliferation while suppressing the apoptosis of intestinal epithelial cells,ameliorating oxidative stress and inflammation and regulating bile acids and aquaporins.However,large-scale,randomized,double-blind clinical trials of TCM for the treatment of CID are lacking,and most preclinical experiments have not been translated to clinical trials.Accordingly,this review highlights the clinical efficacy and molecular mechanisms of TCM against CID via PubMed,Web of Science and China National Knowledge Infrastructure and proposes that future research on TCM against CID should focus on strengthening the connection from bench to bed,which may help to comprehensively evaluate the therapeutic potential of TCM against CID.
基金Application Research of MRI Physiological Quantitative Imaging Technology in the Diagnosis of Cartilage Injury(Project No.:RCYJ2021-04)。
文摘Objective:To retrospectively evaluate the diagnostic efficacy of traditional MRI and T2 Mapping quantitative imaging technology for knee joint cartilage injury,clarify the differences in diagnostic value of the two imaging methods in different injury grades and different cartilage subregions,and provide evidence-based basis for the accurate diagnosis of clinical cartilage injury.Methods:Clinical and imaging data of 286 patients with knee joint lesions admitted to the Affiliated Hospital of Xiangtan Medicine and Health Vocational College from January 2020 to June 2023 were collected retrospectively.All patients underwent both traditional MRI sequences and T2 Mapping sequences.The knee joint cartilage was divided into 14 subregions.Two senior radiologists independently diagnosed the images of the two imaging technologies using a blind method and recorded the cartilage injury grades.The sensitivity,specificity,accuracy,positive predictive value,negative predictive value,and area under the receiver operating characteristic curve(AUC)of the two technologies for diagnosing cartilage injury were calculated and compared,and the differences in their diagnostic efficacy in different injury grades and different subregions were analyzed.Results:A total of 4004 cartilage subregions from 286 patients were included in the analysis,including 1836 injured subregions and 2168 normal subregions.The overall sensitivity(89.7%),accuracy(91.2%),and AUC(0.946)of T2 Mapping quantitative imaging for diagnosing cartilage injury were significantly higher than those of traditional MRI(76.3%,82.5%,and 0.852 respectively),with statistically significant differences(p<0.001);there was no significant difference in specificity between the two(93.5%vs 90.8%,p=0.062).Subgroup analysis showed that T2 Mapping had the most significant diagnostic advantage in early cartilage injury(Grade 1),with sensitivity(78.5%)33.2%higher than that of traditional MRI(45.3%)(p<0.001).Conclusion:The diagnostic efficacy of T2 Mapping quantitative imaging for knee joint cartilage injury is significantly superior to that of traditional MRI,especially in the detection of early cartilage injury and accurate evaluation of weight-bearing area injury.Data verify its clinical applicability and reliability.It can be used as an important supplementary method to traditional MRI,and is recommended for the early diagnosis,grading evaluation,and clinical follow-up of cartilage injury.
文摘Objective: To evaluate the efficacy of noninvasive positive pressure ventilation (NIPPV) in respiratory support for severe pneumonia. Methods: Data were analyzed from 74 patients with severe pneumonia undergoing respiratory support at our hospital between May 2024 and April 2025. Patients were randomly assigned using a random number table to two groups (n = 37 each): the experimental group received NIPPV, while the control group underwent conventional invasive mechanical ventilation. Intergroup differences were compared. Results: Compared with the control group, the experimental group demonstrated significantly higher PaO2 and oxygenation index, significantly lower PaCO2, significantly reduced levels of WBC, CRP, and PCT, significantly higher overall efficacy rate, and significantly lower incidence of adverse reactions after treatment (p < 0.05). Pre-treatment PaO2, oxygenation index, PaCO2, WBC, CRP, and PCT levels showed no significant differences between groups (p > 0.05). Conclusion: Non-invasive positive pressure ventilation demonstrates favorable outcomes in respiratory support for severe pneumonia.
文摘Sarcopenia in the elderly is a syndrome characterized by age-related progressive loss of muscle mass, decline in muscle strength, and deterioration of muscle function. Its high incidence significantly increases the risk of falls, fractures, disability, and mortality among the elderly, posing a global public health challenge for geriatric health. Insulin-like growth factor-1 (IGF-1), a key cytokine regulating muscle growth, repair, and metabolism, exhibits a progressive decline in serum levels with aging and is closely associated with the onset and progression of sarcopenia in the elderly. This study reviews the research progress of IGF-1 in the diagnosis and efficacy prediction of sarcopenia in the elderly, providing theoretical references for precise diagnosis, treatment, and prognosis assessment of sarcopenia in the elderly.
