After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the tim...After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the timing of interventions,combined with the limitations of current methods.To address these challenges,various techniques have been developed to aid in the repair and reconstruction of neural circuits at different stages of injury.Notably,neuromodulation has garnered considerable attention for its potential to enhance nerve regeneration,provide neuroprotection,restore neurons,and regulate the neural reorganization of circuits within the cerebral cortex and corticospinal tract.To improve the effectiveness of these interventions,the implementation of multitarget early interventional neuromodulation strategies,such as electrical and magnetic stimulation,is recommended to enhance functional recovery across different phases of nerve injury.This review concisely outlines the challenges encountered following spinal cord injury,synthesizes existing neurostimulation techniques while emphasizing neuroprotection,repair,and regeneration of impaired connections,and advocates for multi-targeted,task-oriented,and timely interventions.展开更多
Epilepsy,a common neurological disorder,is characterized by recurrent seizures that can lead to cognitive,psychological,and neurobiological consequences.The pathogenesis of epilepsy involves neuronal dysfunction at th...Epilepsy,a common neurological disorder,is characterized by recurrent seizures that can lead to cognitive,psychological,and neurobiological consequences.The pathogenesis of epilepsy involves neuronal dysfunction at the molecular,cellular,and neural circuit levels.Abnormal molecular signaling pathways or dysfunction of specific cell types can lead to epilepsy by disrupting the normal functioning of neural circuits.The continuous emergence of new technologies and the rapid advancement of existing ones have facilitated the discovery and comprehensive understanding of the neural circuit mechanisms underlying epilepsy.Therefore,this review aims to investigate the current understanding of the neural circuit mechanisms in epilepsy based on various technologies,including electroencephalography,magnetic resonance imaging,optogenetics,chemogenetics,deep brain stimulation,and brain-computer interfaces.Additionally,this review discusses these mechanisms from three perspectives:structural,synaptic,and transmitter circuits.The findings reveal that the neural circuit mechanisms of epilepsy encompass information transmission among different structures,interactions within the same structure,and the maintenance of homeostasis at the cellular,synaptic,and neurotransmitter levels.These findings offer new insights for investigating the pathophysiological mechanisms of epilepsy and enhancing its clinical diagnosis and treatment.展开更多
Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after inju...Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury,which limits the ability to observe long-term behavioral recovery.Here,we used a severe stroke rat model with 150 minutes of ischemia,which produced severe behavioral deficiencies that persisted at 12 weeks,to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function,reduced infarction volume,long-term human neural stem cell survival,and improved local inflammatory environment and angiogenesis.We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo,formed stable functional synaptic connections with host neurons,and exhibited the electrophysiological properties of functional mature neurons,indicating that they replaced the damaged host neurons.The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke,which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients.展开更多
A general industrial CCD( ICCD) camera is redesigned to detect the weld pool without arc at the period of short circuiting, so that the interference of arc and spatter during CO2 short circuiting arc welding is elim...A general industrial CCD( ICCD) camera is redesigned to detect the weld pool without arc at the period of short circuiting, so that the interference of arc and spatter during CO2 short circuiting arc welding is eliminated. Through the analysis of weld pool image, both size parameters (such as weld pool area A, weld pool length L1, L2 and weld pool breadth b) and contour parameters (b, which describe the curves of weld pool boundany) ,which could indicate the shape features of weld pool, had been defined to express weld pool information quantitatively. The investigation of the relationships between weld pool shape parameters and welding process parameters may be beneficial to the quality control of CO2 welding.展开更多
Aim at improving the stability of the Short-circuiting Gas Metal Arc Welding （GMAW-S） process for the enhanced speed usage, effects of current waveform parameters during short-term on the welding stability have been...Aim at improving the stability of the Short-circuiting Gas Metal Arc Welding （GMAW-S） process for the enhanced speed usage, effects of current waveform parameters during short-term on the welding stability have been investigated by experimental method. The welding power source used for the research is an inverter with a special current waveform control. It is shown that the spatter decreases at first then increases with each increase of the low current period, current increase rate and the maximum current limit. The test results are provided for welding of 1 mm and 3 mm mild steel at speed of 1.2 m/min. The stable GMA W-S process under high speed welding condition has been achieved by optimizing the parameters.展开更多
A new simulation model of CO 2 short circuiting transfer welding may be employed to develop a new pattern of welding machine and to predict welding process parameters to obtain the optimum welding technology propert...A new simulation model of CO 2 short circuiting transfer welding may be employed to develop a new pattern of welding machine and to predict welding process parameters to obtain the optimum welding technology properties. In this paper, a new simulating model is developed according to the AWP (adapting welding physics process) waveform control method. Good agreement is shown between the predicted and experimentally determined results. The model will make an important promotion in the development of CO 2 arc welding technique.展开更多
