Seamounts are ubiquitous topographic units in global oceans,and their influences on local oceanic circulation have attracted great attention in physical oceanography;however,previous efforts were less made in paleocli...Seamounts are ubiquitous topographic units in global oceans,and their influences on local oceanic circulation have attracted great attention in physical oceanography;however,previous efforts were less made in paleoclimatology and paleoceanography.The Caiwei Guyot in the Magellan Seamounts of the western Pacific is a typical seamount,and in this study,we investigate a well-dated sediment core by magnetic properties to reveal the relationship between deep-sea sedimentary processes and global climate changes.The principal results are as follows:(1)the dominant magnetic minerals in the sediments are low-coercivity magnetite in pseudo-single domain range,probably including a biogenic contribution;(2)the variabilities of magnetic parameters can be clustered into two sections at~500 ka,and the differences between the two units are evident in amplitudes and means;(3)changes in the grainsize-dependent magnetic parameters can be well correlated to records of global ice volume and atmospheric CO;in the middle Pleistocene.Based on these results,a close linkage was proposed between deep-sea sedimentary processes in the Caiwei Guyot and global climate changes.This linkage likely involves different roles of biogenic magnetite in the sediments between interglacial and glacial intervals,responding to changes in marine productivity and deep-sea circulation and displaying a major change in the MidBrunhes climate event.Therefore,we proposed that the sedimentary archives at the bottom of the Caiwei Guyot record some key signals of global climate changes,providing a unique window to observe interactions between various environmental systems on glacial-interglacial timescales.展开更多
Precipitation events,which follow a life cycle of initiation,development,and decay,represent the fundamental form of precipitation.Comprehensive and accurate detection of these events is crucial for effective water re...Precipitation events,which follow a life cycle of initiation,development,and decay,represent the fundamental form of precipitation.Comprehensive and accurate detection of these events is crucial for effective water resource management and flood control.However,current investigations on their spatio-temporal patterns remain limited,largely because of the lack of systematic detection indices that are specifically designed for precipitation events,which constrains event-scale research.In this study,we defined a set of precipitation event detection indices(PEDI)that consists of five conventional and fourteen extreme indices to characterize precipitation events from the perspectives of intensity,duration,and frequency.Applications of the PEDI revealed the spatial patterns of hourly precipitation events in China and its first-and second-order river basins from 2008 to 2017.Both conventional and extreme precipitation events displayed spatial distribution patterns that gradually decreased in intensity,duration,and frequency from southeast to northwest China.Compared with those in northwest China,the average values of most PEDIs in southeast China were usually 2-10 times greater for first-order river basins and 3-15 times greater for second-order basins.The PEDI could serve as a reference method for investigating precipitation events at global,regional,and basin scales.展开更多
This study examines a 1.32 m thick sediment sequence from the Cunge sag pond in the Litang Basin,eastern Tibetan Plateau,to assess the seismicity of the Litang fault during the Holocene.High-resolution geochemical,gra...This study examines a 1.32 m thick sediment sequence from the Cunge sag pond in the Litang Basin,eastern Tibetan Plateau,to assess the seismicity of the Litang fault during the Holocene.High-resolution geochemical,grain size,magnetic susceptibility,and total organic carbon indicators are employed to obtain a continuous record of changes in elemental,physical,and biological properties within the profile to identify seismic events.The seismic event layer generally comprises two sedimentary rhythms:a lower coarse sand layer and an upper fine silt-clay layer.These layers represent rapid deposition associated with fault activity(Earthquake A)and slower deposition during calm periods or earthquake recurrence intervals(Seismic interval A).Through six^(14)C dating,five seismic events have been identified in the Cunge sag pond section:E1(before 3955 a B.P.),E2(3713-3703 a B.P.),E3(3492-3392 a B.P.),E4(2031-1894 a B.P.),and E5(1384-1321 a B.P.).E1-E4 had shown a good consistency with the paleo-earthquake recorded by the trench,and whereas E5 is a newly identified seismic event,further improving the continuous earthquake sequence of the Litang fault.Based on existing trench data and the seismic event record from the Cunge sag pond,a total of 11 paleo-earthquakes are identified along the Litang fault since the Holocene.The paleo-earthquake activity of the Litang fault exhibits a clustered pattern,with recurrence intervals of both long periods(1000 a)and short periods(500 a).Since 5000 a,the interval between strong earthquake recurrences gradually decreases,indicating an increasing risk of strong earthquakes along the Litang fault.This study presents a continuous record of paleo-earthquakes along the Litang fault,eastern Tibetan Plateau,and can enhance the understanding of regional seismic activity.展开更多
Type 2 diabetes(T2D)is an insidious disease associated with neural and vascular complications,acceleration of cardiovascular disease,changes in heart function,and premature death.In the newly released article of the J...Type 2 diabetes(T2D)is an insidious disease associated with neural and vascular complications,acceleration of cardiovascular disease,changes in heart function,and premature death.In the newly released article of the Journal of Sport and Health Science,Liang et al.1 describe results from the UK Biobank data showing the benefits of moderate-to-vigorous intensity physical activity(MVPA)on reducing the risks for vascular events in 11,474 adults with T2D and prediabetes.展开更多
Although air pollutant emissions have sharply reduced in recent years,the occurrence of PM_(2.5) pollution events remains an intractable environmental problem in Beijing,and regional transport is the key influence fac...Although air pollutant emissions have sharply reduced in recent years,the occurrence of PM_(2.5) pollution events remains an intractable environmental problem in Beijing,and regional transport is the key influence factor.However,it has been difficult to identify regional transport characteristics and the main contributors to pollution events in recent years.In this study,the relative contribution of regional transport was quantified(61.3%)in PM_(2.5) pollution events during 2018-2021 by the Community Multiscale Air Quality model embedded with the Integrated Source Apportionment Model(CMAQ-ISAM).The four regions with the largest fractional contributions to Beijing for all events were Shandong(7.7%),South Hebei(7.3%),Baoding(6.2%),and Langfang(5.8%).Pollution events were classified into the following types based on regional transport directions:local,southwest(SW),southeast(SE),south-mixed(SM),and others.Based on the transport distance,the SW,SE,and SM types can be subdivided into SW-short,SW-long,SE-short,SE-long,SM-short,SM-long distance from southwest,SM-long distance from southeast,and SM-long distance from southwest and southeast.SE-long was regarded as the most important type,with the highest relative frequency(20%).The transport directions were related to the southwest wind at 925 hPa and southeast wind at 1000 hPa in the south of the Beijing–Tianjin–Hebei(BTH)region,and the distance was mainly controlled by wind strength.The wind-field difference can be attributed to the low-pressure and high-pressure systems that control the BTH region.The results suggest that regional joint pollution control should be optimized based on the transport type.展开更多
BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery ...BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term survival.Accurate preoperative identification of high-risk patients is critical for improving outcomes.AIM To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with MIE.METHODS This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February 2024.Patients were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of SAEs.RESULTS SAEs occurred in 10.2%of patients in train set and 13.6%in the validation set.Patients with SAE had significantly higher complication rate and a longer hospital stay after surgery.The key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin levels.The stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation set.CONCLUSION The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.展开更多
This study examines the “V + Dào” construction as a state change event through the lens of the Event Integration Hypothesis. It focuses on how these constructions represent state changes, exploring distinctions...This study examines the “V + Dào” construction as a state change event through the lens of the Event Integration Hypothesis. It focuses on how these constructions represent state changes, exploring distinctions between “change” and “stasis”. Using a corpus-based approach, the analysis covers the semantic and syntactic features of “V + Dào” constructions and their event integration patterns. The findings highlight the distribution of agency, animacy, and support relations in state change events, emphasizing the complex interaction of internal and external event integrations and their correlation with the conceptual primitives of change and transition. This study offers insights into the lexicalization and grammaticalization processes of the “V + Dào” construction, and potentially the broader verb-complement constructions in Mandarin.展开更多
The World Wide Web provides a wealth of information about everything, including contemporary audio and visual art events, which are discussed on media outlets, blogs, and specialized websites alike. This information m...The World Wide Web provides a wealth of information about everything, including contemporary audio and visual art events, which are discussed on media outlets, blogs, and specialized websites alike. This information may become a robust source of real-world data, which may form the basis of an objective data-driven analysis. In this study, a methodology for collecting information about audio and visual art events in an automated manner from a large array of websites is presented in detail. This process uses cutting edge Semantic Web, Web Search and Generative AI technologies to convert website documents into a collection of structured data. The value of the methodology is demonstrated by creating a large dataset concerning audiovisual events in Greece. The collected information includes event characteristics, estimated metrics based on their text descriptions, outreach metrics based on the media that reported them, and a multi-layered classification of these events based on their type, subjects and methods used. This dataset is openly provided to the general and academic public through a Web application. Moreover, each event’s outreach is evaluated using these quantitative metrics, the results are analyzed with an emphasis on classification popularity and useful conclusions are drawn concerning the importance of artistic subjects, methods, and media.展开更多
BACKGROUND Left ventricular noncompaction(LVNC)is a genetic cardiomyopathy.It is characterized by intensely developed trabeculae in the ventricles with deep intertrabecular lacunae.LVNC manifests as arrhythmias and he...BACKGROUND Left ventricular noncompaction(LVNC)is a genetic cardiomyopathy.It is characterized by intensely developed trabeculae in the ventricles with deep intertrabecular lacunae.LVNC manifests as arrhythmias and heart failure with a predisposition for thrombus formation.AIM To study predictors of arrhythmic,thromboembolic events and adverse outcomes(death/transplantation)in adult patients with LVNC.METHODS Adult patients with LVNC were included(n=125;mean follow-up:14 months).Electrocardiography,echocardiography,and 24-hour electrocardiography monitoring were performed.Other procedures were conducted for some patients including:Coronary angiography;cardiac magnetic resonance imaging;cardiac computed tomography;genetic testing;myocardial pathological examination;and anti-cardiac antibody level estimation.Primary endpoints were death,heart transplantation,combined endpoint(death+transplantation),and sudden cardiac death.Secondary endpoints were intracardiac thrombosis,embolic events,myocardial infarction,sustained ventricular tachycardia(VT),and implantable cardioverter-defibrillator intervention.RESULTS LVNC manifestations included non-sustained VT,thrombosis/embolism,sustained VT, and sudden cardiac death. Non-sustained VT was associated with the New York Heart Association(NYHA) chronic heart failure (CHF) class, poor R-wave progression, superimposed myocarditis, and highermortality. Thrombosis/embolism was associated with NYHA CHF class ≥ 3, right ventricular end-diastolicdiameter ≥ 3 cm, right atrium volume ≥ 67 mL, left ventricle end-diastolic diameter ≥ 6.3 cm, and velocity timeintegral ≤ 11.2 cm. Sustained VT was associated with premature ventricular contractions (PVCs), low QRS voltage,and atrioventricular block. PVCs > 500/day were predictive of defibrillator intervention. Fatal outcomes wereassociated with E wave/A wave ratio > 1.9, left ventricle ejection fraction < 35%, NYHA CHF class ≥ 3, VT, andmyocarditis.CONCLUSIONFrequent PVCs, non-sustained VT, low QRS voltage, and signs of systolic dysfunction on echocardiogram arepredictors of life-threatening events in patients with LVNC.展开更多
In the summer of 2024, following a strong El Ni?o event in the preceding winter, the tropical Indian Ocean and tropical North Atlantic recorded their highest SSTs since 1961, along with a significant westward shift an...In the summer of 2024, following a strong El Ni?o event in the preceding winter, the tropical Indian Ocean and tropical North Atlantic recorded their highest SSTs since 1961, along with a significant westward shift and intensification of the western Pacific subtropical high(WPSH). Under these conditions, China experienced its hottest summer since 1961,and was hit by a series of high-impact extreme weather and climate events. From 9 June to 2 July, southern China experienced an unprecedented extreme precipitation event that exceeded the well-known 1998 summer precipitation event in both duration and impact scope, resulting in devastating floods in the Yangtze River basin. Subsequently, in early to midJuly, the Huanghe-Huaihe Basin suffered from a severe drought–flood abrupt alternation event, heavily affecting Henan and Shandong. Meanwhile, southern China underwent a widespread heatwave event lasting 74 days, ranking as the second most intense since 1961. From late July to the end of August, northern China faced unusually frequent heavy precipitation events, with cumulative precipitation reaching the second highest for the same period since 1961, causing floods in many rivers of northern China. This study provides a timely summary and assessment of the characteristics and impacts of these extreme events. It serves as a reference for climate change research, including mechanism analysis, numerical simulation,and climate event attribution, and also offers valuable insights for improving meteorological disaster prevention and mitigation strategies.展开更多