文摘Objective:To evaluate the clinical efficacy of blood-letting cupping combined with manual lymphatic drainage in treating breast cancer-related lymphedema(BCRL)and explore its mechanism of action from both traditional Chinese medicine and modern medical perspectives,providing a scientific basis and novel therapeutic approaches for clinical management of BCRL.Methods:Patients with BCRL admitted to the outpatient and inpatient departments of Hebei University Affiliated Hospital were enrolled.A prospective randomized controlled trial design was adopted,with eligible patients randomly assigned to a treatment group and a control group.The control group received manual lymphatic drainage alone,while the treatment group received manual lymphtic drainage combined with blood-letting cupping therapy.Posttreatment comparisons evaluated upper limb circumference reduction,edema severity grading,and upper limb functional scores.Vital signs and adverse reactions during treatment were recorded for both groups.Statistical software analyzed the data.Results:The treatment group demonstrated significantly greater reduction in upper limb circumference,improvement in edema severity,and higher upper limb function scores compared to the control group(P<0.05).Vital signs remained stable throughout treatment in both groups.No severe adverse reactions occurred in the treatment group;only isolated cases of mild skin itching were reported,which resolved after symptomatic management.Conclusion:The combination of bloodletting cupping and manual lymphatic drainage demonstrates reliable efficacy in treating BCRL,effectively alleviating edema symptoms and improving upper limb function with high safety.Its mechanism may relate to traditional Chinese medicine principles of“unblocking meridians,promoting blood circulation,and resolving stasis”and modern medical concepts of“enhancing local blood circulation,facilitating lymphatic drainage,and reducing inflammatory responses”.
基金Supported by the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences,No.CI2021A00806High Level Chinese Medical Hospital Promotion Project,No.HLCMHPP2023086the Fundamental Research Funds for the Central Public Welfare Research Institutes,No.ZZ17-XRZ-041.
文摘Chronic atrophic gastritis(CAG)is an important stage of precancerous lesions of gastric cancer.Effective treatment and regulation of CAG are essential to prevent its progression to malignancy.Traditional Chinese medicine(TCM)has shown multi-targeted efficacy in CAG treatment,with advantages in enhancing gastric mucosal barrier defense,improving microcirculation,modulating inflammatory and immune responses,and promoting lesion healing,etc.Clinical studies and meta-analyses indicate that TCM provides significant benefits,with specific Chinese herbal compounds and monomers demonstrating protective effects on the gastric mucosa through mechanisms including anti-inflammation,antioxidation,and regulation of cellular proliferation and apoptosis,etc.Finally,it is pointed out that the efficacy of TCM in the treatment of CAG requires standardized research and unified standards,and constantly clarifies and improves the evaluation criteria of each dimension of gastric mucosal barrier function.
基金Supported by the Wu Jieping Medical Fund,No.320.6750.2022-09-14the Climbing Fund of PhD Workstation,Zhangzhou Affiliated Hospital of Fujian Medical University,No.PDB202412。
文摘BACKGROUND Gastric cancer is a leading global cause of cancer mortality,with poor survival in locally advanced stages.While immune checkpoint inhibitors(ICIs)like sintilimab have improved outcomes in advanced disease,their role as neoadjuvant therapy remains understudied.This study investigates sintilimab combined with nabpaclitaxel/S-1 as preoperative treatment for locally advanced gastric cancer(LAGC),addressing an unmet need for effective neoadjuvant strategies.AIM To explore the efficacy and safety of combination treatment with sintilimab and nab-paclitaxel plus S-1 as neoadjuvant therapy for LAGC.METHODS Clinical data from 82 patients diagnosed with LAGC,who underwent preoperative treatment and surgery between April 2020 and December 2022,were included.Patients were divided into 2 groups according to treatment regimen:ICI(sintilimab+nab-paclitaxel+S-1);and non-ICI(nab-paclitaxel+S-1).Imaging and pathological efficacy,intra-and postoperative conditions,molecular subtypes,short-term survival outcomes,and safety were compared between the 2 groups.RESULTS Imaging evaluation of therapeutic efficacy revealed that the inclusion of ICI yielded a significantly higher complete response rate(13.2%vs 0.0%;P=0.048),and objective response rate(69.8%vs 31.0%,P=0.001)compared with non-ICI treatment.Pathological evaluation revealed that the ICI group exhibited a significantly higher pathological complete response rate(13.2%vs 0.0%;P=0.048)and major pathological response rate(35.8%vs 13.8%;P=0.041)than those in the non-ICI group.The two-year disease-free survival rate in the ICI group was greater than that in the non-ICI group(83.0%vs 55.2%;P=0.043).The use of ICI did not increase the incidence of adverse reactions(47.2%vs 41.4%;P=0.614)or perioperative adverse events(18.9%vs 13.8%;P=0.761).CONCLUSION The combination of sintilimab with nab-paclitaxel+S-1 for neoadjuvant treatment of LAGC improved efficacy in patients without increasing adverse drug reactions and perioperative adverse events,suggesting that this treatment regimen is safe and feasible.