Depressive disorder is a chronic,recurring,and potentially life-endangering neuropsychiatric disease.According to a report by the World Health Organization,the global population suffering from depression is experienci...Depressive disorder is a chronic,recurring,and potentially life-endangering neuropsychiatric disease.According to a report by the World Health Organization,the global population suffering from depression is experiencing a significant annual increase.Despite its prevalence and considerable impact on people,little is known about its pathogenesis.One major reason is the scarcity of reliable animal models due to the absence of consensus on the pathology and etiology of depression.Furthermore,the neural circuit mechanism of depression induced by various factors is particularly complex.Considering the variability in depressive behavior patterns and neurobiological mechanisms among different animal models of depression,a comparison between the neural circuits of depression induced by various factors is essential for its treatment.In this review,we mainly summarize the most widely used behavioral animal models and neural circuits under different triggers of depression,aiming to provide a theoretical basis for depression prevention.展开更多
Based on the phase space reconstruction of welding current in short-circuiting transfer arc welding under carbon dioxide, the approximate entropy of welding current and its standard deviation have been calculated and ...Based on the phase space reconstruction of welding current in short-circuiting transfer arc welding under carbon dioxide, the approximate entropy of welding current and its standard deviation have been calculated and analyzed at different welding speeds and different electrode extensions respectively. The experimental and calculated results show that at a certain arc voltage, wire feeding rate and gas flow rate, welding speed and electrode extension have significant effects not only on the approximate entropy of welding current, but also on the stability of welding process. Further analysis proves that when the welding speed and electrode extension are in an appropriate range respectively, the welding current approximate entropy attains maximum and its standard deviation minimum. Just under such circumstances, the welding process is in the most stable state.展开更多
Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse functi...Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse function.We have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine morphogenesis.To investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing chow.We found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection neurons.These findings are further corroborated by increased synaptic activity and transient generation of immature silent synapses.Prolonged MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and connectivity.Our data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult brain.These findings may have implications for regenerative therapy in aging and neurodegeneration conditions.展开更多
The rise of large-scale artificial intelligence(AI)models,such as ChatGPT,Deep-Seek,and autonomous vehicle systems,has significantly advanced the boundaries of AI,enabling highly complex tasks in natural language proc...The rise of large-scale artificial intelligence(AI)models,such as ChatGPT,Deep-Seek,and autonomous vehicle systems,has significantly advanced the boundaries of AI,enabling highly complex tasks in natural language processing,image recognition,and real-time decisionmaking.However,these models demand immense computational power and are often centralized,relying on cloud-based architectures with inherent limitations in latency,privacy,and energy efficiency.To address these challenges and bring AI closer to real-world applications,such as wearable health monitoring,robotics,and immersive virtual environments,innovative hardware solutions are urgently needed.This work introduces a near-sensor edge computing(NSEC)system,built on a bilayer AlN/Si waveguide platform,to provide real-time,energy-efficient AI capabilities at the edge.Leveraging the electro-optic properties of AlN microring resonators for photonic feature extraction,coupled with Si-based thermo-optic Mach-Zehnder interferometers for neural network computations,the system represents a transformative approach to AI hardware design.Demonstrated through multimodal gesture and gait analysis,the NSEC system achieves high classification accuracies of 96.77%for gestures and 98.31%for gaits,ultra-low latency(<10 ns),and minimal energy consumption(<0.34 pJ).This groundbreaking system bridges the gap between AI models and real-world applications,enabling efficient,privacy-preserving AI solutions for healthcare,robotics,and next-generation human-machine interfaces,marking a pivotal advancement in edge computing and AI deployment.展开更多
