In this paper, we combined magnetostatics and laminar flow in microfluidics and studied a particle separation scheme employing magnetophoretic force in inhomogeneous magnetic field. A detailed model and analysis is sh...In this paper, we combined magnetostatics and laminar flow in microfluidics and studied a particle separation scheme employing magnetophoretic force in inhomogeneous magnetic field. A detailed model and analysis is shown and the proposed scheme is capable of efficiently separating magnetic particles with different permeability and sizes. The method shows a way to separate efficient particles and could potentially be implemented in biological and chemical systems.展开更多
An approach was described to produce a wound area in vitro using laminar flow technique to selectively remove cells in micro fluidic channels. Cell migration which plays an important role in the process of wound heali...An approach was described to produce a wound area in vitro using laminar flow technique to selectively remove cells in micro fluidic channels. Cell migration which plays an important role in the process of wound healing can be observed dynamically by this method. In order to prove our system, we have studied its properties by injecting NIH-3T3 cells into main channel and added several reagents to observe the mediatory influence. The results reveal that fibroblast growth factor-2（FGF-2）, insulin-like growth factor 1（IGF-Ⅰ）, platelet-derived growth factor BB（PDGF-BB） and ascorbic acid（Vc） groups can promote cell migration compared with the control group. But the average migration distance was diminished in dexamethasone group. It can be concluded that this system can be used to analyze the process of wound healing.展开更多
The electroosmotic flow of a micropolar fluid in a microchannel bounded by two parallel porous plates undergoing periodic vibration is studied. The equations for conservation of linear and angular momentums and Gauss...The electroosmotic flow of a micropolar fluid in a microchannel bounded by two parallel porous plates undergoing periodic vibration is studied. The equations for conservation of linear and angular momentums and Gauss＇s law of charge distribution are solved within the framework of the Debye-Hückel approximation. The fluid velocity and microrotation are assumed to depend linearly on the Reynolds number. The study shows that the amplitude of microrotation is highly sensitive to the changes in the magnitude of the suction velocity and the width of the microchannel. An increase in the micropolar parameter gives rise to a decrease in the amplitude of microrotation. Numerical estimates reveal that the microrotation of the suspended microelements in blood also plays an important role in controlling the electro-osmotically actuated flow dynamics in microbio-fluidic devices.展开更多
The transports of the dynamic biochemical signals in the non-reversing pulsatile flows in the mixing microchannel of a Y-shaped microfluidic device are ana- lyzed. The results show that the mixing micro-channel acts a...The transports of the dynamic biochemical signals in the non-reversing pulsatile flows in the mixing microchannel of a Y-shaped microfluidic device are ana- lyzed. The results show that the mixing micro-channel acts as a low-pass filter, and the biochemical signals are nonlinearly modulated by the pulsatile flows, which depend on the biochemical signal frequency, the flow signal frequency, and the biochemical signal transporting distance. It is concluded that, the transfer characteristics of the dynamic biochemical signals, which are transported in the time-varying flows, should be carefully considered for better loading biochemical signals on the cells cultured on the bottom of the microfluidic channel.展开更多
This paper presents an analysis of dispersion of dynamic biochemical signals in steady flow in a shallow Y-type microfluidic channel. A method is presented to control the flow widths of two steady flows in the Y-type ...This paper presents an analysis of dispersion of dynamic biochemical signals in steady flow in a shallow Y-type microfluidic channel. A method is presented to control the flow widths of two steady flows in the Y-type microchannel from two inlets.The transfer function for the Y-type microchannel is given by solving the governing equation for the Taylor-Aris dispersion in the microchannel. The amplitude-frequency and phase-frequency relations are provided which show that a shallow Y-type microchannel acts as a low-pass filter. The transports of different dynamic biochemical signals are investigated. In comparison with a fully mixing microfluidic channel, the magnitudes of the dynamic signals at the outlets in a Y-type microchannel are much smaller than those in a fully mixing microchannel, which demonstrates that the amplitude attenuation in a Y-type microchannel is larger than that of a fully mixing microchannel due to the transverse molecular diffusion. In order to control the desired signal in a microchannel, the solution of the inverse problem for the channel is also presented.展开更多
We demonstrate a high-speed rotating slit beam shaping method for femtosecond(fs)laser three-dimensional(3D)isotropic inscription in glass materials.By integrating fs laser direct writing with a real-time rotating sli...We demonstrate a high-speed rotating slit beam shaping method for femtosecond(fs)laser three-dimensional(3D)isotropic inscription in glass materials.By integrating fs laser direct writing with a real-time rotating slit mechanism,a 3D symmetric spherical focal field distribution is created in the laser-irradiated regions of transparent substrates.The corresponding focal field distribution is theoretically calculated and validated by examining the features of laser-inscribed lines in glass samples.Moreover,we investigate the influences of laser writing speed and slit rotational speed on the fabrication resolution in glass,and discuss the formation mechanism of the generated periodic microstructures.To showcase its powerful capability for3D isotropic fabrication,the high-speed rotating slit beam shaping method is applied to create straight optical waveguides,bending optical waveguides,and hollow microchannels in the glass.The proposed method holds great potential for the facile manufacture of diverse 3D isotropic microstructures and devices within transparent materials across various applications,including advanced photonics,microoptics,micro-electromechanical systems,and microfluidics.展开更多
文摘In this paper, we combined magnetostatics and laminar flow in microfluidics and studied a particle separation scheme employing magnetophoretic force in inhomogeneous magnetic field. A detailed model and analysis is shown and the proposed scheme is capable of efficiently separating magnetic particles with different permeability and sizes. The method shows a way to separate efficient particles and could potentially be implemented in biological and chemical systems.
