Sodium-ion batteries(SIBs)are emerging as a promising alternative for large-scale energy storage,particularly in grid applications.Within the array of potential cathode materials,Fe/Mn-based layered oxides are notable...Sodium-ion batteries(SIBs)are emerging as a promising alternative for large-scale energy storage,particularly in grid applications.Within the array of potential cathode materials,Fe/Mn-based layered oxides are notable for their advantageous theoretical specific capacity,economic viability,and environmental sustainability.Nevertheless,the practical application of Fe/Mn-based layered oxides is constrained by their suboptimal cycle performance and rate capability during actual charging and discharging.Ion doping is an effective approach for addressing the aforementioned issues.In this context,we have successfully developed a novel K^(+) and Mg^(2+) codoped P2-Na_(0.7)Fe_(0.5)Mn_(0.5)O_(2) cathode to address these challenges.By doping with 0.05 K^(+) and 0.2 Mg^(2+),the cathode demonstrated excellent cycling stability,retaining 95% of its capacity after 50 cycles at 0.2C,whereas the undoped material retained only 59.7%.Even within a wider voltage range,the co-doped cathode retained 88% of its capacity after 100 cycles at 1C.This work integrated Mg^(2+) to activate oxygen redox reactions in Fe/Mn-based layered cathodes,thereby promoting a reversible hybrid redox process involving both anions and cations.Building on the Mg doping,larger K^(+) ions were introduced into the edge-sharing Na^(+) sites,enhancing the material's cyclic stability and expanding the interplanar distance.The significant improvement of Na^(+) diffusion coefficient by K^(+)/Mg^(2+) co-doping has been further confirmed via the galvanostatic intermittent titration technique(GITT).The study emphasizes the importance of co-doping with different coordination environments in future material design,aiming to achieve high operating voltage and energy density.展开更多
In this editorial,we discuss the recent article by Regassa et al,published in the World Journal of Diabetes,which highlights the potential role of platelet indices(PI)in predicting poor glucoregulation in patients wit...In this editorial,we discuss the recent article by Regassa et al,published in the World Journal of Diabetes,which highlights the potential role of platelet indices(PI)in predicting poor glucoregulation in patients with type 2 diabetes mellitus(T2DM).Given the high morbidity and mortality associated with T2DM,there is a constant need to find new and accessible methods for predicting and treating individuals with this condition.The pathophysiology of T2DM involves systemic inflammation,metabolic dysfunction,and an increased risk of vascular injury,which are commonly associated with the development of microvascular and macrovascular complications,such as cardiovascular diseases and neuropathies.The link between these complications and T2DM requires further elucidation but may be explained by prolonged exposure to high glycemic levels and increased advanced glycation end products.PI might play an important role in determining whether some individuals are prone to poor glucoregulation.Recent evidence encourages the scientific efforts to demonstrate the consistency of this role and its applicability in monitoring glucoregulation,underscoring the importance of the study by Regassa et al.展开更多
BACKGROUND Recent studies have indicated that triglyceride glucose(TyG)-waist height ratio(WHtR)and TyG-waist circumference(TyG-WC)are effective indicators for evaluating insulin resistance.However,research on the ass...BACKGROUND Recent studies have indicated that triglyceride glucose(TyG)-waist height ratio(WHtR)and TyG-waist circumference(TyG-WC)are effective indicators for evaluating insulin resistance.However,research on the association in TyG-WHtR,TyG-WC,and the risk and prognosis of major adverse cardiovascular events(MACEs)in type 2 diabetes mellitus(T2DM)cases are limited.AIM To clarify the relation in TyG-WHtR,TyG-WC,and the risk of MACEs and overall mortality in T2DM patients.METHODS Information for this investigation was obtained from Action to Control Cardiovascular Risk in Diabetes(ACCORD)/ACCORD Follow-On(ACCORDION)study database.The Cox regression model was applied to assess the relation among TyG-WHtR,TyG-WC and future MACEs risk and overall mortality in T2DM cases.The RCS analysis was utilized to explore the nonlinear correlation.Subgroup and interaction analyses were conducted to prove the robustness.The receiver operating characteristic curves were applied to analysis the additional predicting value of TyG-WHtR and TyG-WC.RESULTS After full adjustment for confounding variables,the highest baseline TyG-WHtR cohort respectively exhibited a 1.353-fold and 1.420-fold higher risk for MACEs and overall mortality,than the lowest quartile group.Similarly,the highest baseline TyG-WC cohort showed a 1.314-fold and 1.480-fold higher risk for MACEs and overall mortality,respectively.Each 1 SD increase in TyG-WHtR was significantly related to an 11.7%increase in MACEs and a 14.9%enhance in overall mortality.Each 1 SD increase in TyG-WC corresponded to an 11.5%in MACEs and a 16.6%increase in overall mortality.Including these two indexes in conventional models significantly improved the predictive power for MACEs and overall mortality.CONCLUSION TyG-WHtR and TyG-WC were promising predictors of MACEs and overall mortality risk in T2DM cases.展开更多