In a pulsed plasma thruster,the voltage distribution between the electrodes is a key factor that influences the ionization process.However,few researchers have conducted in-depth studies of this phenomenon in the past...In a pulsed plasma thruster,the voltage distribution between the electrodes is a key factor that influences the ionization process.However,few researchers have conducted in-depth studies of this phenomenon in the past.Reported here are measurements of the voltage distribution between the plates of a parallel-plate pulsed plasma thruster under different discharge voltages,based on which the variations in the total circuit inductance and resistance as well as those between the plates are calculated.The results show that the time-averaged voltage across the plates accounts for 28.7%-50.4%of the capacitor voltage.As the capacitor initial voltage increases from 1250 V to 2000 V,the voltage across the plates rises,but its proportion relative to the capacitor voltage decreases.For every 250 V increase in the capacitor initial voltage,the average voltage proportion across the plates decreases by approximately 2%-3%.Additionally,the voltage proportion decreases gradually from the end near the propellant outward.The voltage distribution ratio between the plates is correlated with the proportions of the resistance and inductance between the plates relative to the total circuit.展开更多
In this paper,we propose an RLC equivalent circuit model theory which can accurately predict the spectral response and resonance characteristics of metamaterial absorption structures,extend its design,and characterize...In this paper,we propose an RLC equivalent circuit model theory which can accurately predict the spectral response and resonance characteristics of metamaterial absorption structures,extend its design,and characterize the parameters of the model in detail.By employing this model,we conducted computations to characterize the response wavelength and bandwidth of variously sized metamaterial absorbers.A comparative analysis with Finite Difference Time Domain(FDTD)simulations demonstrated a remarkable level of consistency in the results.The designed absorbers were fabricated using micro-nano fabrication processes,and were experimentally tested to demonstrate absorption rates exceeding 90%at a wavelength of 9.28μm.The predicted results are then compared with test results.The comparison reveals good consistency in two aspects of the resonance responses,thereby confirming the rationality and accuracy of this model.展开更多
The advent of Grover’s algorithm presents a significant threat to classical block cipher security,spurring research into post-quantum secure cipher design.This study engineers quantum circuit implementations for thre...The advent of Grover’s algorithm presents a significant threat to classical block cipher security,spurring research into post-quantum secure cipher design.This study engineers quantum circuit implementations for three versions of the Ballet family block ciphers.The Ballet‑p/k includes a modular-addition operation uncommon in lightweight block ciphers.Quantum ripple-carry adder is implemented for both“32+32”and“64+64”scale to support this operation.Subsequently,qubits,quantum gates count,and quantum circuit depth of three versions of Ballet algorithm are systematically evaluated under quantum computing model,and key recovery attack circuits are constructed based on Grover’s algorithm against each version.The comprehensive analysis shows:Ballet-128/128 fails to NIST Level 1 security,while when the resource accounting is restricted to the Clifford gates and T gates set for the Ballet-128/256 and Ballet-256/256 quantum circuits,the design attains Level 3.展开更多
With the rapid development of Internet technology,the application of electronic circuit simulation technology is more and more extensive,and now it has been applied to integrated circuit design.Because the electronic ...With the rapid development of Internet technology,the application of electronic circuit simulation technology is more and more extensive,and now it has been applied to integrated circuit design.Because the electronic circuit simulation technology has high efficiency,flexible and simple application,as well as stable performance,it has shown more and more good application prospects in integrated circuit design.Based on the strong development trend of electronic circuit simulation technology,it will be more and more widely used in daily life in the future,so the research on electronic circuit simulation technology is more and more in-depth.In this paper,the application of electronic circuit technology in integrated circuit design is studied,hoping that the technology can provide a more concise and efficient research and development way for electronic applications.展开更多
This Special Topic of the Journal of Semiconductors(JOS)features expanded versions of key articles presented at the 2024 IEEE International Conference on Integrated Circuits Technologies and Applications(ICTA),which w...This Special Topic of the Journal of Semiconductors(JOS)features expanded versions of key articles presented at the 2024 IEEE International Conference on Integrated Circuits Technologies and Applications(ICTA),which was held in Hangzhou,Zhejiang,China,from October 25 to 27,2024.展开更多
A simulation model is introduced about the non-linearity process of short-circuiting transfer in CO2 arc welding for displaying the interaction between the inverter power source and welding arc under waveform control....A simulation model is introduced about the non-linearity process of short-circuiting transfer in CO2 arc welding for displaying the interaction between the inverter power source and welding arc under waveform control. In the simulation model, the feedback signals of current and voltage are taken respectively at the different phase in a short circuit periodic time and applied to the PWM （pulse width modulation） module in a model of inverter power source to control the output of power source. The simulation operation about the dynamic process of CO2 short-circuiting transfer welding is implemented on the founded simulation model with a peak arc current of 400 A and a peak voltage of 35 V, producing the dynamic arc waveforms which can embody the effect of inverter harmonic wave. The simulating waveforms are close to that of welding experiments.展开更多
