Methamphetamine addiction is a brain disorder characterized by persistent drug-seeking behavior, which has been linked with aberrant synaptic plasticity. An increasing body of evidence suggests that aberrant synaptic ...Methamphetamine addiction is a brain disorder characterized by persistent drug-seeking behavior, which has been linked with aberrant synaptic plasticity. An increasing body of evidence suggests that aberrant synaptic plasticity is associated with the activation of the NOD-like receptor family pyrin domain containing-3(NLRP3) inflammasome. 3′-Deoxyadenosin, an active component of the Chinese fungus Cordyceps militaris, has strong anti-inflammatory effects. However, whether 3′-deoxyadenosin attenuates methamphetamine-induced aberrant synaptic plasticity via an NLRP3-mediated inflammatory mechanism remains unclear. We first observed that 3′-deoxyadenosin attenuated conditioned place preference scores in methamphetamine-treated mice and decreased the expression of c-fos in hippocampal neurons. Furthermore, we found that 3′-deoxyadenosin reduced the aberrant potentiation of glutamatergic transmission and restored the methamphetamine-induced impairment of synaptic plasticity. We also found that 3′-deoxyadenosin decreased the expression of NLRP3 and neuronal injury. Importantly, a direct NLRP3 deficiency reduced methamphetamine-induced seeking behavior, attenuated the impaired synaptic plasticity, and prevented neuronal damage. Finally, NLRP3 activation reversed the effect of 3′-deoxyadenosin on behavior and synaptic plasticity, suggesting that the anti-neuroinflammatory mechanism of 3′-deoxyadenosin on aberrant synaptic plasticity reduces methamphetamine-induced seeking behavior. Taken together, 3′-deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome.展开更多
为探究考虑心理因素影响下我国城市潜在MaaS(Mobility as a Service)用户的套餐选择行为与支付意愿的影响因素,综合考虑了受访者个人属性、心理属性与套餐属性3个方面,分别在北京和大连开展了RP与SP调查。在此基础上,构建了结构方程模...为探究考虑心理因素影响下我国城市潜在MaaS(Mobility as a Service)用户的套餐选择行为与支付意愿的影响因素,综合考虑了受访者个人属性、心理属性与套餐属性3个方面,分别在北京和大连开展了RP与SP调查。在此基础上,构建了结构方程模型和离散选择模型,对受访者的MaaS套餐选择行为和支付意愿进行了定性与定量研究。研究结果显示:个人属性方面,北京样本中男性和收入为1万~2万元对MaaS套餐选择行为有显著正面影响;本科教育水平和家中儿童数为2个及以上有显著负面影响;大连样本中本科及以上教育水平、家中老人数为2个及以上、收入2万元及以上、工作有弹性等因素对MaaS套餐选择行为有显著正面影响;年龄在36~60岁、家中有私家车、家中有儿童等因素有显著负面影响。心理属性方面,行为态度对MaaS套餐选择行为具有显著影响,其中北京受访者表现尤为明显;套餐属性方面,套餐价格、公共交通次数及共享单车次数对MaaS套餐选择行为均有显著影响。支付意愿方面,北京和大连受访者对出租车和网约车支付意愿均最高,每增加一公里出租车或网约车均愿为套餐多花费1元。研究结果可为我国未来MaaS套餐的设计与推广提供理论支撑。展开更多
目的探讨慢性自发性荨麻疹(CSU)患者血清Mas相关G蛋白偶联受体成员X2(MRGPRX2)、白细胞介素-6(IL-6)及IL-24的水平在发病中的意义。方法收集2023年9月—2023年12月就诊于徐州医科大学附属医院的CSU患者75例,作为病例组,并根据病情严重...目的探讨慢性自发性荨麻疹(CSU)患者血清Mas相关G蛋白偶联受体成员X2(MRGPRX2)、白细胞介素-6(IL-6)及IL-24的水平在发病中的意义。方法收集2023年9月—2023年12月就诊于徐州医科大学附属医院的CSU患者75例,作为病例组,并根据病情严重程度分为轻度组、中度组、重度组,完成荨麻疹活动评分(urticaria activity score,UAS7)与慢性荨麻疹生活质量问卷评分(chronic urticaria quality of life questionnaire,CU-Q2oL);另选取60例健康者作为对照组。比较各组血清MRGPRX2、IL-6及IL-24水平,分析其与UAS7、CU-Q2oL得分的相关性。结果病例组血清MRGPRX2、IL-6及IL-24水平均高于对照组(P<0.05),CSU患者血清MRGPRX2、IL-6水平升高与其病情严重程度呈正相关(r=0.531,P<0.05;r=0.462,P<0.05),但IL-24水平升高与CSU患者病情严重程度无显著相关性(r=0.015,P>0.05)。经logistic回归分析显示,血清中MRGPRX2、IL-6、IL-24水平升高均是CSU发生的独立危险因素(P<0.05)。经受试者操作特征(ROC)曲线分析结果显示,血清中MRGPRX2、IL-6、IL-24水平3项指标联合预测的曲线下面积(AUC)高于单独指标(P<0.05)。结论血清MRGPRX2、IL-6及IL-24水平在CSU患者血清中呈高表达,且血清MRGPRX2、IL-6与其病情严重程度相关,三者联合检测CSU发生的效能优于各指标单独检测。展开更多