Objective:Despite established associations between certain medications and urticaria,the risk profiles of most pharmaceutical agents remain poorly characterized.This investigation aimed to identify risk factors for me...Objective:Despite established associations between certain medications and urticaria,the risk profiles of most pharmaceutical agents remain poorly characterized.This investigation aimed to identify risk factors for medication-induced urticaria through comprehensive analysis of the FDA Adverse Event Reporting System(FAERS)database.Methods:We employed reporting odds ratios(ROR)to evaluate drug-urticaria associations using FAERS data spanning from Q12004 to Q32024.Analytical approaches included univariate screening,LASSO regression,and multivariate logistic regression to identify potential risk factors.Multiple comparison adjustments were implemented using the Bonferroni method.Results:The study identified 1807 pharmaceutical agents potentially associated with urticaria development.Univariate analysis categorized these agents into several therapeutic classes:antimicrobials(19/85),biologics(16/85),analgesics(8/85),dermatologicals(3/85),anti-rheumatic agents(4/85),hormonal preparations(3/85),antihypertensives(2/85),neuropsychiatric medications(2/85),uric acid-lowering drugs(2/85),multiple sclerosis therapies(2/85),and miscellaneous agents(17/85).Multivariate analysis identified three significant risk determinants:middle-aged individuals(36-53 years),female gender,and exposure to any of 82 specific medications.Conclusion:These evidence-based findings provide valuable insights for early clinical recognition of drug-induced urticaria and establish a foundation for subsequent mechanistic investigations into medication-related hypersensitivity reactions.展开更多
With the development of cyber-physical systems,system security faces more risks from cyber-attacks.In this work,we study the problem that an external attacker implements covert sensor and actuator attacks with resourc...With the development of cyber-physical systems,system security faces more risks from cyber-attacks.In this work,we study the problem that an external attacker implements covert sensor and actuator attacks with resource constraints(the total resource consumption of the attacks is not greater than a given initial resource of the attacker)to mislead a discrete event system under supervisory control to reach unsafe states.We consider that the attacker can implement two types of attacks:One by modifying the sensor readings observed by a supervisor and the other by enabling the actuator commands disabled by the supervisor.Each attack has its corresponding resource consumption and remains covert.To solve this problem,we first introduce a notion of combined-attackability to determine whether a closedloop system may reach an unsafe state after receiving attacks with resource constraints.We develop an algorithm to construct a corrupted supervisor under attacks,provide a verification method for combined-attackability in polynomial time based on a plant,a corrupted supervisor,and an attacker's initial resource,and propose a corresponding attack synthesis algorithm.The effectiveness of the proposed method is illustrated by an example.展开更多
BACKGROUND Patients with type 2 diabetes mellitus(T2DM)face a heightened risk of future cardiovascular events.It is therefore important to stratify these patients according to their future cardiovascular event risk to...BACKGROUND Patients with type 2 diabetes mellitus(T2DM)face a heightened risk of future cardiovascular events.It is therefore important to stratify these patients according to their future cardiovascular event risk to allow early intervention and improve prognosis.Recent proposals have indicated that nontraditional lipoprotein ratios may be superior predictors of cardiovascular events compared to traditional lipid parameters.However,further evidence is required for widespread clinical ap-plication.AIM To elucidate the associations of nontraditional lipoprotein ratios with future cardiovascular events in patients with T2DM.METHODS This study performed post-hoc analysis of data obtained during a clinical trial involving 10182 participants.To ascertain the correlations between nontraditional lipoprotein ratios and future cardiovascular events,including major adverse cardiovascular events(MACEs)and congestive heart failure(CHF).We employed univariable and multivariable-adjusted Cox proportional hazards regression models.Potential dose-response relationships and threshold values were explored by conducting restricted cubic spline analyses and two-piecewise linear regression models.Possible relevant interactions influencing independent relationships were tested using subgroup and interaction analyses.RESULTS After adjustment for confounding factors,all nontraditional lipoprotein ratios studied were strongly associated with MACE risk in patients with T2DM.In comparison with patients in the lowest quartile,the hazard ratios(95%confidence intervals)of those in the highest quartile were 1.50(1.29-1.73),1.51(1.30-1.74),1.50(1.29-1.73),and 1.30(1.12-1.50)for total cholesterol/high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol/HDL-C,non-HDL-C/HDL-C,and remnant cholesterol/HDL-C,respectively.Similar findings were noted for CHF.Dose-response relationships between nontraditional lipoprotein ratios and MACE were observed,with threshold values of 7.29,6.29,and 2.15 for total cholesterol/HDL-C,non-HDL-C/HDL-C,and remnant cholesterol/HDL-C,respectively.However,no notable dose-response relationships were detected between nontraditional lipoprotein ratios and CHF.CONCLUSION Elevated nontraditional lipoprotein ratios may independently predict the risk of MACE and CHF in patients with T2DM.展开更多
Objective:To investigate the differences in childhood trauma and life events between adolescents with depression and healthy controls,and to analyze the correlations between these factors and depressive symptoms.As su...Objective:To investigate the differences in childhood trauma and life events between adolescents with depression and healthy controls,and to analyze the correlations between these factors and depressive symptoms.As such,we aim to provide theoretical foundations for early identification and intervention.Methods:This cross-sectional study enrolled 90 hospitalized adolescents with depression(case group)and 91 healthy adolescents(control group).Childhood Trauma Questionnaire(CTQ),Adolescent Self-Rating Life Events Checklist(ASLEC),and Children’s Depression Inventory(CDI)were administered to assess trauma history,life event stressors,and depressive symptoms.Statistical analyses included independent samples t-tests,chi-square tests,and Pearson correlation analysis.Results:The case group demonstrated a significantly higher proportion of only-child families(28.9%).ASLEC and CDI scores were significantly elevated in the case group compared to the control group(P<0.05).In comparison,CTQ scores were lower in the case group(P=0.025).Positive correlations were identified between CDI scores and both CTQ(r=0.261)and ASLEC(r=0.218)in the case group.Conclusion:Child-hood trauma and recent life event stressors demonstrate significant associations with adolescent depressive symp-toms,potentially mediated through emotional dysregulation and negative cognitive bias.Implementation of early trauma screening protocols combined with stress management interventions(e.g.,cognitive behavioral therapy)and family system optimization strategies may effectively mitigate depression risk in this population.展开更多
Efficient flight path design for unmanned aerial vehicles(UAVs)in urban environmental event monitoring remains a critical challenge,particularly in prioritizing high-risk zones within complex urban landscapes.Current ...Efficient flight path design for unmanned aerial vehicles(UAVs)in urban environmental event monitoring remains a critical challenge,particularly in prioritizing high-risk zones within complex urban landscapes.Current UAV path planning methodologies often inadequately account for environmental risk factors and exhibit limitations in balancing global and local optimization efficiency.To address these gaps,this study proposes a hybrid path planning framework integrating an improved Ant Colony Optimization(ACO)algorithm with an Orthogonal Jump Point Search(OJPS)algorithm.Firstly,a two-dimensional grid model is constructed to simulate urban environments,with key monitoring nodes selected based on grid-specific environmental risk values.Subsequently,the improved ACO algorithm is used for global path planning,and the OJPS algorithm is integrated to optimize the local path.The improved ACO algorithm introduces the risk value of environmental events,which is used to direct the UAV to the area with higher risk.In the OJPS algorithm,the path search direction is restricted to the orthogonal direction,which improves the computational efficiency of local path optimization.In order to evaluate the performance of the model,this paper utilizes the metrics of the average risk value of the path,the flight time,and the number of turns.The experimental results demonstrate that the proposed improved ACO algorithm performs well in the average risk value of the paths traveled within the first 5 min,within the first 8 min,and within the first 10 min,with improvements of 48.33%,26.10%,and 6.746%,respectively,over the Particle Swarm Optimization(PSO)algorithm and 70.33%,19.08%,and 10.246%,respectively,over theArtificial Rabbits Optimization(ARO)algorithm.TheOJPS algorithmdemonstrates superior performance in terms of flight time and number of turns,exhibiting a reduction of 40%,40%and 57.1%in flight time compared to the other three algorithms,and a reduction of 11.1%,11.1%and 33.8%in the number of turns compared to the other three algorithms.These results highlight the effectiveness of the proposed method in improving the UAV’s ability to respond efficiently to urban environmental events,offering significant implications for the future of UAV path planning in complex urban settings.展开更多