Quantum circuit fidelity is a crucial metric for assessing the accuracy of quantum computation results and indicating the precision of quantum algorithm execution. The primary methods for assessing quantum circuit fid...Quantum circuit fidelity is a crucial metric for assessing the accuracy of quantum computation results and indicating the precision of quantum algorithm execution. The primary methods for assessing quantum circuit fidelity include direct fidelity estimation and mirror circuit fidelity estimation. The former is challenging to implement in practice, while the latter requires substantial classical computational resources and numerous experimental runs. In this paper, we propose a fidelity estimation method based on Layer Interleaved Randomized Benchmarking, which decomposes a complex quantum circuit into multiple sublayers. By independently evaluating the fidelity of each layer, one can comprehensively assess the performance of the entire quantum circuit. This layered evaluation strategy not only enhances accuracy but also effectively identifies and analyzes errors in specific quantum gates or qubits through independent layer evaluation. Simulation results demonstrate that the proposed method improves circuit fidelity by an average of 6.8% and 4.1% compared to Layer Randomized Benchmarking and Interleaved Randomized Benchmarking methods in a thermal relaxation noise environment, and by 40% compared to Layer RB in a bit-flip noise environment. Moreover, the method detects preset faulty quantum gates in circuits generated by the Munich Quantum Toolkit Benchmark, verifying the model’s validity and providing a new tool for faulty gate detection in quantum circuits.展开更多
Memristor chaotic research has become a hotspot in the academic world.However,there is little exploration combining memristor and stochastic resonance,and the correlation research between chaos and stochastic resonanc...Memristor chaotic research has become a hotspot in the academic world.However,there is little exploration combining memristor and stochastic resonance,and the correlation research between chaos and stochastic resonance is still in the preliminary stage.In this paper,we focus on the stochastic resonance induced by memristor chaos,which enhances the dynamics of chaotic systems through the introduction of memristor and induces memristor stochastic resonance under certain conditions.First,the memristor chaos model is constructed,and the memristor stochastic resonance model is constructed by adjusting the parameters of the memristor chaos model.Second,the combination of dynamic analysis and experimental verification is used to analyze the memristor stochastic resonance and to investigate the trend of the output signal of the system under different amplitudes of the input signal.Finally,the practicality and reliability of the constructed model are further verified through the design and testing of the analog circuit,which provides strong support for the practical application of the memristor chaos-induced stochastic resonance model.展开更多
Micro-short dramas have created a context for the international communication of China’s fine traditional culture,addressing“what to say,”“how to say it,”and“why to say it.”However,a systematic path for interna...Micro-short dramas have created a context for the international communication of China’s fine traditional culture,addressing“what to say,”“how to say it,”and“why to say it.”However,a systematic path for international cultural communication has yet to be established.By taking micro-short dramas as a medium and drawing on a three-tier cultural dimensional elevation model of“symbol cognition-narrative circulation-cultural identity,”this paper explores the natural internalization process from symbol cognition to cultural identity among audiences during the international communication of China’s fine traditional culture.Research shows that micro-short dramas have established a cultural cognitive interface for international audiences through the innovative use of symbols related to China’s fine traditional culture.The use of internet-based narratives has enabled cross-contextual reinterpretation and emotional resonance of China’s fine traditional culture.Furthermore,integration and reconstruction have facilitated cultural identity among international audiences regarding China’s fine traditional culture.The interplay of these three aspects forms a three-tier path for cultural dimensional elevation in the international communication of China’s fine traditional culture through micro-short dramas.This path can effectively reduce cultural discount and contribute to the paradigm shift of China’s fine traditional culture from geographical expansion to cultural identity.展开更多
Strand displacement-based DNA circuits have emerged as highly effective tools for molecular computation,serving purposes of amplification or decision-making.They are favored for their inherent occurrence and sensitivi...Strand displacement-based DNA circuits have emerged as highly effective tools for molecular computation,serving purposes of amplification or decision-making.They are favored for their inherent occurrence and sensitivity to external conditions.However,achieving enhanced amplification or decision-making necessitates the incorporation of multiple strands,thereby increasing the risk of contamination.Recent advancements have led to the development of CRISPR-Cas-based DNA circuits.These systems aim to simplify the complexity associated with conventional circuits,mitigate contamination risks,and enable more substantial amplification or decision-making capabilities.Here,the review article centers on current strategies of CRISPR-Cas(Cas9,Cas12a,Cas13a)system-assisted circuits in amplification and decisionmaking,and assesses their tendencies and limitations in amplification circuits and decision-making circuits.Furthermore,we discuss the challenges of CRISPR-Cas in circuits and propose prospects that will contribute to constructing more efficient and diverse CRISPR-Cas-based DNA functional circuits.展开更多
基金supported by the National Key Research and Development Program of China,No.2023YFC3603705(to DX)the National Natural Science Foundation of China,No.82302866(to YZ).