BACKGROUND Diabetes is a chronic metabolic syndrome that has become a global public health problem with significant morbidity and mortality.It is a pro-inflammatory and pro-thrombotic condition characterized by increa...BACKGROUND Diabetes is a chronic metabolic syndrome that has become a global public health problem with significant morbidity and mortality.It is a pro-inflammatory and pro-thrombotic condition characterized by increased platelet activation and alterations in platelet indices.However,the use of platelet indices as predictors of poor glucoregulation has not been fully evaluated in this context,and evidence for their role as predictors of poor glycemic status in diabetic patients is limited.AIM To evaluate platelet indices and determine their prognostic significance in relation to inadequate glucoregulation among individuals diagnosed with type 2 diabetes at Bishoftu General Hospital in Ethiopia,from June 15 to August 12,2022.METHODS A comparative cross-sectional study was conducted in 261 participants including 174 individuals with type 2 diabetes mellitus(T2DM)and 87 non-diabetic controls.The systematic random sampling technique was used to select participants.Data were collected using structured questionnaires,physical measurements,checklists,and laboratory tests.Platelet parameters and fasting blood glucose levels were determined from blood samples using Sysmex-XN550 and CobasC311 analyzers,respectively.The hematology analyzer output was checked and participants were also screened for malaria parasites using a prepared blood smear.Collected data were entered into Epi-data version 3.1 and exported to SPSS version 25 for analysis.Theχ^(2) test,Mann-Whitney U test,Kruskal-Wallis test,post hoc test,Spearman correlation,and receiver operating characteristic curve were used for analysis.A P value<0.05 was considered statistically significant.RESULTS The results of our study indicate that diabetic patients have significantly higher levels of platelet distribution width(PDW),mean platelet volume(MPV),platelet large cell ratio(PLCR),and plateletcrit(PCT)compared to healthy individuals(P<0.001).Furthermore,these indices were found to be significantly elevated in individuals with poor glycemic control in T2DM compared to those with good glycemic control and healthy controls.We also observed significant correlations between these indices and various anthropometric and clinical variables.Our findings suggest that PDW,with a cut-off value of 15.75 fL and an area under the curve(AUC)of 0.803,MPV,with a cut-off value of 12.25 fL and an AUC of 0.774,PLCR,with a cut-off value of 36.3%and an AUC of 0.775,and PCT,with a cut-off value of 0.24%and an AUC of 0.761,can serve as predictors of poor glycemic control in patients with diabetes mellitus.CONCLUSION The observed correlation between diabetic patients and a significant increase in platelet indices has highlighted their potential as predictors of poor glycemic control in diabetes.Therefore,regular screening and profiling of platelet indices is recommended as part of the follow-up process for individuals with diabetes mellitus.展开更多
基金financially supported by the National Natural Science Foundation of China(12175089,12205127,52220105010)the Key Research and Development Program of Yunnan Province(202103AF140006)+3 种基金the Applied Basic Research Programs of Yunnan Provincial Science and Technology Department(202001AW070004,202301AS070051,202301AU070064)Yunnan Industrial Innovative Talents Program for“Xingdian Talent Support Plan”(KKXY202252001)Yunnan Program for Introducing Foreign Talents(202305AO350042)Yunnan Major Scientific and Technological Projects(202202AG050003).
文摘Sodium-ion batteries(SIBs)are emerging as a promising alternative for large-scale energy storage,particularly in grid applications.Within the array of potential cathode materials,Fe/Mn-based layered oxides are notable for their advantageous theoretical specific capacity,economic viability,and environmental sustainability.Nevertheless,the practical application of Fe/Mn-based layered oxides is constrained by their suboptimal cycle performance and rate capability during actual charging and discharging.Ion doping is an effective approach for addressing the aforementioned issues.In this context,we have successfully developed a novel K^(+) and Mg^(2+) codoped P2-Na_(0.7)Fe_(0.5)Mn_(0.5)O_(2) cathode to address these challenges.By doping with 0.05 K^(+) and 0.2 Mg^(2+),the cathode demonstrated excellent cycling stability,retaining 95% of its capacity after 50 cycles at 0.2C,whereas the undoped material retained only 59.7%.Even within a wider voltage range,the co-doped cathode retained 88% of its capacity after 100 cycles at 1C.This work integrated Mg^(2+) to activate oxygen redox reactions in Fe/Mn-based layered cathodes,thereby promoting a reversible hybrid redox process involving both anions and cations.Building on the Mg doping,larger K^(+) ions were introduced into the edge-sharing Na^(+) sites,enhancing the material's cyclic stability and expanding the interplanar distance.The significant improvement of Na^(+) diffusion coefficient by K^(+)/Mg^(2+) co-doping has been further confirmed via the galvanostatic intermittent titration technique(GITT).The study emphasizes the importance of co-doping with different coordination environments in future material design,aiming to achieve high operating voltage and energy density.
