Background and objectives:Recent studies have highlighted a link between amyotrophic lateral sclerosis(ALS)and gut microbiota.This prospective study aimed to evaluate the effects of electroacupuncture combined with Ch...Background and objectives:Recent studies have highlighted a link between amyotrophic lateral sclerosis(ALS)and gut microbiota.This prospective study aimed to evaluate the effects of electroacupuncture combined with Chinese herbal medicine on gut microbiota and metabolomics in ALS patients.Methods:Ten ALS patients were randomly assigned to either a treatment group(electroacupuncture with Chinese herbal medicine,n=6)or a control group(waiting treatment,n=4).Healthy controls(age-and sex-matched,n=10)were also included.Data were collected after 12 sessions of electroacupuncture and follow-ups at three and six months.ALS functional rating scale scores were documented pre-and post-treatment.Stool samples were collected at two time points(T0 and T4 weeks)and analyzed,and metabolomic profiles from urine samples were analyzed post-treatment.Heatmap correlation analysis was used to explore relationships between microbiota,metabolomics,and clinical outcomes.Results:Treatment with electroacupuncture reduced Eisenbergiella abundance in the treatment group.A significant positive correlation was found between Lachnospiraceae and ALS functional rating scale scores(P<0.005 and P<0.001,respectively).Differential expression of purine metabolism was observed in ALS patients(P=0.0017).Conclusions:Imbalances in the gut microbiome and metabolic disorders have been found among patients with ALS.These imbalances appear to be partially mitigated by treatment with electroacupuncture combined with Chinese herbal medicine.Our research suggests that Eisenbergiella might be a diagnostic biomarker and a potential therapeutic target for ALS.展开更多
Melon(Cucumis melo L.)is a globally important fruit crop appreciated for its sweet taste,unique aroma,and nutritional value(Kaleem et al.,2024).Aroma,shaped by volatile organic compounds(VOCs),is a key trait influenci...Melon(Cucumis melo L.)is a globally important fruit crop appreciated for its sweet taste,unique aroma,and nutritional value(Kaleem et al.,2024).Aroma,shaped by volatile organic compounds(VOCs),is a key trait influencing consumer preference.These VOCs are mainly derived from amino acids,fatty acids,and terpenoid pathways(Chen et al.,2023).Esters contribute to fruity and sweet notes,whereas terpenes and C_(9) aldehydes/alcohols impart floral and melon-like aromas,respectively(Mayobre et al.,2024).展开更多
Dear Editor,Recently,Liang et al.(2024)conducted comprehensive genome resequencing and metabolomic analyses of 299 representative accessions from extant citrus species,offering an extensive overview of genetic diversi...Dear Editor,Recently,Liang et al.(2024)conducted comprehensive genome resequencing and metabolomic analyses of 299 representative accessions from extant citrus species,offering an extensive overview of genetic diversity and metabolic profiles across citrus populations.Their study included a correlation analysis that assessed the relationship between metabolite content and bioactivities,resulting in the selection of the top 100 annotated metabolites exhibiting the highest correlation coefficients(Pearson’s r)across various chemical assays,cell lines,and CYP450 enzymes(Liang et al.,2024).展开更多
基金2023 Research and Cultivation Fund of Capital Medical University-Study on the correlation between intestinal flora and neurofilament light chain in mice with amyotrophic lateral sclerosis induced by acupuncture(PYZ23032)R&D Program of Beijing Municipal Education Commission 2024:Study on the improvement of clinical symptoms and mechanism of acupuncture in amyotrophic lateral sclerosis(KM202410025018)+1 种基金China National Natural Science Foundation of Youth Project(No.82405557)2024-2026 Chinese Association of Chinese Medicine Young Talent Lifting Project(2024-QNRC2-B08).
文摘Background and objectives:Recent studies have highlighted a link between amyotrophic lateral sclerosis(ALS)and gut microbiota.This prospective study aimed to evaluate the effects of electroacupuncture combined with Chinese herbal medicine on gut microbiota and metabolomics in ALS patients.Methods:Ten ALS patients were randomly assigned to either a treatment group(electroacupuncture with Chinese herbal medicine,n=6)or a control group(waiting treatment,n=4).Healthy controls(age-and sex-matched,n=10)were also included.Data were collected after 12 sessions of electroacupuncture and follow-ups at three and six months.ALS functional rating scale scores were documented pre-and post-treatment.Stool samples were collected at two time points(T0 and T4 weeks)and analyzed,and metabolomic profiles from urine samples were analyzed post-treatment.Heatmap correlation analysis was used to explore relationships between microbiota,metabolomics,and clinical outcomes.Results:Treatment with electroacupuncture reduced Eisenbergiella abundance in the treatment group.A significant positive correlation was found between Lachnospiraceae and ALS functional rating scale scores(P<0.005 and P<0.001,respectively).Differential expression of purine metabolism was observed in ALS patients(P=0.0017).Conclusions:Imbalances in the gut microbiome and metabolic disorders have been found among patients with ALS.These imbalances appear to be partially mitigated by treatment with electroacupuncture combined with Chinese herbal medicine.Our research suggests that Eisenbergiella might be a diagnostic biomarker and a potential therapeutic target for ALS.
基金supported by Project of Renovation Capacity Building for the Young Sci-Tech Talents Sponsored by Xinjiang Academy of Agricultural Sciences(Grant No.xjnkq-2021011)Key Research and Development Program of Hainan Province(Grant No.ZDYF2025XDNY089)+2 种基金Project of Fund for Stable Support to Agricultural Sci-Tech Renovation(Grant No.xjnkywdzc-2023001-35)Guangxi Agricultural Science and Technology Project,China Agriculture Research System of MOF and MORA(CARS-25)the Fundamental Research Funds for the Central Universities(Grant No.2662024JC004)。
文摘Melon(Cucumis melo L.)is a globally important fruit crop appreciated for its sweet taste,unique aroma,and nutritional value(Kaleem et al.,2024).Aroma,shaped by volatile organic compounds(VOCs),is a key trait influencing consumer preference.These VOCs are mainly derived from amino acids,fatty acids,and terpenoid pathways(Chen et al.,2023).Esters contribute to fruity and sweet notes,whereas terpenes and C_(9) aldehydes/alcohols impart floral and melon-like aromas,respectively(Mayobre et al.,2024).
文摘Dear Editor,Recently,Liang et al.(2024)conducted comprehensive genome resequencing and metabolomic analyses of 299 representative accessions from extant citrus species,offering an extensive overview of genetic diversity and metabolic profiles across citrus populations.Their study included a correlation analysis that assessed the relationship between metabolite content and bioactivities,resulting in the selection of the top 100 annotated metabolites exhibiting the highest correlation coefficients(Pearson’s r)across various chemical assays,cell lines,and CYP450 enzymes(Liang et al.,2024).