Photos of a 31‑year‑old man carrying his mother on his back at Tiananmen Square went viral on Chinese social media,drawing the praise of millions around the country,but Xiao Ma has been carrying his disabled mother fo...Photos of a 31‑year‑old man carrying his mother on his back at Tiananmen Square went viral on Chinese social media,drawing the praise of millions around the country,but Xiao Ma has been carrying his disabled mother for years and documenting their travels through short videos.展开更多
Mafic rocks generated from subduction settings have recorded valuable source information about the mantle source.In this study,we present a comprehensive analysis of zircon U–Pb dating,whole-rock major and trace elem...Mafic rocks generated from subduction settings have recorded valuable source information about the mantle source.In this study,we present a comprehensive analysis of zircon U–Pb dating,whole-rock major and trace elements,and Sr–Nd isotopic data for the mafic gabbro located in the Yumen area,on the western part of the Yangtze Block,South China,aiming to constrain the processes of mantle metaso-matism within subduction settings.U–Pb dating results for zircon yield crystallization ages of 800 Ma for type 1 mafic gabbro and 753–734 Ma for type 2 mafic gabbro.Type 1 mafic gabbro exhibits higher SiO_(2)(44.13%–48.93%)and Al_(2)O_(3)content but lower total Fe2O3 and MgO content than type 2 gabbro(SiO_(2):41.02%–43.28%).These gabbros dis-play a high-Mg^(#)signature(52.50–62.81 for type 1,50.89–57.04 for type 2),while they are enriched in significant large-ion lithophile elements(LILEs:Rb,Ba,Sr,K)and depleted in high-field-strength elements(HFSEs:Zr,Hf,Nd,Ta,Ti),which indicates an arc-like element signature.The positive whole-rockεNd(t)values(type 1:3.5–4.4,type 2:5.6–6.3)combined with a narrow range of(^(87)Sr/^(86)Sr)_(i)(type 1:0.7035–0.7043,type 2:0.7035–0.7036)of both gabbro types suggest a depleted lithospheric mantle origin.There-fore,these mafic rocks may derive from a metasomatized spinel lherzolite mantle source(with amphibole)due to the interactions of the deep mantle source and subductionfluid materials.We propose that the long-term metasomatism recorded by mafic gabbro in this study supports the fact that the subduction during the Neoproterozoic contributed to the formation of a metasomatized mantle source in the Yumen area,western Yangtze Block,South China.展开更多