文摘After spinal cord injury,impairment of the sensorimotor circuit can lead to dysfunction in the motor,sensory,proprioceptive,and autonomic nervous systems.Functional recovery is often hindered by constraints on the timing of interventions,combined with the limitations of current methods.To address these challenges,various techniques have been developed to aid in the repair and reconstruction of neural circuits at different stages of injury.Notably,neuromodulation has garnered considerable attention for its potential to enhance nerve regeneration,provide neuroprotection,restore neurons,and regulate the neural reorganization of circuits within the cerebral cortex and corticospinal tract.To improve the effectiveness of these interventions,the implementation of multitarget early interventional neuromodulation strategies,such as electrical and magnetic stimulation,is recommended to enhance functional recovery across different phases of nerve injury.This review concisely outlines the challenges encountered following spinal cord injury,synthesizes existing neurostimulation techniques while emphasizing neuroprotection,repair,and regeneration of impaired connections,and advocates for multi-targeted,task-oriented,and timely interventions.
基金supported by Basic Research Programs of Science and Technology Commission Foundation of Shanxi Province,No.20210302123486(to WJ).
文摘Epilepsy,a common neurological disorder,is characterized by recurrent seizures that can lead to cognitive,psychological,and neurobiological consequences.The pathogenesis of epilepsy involves neuronal dysfunction at the molecular,cellular,and neural circuit levels.Abnormal molecular signaling pathways or dysfunction of specific cell types can lead to epilepsy by disrupting the normal functioning of neural circuits.The continuous emergence of new technologies and the rapid advancement of existing ones have facilitated the discovery and comprehensive understanding of the neural circuit mechanisms underlying epilepsy.Therefore,this review aims to investigate the current understanding of the neural circuit mechanisms in epilepsy based on various technologies,including electroencephalography,magnetic resonance imaging,optogenetics,chemogenetics,deep brain stimulation,and brain-computer interfaces.Additionally,this review discusses these mechanisms from three perspectives:structural,synaptic,and transmitter circuits.The findings reveal that the neural circuit mechanisms of epilepsy encompass information transmission among different structures,interactions within the same structure,and the maintenance of homeostasis at the cellular,synaptic,and neurotransmitter levels.These findings offer new insights for investigating the pathophysiological mechanisms of epilepsy and enhancing its clinical diagnosis and treatment.
文摘Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury,which limits the ability to observe long-term behavioral recovery.Here,we used a severe stroke rat model with 150 minutes of ischemia,which produced severe behavioral deficiencies that persisted at 12 weeks,to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function,reduced infarction volume,long-term human neural stem cell survival,and improved local inflammatory environment and angiogenesis.We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo,formed stable functional synaptic connections with host neurons,and exhibited the electrophysiological properties of functional mature neurons,indicating that they replaced the damaged host neurons.The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke,which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients.
基金This project is supported by National 863 project( No.412-9913-02)and National Natural Science Foundation of China(No.599750
文摘A general industrial CCD( ICCD) camera is redesigned to detect the weld pool without arc at the period of short circuiting, so that the interference of arc and spatter during CO2 short circuiting arc welding is eliminated. Through the analysis of weld pool image, both size parameters (such as weld pool area A, weld pool length L1, L2 and weld pool breadth b) and contour parameters (b, which describe the curves of weld pool boundany) ,which could indicate the shape features of weld pool, had been defined to express weld pool information quantitatively. The investigation of the relationships between weld pool shape parameters and welding process parameters may be beneficial to the quality control of CO2 welding.
文摘Aim at improving the stability of the Short-circuiting Gas Metal Arc Welding （GMAW-S） process for the enhanced speed usage, effects of current waveform parameters during short-term on the welding stability have been investigated by experimental method. The welding power source used for the research is an inverter with a special current waveform control. It is shown that the spatter decreases at first then increases with each increase of the low current period, current increase rate and the maximum current limit. The test results are provided for welding of 1 mm and 3 mm mild steel at speed of 1.2 m/min. The stable GMA W-S process under high speed welding condition has been achieved by optimizing the parameters.