As a renowned historical and cultural city,Luoyang boasts a wealth of tourism resources,including sports venues,natural landscapes,and cultural heritage sites,laying a solid foundation for the integrated development o...As a renowned historical and cultural city,Luoyang boasts a wealth of tourism resources,including sports venues,natural landscapes,and cultural heritage sites,laying a solid foundation for the integrated development of the tourism industry and sports events in recent years,with remarkable achievements in practice.However,from the perspective of sports-tourism integration,Luoyang’s event tourism still faces a prominent issue of uneven development:a surge in tourists during peak seasons,leading to overcrowded attractions,and a scarcity of visitors during off-peak seasons,resulting in idle resources.This not only leads to inefficient resource utilization but also restricts the enhancement of economic benefits and hinders sustainable development.In light of this,this paper comprehensively employs literature research,case analysis,and fieldwork methods to systematically analyze the current development status of event tourism in Luoyang within the context of sports-tourism integration.The aim is to provide theoretical and practical support for achieving high-quality and balanced development of local event tourism,offering valuable references for addressing the issue of uneven development and moving towards a sustainable future.展开更多
BACKGROUND Intra-arterial chemotherapy(IAC)has become a first-line standard treatment for retinoblastoma(RB).However,studies describing its adverse events are sparse,especially from the developing world.Our study desc...BACKGROUND Intra-arterial chemotherapy(IAC)has become a first-line standard treatment for retinoblastoma(RB).However,studies describing its adverse events are sparse,especially from the developing world.Our study described the outcomes and adverse events from a single center in South India.AIM To describe the challenges,treatment outcomes,and complications of selective IAC for RB in Indian eyes.METHODS This study was a single center,retrospective study that included 17 patients with RB who underwent IAC using melphalan(5/7.5 mg)and topotecan(1/2 mg)(n=12)or melphalan(5 mg)alone(n=3)or triple therapy that included carboplatin(30 mg)along with these drugs(n=2)between January 2018 and December 2023.In all,17 IAC procedures were performed using selective ophthalmic artery cannulation.Treatment outcomes were evaluated in terms of tumor control,vitreous and subretinal seed control,complications,and globe salvage rates.RESULTS Out of the 17 patients,11 were diagnosed with unilateral RB and 6 were diag-nosed with bilateral RB.The mean age at the time of diagnosis was 19.8 months.The mean interval between the first symptom and presentation was 6.5 months.IAC was employed as the primary(n=9)or secondary(n=8)modality of treatment.Each eye received a mean of 1.5 IAC sessions(median:1 session;range:1-3 sessions).Eyes were classified according to the international classification of RB as group B(n=5),group C(n=1),group D(n=4),and group E(n=7).Following IAC,complete regression of the main tumor was seen in 15 eyes(88%)and partial regression in 2 eyes(12%).Globe salvage was achieved in 15 eyes(88%).Adverse effects included vitreous hemorrhage(n=3),rhegmatogenous retinal de-tachment(n=2),choroidal ischemia(n=1),isolated subretinal hemorrhage(n=2),retinal pigment epithelium degeneration(n=2),forehead pigmentation(n=1),third nerve palsy with complete ptosis(n=1),and 30-degree exotropia(n=1).The mean follow-up period was 28.6 months(median:24 months,range:1–72 months).CONCLUSION IAC is an effective way to control RB and globe preservation.In the Indian context we encountered many cha-llenges highlighting the importance of case selection.Further studies in India are required to thoroughly un-derstand IAC as a treatment for RB.展开更多
This article centers on The Call of the Wild,an English novel by American author Jack London,alongside two Chinese translations by Dajie Liu and Menglin Zhang,and Rongyue Liu.Seventy sentences containing motion events...This article centers on The Call of the Wild,an English novel by American author Jack London,alongside two Chinese translations by Dajie Liu and Menglin Zhang,and Rongyue Liu.Seventy sentences containing motion events and their corresponding translations were randomly selected for analysis.The study focuses on the primary elements of motion events-manner,path,and ground-and examines their Chinese translations through the lens of Skopos theory.Skopos theory emphasizes whether translators can adopt appropriate translation strategies according to various contextual factors during the translation process.Compared to verb-framed languages,satellite-framed languages possess a richer vocabulary for manner verbs,express more detailed manner information,use more satellite words to indicate paths,and incorporate more background information.Verb-framed languages,by contrast,typically express manner information only when necessary and tend to include less background information.The analysis reveals that both Chinese translations embody the core principle of Skopos theory:translation strategies are determined by their purpose.To fulfill the novel’s translation objectives,the translators adeptly adjust their strategies for motion event components based on different contextual needs.It is noted that the Chinese translations do not fully retain the characteristics of English as a typical satellite-framed language.This observation aligns with Skopos theory’s purpose-oriented approach,which prioritizes translation goals over strict adherence to source text characteristics.展开更多
The southern part of East Siberia(SES)is highly vulnerable to flooding caused by the extreme precipitation events(EPEs)during summer.Building on previously detected EPEs in SES and Mongolia,we examined wave propagatio...The southern part of East Siberia(SES)is highly vulnerable to flooding caused by the extreme precipitation events(EPEs)during summer.Building on previously detected EPEs in SES and Mongolia,we examined wave propagation patterns for two periods:1982-98 and 1999-2019.Our analysis revealed distinct wave train configurations and geopotential anomalies preceding EPEs,with an increase in wave activity flux across the Northern Hemisphere,followed by a subsequent decrease during EPEs.Consequently,Eastern Siberia has experienced a significant rise in wave activity.Based on geopotential anomalies over Central Siberia accompanying EPEs,we identified two main types.The first,the ridge type,is predominant during the first period and features a meridional contrast with a positive geopotential(and temperature)anomaly over Central Siberia and a negative anomaly over the subtropical regions along the same longitude.The second type,termed the trough type,is more typical for the second period.It involves either a negative geopotential anomaly or the zonal proximity of positive and negative geopotential anomalies over Central Siberia.The trough type,marked by zonally oriented anomalies in geopotential and temperature,results in a more pronounced temperature decrease before EPEs and significant zonal temperature contrasts.Further,it is related to more stationary waves over Northern Eurasia,with persistent positive geopotential anomalies over Europe linked to quasi-stationary troughs over Central Siberia and positive anomalies east of Lake Baikal.Our findings align with shifts in boreal summer teleconnection patterns,reflecting significant changes in wave propagation patterns that have occurred since the late 1990s.展开更多
