目的探讨β胶原特殊序列(β-crosslaps,β-CTX)、总1型胶原氨基端延长肽(t-P1NP)及N端中段骨钙素(N-MID-OT)在绝经后女性骨质疏松性骨折风险评估中的应用价值。方法回顾性分析2020年2月至2022年12月解放军总医院第六医学中心收治的102...目的探讨β胶原特殊序列(β-crosslaps,β-CTX)、总1型胶原氨基端延长肽(t-P1NP)及N端中段骨钙素(N-MID-OT)在绝经后女性骨质疏松性骨折风险评估中的应用价值。方法回顾性分析2020年2月至2022年12月解放军总医院第六医学中心收治的102例绝经后骨质疏松(postmenopausal osteoporosis,PMOP)患者的临床资料,将其作为研究组,并根据是否发生骨折将其分为PMOP骨折组(39例)与PMOP未骨折组(63例),另选100名健康体检者作为对照组。记录所有研究对象的β-CTX、t-P1NP及N-MID-OT水平并进行比较,用ROC曲线评价β-CTX、t-P1NP及N-MID-OT在绝经后女性骨质疏松性骨折风险评估中的应用价值。结果研究组的平均体重、体质量指数、股骨颈骨密度(bone mineral density,BMD)、左髋总和BMD及L 1~4总和BMD均明显低于对照组(P<0.05);而两组研究对象的平均年龄、平均身高及绝经年龄等比较差异均无统计学意义(P>0.05)。研究组的β-CTX、t-P1NP及N-MID-OT均明显高于对照组(t值依次为12.688、37.430、26.599,P<0.05)。β-CTX+t-P1NP+N-MID-OT联合检测用于预测PMOP的AUC值为0.978,敏感度为98.04%,特异度为97.00%,表明β-CTX+t-P1NP+N-MID-OT三指标联合检测用于预测PMOP的效能更高。PMOP骨折组的β-CTX、t-P1NP及N-MID-OT均明显高于PMOP未骨折组(t值依次为6.078、16.363、12.227,P<0.05)。β-CTX+t-P1NP+N-MID-OT联合检测用于评估PMOP骨折风险的AUC值为0.939,敏感度为94.87%,特异度为95.24%,表明β-CTX+t-P1NP+N-MID-OT联合检测用于评估PMOP骨折风险的效能更高。结论PMOP患者β-CTX、t-P1NP及N-MID-OT水平均明显升高,而PMOP骨折患者β-CTX、t-P1NP及N-MID-OT水平升高更为明显,且β-CTX+t-P1NP+N-MID-OT联合检测可显著提高对PMOP预测及骨折风险评估效能,值得借鉴。展开更多
The amber deposits from the Albian-Cenomanian in Myanmar have emerged as a pivotal source for exceptionally abundant fossil insect fauna since their initial discovery. Recent studies have increasingly focused on eluci...The amber deposits from the Albian-Cenomanian in Myanmar have emerged as a pivotal source for exceptionally abundant fossil insect fauna since their initial discovery. Recent studies have increasingly focused on elucidating the fern inventory and examining newly available fossils from Myanmar amber, suggesting a diverse fern flora that once thrived in Cretaceous forests. Through investigations of amber collections, with particular emphasis on sporangium structures—especially the annulus types preserved in amber inclusions—this study revealed additional novelties within the Cyatheales and Schizaeales in mid-Cretaceous Myanmar amber forests. The described specimens and newly discovered fossils provide compelling evidence that Polypodiales were not only diverse and abundant but also that other fern lineages, such as Cyatheales and Schizaeales, coexisted in these ancient forest ecosystems. This study reveals the high diversity of ferns in the mid-Cretaceous Myanmar area, while also implying the paleoecological and paleogeographical significance of the Mesozoic Burmese amber forests.展开更多
目的 :分析血清骨代谢标志物Ⅰ型胶原羧基端肽β特殊序列(βisomer of the C-terminal telopeptide of typeⅠcollagen,β-CTX)和骨钙素N-端中分子片段(N-terminal midfragment of osteocalcin,N-MID)在老年肺癌骨转移患者接受唑来膦酸...目的 :分析血清骨代谢标志物Ⅰ型胶原羧基端肽β特殊序列(βisomer of the C-terminal telopeptide of typeⅠcollagen,β-CTX)和骨钙素N-端中分子片段(N-terminal midfragment of osteocalcin,N-MID)在老年肺癌骨转移患者接受唑来膦酸治疗过程中的变化情况,探讨二者对老年肺癌骨转移患者临床预后的预测价值。方法:在本项前瞻性研究中,选取年龄>60岁的肺癌骨转移患者126例,肺癌无骨转移患者110例,同时入组的正常对照为89例。所有肺癌骨转移患者均应用唑来膦酸治疗,每4周1次(4 mg静脉滴注)。采用放射免疫法动态监测肺癌骨转移患者在治疗前和唑来膦酸治疗后2、4、6、8、10和12个月的血清β-CTX和N-MID水平,并记录研究期间患者发生骨相关事件(skeletal-related events,SREs)和总生存的情况。结果:肺癌骨转移组血清β-CTX和N-MID基线水平明显高于肺癌无骨转移组及正常对照组(P值均<0.001),而唑来膦酸治疗后肺癌骨转移组的β-CTX和N-MID水平较治疗前基线水平明显下降(P值均<0.01)。多因素分析结果显示,β-CTX和N-MID是影响SREs发生的独立危险因素[比值比(odds ratio,OR)=6.367,P=0.001;OR=3.015,P=0.025)。高水平β-CTX组发生SREs的中位时间和中位生存时间均短于低水平β-CTX组,差异均有统计学意义(6.0个月vs 10.5个月,P=0.031;13.0个月vs 16.5个月,P=0.028);高水平N-MID组发生SREs的中位时间也低于低水平N-MID组(6.5个月vs 10.5个月,P=0.046),但是二者的中位生存时间无明显差异(14.5个月vs 17.0个月,P=0.226)。结论:血清β-CTX和N-MID是预测老年肺癌骨转移患者发生SREs的有效指标,同时β-CTX可能对评估老年肺癌骨转移患者的预后有一定价值。展开更多
