Objective:To study the effect of nephrotic enteral nutrition preparation on the nutritional status and microinflammatory state in patients with maintenance hemodialysis complicated by malnutrition.Methods: A total of ...Objective:To study the effect of nephrotic enteral nutrition preparation on the nutritional status and microinflammatory state in patients with maintenance hemodialysis complicated by malnutrition.Methods: A total of 68 patients who received maintenance hemodialysis and had malnutrition in our hospital between January 2013 and July 2016 were collected and divided into control group (n=34) and observation group (n=34) according to random number table. Control group received regular dietary intervention, and observation group received nephrotic enteral nutrition preparation based on routine intervention. Nutritional status and microinflammatory state before and after intervention were compared between two groups of patients.Results: Before intervention, the differences in peripheral blood levels of protein indexes and trace elements as well as serum levels of inflammatory factors were not statistically significant between two groups of patients. After intervention, peripheral blood nutrition-related proteins TP, ALB, PA, Hb and TRF levels of observation group were higher than those of control group;peripheral blood trace elements Zn and Fe levels were higher than those of control group while Ca level was lower than that of control group;serum inflammatory factors IL-6, hs-CRP and TNF-α levels were lower than those of control group. Conclusion:Nephrotic enteral nutrition preparation can effectively optimize the nutritional status and reduce the microinflammation degree in patients with maintenance hemodialysis complicated by malnutrition.展开更多
Objective: To study the correlation of serum vitamin C content with renal anemia, oxidative stress and microinflammatory state in patients with peritoneal dialysis. Methods: A total of 96 patients undergoing peritonea...Objective: To study the correlation of serum vitamin C content with renal anemia, oxidative stress and microinflammatory state in patients with peritoneal dialysis. Methods: A total of 96 patients undergoing peritoneal dialysis in the First Affiliated Hospital of Soochow University between January 2016 and January 2017 were selected as the peritoneal dialysis group, and 50 healthy volunteers receiving physical examination in the First Affiliated Hospital of Soochow University during the same period were selected as the normal control group. The contents of VitC as well as renal anemia, oxidative stress and microinflammation-related indexes in peripheral blood of two groups of subjects were detected, and Pearson test was used to evaluate the correlation of serum VitC content with renal anemia, oxidative stress and microinflammatory state in patients with peritoneal dialysis. Results: VitC content in peripheral blood of peritoneal dialysis group was lower than that of normal control group;renal anemia-related indexes Hb, RBC and TIBC levels in peripheral blood were lower than those of normal control group;oxidative stress indexes LHP, MPO and AOPPs contents in serum were higher than those of control group while SOD and GSH-Px contents were lower than those of control group;inflammatory factors CRP, IL-6, IL-8, IL-10 and IL-13 contents in serum were higher than those of normal control group. VitC content in serum of patients with peritoneal dialysis was positively correlated with Hb, RBC, TIBC, SOD and GSH-Px levels, and negatively correlated with LHP, MPO, AOPPs, CRP, IL-6, IL-8, IL-10 and IL-13 contents. Conclusion: Serum VitC content is lower in patients with peritoneal dialysis, and the specific content is directly correlated with the severity of renal anemia, oxidative stress and microinflammatory state.展开更多
BACKGROUND The specific mechanism of diabetic nephropathy(DN)has not been fully elucidated,and more and more evidence shows that the development of DN is related to intestinal flora imbalance and micro-inflammatory st...BACKGROUND The specific mechanism of diabetic nephropathy(DN)has not been fully elucidated,and more and more evidence shows that the development of DN is related to intestinal flora imbalance and micro-inflammatory state process,and this mechanism urgently needs to be further clarified by relevant research.AIM To investigate the correlation between intestinal microbiota dysbiosis,low-grade inflammatory status,renal function impairment,and disease severity in older patients with DN,in order to provide a basis for the prevention and therapeutic intervention of DN.METHODS We enrolled 167 older patients with DN,diagnosed in the Department of Nephrology between June 2020 and June 2023.Eighty-five patients with type 2 diabetes mellitus(without DN)were enrolled to serve as the control group.A one-year follow-up observation was conducted.We compared the differences in gut microbiota composition,levels of inflammatory markers,and renal function indicators between the two groups,and the characteristics of gut microbiota and the changing patterns of inflammatory markers across different stages of disease progression.RESULTS In the DN group,the Chao,Ace,and Shannon indices were significantly lower,while the Simpson index was significantly higher than the control group.The relative abundances of Bacteroides and Bifidobacterium were significantly lower,whereas the relative abundances of Clostridium,Butyricimonas,Klebsiella,Enterococcus,Veillonella,and Megamonas were significantly higher than those in the control group(P<0.05).Estimated glomerular filtration rate was positively correlated with the Chao,Ace,and Shannon diversity indices of the gut microbiota,as well as with the relative abundances of Bacteroides,Bifidobacterium,and Akkermansia,and was negatively correlated with the relative abundances of Clostridium,Klebsiella,and Enterococcus(P<0.05).Logistic regression analysis indicated that lower Chao,Ace,and Shannon indices and higher Simpson index were associated with an increased risk of developing DN.After one year of follow-up,patients in the progression group exhibited a significantly greater decrease in Chao,Ace,and Shannon indices and a greater increase in Simpson index than the stable group.The reduction in the relative abundances of Bacteroides,Clostridium,Bifidobacterium,and Butyricimonas,as well as the increase in Klebsiella,Enterococcus,Veillonella,and Megamonas,were significantly more pronounced in the progression group than in the stable group(P<0.05).Regression analysis indicated that greater declines in Chao,Ace,and Shannon indices and Bacteroides relative abundance,along with greater increases in Simpson index and Enterococcus relative abundance,were associated with a more rapid decline in renal function.CONCLUSION The onset and progression of DN in older patients with diabetes are closely associated with gut microbiota composition.The more severe the dysbiosis,the lower the abundance of beneficial bacteria and the higher the abundance of harmful bacteria,leading to an increased risk of both DN occurrence and disease progression.展开更多