基金The Natural Science Foundation of Shanghai under contract No.19ZR1459800the Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)under contract No.GML2019ZD0106the Project of Global Changing and Air-sea Interaction under contract No.GASI-GEOGE-04
文摘Seamounts are ubiquitous topographic units in global oceans,and their influences on local oceanic circulation have attracted great attention in physical oceanography;however,previous efforts were less made in paleoclimatology and paleoceanography.The Caiwei Guyot in the Magellan Seamounts of the western Pacific is a typical seamount,and in this study,we investigate a well-dated sediment core by magnetic properties to reveal the relationship between deep-sea sedimentary processes and global climate changes.The principal results are as follows:(1)the dominant magnetic minerals in the sediments are low-coercivity magnetite in pseudo-single domain range,probably including a biogenic contribution;(2)the variabilities of magnetic parameters can be clustered into two sections at~500 ka,and the differences between the two units are evident in amplitudes and means;(3)changes in the grainsize-dependent magnetic parameters can be well correlated to records of global ice volume and atmospheric CO;in the middle Pleistocene.Based on these results,a close linkage was proposed between deep-sea sedimentary processes in the Caiwei Guyot and global climate changes.This linkage likely involves different roles of biogenic magnetite in the sediments between interglacial and glacial intervals,responding to changes in marine productivity and deep-sea circulation and displaying a major change in the MidBrunhes climate event.Therefore,we proposed that the sedimentary archives at the bottom of the Caiwei Guyot record some key signals of global climate changes,providing a unique window to observe interactions between various environmental systems on glacial-interglacial timescales.
基金National Key Research and Development Program of China,No.2023YFC3206605,No.2021YFC3201102National Natural Science Foundation of China,No.41971035。
文摘Precipitation events,which follow a life cycle of initiation,development,and decay,represent the fundamental form of precipitation.Comprehensive and accurate detection of these events is crucial for effective water resource management and flood control.However,current investigations on their spatio-temporal patterns remain limited,largely because of the lack of systematic detection indices that are specifically designed for precipitation events,which constrains event-scale research.In this study,we defined a set of precipitation event detection indices(PEDI)that consists of five conventional and fourteen extreme indices to characterize precipitation events from the perspectives of intensity,duration,and frequency.Applications of the PEDI revealed the spatial patterns of hourly precipitation events in China and its first-and second-order river basins from 2008 to 2017.Both conventional and extreme precipitation events displayed spatial distribution patterns that gradually decreased in intensity,duration,and frequency from southeast to northwest China.Compared with those in northwest China,the average values of most PEDIs in southeast China were usually 2-10 times greater for first-order river basins and 3-15 times greater for second-order basins.The PEDI could serve as a reference method for investigating precipitation events at global,regional,and basin scales.
基金supported by the National Natural Science Foundation of China(42202131 and 42177184).
文摘This study examines a 1.32 m thick sediment sequence from the Cunge sag pond in the Litang Basin,eastern Tibetan Plateau,to assess the seismicity of the Litang fault during the Holocene.High-resolution geochemical,grain size,magnetic susceptibility,and total organic carbon indicators are employed to obtain a continuous record of changes in elemental,physical,and biological properties within the profile to identify seismic events.The seismic event layer generally comprises two sedimentary rhythms:a lower coarse sand layer and an upper fine silt-clay layer.These layers represent rapid deposition associated with fault activity(Earthquake A)and slower deposition during calm periods or earthquake recurrence intervals(Seismic interval A).Through six^(14)C dating,five seismic events have been identified in the Cunge sag pond section:E1(before 3955 a B.P.),E2(3713-3703 a B.P.),E3(3492-3392 a B.P.),E4(2031-1894 a B.P.),and E5(1384-1321 a B.P.).E1-E4 had shown a good consistency with the paleo-earthquake recorded by the trench,and whereas E5 is a newly identified seismic event,further improving the continuous earthquake sequence of the Litang fault.Based on existing trench data and the seismic event record from the Cunge sag pond,a total of 11 paleo-earthquakes are identified along the Litang fault since the Holocene.The paleo-earthquake activity of the Litang fault exhibits a clustered pattern,with recurrence intervals of both long periods(1000 a)and short periods(500 a).Since 5000 a,the interval between strong earthquake recurrences gradually decreases,indicating an increasing risk of strong earthquakes along the Litang fault.This study presents a continuous record of paleo-earthquakes along the Litang fault,eastern Tibetan Plateau,and can enhance the understanding of regional seismic activity.
文摘Type 2 diabetes(T2D)is an insidious disease associated with neural and vascular complications,acceleration of cardiovascular disease,changes in heart function,and premature death.In the newly released article of the Journal of Sport and Health Science,Liang et al.1 describe results from the UK Biobank data showing the benefits of moderate-to-vigorous intensity physical activity(MVPA)on reducing the risks for vascular events in 11,474 adults with T2D and prediabetes.
基金supported by the National Key R&D program of China(No.2022YFC3703404)the National Natural Science Foundation of China(No.22188102)the Samsung Advanced Institute of Technology.
文摘Although air pollutant emissions have sharply reduced in recent years,the occurrence of PM_(2.5) pollution events remains an intractable environmental problem in Beijing,and regional transport is the key influence factor.However,it has been difficult to identify regional transport characteristics and the main contributors to pollution events in recent years.In this study,the relative contribution of regional transport was quantified(61.3%)in PM_(2.5) pollution events during 2018-2021 by the Community Multiscale Air Quality model embedded with the Integrated Source Apportionment Model(CMAQ-ISAM).The four regions with the largest fractional contributions to Beijing for all events were Shandong(7.7%),South Hebei(7.3%),Baoding(6.2%),and Langfang(5.8%).Pollution events were classified into the following types based on regional transport directions:local,southwest(SW),southeast(SE),south-mixed(SM),and others.Based on the transport distance,the SW,SE,and SM types can be subdivided into SW-short,SW-long,SE-short,SE-long,SM-short,SM-long distance from southwest,SM-long distance from southeast,and SM-long distance from southwest and southeast.SE-long was regarded as the most important type,with the highest relative frequency(20%).The transport directions were related to the southwest wind at 925 hPa and southeast wind at 1000 hPa in the south of the Beijing–Tianjin–Hebei(BTH)region,and the distance was mainly controlled by wind strength.The wind-field difference can be attributed to the low-pressure and high-pressure systems that control the BTH region.The results suggest that regional joint pollution control should be optimized based on the transport type.