文摘In this editorial,we discuss the recent article by Regassa et al,published in the World Journal of Diabetes,which highlights the potential role of platelet indices(PI)in predicting poor glucoregulation in patients with type 2 diabetes mellitus(T2DM).Given the high morbidity and mortality associated with T2DM,there is a constant need to find new and accessible methods for predicting and treating individuals with this condition.The pathophysiology of T2DM involves systemic inflammation,metabolic dysfunction,and an increased risk of vascular injury,which are commonly associated with the development of microvascular and macrovascular complications,such as cardiovascular diseases and neuropathies.The link between these complications and T2DM requires further elucidation but may be explained by prolonged exposure to high glycemic levels and increased advanced glycation end products.PI might play an important role in determining whether some individuals are prone to poor glucoregulation.Recent evidence encourages the scientific efforts to demonstrate the consistency of this role and its applicability in monitoring glucoregulation,underscoring the importance of the study by Regassa et al.
文摘BACKGROUND Recent studies have indicated that triglyceride glucose(TyG)-waist height ratio(WHtR)and TyG-waist circumference(TyG-WC)are effective indicators for evaluating insulin resistance.However,research on the association in TyG-WHtR,TyG-WC,and the risk and prognosis of major adverse cardiovascular events(MACEs)in type 2 diabetes mellitus(T2DM)cases are limited.AIM To clarify the relation in TyG-WHtR,TyG-WC,and the risk of MACEs and overall mortality in T2DM patients.METHODS Information for this investigation was obtained from Action to Control Cardiovascular Risk in Diabetes(ACCORD)/ACCORD Follow-On(ACCORDION)study database.The Cox regression model was applied to assess the relation among TyG-WHtR,TyG-WC and future MACEs risk and overall mortality in T2DM cases.The RCS analysis was utilized to explore the nonlinear correlation.Subgroup and interaction analyses were conducted to prove the robustness.The receiver operating characteristic curves were applied to analysis the additional predicting value of TyG-WHtR and TyG-WC.RESULTS After full adjustment for confounding variables,the highest baseline TyG-WHtR cohort respectively exhibited a 1.353-fold and 1.420-fold higher risk for MACEs and overall mortality,than the lowest quartile group.Similarly,the highest baseline TyG-WC cohort showed a 1.314-fold and 1.480-fold higher risk for MACEs and overall mortality,respectively.Each 1 SD increase in TyG-WHtR was significantly related to an 11.7%increase in MACEs and a 14.9%enhance in overall mortality.Each 1 SD increase in TyG-WC corresponded to an 11.5%in MACEs and a 16.6%increase in overall mortality.Including these two indexes in conventional models significantly improved the predictive power for MACEs and overall mortality.CONCLUSION TyG-WHtR and TyG-WC were promising predictors of MACEs and overall mortality risk in T2DM cases.
文摘BACKGROUND Diabetes is a chronic metabolic syndrome that has become a global public health problem with significant morbidity and mortality.It is a pro-inflammatory and pro-thrombotic condition characterized by increased platelet activation and alterations in platelet indices.However,the use of platelet indices as predictors of poor glucoregulation has not been fully evaluated in this context,and evidence for their role as predictors of poor glycemic status in diabetic patients is limited.AIM To evaluate platelet indices and determine their prognostic significance in relation to inadequate glucoregulation among individuals diagnosed with type 2 diabetes at Bishoftu General Hospital in Ethiopia,from June 15 to August 12,2022.METHODS A comparative cross-sectional study was conducted in 261 participants including 174 individuals with type 2 diabetes mellitus(T2DM)and 87 non-diabetic controls.The systematic random sampling technique was used to select participants.Data were collected using structured questionnaires,physical measurements,checklists,and laboratory tests.Platelet parameters and fasting blood glucose levels were determined from blood samples using Sysmex-XN550 and CobasC311 analyzers,respectively.The hematology analyzer output was checked and participants were also screened for malaria parasites using a prepared blood smear.Collected data were entered into Epi-data version 3.1 and exported to SPSS version 25 for analysis.Theχ^(2) test,Mann-Whitney U test,Kruskal-Wallis test,post hoc test,Spearman correlation,and receiver operating characteristic curve were used for analysis.A P value<0.05 was considered statistically significant.RESULTS The results of our study indicate that diabetic patients have significantly higher levels of platelet distribution width(PDW),mean platelet volume(MPV),platelet large cell ratio(PLCR),and plateletcrit(PCT)compared to healthy individuals(P<0.001).Furthermore,these indices were found to be significantly elevated in individuals with poor glycemic control in T2DM compared to those with good glycemic control and healthy controls.We also observed significant correlations between these indices and various anthropometric and clinical variables.Our findings suggest that PDW,with a cut-off value of 15.75 fL and an area under the curve(AUC)of 0.803,MPV,with a cut-off value of 12.25 fL and an AUC of 0.774,PLCR,with a cut-off value of 36.3%and an AUC of 0.775,and PCT,with a cut-off value of 0.24%and an AUC of 0.761,can serve as predictors of poor glycemic control in patients with diabetes mellitus.CONCLUSION The observed correlation between diabetic patients and a significant increase in platelet indices has highlighted their potential as predictors of poor glycemic control in diabetes.Therefore,regular screening and profiling of platelet indices is recommended as part of the follow-up process for individuals with diabetes mellitus.