基金ThisresearchissupportedbytheNationalNatureScienceFoundation (No .5 9975068)andTianjinNatureScienceFoundation (No .993 60 2 911)
文摘A new simulation model of CO 2 short circuiting transfer welding may be employed to develop a new pattern of welding machine and to predict welding process parameters to obtain the optimum welding technology properties. In this paper, a new simulating model is developed according to the AWP (adapting welding physics process) waveform control method. Good agreement is shown between the predicted and experimentally determined results. The model will make an important promotion in the development of CO 2 arc welding technique.
基金supported by the Brain&Behavior Research Foundation(30233).
文摘Depressive disorder is a chronic,recurring,and potentially life-endangering neuropsychiatric disease.According to a report by the World Health Organization,the global population suffering from depression is experiencing a significant annual increase.Despite its prevalence and considerable impact on people,little is known about its pathogenesis.One major reason is the scarcity of reliable animal models due to the absence of consensus on the pathology and etiology of depression.Furthermore,the neural circuit mechanism of depression induced by various factors is particularly complex.Considering the variability in depressive behavior patterns and neurobiological mechanisms among different animal models of depression,a comparison between the neural circuits of depression induced by various factors is essential for its treatment.In this review,we mainly summarize the most widely used behavioral animal models and neural circuits under different triggers of depression,aiming to provide a theoretical basis for depression prevention.
基金Supported by Project of the National Natural Science Foundation of China(50375053,50575077)
文摘Based on the phase space reconstruction of welding current in short-circuiting transfer arc welding under carbon dioxide, the approximate entropy of welding current and its standard deviation have been calculated and analyzed at different welding speeds and different electrode extensions respectively. The experimental and calculated results show that at a certain arc voltage, wire feeding rate and gas flow rate, welding speed and electrode extension have significant effects not only on the approximate entropy of welding current, but also on the stability of welding process. Further analysis proves that when the welding speed and electrode extension are in an appropriate range respectively, the welding current approximate entropy attains maximum and its standard deviation minimum. Just under such circumstances, the welding process is in the most stable state.
基金supported by NIH/NIMH grant R01MH111619(to SQ),R21AG078700(to SQ)Institute of Mental Health Research(IMHR,Level 1 funding,to SQ and DF)institution startup fund from The University of Arizona(to SQ)。
文摘Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse function.We have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine morphogenesis.To investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing chow.We found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection neurons.These findings are further corroborated by increased synaptic activity and transient generation of immature silent synapses.Prolonged MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and connectivity.Our data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult brain.These findings may have implications for regenerative therapy in aging and neurodegeneration conditions.
基金the National Research Foundation(NRF)Singapore mid-sized center grant(NRF-MSG-2023-0002)FrontierCRP grant(NRF-F-CRP-2024-0006)+2 种基金A*STAR Singapore MTC RIE2025 project(M24W1NS005)IAF-PP project(M23M5a0069)Ministry of Education(MOE)Singapore Tier 2 project(MOE-T2EP50220-0014).
文摘The rise of large-scale artificial intelligence(AI)models,such as ChatGPT,Deep-Seek,and autonomous vehicle systems,has significantly advanced the boundaries of AI,enabling highly complex tasks in natural language processing,image recognition,and real-time decisionmaking.However,these models demand immense computational power and are often centralized,relying on cloud-based architectures with inherent limitations in latency,privacy,and energy efficiency.To address these challenges and bring AI closer to real-world applications,such as wearable health monitoring,robotics,and immersive virtual environments,innovative hardware solutions are urgently needed.This work introduces a near-sensor edge computing(NSEC)system,built on a bilayer AlN/Si waveguide platform,to provide real-time,energy-efficient AI capabilities at the edge.Leveraging the electro-optic properties of AlN microring resonators for photonic feature extraction,coupled with Si-based thermo-optic Mach-Zehnder interferometers for neural network computations,the system represents a transformative approach to AI hardware design.Demonstrated through multimodal gesture and gait analysis,the NSEC system achieves high classification accuracies of 96.77%for gestures and 98.31%for gaits,ultra-low latency(<10 ns),and minimal energy consumption(<0.34 pJ).This groundbreaking system bridges the gap between AI models and real-world applications,enabling efficient,privacy-preserving AI solutions for healthcare,robotics,and next-generation human-machine interfaces,marking a pivotal advancement in edge computing and AI deployment.