BACKGROUND Chronic heart failure(CHF)is a serious and prevalent condition characterized by impaired cardiac function and inflammation.Standard therapy for CHF has limitations,prompting the exploration of alternative t...BACKGROUND Chronic heart failure(CHF)is a serious and prevalent condition characterized by impaired cardiac function and inflammation.Standard therapy for CHF has limitations,prompting the exploration of alternative treatments.Recombinant human brain natriuretic peptide(BNP)has emerged as a potential therapy,with evidence suggesting that it can improve cardiac function and reduce inflammation in patients with CHF.However,further research is required to determine the efficacy and safety of lyophilized recombinant human BNP in CHF patients and its impact on microinflammatory status.This study aimed to investigate the effects of lyophilized recombinant human BNP therapy on CHF patients’cardiac function and microinflammatory status.AIM To investigate the effects of freeze-dried recombinant human BNP therapy on cardiac function and microinflammatory status in patients with CHF.METHODS In total,102 CHF patients admitted to our hospital from January 2021 to January 2022 were randomly assigned to control and observation groups(n=51 patients/group).The control patients were treated with standard HF therapy for 3 d,whereas the observational patients were injected with the recombinant human BNP for 3 d.Clinical efficacy,inflammatory factor levels,myocardial damage,cardiac function before and after the treatment,and adverse reactions during treatment were compared between the two groups.RESULTS The overall clinical efficacy was higher in the observation group than in the control group.Compared with baseline,serum hypersensitive C-reactive protein,N-terminal proBNP,and troponin I level,and physical,emotional,social,and economic scores were lower in both groups after treatment,with greater reductions in levels and scores noted in the observation group than in the control group.The overall incidence of adverse reactions in the observation group was not significantly different compared with that in the control group(P>0.05).CONCLUSION Freeze-dried recombinant human BNP therapy can improve heart function and enhance microinflammatory status,thereby improving overall quality of life without any obvious side effects.This therapy is safe and reliable.展开更多
文摘Objective:To study the effect of nephrotic enteral nutrition preparation on the nutritional status and microinflammatory state in patients with maintenance hemodialysis complicated by malnutrition.Methods: A total of 68 patients who received maintenance hemodialysis and had malnutrition in our hospital between January 2013 and July 2016 were collected and divided into control group (n=34) and observation group (n=34) according to random number table. Control group received regular dietary intervention, and observation group received nephrotic enteral nutrition preparation based on routine intervention. Nutritional status and microinflammatory state before and after intervention were compared between two groups of patients.Results: Before intervention, the differences in peripheral blood levels of protein indexes and trace elements as well as serum levels of inflammatory factors were not statistically significant between two groups of patients. After intervention, peripheral blood nutrition-related proteins TP, ALB, PA, Hb and TRF levels of observation group were higher than those of control group;peripheral blood trace elements Zn and Fe levels were higher than those of control group while Ca level was lower than that of control group;serum inflammatory factors IL-6, hs-CRP and TNF-α levels were lower than those of control group. Conclusion:Nephrotic enteral nutrition preparation can effectively optimize the nutritional status and reduce the microinflammation degree in patients with maintenance hemodialysis complicated by malnutrition.
文摘Objective: To study the correlation of serum vitamin C content with renal anemia, oxidative stress and microinflammatory state in patients with peritoneal dialysis. Methods: A total of 96 patients undergoing peritoneal dialysis in the First Affiliated Hospital of Soochow University between January 2016 and January 2017 were selected as the peritoneal dialysis group, and 50 healthy volunteers receiving physical examination in the First Affiliated Hospital of Soochow University during the same period were selected as the normal control group. The contents of VitC as well as renal anemia, oxidative stress and microinflammation-related indexes in peripheral blood of two groups of subjects were detected, and Pearson test was used to evaluate the correlation of serum VitC content with renal anemia, oxidative stress and microinflammatory state in patients with peritoneal dialysis. Results: VitC content in peripheral blood of peritoneal dialysis group was lower than that of normal control group;renal anemia-related indexes Hb, RBC and TIBC levels in peripheral blood were lower than those of normal control group;oxidative stress indexes LHP, MPO and AOPPs contents in serum were higher than those of control group while SOD and GSH-Px contents were lower than those of control group;inflammatory factors CRP, IL-6, IL-8, IL-10 and IL-13 contents in serum were higher than those of normal control group. VitC content in serum of patients with peritoneal dialysis was positively correlated with Hb, RBC, TIBC, SOD and GSH-Px levels, and negatively correlated with LHP, MPO, AOPPs, CRP, IL-6, IL-8, IL-10 and IL-13 contents. Conclusion: Serum VitC content is lower in patients with peritoneal dialysis, and the specific content is directly correlated with the severity of renal anemia, oxidative stress and microinflammatory state.
