Small open reading frames(sORFs) are distributed over a wide variety of transcripts. sORFs encoding functional peptides have been identified in various configurations within apparently long noncoding RNAs. Many transl...Small open reading frames(sORFs) are distributed over a wide variety of transcripts. sORFs encoding functional peptides have been identified in various configurations within apparently long noncoding RNAs. Many translated sORFs have been identified across mRNAs, including 5’-upstream, coding domain, and 3’-downstream. sORFs have also been found in circular RNAs, pri-miRNAs, and ribosomal RNAs. Here, we present an overview of the wide distribution of the sORFs in transcripts and their functional roles in organisms.展开更多
With the development of modern sequencing techniques and bioinformatics, genomes that were once thought to be noncoding have been found to encode abundant functional micropeptides(miPs), a kind of small polypeptides. ...With the development of modern sequencing techniques and bioinformatics, genomes that were once thought to be noncoding have been found to encode abundant functional micropeptides(miPs), a kind of small polypeptides. Although miPs are difficult to analyze and identify, a number of studies have begun to focus on them. More and more miPs have been revealed as essential for energy metabolism homeostasis, immune regulation, and tumor growth and development. Many reports have shown that miPs are especially essential for regulating glucose and lipid metabolism and regulating mitochondrial function.MiPs are also involved in the progression of related diseases. This paper reviews the sources and identification of miPs, as well as the functional significance of miPs for metabolism-related diseases, with the aim of revealing their potential clinical applications.展开更多
Long noncoding RNA(lncRNA)is a type of non-coding RNA with a length greater than 200 nucleotides.Classic research suggests that lncRNAs do not encode proteins.In recent years,with the advancement of high-throughput RN...Long noncoding RNA(lncRNA)is a type of non-coding RNA with a length greater than 200 nucleotides.Classic research suggests that lncRNAs do not encode proteins.In recent years,with the advancement of high-throughput RNA sequencing technology and omics analysis,researchers have found that many lncRNAs have short open reading frames(sORFs)that encode functional micropeptides.By regulating key biological processes such as transcription and translation,these micropeptides play important roles in the different stages of the occurrence and development of various diseases,such as cancer.Micropeptides have a small molecular weight,simple structure,and high biological activity,making them potentially valuable for drug development.This article mainly focuses on the prediction and identification methods,biological functions,and molecular mechanisms of lncRNA-encoded micropeptides,aiming to provide new ideas for the early diagnosis,effective treatment,and prognostication of malignant tumors.展开更多
基金supported by the Project Program of State Key Laboratory of Natural Medicines(No. SKLNMBZ201403)the National Science and Technology Major Projects of New Drugs (Nos.2012ZX09103301-004 and 2014ZX09508007) in ChinaThis project was also funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
文摘Small open reading frames(sORFs) are distributed over a wide variety of transcripts. sORFs encoding functional peptides have been identified in various configurations within apparently long noncoding RNAs. Many translated sORFs have been identified across mRNAs, including 5’-upstream, coding domain, and 3’-downstream. sORFs have also been found in circular RNAs, pri-miRNAs, and ribosomal RNAs. Here, we present an overview of the wide distribution of the sORFs in transcripts and their functional roles in organisms.
基金supported by the National Natural Science Foundation of China(No.81870237)。
文摘With the development of modern sequencing techniques and bioinformatics, genomes that were once thought to be noncoding have been found to encode abundant functional micropeptides(miPs), a kind of small polypeptides. Although miPs are difficult to analyze and identify, a number of studies have begun to focus on them. More and more miPs have been revealed as essential for energy metabolism homeostasis, immune regulation, and tumor growth and development. Many reports have shown that miPs are especially essential for regulating glucose and lipid metabolism and regulating mitochondrial function.MiPs are also involved in the progression of related diseases. This paper reviews the sources and identification of miPs, as well as the functional significance of miPs for metabolism-related diseases, with the aim of revealing their potential clinical applications.
基金supported by the the National Natural Science Foundation of China(82173332 to Yongmei Song).
文摘Long noncoding RNA(lncRNA)is a type of non-coding RNA with a length greater than 200 nucleotides.Classic research suggests that lncRNAs do not encode proteins.In recent years,with the advancement of high-throughput RNA sequencing technology and omics analysis,researchers have found that many lncRNAs have short open reading frames(sORFs)that encode functional micropeptides.By regulating key biological processes such as transcription and translation,these micropeptides play important roles in the different stages of the occurrence and development of various diseases,such as cancer.Micropeptides have a small molecular weight,simple structure,and high biological activity,making them potentially valuable for drug development.This article mainly focuses on the prediction and identification methods,biological functions,and molecular mechanisms of lncRNA-encoded micropeptides,aiming to provide new ideas for the early diagnosis,effective treatment,and prognostication of malignant tumors.
