Objective： Many studies reported that matrix metalloproteinase-9 （MMP-9） participated in the development of esophageal squamous cell carcinoma （ESCC） and resulted in poor prognosis, however, they all included few...Objective： Many studies reported that matrix metalloproteinase-9 （MMP-9） participated in the development of esophageal squamous cell carcinoma （ESCC） and resulted in poor prognosis, however, they all included few patients and had inconsistent results. So we conducted a meta-analysis to explore the correlation between overexpression of MMP-9 and the clinicopathological characteristics and overall survival （OS） of ESCC. Methods： PubMed, EMBASE, Web of Science, Chinese Biomedical Literature Database, Google Scholar and other databases were searched for relevant studies. The Newcastle-Ottawa quality assessment scale was used to assess the methodological quality of included study and RevMan 5.2 software was used to conduct meta-analysis. Results： A total of 35 studies were included, and the results of meta-analysis showed that overexpression of MMP-9 was associated with grade of differentiation [well/moderate vs. poor： odds ratio （OR）： 0.39, 95% confidence interval （CI）： 0.29-0.52; P〈0.00001], lymph node metastasis （negative vs. positive： OR： 0.24, 95% CI： 0.16-0.34; P〈0.00001）, TNM stage （T1/T2 vs. T3/T4： OR： 0.28, 95% CI： 0.14-0.54; P=0.0002）, the depth of invasion （T1/T2 vs. T3/T4： OR： 0.29, 95% CI： 0.17-0.49; P〈0.00001）, and vascular invasion of ESCC （negative vs. positive： OR： 0.35, 95% CI： 0.21-0.58; P〈0.0001）, and also associated with poor overall survival ofESCC （HR： 2.17, 95% CI： 1.32-3.57; P=0.002）. Subgroup analysis showed that more than 10% of carcinoma cell staining was associated with significant increase of mortality risk （HR： 2.44, 95 % CI： 1.16-5.15; P=0.02）, and sensitive analysis suggested that MMP-9 was an independent prognostic factor in ESCC （HR： 1.49, 95% CI： 1.16-1.91; P=0.002）. Conclusions：On the basis of limited evidence, overexpression of MMP-9 may be a potential independent prognosis factor of ESCC patients in Asia, and high-quality studies assessing the prognostic significance of MMP-9 for ESCC patients are still needed.展开更多
目的:通过对柴胡加龙骨牡蛎汤对抑郁症的治疗效果进行Meta分析,为该方剂的临床应用提供参考。方法:以"柴胡加龙骨牡蛎汤""抑郁症""随机"等为关键词,检索2017年6月以前CNKI数据库、维普中文科技期刊数据...目的:通过对柴胡加龙骨牡蛎汤对抑郁症的治疗效果进行Meta分析,为该方剂的临床应用提供参考。方法:以"柴胡加龙骨牡蛎汤""抑郁症""随机"等为关键词,检索2017年6月以前CNKI数据库、维普中文科技期刊数据库、万方数据库、中国生物医学文献数据库,Cochrane Library,Web of Science,Pub Med等数据库,4名研究者采用Cochrane系统评价手册的方法学和质量评价标准进行系统评价,采用Revman5.3软件进行Meta分析。结果:亚组单独使用柴胡加龙骨牡蛎汤[OR=1.55,95%CI(0.73,3.32)],亚组联合抗抑郁药[OR=3.29,95%CI(1.14,9.47)],总体[OR=2.13,95%CI(1.16,3.90)]。总体异质性I2=10%,异质性较小。文献质量分析显示所纳入文献存在一定的发表性偏倚。对比两个亚组可知,联合抗抑郁药的疗效优于单独使用柴胡加龙骨牡蛎汤。8篇文献中有5篇文献提到了不良反应,5篇文献中共有病例干预组174例,对照组171例,其中干预组出现14例不良反应,对照组出现38例不良反应。服用抗抑郁药患者的不良反应率明显高于服用柴胡加龙骨牡蛎汤患者的不良反应率。结论:单用柴胡加龙骨牡蛎汤或者联合抗抑郁药在治疗抑郁症方面效果优于单独使用抗抑郁药,同时柴胡加龙骨牡蛎汤的使用明显降低了服药期间的不良反应发生率。展开更多
The rapid advancements in hardware, software, and computer networks have facilitated the shift of the computing paradigm from mainframe to cloud computing, in which users can get their desired services anytime, anywhe...The rapid advancements in hardware, software, and computer networks have facilitated the shift of the computing paradigm from mainframe to cloud computing, in which users can get their desired services anytime, anywhere, and by any means. However, cloud computing also presents many challenges, one of which is the difficulty in allowing users to freely obtain desired services, such as heterogeneous OSes and applications, via different light-weight devices. We have proposed a new paradigm by spatio-temporally extending the von Neumann architecture, called transparent computing, to centrally store and manage the commodity programs including OS codes, while streaming them to be run in non-state clients. This leads to a service-centric computing environment, in which users can select the desired services on demand, without concern for these services＇ administration, such as their installation, maintenance, management, and upgrade. In this paper, we introduce a novel concept, namely Meta OS, to support such program streaming through a distributed 4VP~ platform. Based on this platform, a pilot system has been implemented, which supports Windows and Linux environments. We verify the effectiveness of the platform through both real deployments and testbed experiments. The evaluation results suggest that the 4VP~ platform is a feasible and promising solution for the future computing infrastructure for cloud services.展开更多