基金Supported by National Science and Technology Major Project,No.2024ZD0521002The Innovation Team Project of Traditional Chinese Medicine of Liaoning Province,No.LNZYYCXTD-CCCX-003+1 种基金General Program of the National Natural Science Foundation of China,No.82074296Construction Project of Inheritance Studios of Famous Chinese Medicine Experts in China,No.[2022]No.75.
文摘Peptic ulcer(PU)is characterized by inflammation,necrosis,and erosion of the gastrointestinal mucosa caused by various pathogenic factors,leading to ulcer formation.The stomach and duodenum are the most commonly affected sites.Bletilla striata,a traditional Chinese medicinal herb,contains diverse chemical constituents and exhibits multiple pharmacological effects.As a key component in various traditional Chinese medicine compound formulations,it has demonstrated notable clinical efficacy.Moreover,it has a solid research foundation and broad application prospects in the treatment of gastrointestinal diseases.This paper systematically elaborates on the clinical efficacy and mechanisms of action of Bletilla striata in the treatment of PUs,drawing from ancient medical literature and traditional formula applications to provide support for clinical use.
基金funded by the National Key Research and Development Plan of the Traditional Chinese Medicine Modernization Research Key Project(2018YFC1706800).
文摘Objective:To investigate the potential efficacy and safety of Lutai Danshen Baishao granules(LDBG)for treating female melasma associated with kidney deficiency and blood stasis patterns.Methods:A randomized,double-blind,placebo-controlled trial was conducted at the Third Central Hospital of Tianjin,China from March to December 2023.A total of 110 female patients with melasma linked to kidney deficiency and blood stasis were enrolled and treated with either LDBG or a placebo twice daily for 60 days.Efficacy was assessed through measures such as the total melasma area,reduced melasma area,reduction rate of melasma area,melasma color score,Melasma Area and Severity Index(MASI)score,and traditional Chinese medicine(TCM)symptom score scale.Safety assessments included routine blood and biochemical tests.Results:Participants in both groups were aged 52-63 years,with no significant differences.After the 2-month intervention,the total melasma area decreased in both groups;however,a greater reduction was observed in the test group[462.50 mm^(2)(12.81%)vs.100.00 mm2(3.11%),P<.001].Moreover,LDBG treatment significantly reduced the MASI and melasma color scores in the test group(P<.05).The total TCM symptom evaluation score significantly decreased(test group:6.00 vs.placebo group:7.00,P=.001),with significant relief in symptoms such as improvement in dark lips,nails,and waist soreness in the test group,compared with that in the placebo group(P<.05).Within-group comparisons revealed that TCM syndrome was significantly alleviated in the test group(P<.05).Conclusion:LDBG intervention shows promising effectiveness in reducing female melasma and alleviating TCM syndromes.