基金Supported by Joint Funds for the Innovation of Science and Technology,Fujian Province,No.2023Y9187 and No.2021Y9057.
文摘BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term survival.Accurate preoperative identification of high-risk patients is critical for improving outcomes.AIM To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with MIE.METHODS This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February 2024.Patients were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of SAEs.RESULTS SAEs occurred in 10.2%of patients in train set and 13.6%in the validation set.Patients with SAE had significantly higher complication rate and a longer hospital stay after surgery.The key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin levels.The stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation set.CONCLUSION The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.
文摘This study examines the “V + Dào” construction as a state change event through the lens of the Event Integration Hypothesis. It focuses on how these constructions represent state changes, exploring distinctions between “change” and “stasis”. Using a corpus-based approach, the analysis covers the semantic and syntactic features of “V + Dào” constructions and their event integration patterns. The findings highlight the distribution of agency, animacy, and support relations in state change events, emphasizing the complex interaction of internal and external event integrations and their correlation with the conceptual primitives of change and transition. This study offers insights into the lexicalization and grammaticalization processes of the “V + Dào” construction, and potentially the broader verb-complement constructions in Mandarin.
文摘The World Wide Web provides a wealth of information about everything, including contemporary audio and visual art events, which are discussed on media outlets, blogs, and specialized websites alike. This information may become a robust source of real-world data, which may form the basis of an objective data-driven analysis. In this study, a methodology for collecting information about audio and visual art events in an automated manner from a large array of websites is presented in detail. This process uses cutting edge Semantic Web, Web Search and Generative AI technologies to convert website documents into a collection of structured data. The value of the methodology is demonstrated by creating a large dataset concerning audiovisual events in Greece. The collected information includes event characteristics, estimated metrics based on their text descriptions, outreach metrics based on the media that reported them, and a multi-layered classification of these events based on their type, subjects and methods used. This dataset is openly provided to the general and academic public through a Web application. Moreover, each event’s outreach is evaluated using these quantitative metrics, the results are analyzed with an emphasis on classification popularity and useful conclusions are drawn concerning the importance of artistic subjects, methods, and media.
文摘BACKGROUND Left ventricular noncompaction(LVNC)is a genetic cardiomyopathy.It is characterized by intensely developed trabeculae in the ventricles with deep intertrabecular lacunae.LVNC manifests as arrhythmias and heart failure with a predisposition for thrombus formation.AIM To study predictors of arrhythmic,thromboembolic events and adverse outcomes(death/transplantation)in adult patients with LVNC.METHODS Adult patients with LVNC were included(n=125;mean follow-up:14 months).Electrocardiography,echocardiography,and 24-hour electrocardiography monitoring were performed.Other procedures were conducted for some patients including:Coronary angiography;cardiac magnetic resonance imaging;cardiac computed tomography;genetic testing;myocardial pathological examination;and anti-cardiac antibody level estimation.Primary endpoints were death,heart transplantation,combined endpoint(death+transplantation),and sudden cardiac death.Secondary endpoints were intracardiac thrombosis,embolic events,myocardial infarction,sustained ventricular tachycardia(VT),and implantable cardioverter-defibrillator intervention.RESULTS LVNC manifestations included non-sustained VT,thrombosis/embolism,sustained VT, and sudden cardiac death. Non-sustained VT was associated with the New York Heart Association(NYHA) chronic heart failure (CHF) class, poor R-wave progression, superimposed myocarditis, and highermortality. Thrombosis/embolism was associated with NYHA CHF class ≥ 3, right ventricular end-diastolicdiameter ≥ 3 cm, right atrium volume ≥ 67 mL, left ventricle end-diastolic diameter ≥ 6.3 cm, and velocity timeintegral ≤ 11.2 cm. Sustained VT was associated with premature ventricular contractions (PVCs), low QRS voltage,and atrioventricular block. PVCs > 500/day were predictive of defibrillator intervention. Fatal outcomes wereassociated with E wave/A wave ratio > 1.9, left ventricle ejection fraction < 35%, NYHA CHF class ≥ 3, VT, andmyocarditis.CONCLUSIONFrequent PVCs, non-sustained VT, low QRS voltage, and signs of systolic dysfunction on echocardiogram arepredictors of life-threatening events in patients with LVNC.
基金supported by the National Natural Science Foundation of China (Grant Nos.42005029 and 41701103)the China Meteorological Administration Special Foundation for Innovation and Development (Grant No.CXFZ2024Q007)。
文摘In the summer of 2024, following a strong El Ni?o event in the preceding winter, the tropical Indian Ocean and tropical North Atlantic recorded their highest SSTs since 1961, along with a significant westward shift and intensification of the western Pacific subtropical high(WPSH). Under these conditions, China experienced its hottest summer since 1961,and was hit by a series of high-impact extreme weather and climate events. From 9 June to 2 July, southern China experienced an unprecedented extreme precipitation event that exceeded the well-known 1998 summer precipitation event in both duration and impact scope, resulting in devastating floods in the Yangtze River basin. Subsequently, in early to midJuly, the Huanghe-Huaihe Basin suffered from a severe drought–flood abrupt alternation event, heavily affecting Henan and Shandong. Meanwhile, southern China underwent a widespread heatwave event lasting 74 days, ranking as the second most intense since 1961. From late July to the end of August, northern China faced unusually frequent heavy precipitation events, with cumulative precipitation reaching the second highest for the same period since 1961, causing floods in many rivers of northern China. This study provides a timely summary and assessment of the characteristics and impacts of these extreme events. It serves as a reference for climate change research, including mechanism analysis, numerical simulation,and climate event attribution, and also offers valuable insights for improving meteorological disaster prevention and mitigation strategies.