Yangshao culture is the most important mid-Holocene Neolithic culture in the Yellow River catchment, and thus, a study on the impact of human activities on the environment is important. In the current study, the distr...Yangshao culture is the most important mid-Holocene Neolithic culture in the Yellow River catchment, and thus, a study on the impact of human activities on the environment is important. In the current study, the distribution pattern of the cultivated land in late Yangshao culture is reconstructed using GIS tool and site domain analysis （SDA）. The results show that the cultivated land during 5.5-5.0 ka BP was mainly distributed in the Weihe River valley, Luohe River valley, northwestern Henan Plain, Fenhe River valley and eastern Gansu region, especially concentrated in the Xi＇an-Baoji line of the Weihe River valley. At that time, at least 37,000 km2 of lands were reclaimed in the middle and lower reaches of the Yellow River, and 132,000 km2 of lands were affected by agricultural activities. Human activities had become the driving force of land use/land coverage. Charcoal records indicate that the ancestors of Yangshao culture burnt forests for reclamation, leading to the decrease of arbor pollen at 5 ka BP in core areas of the Yangshao culture. The areas that were significantly affected by human activities accounted for 3.2% of the Yangshao culture influenced area, while the moderately affected areas accounted for 20.1% of Yangshao culture influenced area. Meanwhile, 92% of the land areas on the edge and outside of the Yangshao culture influenced area were not affected by human activities. The arbor pollen in these areas did not decrease until 4.0 ka BP.展开更多
文摘目的探讨β胶原特殊序列(β-crosslaps,β-CTX)、总1型胶原氨基端延长肽(t-P1NP)及N端中段骨钙素(N-MID-OT)在绝经后女性骨质疏松性骨折风险评估中的应用价值。方法回顾性分析2020年2月至2022年12月解放军总医院第六医学中心收治的102例绝经后骨质疏松(postmenopausal osteoporosis,PMOP)患者的临床资料,将其作为研究组,并根据是否发生骨折将其分为PMOP骨折组(39例)与PMOP未骨折组(63例),另选100名健康体检者作为对照组。记录所有研究对象的β-CTX、t-P1NP及N-MID-OT水平并进行比较,用ROC曲线评价β-CTX、t-P1NP及N-MID-OT在绝经后女性骨质疏松性骨折风险评估中的应用价值。结果研究组的平均体重、体质量指数、股骨颈骨密度(bone mineral density,BMD)、左髋总和BMD及L 1~4总和BMD均明显低于对照组(P<0.05);而两组研究对象的平均年龄、平均身高及绝经年龄等比较差异均无统计学意义(P>0.05)。研究组的β-CTX、t-P1NP及N-MID-OT均明显高于对照组(t值依次为12.688、37.430、26.599,P<0.05)。β-CTX+t-P1NP+N-MID-OT联合检测用于预测PMOP的AUC值为0.978,敏感度为98.04%,特异度为97.00%,表明β-CTX+t-P1NP+N-MID-OT三指标联合检测用于预测PMOP的效能更高。PMOP骨折组的β-CTX、t-P1NP及N-MID-OT均明显高于PMOP未骨折组(t值依次为6.078、16.363、12.227,P<0.05)。β-CTX+t-P1NP+N-MID-OT联合检测用于评估PMOP骨折风险的AUC值为0.939,敏感度为94.87%,特异度为95.24%,表明β-CTX+t-P1NP+N-MID-OT联合检测用于评估PMOP骨折风险的效能更高。结论PMOP患者β-CTX、t-P1NP及N-MID-OT水平均明显升高,而PMOP骨折患者β-CTX、t-P1NP及N-MID-OT水平升高更为明显,且β-CTX+t-P1NP+N-MID-OT联合检测可显著提高对PMOP预测及骨折风险评估效能,值得借鉴。
文摘The amber deposits from the Albian-Cenomanian in Myanmar have emerged as a pivotal source for exceptionally abundant fossil insect fauna since their initial discovery. Recent studies have increasingly focused on elucidating the fern inventory and examining newly available fossils from Myanmar amber, suggesting a diverse fern flora that once thrived in Cretaceous forests. Through investigations of amber collections, with particular emphasis on sporangium structures—especially the annulus types preserved in amber inclusions—this study revealed additional novelties within the Cyatheales and Schizaeales in mid-Cretaceous Myanmar amber forests. The described specimens and newly discovered fossils provide compelling evidence that Polypodiales were not only diverse and abundant but also that other fern lineages, such as Cyatheales and Schizaeales, coexisted in these ancient forest ecosystems. This study reveals the high diversity of ferns in the mid-Cretaceous Myanmar area, while also implying the paleoecological and paleogeographical significance of the Mesozoic Burmese amber forests.