文摘Yttrium-90(Y-90)microsphere therapy,known as radioembolization,has emerged as a pivotal treatment modality for hepatocellular carcinoma(HCC),delivering targeted radiation with minimal collateral damage to healthy liver tissues.This review meticulously synthesizes current evidence regarding the clinical efficacy,underlying therapeutic mechanisms,patient selection criteria,and comparative advantages of Y-90 therapy.Clinical studies consistently demonstrate significant improvements in overall survival and progression-free survival,coupled with robust tumor response rates and manageable adverse events.The therapy’s efficacy is substantially enhanced by advanced dosimetric techniques,enabling precise radiation delivery tailored to individual tumor profiles.Comparative analyses reveal that Y-90 therapy provides superior local tumor control and a preferable safety profile compared to conventional treatments such as transarterial chemoembolization and external beam radiation therapy.Additionally,its clinical outcomes are comparable to those achieved with contemporary systemic therapies.Ongoing research into combination treatments incorporating Y-90 with systemic therapies,including targeted agents and immune checkpoint inhibitors,suggests promising advancements in comprehensive HCC management.Future directions highlight the necessity for continued refinement of dosimetry and patient stratification approaches,aiming to further optimize therapeutic outcomes.
文摘BACKGROUND Cirrhosis-related upper gastrointestinal bleeding(UGIB)poses a fatal risk,and endoscopic ligation as a sole intervention shows inadequate effectiveness.AIM To evaluate the therapeutic efficacy of endoscopic variceal ligation(EVL)plus pro-pranolol vs EVL monotherapy in patients with cirrhosis complicated with acute UGIB and identify predictors for clinical outcomes.METHODS This study enrolled 99 consecutive patients with cirrhosis presenting with acute UGIB between January 2024 and January 2025.Participants were allocated to either the control group(n=49)receiving EVL alone or(2)the research group(n=50)receiving EVL plus propranolol.Primary outcomes included treatment efficacy,venous blood flow[portal venous flow(PVF)/splenic venous flow(SVF)],and postoperative outcomes(hemostasis time,length of hospital stay,and rebleeding rates).Univariate and multivariate regression analyses were conducted to determine independent predictors of treatment response.RESULTS Compared with the control group,the research group demonstrated significantly better outcomes,including higher overall treatment efficacy,greater reductions in PVF and SVF,shorter hemostasis time and hospital stay,and lower rebleeding rates.Univariate analysis demonstrated significant associations between treatment efficacy and age,cirrhosis duration,Child-Pugh grade,bleeding duration,and treatment approach in patients with cirrhosis complicated with acute UGIB.Multivariate logistic regression identified three independent risk factors for poor outcomes,namely,advanced age(>55 years),prolonged cirrhosis duration(≥4 years),and delayed bleeding intervention(>24 hours).CONCLUSION The EVL plus propranolol regimen demonstrates significant efficacy in treating UGIB in cirrhosis,outperforming EVL alone in improving hemodynamics(PVF/SVF),shortening hemostasis and hospitalization duration,and reducing rebleeding rates.Moreover,advanced age,prolonged disease duration,and longer bleeding times are independent risk factors for poor therapeutic outcomes.
文摘This paper thoroughly explores the multifaceted factors influencing the efficacy of Chinese medicinals and categorizes them into three main groups:medicinal related factors,patient related factors,and practitioner related factors.Regarding medicinal related factors,the place of origin,growing environment,harvesting time,storage conditions,quality control,dosage form selection,compatibility of medicinals,precise dosing,decoction methods,and administration routes all significantly impact efficacy.The place of origin determines the authenticity of medicinals,the growing environment affects their composition,harvesting time influences potency,improper storage leads to deterioration,quality control forms the foundation of efficacy,dosage forms and compatibility of medicinals affect absorption,dosing and decoction methods require precision,and administration routes should be tailored to individuals.Patient related factors include psychological state,individual differences,background,and disease condition.Psychological state affects treatment compliance,individual differences determine medicine responses,background influences patients’understanding of Chinese medicinals,and disease condition directly reflects efficacy.Practitioner related factors encompass theoretical knowledge,clinical experience,inherited practices,psychological state,and professional ethics.Theoretical knowledge guides medication use,clinical experience enhances efficacy,inherited practices influence prescribing styles,psychological state affects doctor–patient communication,and professional ethics ensure medical quality.These interrelated factors collectively influence the efficacy of Chinese medicinals,emphasizing the need for comprehensive consideration in clinical applications to achieve optimal therapeutic outcomes.