文摘Objective:Despite established associations between certain medications and urticaria,the risk profiles of most pharmaceutical agents remain poorly characterized.This investigation aimed to identify risk factors for medication-induced urticaria through comprehensive analysis of the FDA Adverse Event Reporting System(FAERS)database.Methods:We employed reporting odds ratios(ROR)to evaluate drug-urticaria associations using FAERS data spanning from Q12004 to Q32024.Analytical approaches included univariate screening,LASSO regression,and multivariate logistic regression to identify potential risk factors.Multiple comparison adjustments were implemented using the Bonferroni method.Results:The study identified 1807 pharmaceutical agents potentially associated with urticaria development.Univariate analysis categorized these agents into several therapeutic classes:antimicrobials(19/85),biologics(16/85),analgesics(8/85),dermatologicals(3/85),anti-rheumatic agents(4/85),hormonal preparations(3/85),antihypertensives(2/85),neuropsychiatric medications(2/85),uric acid-lowering drugs(2/85),multiple sclerosis therapies(2/85),and miscellaneous agents(17/85).Multivariate analysis identified three significant risk determinants:middle-aged individuals(36-53 years),female gender,and exposure to any of 82 specific medications.Conclusion:These evidence-based findings provide valuable insights for early clinical recognition of drug-induced urticaria and establish a foundation for subsequent mechanistic investigations into medication-related hypersensitivity reactions.
基金partially supported by the Science Technology Development Fund,Macao Special Administrative Region(0029/2023/RIA1)the National Research Foundation Singapore under its AI Singapore Programme(AISG2-GC-2023-007)
文摘With the development of cyber-physical systems,system security faces more risks from cyber-attacks.In this work,we study the problem that an external attacker implements covert sensor and actuator attacks with resource constraints(the total resource consumption of the attacks is not greater than a given initial resource of the attacker)to mislead a discrete event system under supervisory control to reach unsafe states.We consider that the attacker can implement two types of attacks:One by modifying the sensor readings observed by a supervisor and the other by enabling the actuator commands disabled by the supervisor.Each attack has its corresponding resource consumption and remains covert.To solve this problem,we first introduce a notion of combined-attackability to determine whether a closedloop system may reach an unsafe state after receiving attacks with resource constraints.We develop an algorithm to construct a corrupted supervisor under attacks,provide a verification method for combined-attackability in polynomial time based on a plant,a corrupted supervisor,and an attacker's initial resource,and propose a corresponding attack synthesis algorithm.The effectiveness of the proposed method is illustrated by an example.
文摘BACKGROUND Patients with type 2 diabetes mellitus(T2DM)face a heightened risk of future cardiovascular events.It is therefore important to stratify these patients according to their future cardiovascular event risk to allow early intervention and improve prognosis.Recent proposals have indicated that nontraditional lipoprotein ratios may be superior predictors of cardiovascular events compared to traditional lipid parameters.However,further evidence is required for widespread clinical ap-plication.AIM To elucidate the associations of nontraditional lipoprotein ratios with future cardiovascular events in patients with T2DM.METHODS This study performed post-hoc analysis of data obtained during a clinical trial involving 10182 participants.To ascertain the correlations between nontraditional lipoprotein ratios and future cardiovascular events,including major adverse cardiovascular events(MACEs)and congestive heart failure(CHF).We employed univariable and multivariable-adjusted Cox proportional hazards regression models.Potential dose-response relationships and threshold values were explored by conducting restricted cubic spline analyses and two-piecewise linear regression models.Possible relevant interactions influencing independent relationships were tested using subgroup and interaction analyses.RESULTS After adjustment for confounding factors,all nontraditional lipoprotein ratios studied were strongly associated with MACE risk in patients with T2DM.In comparison with patients in the lowest quartile,the hazard ratios(95%confidence intervals)of those in the highest quartile were 1.50(1.29-1.73),1.51(1.30-1.74),1.50(1.29-1.73),and 1.30(1.12-1.50)for total cholesterol/high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol/HDL-C,non-HDL-C/HDL-C,and remnant cholesterol/HDL-C,respectively.Similar findings were noted for CHF.Dose-response relationships between nontraditional lipoprotein ratios and MACE were observed,with threshold values of 7.29,6.29,and 2.15 for total cholesterol/HDL-C,non-HDL-C/HDL-C,and remnant cholesterol/HDL-C,respectively.However,no notable dose-response relationships were detected between nontraditional lipoprotein ratios and CHF.CONCLUSION Elevated nontraditional lipoprotein ratios may independently predict the risk of MACE and CHF in patients with T2DM.
基金Research Project of Yunnan Provincial Psychiatric Hospital(SJKY-2023-10).
文摘Objective:To investigate the differences in childhood trauma and life events between adolescents with depression and healthy controls,and to analyze the correlations between these factors and depressive symptoms.As such,we aim to provide theoretical foundations for early identification and intervention.Methods:This cross-sectional study enrolled 90 hospitalized adolescents with depression(case group)and 91 healthy adolescents(control group).Childhood Trauma Questionnaire(CTQ),Adolescent Self-Rating Life Events Checklist(ASLEC),and Children’s Depression Inventory(CDI)were administered to assess trauma history,life event stressors,and depressive symptoms.Statistical analyses included independent samples t-tests,chi-square tests,and Pearson correlation analysis.Results:The case group demonstrated a significantly higher proportion of only-child families(28.9%).ASLEC and CDI scores were significantly elevated in the case group compared to the control group(P<0.05).In comparison,CTQ scores were lower in the case group(P=0.025).Positive correlations were identified between CDI scores and both CTQ(r=0.261)and ASLEC(r=0.218)in the case group.Conclusion:Child-hood trauma and recent life event stressors demonstrate significant associations with adolescent depressive symp-toms,potentially mediated through emotional dysregulation and negative cognitive bias.Implementation of early trauma screening protocols combined with stress management interventions(e.g.,cognitive behavioral therapy)and family system optimization strategies may effectively mitigate depression risk in this population.
基金supported by the Special Project forKey Fields of Ordinary Universities in Guangdong Province(Number:2023ZDZX1076).
文摘Efficient flight path design for unmanned aerial vehicles(UAVs)in urban environmental event monitoring remains a critical challenge,particularly in prioritizing high-risk zones within complex urban landscapes.Current UAV path planning methodologies often inadequately account for environmental risk factors and exhibit limitations in balancing global and local optimization efficiency.To address these gaps,this study proposes a hybrid path planning framework integrating an improved Ant Colony Optimization(ACO)algorithm with an Orthogonal Jump Point Search(OJPS)algorithm.Firstly,a two-dimensional grid model is constructed to simulate urban environments,with key monitoring nodes selected based on grid-specific environmental risk values.Subsequently,the improved ACO algorithm is used for global path planning,and the OJPS algorithm is integrated to optimize the local path.The improved ACO algorithm introduces the risk value of environmental events,which is used to direct the UAV to the area with higher risk.In the OJPS algorithm,the path search direction is restricted to the orthogonal direction,which improves the computational efficiency of local path optimization.In order to evaluate the performance of the model,this paper utilizes the metrics of the average risk value of the path,the flight time,and the number of turns.The experimental results demonstrate that the proposed improved ACO algorithm performs well in the average risk value of the paths traveled within the first 5 min,within the first 8 min,and within the first 10 min,with improvements of 48.33%,26.10%,and 6.746%,respectively,over the Particle Swarm Optimization(PSO)algorithm and 70.33%,19.08%,and 10.246%,respectively,over theArtificial Rabbits Optimization(ARO)algorithm.TheOJPS algorithmdemonstrates superior performance in terms of flight time and number of turns,exhibiting a reduction of 40%,40%and 57.1%in flight time compared to the other three algorithms,and a reduction of 11.1%,11.1%and 33.8%in the number of turns compared to the other three algorithms.These results highlight the effectiveness of the proposed method in improving the UAV’s ability to respond efficiently to urban environmental events,offering significant implications for the future of UAV path planning in complex urban settings.
