目的通过评价中药复方防治胃癌前病变(PLGC)动物实验研究的方法学质量及报告质量,分析实验过程中的偏倚风险及研究报告的不足,为提高中药复方防治PLGC动物实验研究质量提供参考。方法计算机检索中国知识资源总库(CNKI)、万方数据知识服...目的通过评价中药复方防治胃癌前病变(PLGC)动物实验研究的方法学质量及报告质量,分析实验过程中的偏倚风险及研究报告的不足,为提高中药复方防治PLGC动物实验研究质量提供参考。方法计算机检索中国知识资源总库(CNKI)、万方数据知识服务平台(WanfangData)、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed、Cochrane Library、Web of Science和Embase数据库2014年1月1日-2024年2月23日发表的关于中药复方防治PLGC动物实验文献,采用SYRCLE工具和ARRIVE2.0指南对纳入文献进行评分并计算各条目“低风险”符合率。结果共纳入文献213篇,其中中文文献189篇、英文文献24篇。SYRCLE工具评分为(12.86±1.29)分,“低风险”符合率为32.79%。ARRIVE2.0指南必备条目评分为(24.15±2.80)分,“低风险”符合率为49.08%;推荐条目评分为(11.28±3.40)分,“低风险”符合率为30.27%。SYRCLE工具评价中,144项(67.61%)研究未详细阐述分配序列产生的方法,所有研究均未描述分配隐藏充分与否及实施偏倚过程中的盲法,7项(3.29%)研究描述对结果评价者施盲。ARRIVE2.0指南中,所有研究均未报告样本量的确定方法、均未提供用于确定样本量的结局指标及实验方案注册声明,51项(23.94%)研究明确提出PLGC造模成功标准,66项(30.96%)研究提供所使用统计方法的详细信息,29项(13.62%)研究提供完整的伦理声明,22项(10.33%)报告了利益冲突。结论2014-2024年发表的中药复方防治PLGC动物实验文献方法学质量及报告质量存在较多问题,尤其是在实验过程中随机盲法策略的实施、样本量计算细节及纳入排除标准报告等方面存在缺陷,建议今后研究参考SYRCLE工具及ARRIVE2.0指南清单,以优化研究方案和报告,提高PLGC动物实验研究结果的可信度与规范性。展开更多
This paper aims to explain the construction of the autonomous subject from Foucault's ethical perspective for the qualitative analysis of interprofessional relationships,patient-professional relationships,and mora...This paper aims to explain the construction of the autonomous subject from Foucault's ethical perspective for the qualitative analysis of interprofessional relationships,patient-professional relationships,and moral ethics critique.Foucault tried to break loose from the self,which is merely the result of a biopol-itical subjectivation and constituted an interpersonal level.From this,different elements involved in the decision-making capacity of patients in a clinical setting were analysed.Firstly,the context in which decision-making occurs has been explained,distinguishing between traditional practices involved in self-care and the more modern conceptions that make certain possible transformations.Secondly,an attempt is made to explain the formation of the medicalisation of society using the transformations of what Foucault called"techniques of the self".Finally,the ethical framework for a subject's"self-creation",insisting more on the exercises of self-subjectivation,reinforcing the ethics of the self by itself,the"care of the self",has been explained.The role of the patient is understood as an autonomous subject to the extent that the clinical institution and the professionals involved comprehend how the patient’s autonomy in the clinical environment is constituted.All these elements could generate grounded theory on the qualitative methodology of this phenomenon.The current ethical model based on universal principles is not useful to provide a capacity for patients decision-making,relegating to the background their opinions and beliefs.Consequently,a new ethical perspective emerges that aims to return the patient to the fundamental axis of attention.展开更多
This paper contests the notion that language learner autonomy is a monolithic construct, by offering evidence that learner autonomy （LA） is comprised of different ＂modes of autonomy＂. Thirty language learners base...This paper contests the notion that language learner autonomy is a monolithic construct, by offering evidence that learner autonomy （LA） is comprised of different ＂modes of autonomy＂. Thirty language learners based in Asia and the UK, completed a Q methodology card sort and were interviewed on how learning in an autonomous environment had impacted upon their development as learners. The results indicated that at least six modes of autonomy were identifiable within these language learners. Further analysis showed that social dimensions of autonomy were central to each mode, and thus reconceptualizing LA in this way allows for multiple understandings of the construct which are culturally rooted and embedded in sociocultural notions of what it means to be a language learner.展开更多
