Objective: To study the expression of caveolin-1 in colorectal adenocarcinoma tissues and its correlation with microlymphatic vessel density(LMVD), and to investigate the clinical pathological prognostic significance ...Objective: To study the expression of caveolin-1 in colorectal adenocarcinoma tissues and its correlation with microlymphatic vessel density(LMVD), and to investigate the clinical pathological prognostic significance of caveolin-1 and LMVD in patients with colorectal cancer. Methods: The expression of caveolin-1 and LMVD in 45 specimens of normal colorectal tissues, and 90 specimens of colorectal adenocarcinoma tissues were detected by immunohistochemistry technique. The correlation between their expression and the clinicopathologic features was analyzed. Muhivariable Cox regression was used to analyze the association between the laboratory indices and overall survival time. Results: The positive rates of caveolin-1 in colorectal adenocarcinoma tissues were significantly higher than those in normal colorectal tissues(P<0.01). LMVD in colorectal adenocarcinoma tissues were significantly higher than those in normal colorectal tissues(P<0.01). Mean LMVD in group with caveolin-1 positive was significantly higher than in that with caveolin-1 negative. The median survival time was 26.7 months. Cox regression analysis showed that the caveolin-1 expression, invation depth, lymph nodemetastasis, TNM stage, liver metastasis and LMVD were independent risk factors of overall survival time of patients with colorectal carcinoma. Conclusions: Caveolin-1 may contribute to the lymphangiogenesis in the tumor. During the occurrence and development of colorectal adenocarcinoma, there is a close relationship between the expression of caveolin-1 and lymphatic microvessel of tumor. Caveolin-1 expression and microlymphatic vessel density are significant prognostic value of colorectal carcinoma.展开更多
Objective： To investigate the role the vascular endothelial growth factor C （VEGF-C） expression in lymphangiogenesis and lymph node metastasis in pancreatic cancer. Methods： The expression of VEGF-C in pancreatic ...Objective： To investigate the role the vascular endothelial growth factor C （VEGF-C） expression in lymphangiogenesis and lymph node metastasis in pancreatic cancer. Methods： The expression of VEGF-C in pancreatic cancer tissue of 42 cases and normal pancreatic tissue of 10 cases was detected by using immunohistochemical S-P method. The microlymphatic vessel density （MLVD） of both tissues was measured by enzyme-histochemical method at the same time. Results： The VEGF-C positive expression rate was significantly higher in pancreatic cancer tissue （64.3%） than in normal pancreatic tissue （20%, P〈0.05）. The MLVD was significantly higher in pancreatic cancer tissue （21.93±6.39） than that in normal pancreatic tissue （4.40±2.07, P〈0.001）. The VEGF-C positive expression rate, MLVD and lymph node metastasis had a positive correlation. Conclusion： The VEGF-C may play an important role in the lymphangiogenesis and lymph node metastasis of pancreatic cancer.展开更多
基金supported by 2013 Mandatory Planning Project of Scientific and Technological Bureau of Zhangjiakou City(1311055D)
文摘Objective: To study the expression of caveolin-1 in colorectal adenocarcinoma tissues and its correlation with microlymphatic vessel density(LMVD), and to investigate the clinical pathological prognostic significance of caveolin-1 and LMVD in patients with colorectal cancer. Methods: The expression of caveolin-1 and LMVD in 45 specimens of normal colorectal tissues, and 90 specimens of colorectal adenocarcinoma tissues were detected by immunohistochemistry technique. The correlation between their expression and the clinicopathologic features was analyzed. Muhivariable Cox regression was used to analyze the association between the laboratory indices and overall survival time. Results: The positive rates of caveolin-1 in colorectal adenocarcinoma tissues were significantly higher than those in normal colorectal tissues(P<0.01). LMVD in colorectal adenocarcinoma tissues were significantly higher than those in normal colorectal tissues(P<0.01). Mean LMVD in group with caveolin-1 positive was significantly higher than in that with caveolin-1 negative. The median survival time was 26.7 months. Cox regression analysis showed that the caveolin-1 expression, invation depth, lymph nodemetastasis, TNM stage, liver metastasis and LMVD were independent risk factors of overall survival time of patients with colorectal carcinoma. Conclusions: Caveolin-1 may contribute to the lymphangiogenesis in the tumor. During the occurrence and development of colorectal adenocarcinoma, there is a close relationship between the expression of caveolin-1 and lymphatic microvessel of tumor. Caveolin-1 expression and microlymphatic vessel density are significant prognostic value of colorectal carcinoma.
文摘Objective： To investigate the role the vascular endothelial growth factor C （VEGF-C） expression in lymphangiogenesis and lymph node metastasis in pancreatic cancer. Methods： The expression of VEGF-C in pancreatic cancer tissue of 42 cases and normal pancreatic tissue of 10 cases was detected by using immunohistochemical S-P method. The microlymphatic vessel density （MLVD） of both tissues was measured by enzyme-histochemical method at the same time. Results： The VEGF-C positive expression rate was significantly higher in pancreatic cancer tissue （64.3%） than in normal pancreatic tissue （20%, P〈0.05）. The MLVD was significantly higher in pancreatic cancer tissue （21.93±6.39） than that in normal pancreatic tissue （4.40±2.07, P〈0.001）. The VEGF-C positive expression rate, MLVD and lymph node metastasis had a positive correlation. Conclusion： The VEGF-C may play an important role in the lymphangiogenesis and lymph node metastasis of pancreatic cancer.