文摘The soothing efficacy of baby moisturizer was evaluated by analyzing the changes of inflammatory cytokines in vitro and human efficacy tests.RAW264.7 cells were induced by Lipopolysaccharide(LPS) to establish a cell inflammation model in vitro,and the inflammatory cytokines of Interleukin-6 (IL-6) and NO were detected to observe the inhibitory effect of baby moisturizer in vitro.The non-toxic concentration of baby moisturizer was detected by MTT assay,the level of IL-6 in RAW264.7 cells supernatant was detected by ELISA kits,and the level of NO in RAW 264.7 cells supernatant was detected by Griess reagent.Dexamethasone was used as the positive control.At the same time,the hydration of the stratum corneum,transepidermal water loss (TEWL),erythema index,the redness of skin (a^(*) value) and the proportion of redness area in facial cheekbones were detected after using the baby moisturizer for 28 days.The experiment results showed that the baby moisturizer at a non-toxic concentration of 0.3 mg/mL,could significantly reduce IL-6 and NO in RAW264.7 cells supernatant,meanwhile it could significantly enhance the hydration of the stratum corneum,and reduce the TEWL,erythema index,the redness of skin (a^(*) value) and the proportion of redness area.In conclusion,the baby moisturizer (0.3 mg/mL) can restrain inflammatory cytokines in vitro and can also significantly improve human facial skin irritation,which can be considered to have soothing efficacy.
文摘An acute skin injury model using continuous tape tearing was established,and studies the application of this model in the evaluation of soothing effects through instrument evaluation.30 healthy adult subjects were selected as the research subjects,and an acute skin model was established on the forearm flexion side of the subjects.The skin color a^(*)value and transdermal water loss rate(TEWL)value of the blank and experimental groups were tested using instruments.The results showed that at 15 and 30 minutes after using the sample,the growth values of a^(*)value and TEWL value in the experimental group were significantly lower than those in the blank group(P<0.05),the acute skin lesion model can effectively evaluate the soothing effect of cosmetics.
文摘BACKGROUND Schizophrenia,a complex group of mental disorders,is primarily managed with antipsychotic medications.The safety and efficacy of different initial doses of lurasidone for acute schizophrenia remain uncertain,particularly concerning discontinuation rates due to adverse events(AEs).AIM To compare the safety of two initial doses of lurasidone for the treatment of acute schizophrenia in Chinese patients.METHODS This 6-week,randomized,open-label,multicenter trial allocated participants to receive either 40 mg/day or 80 mg/day lurasidone initially,with dose adjustment allowed after a one-week fixed-dose period.Safety assessments included the primary endpoint of discontinuation due to AEs,as well as evaluations of AEs,weight changes,and laboratory parameters.Efficacy assessments included responder rates and changes in scores on the Positive and Negative Syndrome Scale(PANSS),Clinical Global Impression-Severity scale,and Calgary Depression Scale for Schizophrenia.RESULTS Among 197 participants,no significant difference was found in discontinuation rate due to AEs between groups(3.03% vs 5.10%,P=0.707).Treatment-emergent AEs were reported in 64.6%and 71.4%of participants in the 40 mg/day and 80 mg/day initiation groups,respectively.Response rates at weeks 1 and 2 showed no statistically significant differences.Both groups demonstrated significant improvements in PANSS total,Clinical Global Impression-Severity,and Calgary Depression Scale for Schizophrenia scores from baseline(all P<0.01).Notably,the 80 mg/day initiation group showed greater improvement in the PANSS positive subscale score at visits 1 and 2 compared to the 40 mg/day initiation group(P<0.05).CONCLUSION Initial doses of 40 mg/day and 80 mg/day lurasidone are safe and effective for acute schizophrenia,with no significant increase in AEs-related discontinuation rate at the higher dose.
文摘To verify the inhibitory ability of the combination on the biofilm production of Propionibacterium acnes and its ameliorative effect on facial acne problems.The ability of the combination to inhibit the biofilm formation of Propionibacterium acnes was verified by suspension quantification and crystal violet staining,and then 60 effective volunteers were selected for the efficacy measurement of topical acne elimination combinations+bases for 4 consecutive weeks,which were measured by a professional instrument,and the volunteers’facial acne lesion areas and acne lesion colours were evaluated respectively.In vitro tests verified that the combination can inhibit the formation of P.acnes biofilm and will not completely kill P.acnes and will not disrupt the micro-ecological balance of the skin;3%and 5%acne combinations can reduce the biofilm of P.acnes by 61.3%and 61.6%respectively;after 4 weeks of continuous use,the area of acne lesions of the samples with 5%acne combinations decreased by 54.61%and the colour of acne lesions decreased by 54.61%compared with the area of acne lesions before the use of the combination.54.61%,acne lesion colour a^(*)decreased by 13.74%,and the subjects’self-assessment of the mildness and non-irritation of the samples in the test group had a 100%agreement rate.The acne combination can improve acne problems by inhibiting the biofilm formation of Propionibacterium acnes,and has a mild and effective acne elimination effect.
