Endometrial cancer(EC)is a malignant tumour that occurs in the epithelial cells of the endometrium and represents one of the most common malignancies involving the female reproductive system,with endometrioid adenocar...Endometrial cancer(EC)is a malignant tumour that occurs in the epithelial cells of the endometrium and represents one of the most common malignancies involving the female reproductive system,with endometrioid adenocarcinoma as the most common type.In recent years,with an increasingly aging society and the growing number of obese people,the incidence of EC is constantly rising,posing a serious threat to women’s health.Some studies have reported that the interruption of digestion and absorption caused by imbalance in intestinal microbiota may lead to conditions such as obesity,hypertension,diabetes,and hormone imbalance,which are all risk factors for EC.Meanwhile,intestinal bacteria produce a series of metabolites during colonization and reproduction,which can rapidly respond to changes in the microenvironment of the body.Changes in their types and quantities can serve as sensitive indicators of physiological and pathological changes in the body.Patients with EC often suffer from metabolic diseases,which can lead to metabolic disorders involving carbohydrates,fats,and amino acid in their bodies.展开更多
Group 1 metabotropic glutamate receptors(Gp1 mGluRs),comprising mGluR1 and mGluR5,are predominantly located at postsynaptic terminals.Gp1 mGluRs induce the activation of phospholipase C-γ.
Alzheimer’s disease (AD) is the leading neurodegenerative disorder globally.Despite this,there is minimal effective therapeutics proven to reduce or prevent the progression of this disease.Glutamate is the main excit...Alzheimer’s disease (AD) is the leading neurodegenerative disorder globally.Despite this,there is minimal effective therapeutics proven to reduce or prevent the progression of this disease.Glutamate is the main excitatory neurotransmitter within the central nervous system and plays a crucial role in neuronal and synaptic functions.展开更多
Numerous instances of poisoning caused by the ingestion of mushrooms are reported annually worldwide,with most mushroom poisoning deaths caused by the ingestion of toxic amanita fungi.Amatoxin is the main toxic compon...Numerous instances of poisoning caused by the ingestion of mushrooms are reported annually worldwide,with most mushroom poisoning deaths caused by the ingestion of toxic amanita fungi.Amatoxin is the main toxic component of amanita,andα-amanitin is one of the most potent toxins present in amatoxin[1].展开更多
Early blood-brain barrier(BBB) disturbance contributes to many different neurological diseases including Alzheimer 's disease, Parkinson's disease and stroke, particularly in the etiology and early stages(Abbo...Early blood-brain barrier(BBB) disturbance contributes to many different neurological diseases including Alzheimer 's disease, Parkinson's disease and stroke, particularly in the etiology and early stages(Abbott et al., 2010).展开更多
In recent years,many investigations have indicated that environmental endocrine disruptors(EEDs)may accelerate the development of obesity[1].One kind of EEDs,di-(2-ethylhexyl)phthalate(DEHP),is ubiquitous in natural e...In recent years,many investigations have indicated that environmental endocrine disruptors(EEDs)may accelerate the development of obesity[1].One kind of EEDs,di-(2-ethylhexyl)phthalate(DEHP),is ubiquitous in natural environments due to its role in the manufacture and use of plastic products[2].展开更多
Bone Mineral Content(BMC), serum cal-cium, phosphorus and AlP were measured in64 epileptic patients on long term treatmentwith one or two kinds of antiepileptic drugs(AEDs) ,and in 14 epileptic patients not tak-ing AE...Bone Mineral Content(BMC), serum cal-cium, phosphorus and AlP were measured in64 epileptic patients on long term treatmentwith one or two kinds of antiepileptic drugs(AEDs) ,and in 14 epileptic patients not tak-ing AEDs. In the epileptic patients takingAEDs, the BMC value was 0.645±0.020g/cm^2,significantly lower than 0.693±0.022g/cm^2, theBMC value of the control group (P【0.01).展开更多