基金supported by the Beijing Natural Science Foundation(No.QY24166).
文摘In a pulsed plasma thruster,the voltage distribution between the electrodes is a key factor that influences the ionization process.However,few researchers have conducted in-depth studies of this phenomenon in the past.Reported here are measurements of the voltage distribution between the plates of a parallel-plate pulsed plasma thruster under different discharge voltages,based on which the variations in the total circuit inductance and resistance as well as those between the plates are calculated.The results show that the time-averaged voltage across the plates accounts for 28.7%-50.4%of the capacitor voltage.As the capacitor initial voltage increases from 1250 V to 2000 V,the voltage across the plates rises,but its proportion relative to the capacitor voltage decreases.For every 250 V increase in the capacitor initial voltage,the average voltage proportion across the plates decreases by approximately 2%-3%.Additionally,the voltage proportion decreases gradually from the end near the propellant outward.The voltage distribution ratio between the plates is correlated with the proportions of the resistance and inductance between the plates relative to the total circuit.
基金Supported by the National Natural Science Foundation of China(62174092)the Open Fund of State Key Laboratory of Infrared Physics(SITP-NLIST-ZD-2023-04)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0580000)。
文摘In this paper,we propose an RLC equivalent circuit model theory which can accurately predict the spectral response and resonance characteristics of metamaterial absorption structures,extend its design,and characterize the parameters of the model in detail.By employing this model,we conducted computations to characterize the response wavelength and bandwidth of variously sized metamaterial absorbers.A comparative analysis with Finite Difference Time Domain(FDTD)simulations demonstrated a remarkable level of consistency in the results.The designed absorbers were fabricated using micro-nano fabrication processes,and were experimentally tested to demonstrate absorption rates exceeding 90%at a wavelength of 9.28μm.The predicted results are then compared with test results.The comparison reveals good consistency in two aspects of the resonance responses,thereby confirming the rationality and accuracy of this model.
基金State Key Lab of Processors,Institute of Computing Technology,Chinese Academy of Sciences(CLQ202516)the Fundamental Research Funds for the Central Universities of China(3282025047,3282024051,3282024009)。
文摘The advent of Grover’s algorithm presents a significant threat to classical block cipher security,spurring research into post-quantum secure cipher design.This study engineers quantum circuit implementations for three versions of the Ballet family block ciphers.The Ballet‑p/k includes a modular-addition operation uncommon in lightweight block ciphers.Quantum ripple-carry adder is implemented for both“32+32”and“64+64”scale to support this operation.Subsequently,qubits,quantum gates count,and quantum circuit depth of three versions of Ballet algorithm are systematically evaluated under quantum computing model,and key recovery attack circuits are constructed based on Grover’s algorithm against each version.The comprehensive analysis shows:Ballet-128/128 fails to NIST Level 1 security,while when the resource accounting is restricted to the Clifford gates and T gates set for the Ballet-128/256 and Ballet-256/256 quantum circuits,the design attains Level 3.
文摘With the rapid development of Internet technology,the application of electronic circuit simulation technology is more and more extensive,and now it has been applied to integrated circuit design.Because the electronic circuit simulation technology has high efficiency,flexible and simple application,as well as stable performance,it has shown more and more good application prospects in integrated circuit design.Based on the strong development trend of electronic circuit simulation technology,it will be more and more widely used in daily life in the future,so the research on electronic circuit simulation technology is more and more in-depth.In this paper,the application of electronic circuit technology in integrated circuit design is studied,hoping that the technology can provide a more concise and efficient research and development way for electronic applications.
文摘This Special Topic of the Journal of Semiconductors(JOS)features expanded versions of key articles presented at the 2024 IEEE International Conference on Integrated Circuits Technologies and Applications(ICTA),which was held in Hangzhou,Zhejiang,China,from October 25 to 27,2024.
基金Supported by National Natural Science Foundation of China ( No59975068)Natural Science Foundation of Tianjin ( No993602911)
文摘A simulation model is introduced about the non-linearity process of short-circuiting transfer in CO2 arc welding for displaying the interaction between the inverter power source and welding arc under waveform control. In the simulation model, the feedback signals of current and voltage are taken respectively at the different phase in a short circuit periodic time and applied to the PWM （pulse width modulation） module in a model of inverter power source to control the output of power source. The simulation operation about the dynamic process of CO2 short-circuiting transfer welding is implemented on the founded simulation model with a peak arc current of 400 A and a peak voltage of 35 V, producing the dynamic arc waveforms which can embody the effect of inverter harmonic wave. The simulating waveforms are close to that of welding experiments.
