目的:探究miR-149,miR-196a2与亚洲人群脑卒中的遗传易感性。方法:通过PubMed、Web of Science、CBM及中国知网、万方、维普数据库,收集有关miR-149,miR-196a2基因多态性与脑卒中相关性的病例-对照研究的文献,检索时限均从建库至2018年1...目的:探究miR-149,miR-196a2与亚洲人群脑卒中的遗传易感性。方法:通过PubMed、Web of Science、CBM及中国知网、万方、维普数据库,收集有关miR-149,miR-196a2基因多态性与脑卒中相关性的病例-对照研究的文献,检索时限均从建库至2018年11月。由两名研究者分别独立按照纳入与排除标准完成对文献的筛选、资料提取及质量评价,采用Stata12.0软件进行数据分析。结果:本研究纳入8个病例研究共6472例,包括3332例患者(病例组)和3140例对照(对照组)。Meta分析结果显示miR-149基因rs2292832多态性与脑卒中的发生有相关性,人群中携带C和CC基因型明显增加脑卒中的发生风险,[C vs.T:OR=1.40,95%CI(1.01,1.93),P=0.04;CC vs.TT:OR=1.31,95%CI(1.09,1.57),P=0.004;CC vs.CT+TT:OR=1.29,95%CI(1.09,1.53),P=0.003]。结论:miR-149基因rs2292832多态性与亚洲人群脑卒中相关,人群中携带C等位基因和CC基因型发生脑卒中的风险明显增加,miR-196a2 rs11614913多态性与脑卒中的发生没有相关性。展开更多
Background: MicroRNAs (miRNAs) negatively regulate the gene expression and act as tumor suppressors or oncogenes in carcinogenesis. The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 ...Background: MicroRNAs (miRNAs) negatively regulate the gene expression and act as tumor suppressors or oncogenes in carcinogenesis. The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 and the susceptibility of digestive system cancers was inconsistent in previous studies. Methods: A standardized search of PubMed, Embase, and Cochrane library databases for publications on miR-196a2 rs11614913 polymorphism and digestive system cancer risk was performed. Then the genotype data were analyzed in a meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association. Test of heterogeneity, sensitivity analysis and assessment of publication bias were conducted in the present meta-analysis by STATA software 12.0. Results: An updated meta-analysis based on 34 independent case-control studies consisting of 13,013 cases and 16,046 controls was performed to address this association. There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations. Moreover, subgroup analysis revealed that variant C allele increased risk of colorectal carcinoma, gastric cancer and hepatocellular carcinoma (HCC), compared with wild T allele. Conclusions: There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations.展开更多
文摘Background: MicroRNAs (miRNAs) negatively regulate the gene expression and act as tumor suppressors or oncogenes in carcinogenesis. The association between single nucleotide polymorphism (SNP) in miR-196a2 rs11614913 and the susceptibility of digestive system cancers was inconsistent in previous studies. Methods: A standardized search of PubMed, Embase, and Cochrane library databases for publications on miR-196a2 rs11614913 polymorphism and digestive system cancer risk was performed. Then the genotype data were analyzed in a meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association. Test of heterogeneity, sensitivity analysis and assessment of publication bias were conducted in the present meta-analysis by STATA software 12.0. Results: An updated meta-analysis based on 34 independent case-control studies consisting of 13,013 cases and 16,046 controls was performed to address this association. There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations. Moreover, subgroup analysis revealed that variant C allele increased risk of colorectal carcinoma, gastric cancer and hepatocellular carcinoma (HCC), compared with wild T allele. Conclusions: There was a remarkable association between miR-196a2 rs11614913 polymorphism and overall digestive system cancer risk, especially in Asian populations.