To the Editor,Coronavirus disease 2019(COVID-19)-related acute respiratory distress syndrome(ARDS)is biologically and clinically heterogeneous with a broad spectrum of organ dysfunction and illness severity.[1] In COV...To the Editor,Coronavirus disease 2019(COVID-19)-related acute respiratory distress syndrome(ARDS)is biologically and clinically heterogeneous with a broad spectrum of organ dysfunction and illness severity.[1] In COVID-19-related ARDS(C-ARDS),two phenotypes have been identified with latent class analysis(LCA)that are associated with divergent clinical outcomes and response to corticosteroids,and correspond to previously identified hypoinflammatory and hyperinflammatory phenotypes,[2,3]Despite insights gained from this work,understanding the biological processes that determine mortality risk in C-ARDS remains imprecise.Here,we report that metabolomic profiling of plasma at the onset of C-ARDS provides insights into pathogenesis and may predict clinical outcomes.展开更多
Kashin-Beck disease(KBD)is a chronic,endemic,degenerative osteoarthropathic condition that is predominantly found in China's Mainland.KBD is a progressive disease,and the signs and symptoms become more severe in a...Kashin-Beck disease(KBD)is a chronic,endemic,degenerative osteoarthropathic condition that is predominantly found in China's Mainland.KBD is a progressive disease,and the signs and symptoms become more severe in adulthood owing to the continuous development of lesions in the joint cartilage[1].Although childhood KBD has largely been controlled,adult KBD is an important health concern in rural regions.Unfortunately,in the last century,many adult KBD patients still remain during serious epidemics.展开更多
Tumor cells exhibit several metabolic abnormalities,such as uptake disorders of glucose and amino acids,increased nutrient consumption rates,use of glycolysis/tricarboxylic acid(TCA)cycle intermediates for biosynthesi...Tumor cells exhibit several metabolic abnormalities,such as uptake disorders of glucose and amino acids,increased nutrient consumption rates,use of glycolysis/tricarboxylic acid(TCA)cycle intermediates for biosynthesis and NADPH production,and increased demand for nitrogen sources[1].As an increasing understanding of cancer cell metabolism has been gained in recent years,the metabolic changes and molecular mechanisms associated with tumors in different tumor stages have been gradually revealed.展开更多
2006162 Change of vascular endothelial function in patients with disorders of glucose metabolism. ZHANG Songjing,(张松菁),et al. Dept Endocrinol ,1st Hosp, Fujian Med Univ ,Fuzhou 350005. Chin J Endocrinol Metab 2006;...2006162 Change of vascular endothelial function in patients with disorders of glucose metabolism. ZHANG Songjing,(张松菁),et al. Dept Endocrinol ,1st Hosp, Fujian Med Univ ,Fuzhou 350005. Chin J Endocrinol Metab 2006;22(1): 11 - 14. Objective: To observe the changes of the endothelium - dependent vasodilation ( EDF) and serum展开更多
2010410 Association of liver fat content with insulin resistance and islet β cell function in individuals with various statuses of glucose metabolism.BIAN Hua(卞华), etal.Dept Endocrinol & Metab, Zhongshan Hosp,F...2010410 Association of liver fat content with insulin resistance and islet β cell function in individuals with various statuses of glucose metabolism.BIAN Hua(卞华), etal.Dept Endocrinol & Metab, Zhongshan Hosp,Fudan Univ, Shanghai 200032.Chin J Endocrinol Metab 2010;26(7):535-540.展开更多
2011306 Association of serum ferritin with β-cell function and insulin resistance in elderly patients with type 2 diabetes and impaired glucose tolerance. ZHA Ying(查英),et al.Dept Endocrinol,Shanghai 5th People’s H...2011306 Association of serum ferritin with β-cell function and insulin resistance in elderly patients with type 2 diabetes and impaired glucose tolerance. ZHA Ying(查英),et al.Dept Endocrinol,Shanghai 5th People’s Hosp,Fudan Univ,Shanghai 200240.Abstract:Objective To investigate the relationship between serum ferritin and β-cell function,insulin resistance in elderly patients(age】60 years) with type 2 diabetes and impaired glucose tolerance. Methods Total 1 143 patients with type 2 diabetes,448展开更多
2011183 Effect of pioglitazone on the expressions of Bax and Bcl-2 protein in mouse osteoblasts. LI Jun-yan (李俊岩) ,et al. Dept Endocrinol,Heji Hosp, Changzhi Med Coll,Changzhi 046000. Chin J Endocrinol Metab 2011; ...2011183 Effect of pioglitazone on the expressions of Bax and Bcl-2 protein in mouse osteoblasts. LI Jun-yan (李俊岩) ,et al. Dept Endocrinol,Heji Hosp, Changzhi Med Coll,Changzhi 046000. Chin J Endocrinol Metab 2011; 27(2):118-121.展开更多
基金funded by the Fundamental Research Program of Shanxi Province(Grant number 202103021224394).