文摘BACKGROUND The specific mechanism of diabetic nephropathy(DN)has not been fully elucidated,and more and more evidence shows that the development of DN is related to intestinal flora imbalance and micro-inflammatory state process,and this mechanism urgently needs to be further clarified by relevant research.AIM To investigate the correlation between intestinal microbiota dysbiosis,low-grade inflammatory status,renal function impairment,and disease severity in older patients with DN,in order to provide a basis for the prevention and therapeutic intervention of DN.METHODS We enrolled 167 older patients with DN,diagnosed in the Department of Nephrology between June 2020 and June 2023.Eighty-five patients with type 2 diabetes mellitus(without DN)were enrolled to serve as the control group.A one-year follow-up observation was conducted.We compared the differences in gut microbiota composition,levels of inflammatory markers,and renal function indicators between the two groups,and the characteristics of gut microbiota and the changing patterns of inflammatory markers across different stages of disease progression.RESULTS In the DN group,the Chao,Ace,and Shannon indices were significantly lower,while the Simpson index was significantly higher than the control group.The relative abundances of Bacteroides and Bifidobacterium were significantly lower,whereas the relative abundances of Clostridium,Butyricimonas,Klebsiella,Enterococcus,Veillonella,and Megamonas were significantly higher than those in the control group(P<0.05).Estimated glomerular filtration rate was positively correlated with the Chao,Ace,and Shannon diversity indices of the gut microbiota,as well as with the relative abundances of Bacteroides,Bifidobacterium,and Akkermansia,and was negatively correlated with the relative abundances of Clostridium,Klebsiella,and Enterococcus(P<0.05).Logistic regression analysis indicated that lower Chao,Ace,and Shannon indices and higher Simpson index were associated with an increased risk of developing DN.After one year of follow-up,patients in the progression group exhibited a significantly greater decrease in Chao,Ace,and Shannon indices and a greater increase in Simpson index than the stable group.The reduction in the relative abundances of Bacteroides,Clostridium,Bifidobacterium,and Butyricimonas,as well as the increase in Klebsiella,Enterococcus,Veillonella,and Megamonas,were significantly more pronounced in the progression group than in the stable group(P<0.05).Regression analysis indicated that greater declines in Chao,Ace,and Shannon indices and Bacteroides relative abundance,along with greater increases in Simpson index and Enterococcus relative abundance,were associated with a more rapid decline in renal function.CONCLUSION The onset and progression of DN in older patients with diabetes are closely associated with gut microbiota composition.The more severe the dysbiosis,the lower the abundance of beneficial bacteria and the higher the abundance of harmful bacteria,leading to an increased risk of both DN occurrence and disease progression.
文摘BACKGROUND Chronic heart failure(CHF)is a serious and prevalent condition characterized by impaired cardiac function and inflammation.Standard therapy for CHF has limitations,prompting the exploration of alternative treatments.Recombinant human brain natriuretic peptide(BNP)has emerged as a potential therapy,with evidence suggesting that it can improve cardiac function and reduce inflammation in patients with CHF.However,further research is required to determine the efficacy and safety of lyophilized recombinant human BNP in CHF patients and its impact on microinflammatory status.This study aimed to investigate the effects of lyophilized recombinant human BNP therapy on CHF patients’cardiac function and microinflammatory status.AIM To investigate the effects of freeze-dried recombinant human BNP therapy on cardiac function and microinflammatory status in patients with CHF.METHODS In total,102 CHF patients admitted to our hospital from January 2021 to January 2022 were randomly assigned to control and observation groups(n=51 patients/group).The control patients were treated with standard HF therapy for 3 d,whereas the observational patients were injected with the recombinant human BNP for 3 d.Clinical efficacy,inflammatory factor levels,myocardial damage,cardiac function before and after the treatment,and adverse reactions during treatment were compared between the two groups.RESULTS The overall clinical efficacy was higher in the observation group than in the control group.Compared with baseline,serum hypersensitive C-reactive protein,N-terminal proBNP,and troponin I level,and physical,emotional,social,and economic scores were lower in both groups after treatment,with greater reductions in levels and scores noted in the observation group than in the control group.The overall incidence of adverse reactions in the observation group was not significantly different compared with that in the control group(P>0.05).CONCLUSION Freeze-dried recombinant human BNP therapy can improve heart function and enhance microinflammatory status,thereby improving overall quality of life without any obvious side effects.This therapy is safe and reliable.