文摘BACKGROUND Surgery is the first choice of treatment for patients with colorectal cancer.Traditional open surgery imparts great damage to the body of the patient and can easily cause adverse stress reactions.With the continuous development of medical technology,laparoscopic minimally invasive surgery has shown great advantages for the treatment of patients with celiac disease.AIM To investigate the short-term efficacy of laparoscopic radical surgery and traditional laparotomy for the treatment of colorectal cancer,and the differences in the risk analysis of unplanned reoperation after operation.METHODS As the research subjects,this study selected 100 patients with colorectal cancer who received surgical treatment at the Yulin First Hospital from January 2018 to January 2022.Among them,50 patients who underwent laparoscopic radical resection were selected as the research group and 50 patients who underwent traditional laparotomy were selected as the control group.Data pertaining to clinical indexes,gastrointestinal hormones,nutrition indexes,the levels of inflammatory factors,quality of life,Visual Analog Scale score,and the postoperative complications of the two groups of patients before and after treatment were collected,and the therapeutic effects in the two groups were analyzed and compared.RESULTS Compared with the control group,perioperative bleeding,peristalsis recovery time,and hospital stays were significantly shorter in the research group.After surgery,the levels of gastrin(GAS)and motilin(MTL)were decreased in both groups,and the fluctuation range of GAS and MTL observed in the research group was significantly lower than that recorded in the control group.The hemoglobin(Hb)levels increased after surgery,and the level of Hb in the research group was significantly higher compared with the control group.After the operation,the expression levels of tumor necrosis factor-α,interleukin-6,and C-reactive protein and the total incidence of complications were significantly lower in the research group compared with the control group.One year after the operation,the quality of life of the two groups was greatly improved,with the quality of life in the research group being significantly better.CONCLUSION Laparoscopy was effective for colorectal surgery by reducing the occurrence of complications and inflammatory stress reaction;moreover,the quality of life of patients was significantly improved,which warrants further promotion.
基金Supported by the Air Force Medical Center Youth Talent Program Project,No.22YXQN034Capital Health Development Research Special Project,No.2020-4-5123Beijing Haidian District Health and Wellness Development Scientific Research Cultivation Program,No.HP2021-03-80803.
文摘BACKGROUND Gastrointestinal angiodysplasias(GIAD)causes recurrent bleeding,and current treatments have limitations.Sirolimus,a mammalian target of rapamycin inhibi-tor,shows promise in inhibiting abnormal angiogenesis.AIM To evaluate the efficacy and safety of sirolimus in reducing bleeding episodes and improving clinical outcomes in patients with GIAD.METHODS We conducted a self-controlled study with 11 patients taking oral sirolimus.Retrospective data were collected prior to treatment,and prospective data were gathered during the study.Efficacy was assessed primarily by comparing blee-ding episodes before and after sirolimus,with measurements at 3 and 6 months post-administration.The initial dose was 0.8 mg/m^(2)once daily,adjusted to main-tain trough blood concentrations between 5-10 ng/mL.Secondary outcomes included hemoglobin(Hb)levels,blood transfusion volume,and vascular lesions.Safety was monitored by tracking adverse reactions.RESULTS The average number of bleeding episodes decreased significantly from 2.09±1.04 to 1.00±0.75 in the 3 months preceding treatment,and from 3.80±1.93 to 2.00±1.63 in the 6 months preceding treatment.Sirolimus also increased Hb levels,reduced the need for transfusions,and decreased vascular lesions,improving clinical outcomes.All adverse effects were mild and resolved or improved within 1 week to 1 month without stopping sirolimus or needing lipid-lowering treatment.CONCLUSION Sirolimus reduced bleeding and transfusion needs while improving Hb levels in GIAD patients.Although these findings are encouraging,the limited sample size and lack of a control group warrant caution.Future controlled trials with larger populations are needed to validate sirolimus’s potential in GIAD.