文摘Endometrial cancer(EC)is a malignant tumour that occurs in the epithelial cells of the endometrium and represents one of the most common malignancies involving the female reproductive system,with endometrioid adenocarcinoma as the most common type.In recent years,with an increasingly aging society and the growing number of obese people,the incidence of EC is constantly rising,posing a serious threat to women’s health.Some studies have reported that the interruption of digestion and absorption caused by imbalance in intestinal microbiota may lead to conditions such as obesity,hypertension,diabetes,and hormone imbalance,which are all risk factors for EC.Meanwhile,intestinal bacteria produce a series of metabolites during colonization and reproduction,which can rapidly respond to changes in the microenvironment of the body.Changes in their types and quantities can serve as sensitive indicators of physiological and pathological changes in the body.Patients with EC often suffer from metabolic diseases,which can lead to metabolic disorders involving carbohydrates,fats,and amino acid in their bodies.
文摘Group 1 metabotropic glutamate receptors(Gp1 mGluRs),comprising mGluR1 and mGluR5,are predominantly located at postsynaptic terminals.Gp1 mGluRs induce the activation of phospholipase C-γ.
文摘Alzheimer’s disease (AD) is the leading neurodegenerative disorder globally.Despite this,there is minimal effective therapeutics proven to reduce or prevent the progression of this disease.Glutamate is the main excitatory neurotransmitter within the central nervous system and plays a crucial role in neuronal and synaptic functions.
基金financially supported by Guizhou Provincial Science and Technology Support Program[No.Qiankehe[2021]496]Science and Technology Fund of Guizhou Health Commission[No.gzwkj2021-407]+1 种基金National Major Research Project[No.2017YFC1601805]Guizhou Provincial Science and Technology Support Program[No.Qiankehe[2017]2972]。
文摘Numerous instances of poisoning caused by the ingestion of mushrooms are reported annually worldwide,with most mushroom poisoning deaths caused by the ingestion of toxic amanita fungi.Amatoxin is the main toxic component of amanita,andα-amanitin is one of the most potent toxins present in amatoxin[1].
基金supported by a Swiss National Science Foundation,No.31003A_170129(to OOO)。
文摘Early blood-brain barrier(BBB) disturbance contributes to many different neurological diseases including Alzheimer 's disease, Parkinson's disease and stroke, particularly in the etiology and early stages(Abbott et al., 2010).
基金supported by the National Natural Science Foundation of China[Grant No.U2004102]the Natural Science Foundation of Henan Province[Grant No.202300410312]+1 种基金conducted in the laboratory of the Key Laboratory of Nutrition and Food Hygiene(Harbin Medical University)Heilongjiang Higher Education Institutions。
文摘In recent years,many investigations have indicated that environmental endocrine disruptors(EEDs)may accelerate the development of obesity[1].One kind of EEDs,di-(2-ethylhexyl)phthalate(DEHP),is ubiquitous in natural environments due to its role in the manufacture and use of plastic products[2].