文摘Quantum circuit fidelity is a crucial metric for assessing the accuracy of quantum computation results and indicating the precision of quantum algorithm execution. The primary methods for assessing quantum circuit fidelity include direct fidelity estimation and mirror circuit fidelity estimation. The former is challenging to implement in practice, while the latter requires substantial classical computational resources and numerous experimental runs. In this paper, we propose a fidelity estimation method based on Layer Interleaved Randomized Benchmarking, which decomposes a complex quantum circuit into multiple sublayers. By independently evaluating the fidelity of each layer, one can comprehensively assess the performance of the entire quantum circuit. This layered evaluation strategy not only enhances accuracy but also effectively identifies and analyzes errors in specific quantum gates or qubits through independent layer evaluation. Simulation results demonstrate that the proposed method improves circuit fidelity by an average of 6.8% and 4.1% compared to Layer Randomized Benchmarking and Interleaved Randomized Benchmarking methods in a thermal relaxation noise environment, and by 40% compared to Layer RB in a bit-flip noise environment. Moreover, the method detects preset faulty quantum gates in circuits generated by the Munich Quantum Toolkit Benchmark, verifying the model’s validity and providing a new tool for faulty gate detection in quantum circuits.
文摘Memristor chaotic research has become a hotspot in the academic world.However,there is little exploration combining memristor and stochastic resonance,and the correlation research between chaos and stochastic resonance is still in the preliminary stage.In this paper,we focus on the stochastic resonance induced by memristor chaos,which enhances the dynamics of chaotic systems through the introduction of memristor and induces memristor stochastic resonance under certain conditions.First,the memristor chaos model is constructed,and the memristor stochastic resonance model is constructed by adjusting the parameters of the memristor chaos model.Second,the combination of dynamic analysis and experimental verification is used to analyze the memristor stochastic resonance and to investigate the trend of the output signal of the system under different amplitudes of the input signal.Finally,the practicality and reliability of the constructed model are further verified through the design and testing of the analog circuit,which provides strong support for the practical application of the memristor chaos-induced stochastic resonance model.
文摘Micro-short dramas have created a context for the international communication of China’s fine traditional culture,addressing“what to say,”“how to say it,”and“why to say it.”However,a systematic path for international cultural communication has yet to be established.By taking micro-short dramas as a medium and drawing on a three-tier cultural dimensional elevation model of“symbol cognition-narrative circulation-cultural identity,”this paper explores the natural internalization process from symbol cognition to cultural identity among audiences during the international communication of China’s fine traditional culture.Research shows that micro-short dramas have established a cultural cognitive interface for international audiences through the innovative use of symbols related to China’s fine traditional culture.The use of internet-based narratives has enabled cross-contextual reinterpretation and emotional resonance of China’s fine traditional culture.Furthermore,integration and reconstruction have facilitated cultural identity among international audiences regarding China’s fine traditional culture.The interplay of these three aspects forms a three-tier path for cultural dimensional elevation in the international communication of China’s fine traditional culture through micro-short dramas.This path can effectively reduce cultural discount and contribute to the paradigm shift of China’s fine traditional culture from geographical expansion to cultural identity.
基金financially supported by the National Natural Science Foundation of China (Nos. 82172372 and 82260290)the Opening Research Fund of State Key Laboratory of Digital Medical Engineering (No. 2023-M04)
文摘Strand displacement-based DNA circuits have emerged as highly effective tools for molecular computation,serving purposes of amplification or decision-making.They are favored for their inherent occurrence and sensitivity to external conditions.However,achieving enhanced amplification or decision-making necessitates the incorporation of multiple strands,thereby increasing the risk of contamination.Recent advancements have led to the development of CRISPR-Cas-based DNA circuits.These systems aim to simplify the complexity associated with conventional circuits,mitigate contamination risks,and enable more substantial amplification or decision-making capabilities.Here,the review article centers on current strategies of CRISPR-Cas(Cas9,Cas12a,Cas13a)system-assisted circuits in amplification and decisionmaking,and assesses their tendencies and limitations in amplification circuits and decision-making circuits.Furthermore,we discuss the challenges of CRISPR-Cas in circuits and propose prospects that will contribute to constructing more efficient and diverse CRISPR-Cas-based DNA functional circuits.