文摘目的 :分析血清骨代谢标志物Ⅰ型胶原羧基端肽β特殊序列(βisomer of the C-terminal telopeptide of typeⅠcollagen,β-CTX)和骨钙素N-端中分子片段(N-terminal midfragment of osteocalcin,N-MID)在老年肺癌骨转移患者接受唑来膦酸治疗过程中的变化情况,探讨二者对老年肺癌骨转移患者临床预后的预测价值。方法:在本项前瞻性研究中,选取年龄>60岁的肺癌骨转移患者126例,肺癌无骨转移患者110例,同时入组的正常对照为89例。所有肺癌骨转移患者均应用唑来膦酸治疗,每4周1次(4 mg静脉滴注)。采用放射免疫法动态监测肺癌骨转移患者在治疗前和唑来膦酸治疗后2、4、6、8、10和12个月的血清β-CTX和N-MID水平,并记录研究期间患者发生骨相关事件(skeletal-related events,SREs)和总生存的情况。结果:肺癌骨转移组血清β-CTX和N-MID基线水平明显高于肺癌无骨转移组及正常对照组(P值均<0.001),而唑来膦酸治疗后肺癌骨转移组的β-CTX和N-MID水平较治疗前基线水平明显下降(P值均<0.01)。多因素分析结果显示,β-CTX和N-MID是影响SREs发生的独立危险因素[比值比(odds ratio,OR)=6.367,P=0.001;OR=3.015,P=0.025)。高水平β-CTX组发生SREs的中位时间和中位生存时间均短于低水平β-CTX组,差异均有统计学意义(6.0个月vs 10.5个月,P=0.031;13.0个月vs 16.5个月,P=0.028);高水平N-MID组发生SREs的中位时间也低于低水平N-MID组(6.5个月vs 10.5个月,P=0.046),但是二者的中位生存时间无明显差异(14.5个月vs 17.0个月,P=0.226)。结论:血清β-CTX和N-MID是预测老年肺癌骨转移患者发生SREs的有效指标,同时β-CTX可能对评估老年肺癌骨转移患者的预后有一定价值。
基金National Natural Science Foundation of China, No.41161018 No.41121001+2 种基金 China Geological Survey, No. 1212011120046 Humanities and Social Sciences Youth Fund Project of Ministry c,f Education of China, No. 10YJCZH041 and The ＂Strategic Priority Research Program＂ of the CAS, No.XDA05120501.
文摘Yangshao culture is the most important mid-Holocene Neolithic culture in the Yellow River catchment, and thus, a study on the impact of human activities on the environment is important. In the current study, the distribution pattern of the cultivated land in late Yangshao culture is reconstructed using GIS tool and site domain analysis （SDA）. The results show that the cultivated land during 5.5-5.0 ka BP was mainly distributed in the Weihe River valley, Luohe River valley, northwestern Henan Plain, Fenhe River valley and eastern Gansu region, especially concentrated in the Xi＇an-Baoji line of the Weihe River valley. At that time, at least 37,000 km2 of lands were reclaimed in the middle and lower reaches of the Yellow River, and 132,000 km2 of lands were affected by agricultural activities. Human activities had become the driving force of land use/land coverage. Charcoal records indicate that the ancestors of Yangshao culture burnt forests for reclamation, leading to the decrease of arbor pollen at 5 ka BP in core areas of the Yangshao culture. The areas that were significantly affected by human activities accounted for 3.2% of the Yangshao culture influenced area, while the moderately affected areas accounted for 20.1% of Yangshao culture influenced area. Meanwhile, 92% of the land areas on the edge and outside of the Yangshao culture influenced area were not affected by human activities. The arbor pollen in these areas did not decrease until 4.0 ka BP.
