Microuidic channels play a vital role in separation of analytes of interest such as bacteria and platelet cells,etc.,in various biochemical diagnosis procedures including urinary tract infections(UTI)and bloodstream i...Microuidic channels play a vital role in separation of analytes of interest such as bacteria and platelet cells,etc.,in various biochemical diagnosis procedures including urinary tract infections(UTI)and bloodstream infections.This paper presents the multi physics computational model specifically designed to study the effects of design parameters of a microuidics channel for the separation of Escherichia coli(E.coli)from various blood constituents including red blood cells(RBC)and platelets.A standard two inlet and a two outlet microchannel of length 805µm with a channel width of 40µm is simulated.The effect of electrode potentials and the effect of electrode placement along the channel length and also the levitation of electrodes from the channel wall are studied to optimize the selective particle separation throughput.Simulated results show the efcient separation of E-coli with a mean diameter 0.68µm is achieved at low voltages(less than 20 V)when electrodes placed near to the micro channel and also noticed that the applied electric potential is inversely proportional to the number of electrodes placed along the microuidic channel.The computer aided multi physics simulations with multiple governing parameters could be advantage in design optimization of microuidics channels and support precise bioparticle separation for better diagnosis.展开更多
文摘Microuidic channels play a vital role in separation of analytes of interest such as bacteria and platelet cells,etc.,in various biochemical diagnosis procedures including urinary tract infections(UTI)and bloodstream infections.This paper presents the multi physics computational model specifically designed to study the effects of design parameters of a microuidics channel for the separation of Escherichia coli(E.coli)from various blood constituents including red blood cells(RBC)and platelets.A standard two inlet and a two outlet microchannel of length 805µm with a channel width of 40µm is simulated.The effect of electrode potentials and the effect of electrode placement along the channel length and also the levitation of electrodes from the channel wall are studied to optimize the selective particle separation throughput.Simulated results show the efcient separation of E-coli with a mean diameter 0.68µm is achieved at low voltages(less than 20 V)when electrodes placed near to the micro channel and also noticed that the applied electric potential is inversely proportional to the number of electrodes placed along the microuidic channel.The computer aided multi physics simulations with multiple governing parameters could be advantage in design optimization of microuidics channels and support precise bioparticle separation for better diagnosis.