文摘Bone Mineral Content(BMC), serum cal-cium, phosphorus and AlP were measured in64 epileptic patients on long term treatmentwith one or two kinds of antiepileptic drugs(AEDs) ,and in 14 epileptic patients not tak-ing AEDs. In the epileptic patients takingAEDs, the BMC value was 0.645±0.020g/cm^2,significantly lower than 0.693±0.022g/cm^2, theBMC value of the control group (P【0.01).
文摘To the Editor,Coronavirus disease 2019(COVID-19)-related acute respiratory distress syndrome(ARDS)is biologically and clinically heterogeneous with a broad spectrum of organ dysfunction and illness severity.[1] In COVID-19-related ARDS(C-ARDS),two phenotypes have been identified with latent class analysis(LCA)that are associated with divergent clinical outcomes and response to corticosteroids,and correspond to previously identified hypoinflammatory and hyperinflammatory phenotypes,[2,3]Despite insights gained from this work,understanding the biological processes that determine mortality risk in C-ARDS remains imprecise.Here,we report that metabolomic profiling of plasma at the onset of C-ARDS provides insights into pathogenesis and may predict clinical outcomes.
基金supported by basic research projects of Qinghai province[2017-ZJ-770]projects of Qinghai province health and family planning commission[2017-wjzdx-38]+1 种基金the 2020"Kunlun TalentsHigh-tech Innovation and Entrepreneurial Talents"project to cultivate leading talents of Qinghai province。
文摘Kashin-Beck disease(KBD)is a chronic,endemic,degenerative osteoarthropathic condition that is predominantly found in China's Mainland.KBD is a progressive disease,and the signs and symptoms become more severe in adulthood owing to the continuous development of lesions in the joint cartilage[1].Although childhood KBD has largely been controlled,adult KBD is an important health concern in rural regions.Unfortunately,in the last century,many adult KBD patients still remain during serious epidemics.
基金supported by the National Natural Science Foundation of China(81974430)the Natural Science Foundation of Guangdong Province(2019A1515012037)the National Heart,Lung,and Blood Institute,NIH,USA(5R00HL136924-03).
文摘Tumor cells exhibit several metabolic abnormalities,such as uptake disorders of glucose and amino acids,increased nutrient consumption rates,use of glycolysis/tricarboxylic acid(TCA)cycle intermediates for biosynthesis and NADPH production,and increased demand for nitrogen sources[1].As an increasing understanding of cancer cell metabolism has been gained in recent years,the metabolic changes and molecular mechanisms associated with tumors in different tumor stages have been gradually revealed.
文摘2006162 Change of vascular endothelial function in patients with disorders of glucose metabolism. ZHANG Songjing,(张松菁),et al. Dept Endocrinol ,1st Hosp, Fujian Med Univ ,Fuzhou 350005. Chin J Endocrinol Metab 2006;22(1): 11 - 14. Objective: To observe the changes of the endothelium - dependent vasodilation ( EDF) and serum
文摘2010410 Association of liver fat content with insulin resistance and islet β cell function in individuals with various statuses of glucose metabolism.BIAN Hua(卞华), etal.Dept Endocrinol & Metab, Zhongshan Hosp,Fudan Univ, Shanghai 200032.Chin J Endocrinol Metab 2010;26(7):535-540.
文摘2011306 Association of serum ferritin with β-cell function and insulin resistance in elderly patients with type 2 diabetes and impaired glucose tolerance. ZHA Ying(查英),et al.Dept Endocrinol,Shanghai 5th People’s Hosp,Fudan Univ,Shanghai 200240.Abstract:Objective To investigate the relationship between serum ferritin and β-cell function,insulin resistance in elderly patients(age】60 years) with type 2 diabetes and impaired glucose tolerance. Methods Total 1 143 patients with type 2 diabetes,448
文摘2011183 Effect of pioglitazone on the expressions of Bax and Bcl-2 protein in mouse osteoblasts. LI Jun-yan (李俊岩) ,et al. Dept Endocrinol,Heji Hosp, Changzhi Med Coll,Changzhi 046000. Chin J Endocrinol Metab 2011; 27(2):118-121.