针对存在输入时滞的多智能体系统(multi-agent system,MAS)滞后一致性问题,提出一种基于时基生成器(time base generator,TBG)的二阶MAS预设时间领导跟随滞后一致性控制方法,使得稳定时间与系统初始状态无关且可预先设定。首先,提出一...针对存在输入时滞的多智能体系统(multi-agent system,MAS)滞后一致性问题,提出一种基于时基生成器(time base generator,TBG)的二阶MAS预设时间领导跟随滞后一致性控制方法,使得稳定时间与系统初始状态无关且可预先设定。首先,提出一种误差变换方法,将具有时滞的误差系统转换为无时滞误差系统。然后,利用TBG函数构造误差辅助变量并构造相应滑模面,进而设计预设时间控制器。同时,证明所设计控制器的预设时间稳定性。最后,通过数值仿真验证所提方法的可行性及有效性。仿真结果表明,MAS能够实现精确的预设时间滞后一致性。展开更多
基金supported by the National Natural Science Foundation of China,No.81971246 (to TM)Opening Foundation of Jiangsu Key Laboratory of Neurodegeneration,Nanjing Medical University,No.KF202204 (to LZ and SF)。
文摘Methamphetamine addiction is a brain disorder characterized by persistent drug-seeking behavior, which has been linked with aberrant synaptic plasticity. An increasing body of evidence suggests that aberrant synaptic plasticity is associated with the activation of the NOD-like receptor family pyrin domain containing-3(NLRP3) inflammasome. 3′-Deoxyadenosin, an active component of the Chinese fungus Cordyceps militaris, has strong anti-inflammatory effects. However, whether 3′-deoxyadenosin attenuates methamphetamine-induced aberrant synaptic plasticity via an NLRP3-mediated inflammatory mechanism remains unclear. We first observed that 3′-deoxyadenosin attenuated conditioned place preference scores in methamphetamine-treated mice and decreased the expression of c-fos in hippocampal neurons. Furthermore, we found that 3′-deoxyadenosin reduced the aberrant potentiation of glutamatergic transmission and restored the methamphetamine-induced impairment of synaptic plasticity. We also found that 3′-deoxyadenosin decreased the expression of NLRP3 and neuronal injury. Importantly, a direct NLRP3 deficiency reduced methamphetamine-induced seeking behavior, attenuated the impaired synaptic plasticity, and prevented neuronal damage. Finally, NLRP3 activation reversed the effect of 3′-deoxyadenosin on behavior and synaptic plasticity, suggesting that the anti-neuroinflammatory mechanism of 3′-deoxyadenosin on aberrant synaptic plasticity reduces methamphetamine-induced seeking behavior. Taken together, 3′-deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome.
文摘为探究考虑心理因素影响下我国城市潜在MaaS(Mobility as a Service)用户的套餐选择行为与支付意愿的影响因素,综合考虑了受访者个人属性、心理属性与套餐属性3个方面,分别在北京和大连开展了RP与SP调查。在此基础上,构建了结构方程模型和离散选择模型,对受访者的MaaS套餐选择行为和支付意愿进行了定性与定量研究。研究结果显示:个人属性方面,北京样本中男性和收入为1万~2万元对MaaS套餐选择行为有显著正面影响;本科教育水平和家中儿童数为2个及以上有显著负面影响;大连样本中本科及以上教育水平、家中老人数为2个及以上、收入2万元及以上、工作有弹性等因素对MaaS套餐选择行为有显著正面影响;年龄在36~60岁、家中有私家车、家中有儿童等因素有显著负面影响。心理属性方面,行为态度对MaaS套餐选择行为具有显著影响,其中北京受访者表现尤为明显;套餐属性方面,套餐价格、公共交通次数及共享单车次数对MaaS套餐选择行为均有显著影响。支付意愿方面,北京和大连受访者对出租车和网约车支付意愿均最高,每增加一公里出租车或网约车均愿为套餐多花费1元。研究结果可为我国未来MaaS套餐的设计与推广提供理论支撑。