基金Supported by the National Natural Science Foundation of China(Nos.21071148,21175140)
文摘An approach was described to produce a wound area in vitro using laminar flow technique to selectively remove cells in micro fluidic channels. Cell migration which plays an important role in the process of wound healing can be observed dynamically by this method. In order to prove our system, we have studied its properties by injecting NIH-3T3 cells into main channel and added several reagents to observe the mediatory influence. The results reveal that fibroblast growth factor-2（FGF-2）, insulin-like growth factor 1（IGF-Ⅰ）, platelet-derived growth factor BB（PDGF-BB） and ascorbic acid（Vc） groups can promote cell migration compared with the control group. But the average migration distance was diminished in dexamethasone group. It can be concluded that this system can be used to analyze the process of wound healing.
文摘The electroosmotic flow of a micropolar fluid in a microchannel bounded by two parallel porous plates undergoing periodic vibration is studied. The equations for conservation of linear and angular momentums and Gauss＇s law of charge distribution are solved within the framework of the Debye-Hückel approximation. The fluid velocity and microrotation are assumed to depend linearly on the Reynolds number. The study shows that the amplitude of microrotation is highly sensitive to the changes in the magnitude of the suction velocity and the width of the microchannel. An increase in the micropolar parameter gives rise to a decrease in the amplitude of microrotation. Numerical estimates reveal that the microrotation of the suspended microelements in blood also plays an important role in controlling the electro-osmotically actuated flow dynamics in microbio-fluidic devices.
基金Project supported by the National Natural Science Foundation of China(Nos.11172060 and11672065)
文摘The transports of the dynamic biochemical signals in the non-reversing pulsatile flows in the mixing microchannel of a Y-shaped microfluidic device are ana- lyzed. The results show that the mixing micro-channel acts as a low-pass filter, and the biochemical signals are nonlinearly modulated by the pulsatile flows, which depend on the biochemical signal frequency, the flow signal frequency, and the biochemical signal transporting distance. It is concluded that, the transfer characteristics of the dynamic biochemical signals, which are transported in the time-varying flows, should be carefully considered for better loading biochemical signals on the cells cultured on the bottom of the microfluidic channel.
基金National Natural Science Foundation of Chinagrant number:11172060the Fundamental Research Funds for the Central Universities in China
文摘This paper presents an analysis of dispersion of dynamic biochemical signals in steady flow in a shallow Y-type microfluidic channel. A method is presented to control the flow widths of two steady flows in the Y-type microchannel from two inlets.The transfer function for the Y-type microchannel is given by solving the governing equation for the Taylor-Aris dispersion in the microchannel. The amplitude-frequency and phase-frequency relations are provided which show that a shallow Y-type microchannel acts as a low-pass filter. The transports of different dynamic biochemical signals are investigated. In comparison with a fully mixing microfluidic channel, the magnitudes of the dynamic signals at the outlets in a Y-type microchannel are much smaller than those in a fully mixing microchannel, which demonstrates that the amplitude attenuation in a Y-type microchannel is larger than that of a fully mixing microchannel due to the transverse molecular diffusion. In order to control the desired signal in a microchannel, the solution of the inverse problem for the channel is also presented.
基金supported by the National Key Research and Development Program of China(2022YFA1404800)National Natural Science Foundation of China(12174107,12004221,12192254,92250304,W2441005,12334014,12192251)+4 种基金Natural Science Foundation of Shandong Province(ZR2024QA024,ZR2021ZD02)Postdoctoral Innovation Talents Support Program of Shandong Province(No.SDBX2019005)Shanghai Municipal Science and Technology Major ProjectFundamental Research Funds for the Central UniversitiesEngineering Research Center for Nanophotonics&Advanced Instrument,Ministry of Education,East China Normal University(No.2023nmc005)。
文摘We demonstrate a high-speed rotating slit beam shaping method for femtosecond(fs)laser three-dimensional(3D)isotropic inscription in glass materials.By integrating fs laser direct writing with a real-time rotating slit mechanism,a 3D symmetric spherical focal field distribution is created in the laser-irradiated regions of transparent substrates.The corresponding focal field distribution is theoretically calculated and validated by examining the features of laser-inscribed lines in glass samples.Moreover,we investigate the influences of laser writing speed and slit rotational speed on the fabrication resolution in glass,and discuss the formation mechanism of the generated periodic microstructures.To showcase its powerful capability for3D isotropic fabrication,the high-speed rotating slit beam shaping method is applied to create straight optical waveguides,bending optical waveguides,and hollow microchannels in the glass.The proposed method holds great potential for the facile manufacture of diverse 3D isotropic microstructures and devices within transparent materials across various applications,including advanced photonics,microoptics,micro-electromechanical systems,and microfluidics.