文摘目的通过评价中药复方防治胃癌前病变(PLGC)动物实验研究的方法学质量及报告质量,分析实验过程中的偏倚风险及研究报告的不足,为提高中药复方防治PLGC动物实验研究质量提供参考。方法计算机检索中国知识资源总库(CNKI)、万方数据知识服务平台(WanfangData)、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)、PubMed、Cochrane Library、Web of Science和Embase数据库2014年1月1日-2024年2月23日发表的关于中药复方防治PLGC动物实验文献,采用SYRCLE工具和ARRIVE2.0指南对纳入文献进行评分并计算各条目“低风险”符合率。结果共纳入文献213篇,其中中文文献189篇、英文文献24篇。SYRCLE工具评分为(12.86±1.29)分,“低风险”符合率为32.79%。ARRIVE2.0指南必备条目评分为(24.15±2.80)分,“低风险”符合率为49.08%;推荐条目评分为(11.28±3.40)分,“低风险”符合率为30.27%。SYRCLE工具评价中,144项(67.61%)研究未详细阐述分配序列产生的方法,所有研究均未描述分配隐藏充分与否及实施偏倚过程中的盲法,7项(3.29%)研究描述对结果评价者施盲。ARRIVE2.0指南中,所有研究均未报告样本量的确定方法、均未提供用于确定样本量的结局指标及实验方案注册声明,51项(23.94%)研究明确提出PLGC造模成功标准,66项(30.96%)研究提供所使用统计方法的详细信息,29项(13.62%)研究提供完整的伦理声明,22项(10.33%)报告了利益冲突。结论2014-2024年发表的中药复方防治PLGC动物实验文献方法学质量及报告质量存在较多问题,尤其是在实验过程中随机盲法策略的实施、样本量计算细节及纳入排除标准报告等方面存在缺陷,建议今后研究参考SYRCLE工具及ARRIVE2.0指南清单,以优化研究方案和报告,提高PLGC动物实验研究结果的可信度与规范性。
基金Supported by the Advanced Research Chair in the College of Nurses of the Balearic Islands,No. IB3389
文摘This paper aims to explain the construction of the autonomous subject from Foucault's ethical perspective for the qualitative analysis of interprofessional relationships,patient-professional relationships,and moral ethics critique.Foucault tried to break loose from the self,which is merely the result of a biopol-itical subjectivation and constituted an interpersonal level.From this,different elements involved in the decision-making capacity of patients in a clinical setting were analysed.Firstly,the context in which decision-making occurs has been explained,distinguishing between traditional practices involved in self-care and the more modern conceptions that make certain possible transformations.Secondly,an attempt is made to explain the formation of the medicalisation of society using the transformations of what Foucault called"techniques of the self".Finally,the ethical framework for a subject's"self-creation",insisting more on the exercises of self-subjectivation,reinforcing the ethics of the self by itself,the"care of the self",has been explained.The role of the patient is understood as an autonomous subject to the extent that the clinical institution and the professionals involved comprehend how the patient’s autonomy in the clinical environment is constituted.All these elements could generate grounded theory on the qualitative methodology of this phenomenon.The current ethical model based on universal principles is not useful to provide a capacity for patients decision-making,relegating to the background their opinions and beliefs.Consequently,a new ethical perspective emerges that aims to return the patient to the fundamental axis of attention.
文摘This paper contests the notion that language learner autonomy is a monolithic construct, by offering evidence that learner autonomy （LA） is comprised of different ＂modes of autonomy＂. Thirty language learners based in Asia and the UK, completed a Q methodology card sort and were interviewed on how learning in an autonomous environment had impacted upon their development as learners. The results indicated that at least six modes of autonomy were identifiable within these language learners. Further analysis showed that social dimensions of autonomy were central to each mode, and thus reconceptualizing LA in this way allows for multiple understandings of the construct which are culturally rooted and embedded in sociocultural notions of what it means to be a language learner.