文摘目的探讨慢性自发性荨麻疹(CSU)患者血清Mas相关G蛋白偶联受体成员X2(MRGPRX2)、白细胞介素-6(IL-6)及IL-24的水平在发病中的意义。方法收集2023年9月—2023年12月就诊于徐州医科大学附属医院的CSU患者75例,作为病例组,并根据病情严重程度分为轻度组、中度组、重度组,完成荨麻疹活动评分(urticaria activity score,UAS7)与慢性荨麻疹生活质量问卷评分(chronic urticaria quality of life questionnaire,CU-Q2oL);另选取60例健康者作为对照组。比较各组血清MRGPRX2、IL-6及IL-24水平,分析其与UAS7、CU-Q2oL得分的相关性。结果病例组血清MRGPRX2、IL-6及IL-24水平均高于对照组(P<0.05),CSU患者血清MRGPRX2、IL-6水平升高与其病情严重程度呈正相关(r=0.531,P<0.05;r=0.462,P<0.05),但IL-24水平升高与CSU患者病情严重程度无显著相关性(r=0.015,P>0.05)。经logistic回归分析显示,血清中MRGPRX2、IL-6、IL-24水平升高均是CSU发生的独立危险因素(P<0.05)。经受试者操作特征(ROC)曲线分析结果显示,血清中MRGPRX2、IL-6、IL-24水平3项指标联合预测的曲线下面积(AUC)高于单独指标(P<0.05)。结论血清MRGPRX2、IL-6及IL-24水平在CSU患者血清中呈高表达,且血清MRGPRX2、IL-6与其病情严重程度相关,三者联合检测CSU发生的效能优于各指标单独检测。
文摘Photos of a 31‑year‑old man carrying his mother on his back at Tiananmen Square went viral on Chinese social media,drawing the praise of millions around the country,but Xiao Ma has been carrying his disabled mother for years and documenting their travels through short videos.
基金The National Natural Science Foundation of China[Grant Nos.42172056,42202048]co-supported this work.
文摘Mafic rocks generated from subduction settings have recorded valuable source information about the mantle source.In this study,we present a comprehensive analysis of zircon U–Pb dating,whole-rock major and trace elements,and Sr–Nd isotopic data for the mafic gabbro located in the Yumen area,on the western part of the Yangtze Block,South China,aiming to constrain the processes of mantle metaso-matism within subduction settings.U–Pb dating results for zircon yield crystallization ages of 800 Ma for type 1 mafic gabbro and 753–734 Ma for type 2 mafic gabbro.Type 1 mafic gabbro exhibits higher SiO_(2)(44.13%–48.93%)and Al_(2)O_(3)content but lower total Fe2O3 and MgO content than type 2 gabbro(SiO_(2):41.02%–43.28%).These gabbros dis-play a high-Mg^(#)signature(52.50–62.81 for type 1,50.89–57.04 for type 2),while they are enriched in significant large-ion lithophile elements(LILEs:Rb,Ba,Sr,K)and depleted in high-field-strength elements(HFSEs:Zr,Hf,Nd,Ta,Ti),which indicates an arc-like element signature.The positive whole-rockεNd(t)values(type 1:3.5–4.4,type 2:5.6–6.3)combined with a narrow range of(^(87)Sr/^(86)Sr)_(i)(type 1:0.7035–0.7043,type 2:0.7035–0.7036)of both gabbro types suggest a depleted lithospheric mantle origin.There-fore,these mafic rocks may derive from a metasomatized spinel lherzolite mantle source(with amphibole)due to the interactions of the deep mantle source and subductionfluid materials.We propose that the long-term metasomatism recorded by mafic gabbro in this study supports the fact that the subduction during the Neoproterozoic contributed to the formation of a metasomatized mantle source in the Yumen area,western Yangtze Block,South China.
文摘针对存在输入时滞的多智能体系统(multi-agent system,MAS)滞后一致性问题,提出一种基于时基生成器(time base generator,TBG)的二阶MAS预设时间领导跟随滞后一致性控制方法,使得稳定时间与系统初始状态无关且可预先设定。首先,提出一种误差变换方法,将具有时滞的误差系统转换为无时滞误差系统。然后,利用TBG函数构造误差辅助变量并构造相应滑模面,进而设计预设时间控制器。同时,证明所设计控制器的预设时间稳定性。最后,通过数值仿真验证所提方法的可行性及有效性。仿真结果表明,MAS能够实现精确的预设时间滞后一致性。
