The objective of this work was to investigate the possibility of taper angle correction in cutting of complex micro-mechanical contours using a TruMicro ultra-short pulse laser in combination with the SCANLAB precSYS ...The objective of this work was to investigate the possibility of taper angle correction in cutting of complex micro-mechanical contours using a TruMicro ultra-short pulse laser in combination with the SCANLAB precSYS micro machining sub system. In a first step, the influence of the process parameters on the kerftaper angle of metallic alloys was systematically investigated without beam inclination. A set of base parameters was derived for the subsequent investigations. In a second step, the kerftaper angle was controlled by static beam inclination. In a third step, the same optics was used in its dynamic precession mode to fabricate micro-mechanical components of complex contours with perpendicular 0~ taper angles. It was found that taper angle adjustments of up to 7.5~ are possible with the used setup for cutting applications. Taper angle control is possible both in the static beam inclination mode and in the dynamic precession mode. The static mode could be interesting for contours with sharp inner radii and for achieving faster cutting times similar to results with fixed optics, but would require excellent synchronization of beam inclination and axis motion. The dynamic precession mode would allow an easier integration of the optics into a laser machine but will result in longer cutting times and limitations with respect to achievable inner radii.展开更多
The currently available compilation techniques are for general computing and are not optimized for physical layer computing in 5G micro base stations.In such cases,the foreseeable data sizes and small code size are ap...The currently available compilation techniques are for general computing and are not optimized for physical layer computing in 5G micro base stations.In such cases,the foreseeable data sizes and small code size are application specific opportunities for baseband algorithm optimizations.Therefore,the special attention can be paid,for example,the specific register allocation algorithm has not been studied so far.The compilation for kernel sub-routines of baseband in 5G micro base stations is our focusing point.For applications of known and fixed data size,we proposed a compilation scheme of parallel data accessing,while operands can be mainly allocated and stored in registers.Based on a small register group(48×32b),the target of our compilation scheme is the optimization of baseband algorithms based on 4×4 or smaller matrices,maximizing the utilization of register files,and eliminating the extra register data exchanging.Meanwhile,when data is allocated into register files,we used VLIW(Very Long Instruction Word)machine to hide the time of data accessing and minimize the cost of data accessing,thus the total execution time is minimum.Experiments indicate that for algorithms with small data size,the cost of data accessing and extra addressing can be minimized.展开更多
Osteoclastogenesis in alveolar bone induced by compression stress triggers orthodontic tooth movement.Compression stress also stimulates angiogenesis,which is essential for osteoclastogenesis.However,the effects of os...Osteoclastogenesis in alveolar bone induced by compression stress triggers orthodontic tooth movement.Compression stress also stimulates angiogenesis,which is essential for osteoclastogenesis.However,the effects of osteoclastogenesis induced by compression on angiogenesis are poorly understood.In vivo,we found the markers of angiogenesis increased during orthodontic bone remodeling.In vitro,osteoclast-derived exosomes increased proliferation,migration,and tube formation of human umbilical vein endothelial cells(HUVECs),as well as expression of vascular endothelial growth factor and CD31.The promotive effects of exosomes derived from compressed osteoclasts were greater than those derived from osteoclasts without compression.Next,we analyzed changes in the micro RNA transcriptome after compression stress and focused on micro RNA146 a-5 p(mi R-146 a),which was significantly decreased by compression.Transfection of an inhibitor of mi R-146 a stimulated angiogenesis of HUVECs while mi R-146 a mimics repressed angiogenesis.Adiponectin(ADP)was confirmed to be a target of mi R-146 a by dual luciferase reporter assay.In HUVECs treated with exosomes,we detected increased ADP which promoted angiogenesis.Knockdown of ADP in HUVECs reduced the promotive effects of exosomes.Our results demonstrate that the decreased mi R-146 a observed in osteoclasts after compression promotes angiogenesis by targeting ADP,suggesting a novel method to interfere with bone remodeling induced by compression stress.展开更多
文摘The objective of this work was to investigate the possibility of taper angle correction in cutting of complex micro-mechanical contours using a TruMicro ultra-short pulse laser in combination with the SCANLAB precSYS micro machining sub system. In a first step, the influence of the process parameters on the kerftaper angle of metallic alloys was systematically investigated without beam inclination. A set of base parameters was derived for the subsequent investigations. In a second step, the kerftaper angle was controlled by static beam inclination. In a third step, the same optics was used in its dynamic precession mode to fabricate micro-mechanical components of complex contours with perpendicular 0~ taper angles. It was found that taper angle adjustments of up to 7.5~ are possible with the used setup for cutting applications. Taper angle control is possible both in the static beam inclination mode and in the dynamic precession mode. The static mode could be interesting for contours with sharp inner radii and for achieving faster cutting times similar to results with fixed optics, but would require excellent synchronization of beam inclination and axis motion. The dynamic precession mode would allow an easier integration of the optics into a laser machine but will result in longer cutting times and limitations with respect to achievable inner radii.
基金supported by the research funding KYQD(ZR)1974 from Hainan University.
文摘The currently available compilation techniques are for general computing and are not optimized for physical layer computing in 5G micro base stations.In such cases,the foreseeable data sizes and small code size are application specific opportunities for baseband algorithm optimizations.Therefore,the special attention can be paid,for example,the specific register allocation algorithm has not been studied so far.The compilation for kernel sub-routines of baseband in 5G micro base stations is our focusing point.For applications of known and fixed data size,we proposed a compilation scheme of parallel data accessing,while operands can be mainly allocated and stored in registers.Based on a small register group(48×32b),the target of our compilation scheme is the optimization of baseband algorithms based on 4×4 or smaller matrices,maximizing the utilization of register files,and eliminating the extra register data exchanging.Meanwhile,when data is allocated into register files,we used VLIW(Very Long Instruction Word)machine to hide the time of data accessing and minimize the cost of data accessing,thus the total execution time is minimum.Experiments indicate that for algorithms with small data size,the cost of data accessing and extra addressing can be minimized.
基金financially supported by grants from the National Natural Science Foundation of China(81700938,81670957)。
文摘Osteoclastogenesis in alveolar bone induced by compression stress triggers orthodontic tooth movement.Compression stress also stimulates angiogenesis,which is essential for osteoclastogenesis.However,the effects of osteoclastogenesis induced by compression on angiogenesis are poorly understood.In vivo,we found the markers of angiogenesis increased during orthodontic bone remodeling.In vitro,osteoclast-derived exosomes increased proliferation,migration,and tube formation of human umbilical vein endothelial cells(HUVECs),as well as expression of vascular endothelial growth factor and CD31.The promotive effects of exosomes derived from compressed osteoclasts were greater than those derived from osteoclasts without compression.Next,we analyzed changes in the micro RNA transcriptome after compression stress and focused on micro RNA146 a-5 p(mi R-146 a),which was significantly decreased by compression.Transfection of an inhibitor of mi R-146 a stimulated angiogenesis of HUVECs while mi R-146 a mimics repressed angiogenesis.Adiponectin(ADP)was confirmed to be a target of mi R-146 a by dual luciferase reporter assay.In HUVECs treated with exosomes,we detected increased ADP which promoted angiogenesis.Knockdown of ADP in HUVECs reduced the promotive effects of exosomes.Our results demonstrate that the decreased mi R-146 a observed in osteoclasts after compression promotes angiogenesis by targeting ADP,suggesting a novel method to interfere with bone remodeling induced by compression stress.