文摘As a renowned historical and cultural city,Luoyang boasts a wealth of tourism resources,including sports venues,natural landscapes,and cultural heritage sites,laying a solid foundation for the integrated development of the tourism industry and sports events in recent years,with remarkable achievements in practice.However,from the perspective of sports-tourism integration,Luoyang’s event tourism still faces a prominent issue of uneven development:a surge in tourists during peak seasons,leading to overcrowded attractions,and a scarcity of visitors during off-peak seasons,resulting in idle resources.This not only leads to inefficient resource utilization but also restricts the enhancement of economic benefits and hinders sustainable development.In light of this,this paper comprehensively employs literature research,case analysis,and fieldwork methods to systematically analyze the current development status of event tourism in Luoyang within the context of sports-tourism integration.The aim is to provide theoretical and practical support for achieving high-quality and balanced development of local event tourism,offering valuable references for addressing the issue of uneven development and moving towards a sustainable future.
文摘BACKGROUND Intra-arterial chemotherapy(IAC)has become a first-line standard treatment for retinoblastoma(RB).However,studies describing its adverse events are sparse,especially from the developing world.Our study described the outcomes and adverse events from a single center in South India.AIM To describe the challenges,treatment outcomes,and complications of selective IAC for RB in Indian eyes.METHODS This study was a single center,retrospective study that included 17 patients with RB who underwent IAC using melphalan(5/7.5 mg)and topotecan(1/2 mg)(n=12)or melphalan(5 mg)alone(n=3)or triple therapy that included carboplatin(30 mg)along with these drugs(n=2)between January 2018 and December 2023.In all,17 IAC procedures were performed using selective ophthalmic artery cannulation.Treatment outcomes were evaluated in terms of tumor control,vitreous and subretinal seed control,complications,and globe salvage rates.RESULTS Out of the 17 patients,11 were diagnosed with unilateral RB and 6 were diag-nosed with bilateral RB.The mean age at the time of diagnosis was 19.8 months.The mean interval between the first symptom and presentation was 6.5 months.IAC was employed as the primary(n=9)or secondary(n=8)modality of treatment.Each eye received a mean of 1.5 IAC sessions(median:1 session;range:1-3 sessions).Eyes were classified according to the international classification of RB as group B(n=5),group C(n=1),group D(n=4),and group E(n=7).Following IAC,complete regression of the main tumor was seen in 15 eyes(88%)and partial regression in 2 eyes(12%).Globe salvage was achieved in 15 eyes(88%).Adverse effects included vitreous hemorrhage(n=3),rhegmatogenous retinal de-tachment(n=2),choroidal ischemia(n=1),isolated subretinal hemorrhage(n=2),retinal pigment epithelium degeneration(n=2),forehead pigmentation(n=1),third nerve palsy with complete ptosis(n=1),and 30-degree exotropia(n=1).The mean follow-up period was 28.6 months(median:24 months,range:1–72 months).CONCLUSION IAC is an effective way to control RB and globe preservation.In the Indian context we encountered many cha-llenges highlighting the importance of case selection.Further studies in India are required to thoroughly un-derstand IAC as a treatment for RB.
基金Humanities and Social Sciences Research Project of China’s Ministry of Education(23YJCZH242)Major Humanities and Social Sciences Research Projects in Zhejiang Higher Education Institutions(2024QN069)Hangzhou Collaborative Innovation Institute of Language Services,Hangzhou City University,China。
文摘This article centers on The Call of the Wild,an English novel by American author Jack London,alongside two Chinese translations by Dajie Liu and Menglin Zhang,and Rongyue Liu.Seventy sentences containing motion events and their corresponding translations were randomly selected for analysis.The study focuses on the primary elements of motion events-manner,path,and ground-and examines their Chinese translations through the lens of Skopos theory.Skopos theory emphasizes whether translators can adopt appropriate translation strategies according to various contextual factors during the translation process.Compared to verb-framed languages,satellite-framed languages possess a richer vocabulary for manner verbs,express more detailed manner information,use more satellite words to indicate paths,and incorporate more background information.Verb-framed languages,by contrast,typically express manner information only when necessary and tend to include less background information.The analysis reveals that both Chinese translations embody the core principle of Skopos theory:translation strategies are determined by their purpose.To fulfill the novel’s translation objectives,the translators adeptly adjust their strategies for motion event components based on different contextual needs.It is noted that the Chinese translations do not fully retain the characteristics of English as a typical satellite-framed language.This observation aligns with Skopos theory’s purpose-oriented approach,which prioritizes translation goals over strict adherence to source text characteristics.
文摘The southern part of East Siberia(SES)is highly vulnerable to flooding caused by the extreme precipitation events(EPEs)during summer.Building on previously detected EPEs in SES and Mongolia,we examined wave propagation patterns for two periods:1982-98 and 1999-2019.Our analysis revealed distinct wave train configurations and geopotential anomalies preceding EPEs,with an increase in wave activity flux across the Northern Hemisphere,followed by a subsequent decrease during EPEs.Consequently,Eastern Siberia has experienced a significant rise in wave activity.Based on geopotential anomalies over Central Siberia accompanying EPEs,we identified two main types.The first,the ridge type,is predominant during the first period and features a meridional contrast with a positive geopotential(and temperature)anomaly over Central Siberia and a negative anomaly over the subtropical regions along the same longitude.The second type,termed the trough type,is more typical for the second period.It involves either a negative geopotential anomaly or the zonal proximity of positive and negative geopotential anomalies over Central Siberia.The trough type,marked by zonally oriented anomalies in geopotential and temperature,results in a more pronounced temperature decrease before EPEs and significant zonal temperature contrasts.Further,it is related to more stationary waves over Northern Eurasia,with persistent positive geopotential anomalies over Europe linked to quasi-stationary troughs over Central Siberia and positive anomalies east of Lake Baikal.Our findings align with shifts in boreal summer teleconnection patterns,reflecting significant changes in wave propagation patterns that have occurred since the late 1990s.