文摘Objective： Many studies reported that matrix metalloproteinase-9 （MMP-9） participated in the development of esophageal squamous cell carcinoma （ESCC） and resulted in poor prognosis, however, they all included few patients and had inconsistent results. So we conducted a meta-analysis to explore the correlation between overexpression of MMP-9 and the clinicopathological characteristics and overall survival （OS） of ESCC. Methods： PubMed, EMBASE, Web of Science, Chinese Biomedical Literature Database, Google Scholar and other databases were searched for relevant studies. The Newcastle-Ottawa quality assessment scale was used to assess the methodological quality of included study and RevMan 5.2 software was used to conduct meta-analysis. Results： A total of 35 studies were included, and the results of meta-analysis showed that overexpression of MMP-9 was associated with grade of differentiation [well/moderate vs. poor： odds ratio （OR）： 0.39, 95% confidence interval （CI）： 0.29-0.52; P〈0.00001], lymph node metastasis （negative vs. positive： OR： 0.24, 95% CI： 0.16-0.34; P〈0.00001）, TNM stage （T1/T2 vs. T3/T4： OR： 0.28, 95% CI： 0.14-0.54; P=0.0002）, the depth of invasion （T1/T2 vs. T3/T4： OR： 0.29, 95% CI： 0.17-0.49; P〈0.00001）, and vascular invasion of ESCC （negative vs. positive： OR： 0.35, 95% CI： 0.21-0.58; P〈0.0001）, and also associated with poor overall survival ofESCC （HR： 2.17, 95% CI： 1.32-3.57; P=0.002）. Subgroup analysis showed that more than 10% of carcinoma cell staining was associated with significant increase of mortality risk （HR： 2.44, 95 % CI： 1.16-5.15; P=0.02）, and sensitive analysis suggested that MMP-9 was an independent prognostic factor in ESCC （HR： 1.49, 95% CI： 1.16-1.91; P=0.002）. Conclusions：On the basis of limited evidence, overexpression of MMP-9 may be a potential independent prognosis factor of ESCC patients in Asia, and high-quality studies assessing the prognostic significance of MMP-9 for ESCC patients are still needed.
文摘目的:通过对柴胡加龙骨牡蛎汤对抑郁症的治疗效果进行Meta分析,为该方剂的临床应用提供参考。方法:以"柴胡加龙骨牡蛎汤""抑郁症""随机"等为关键词,检索2017年6月以前CNKI数据库、维普中文科技期刊数据库、万方数据库、中国生物医学文献数据库,Cochrane Library,Web of Science,Pub Med等数据库,4名研究者采用Cochrane系统评价手册的方法学和质量评价标准进行系统评价,采用Revman5.3软件进行Meta分析。结果:亚组单独使用柴胡加龙骨牡蛎汤[OR=1.55,95%CI(0.73,3.32)],亚组联合抗抑郁药[OR=3.29,95%CI(1.14,9.47)],总体[OR=2.13,95%CI(1.16,3.90)]。总体异质性I2=10%,异质性较小。文献质量分析显示所纳入文献存在一定的发表性偏倚。对比两个亚组可知,联合抗抑郁药的疗效优于单独使用柴胡加龙骨牡蛎汤。8篇文献中有5篇文献提到了不良反应,5篇文献中共有病例干预组174例,对照组171例,其中干预组出现14例不良反应,对照组出现38例不良反应。服用抗抑郁药患者的不良反应率明显高于服用柴胡加龙骨牡蛎汤患者的不良反应率。结论:单用柴胡加龙骨牡蛎汤或者联合抗抑郁药在治疗抑郁症方面效果优于单独使用抗抑郁药,同时柴胡加龙骨牡蛎汤的使用明显降低了服药期间的不良反应发生率。
基金supported in part by the National High-Tech Research and Development(863)Program of China(No.2011AA01A203)the National Key Basic Research and Development Program(973)in China(No.2012BAH13F04)the research fund of Tsinghua-Tencent Joint Laboratory for Internet Innovation Technology
文摘The rapid advancements in hardware, software, and computer networks have facilitated the shift of the computing paradigm from mainframe to cloud computing, in which users can get their desired services anytime, anywhere, and by any means. However, cloud computing also presents many challenges, one of which is the difficulty in allowing users to freely obtain desired services, such as heterogeneous OSes and applications, via different light-weight devices. We have proposed a new paradigm by spatio-temporally extending the von Neumann architecture, called transparent computing, to centrally store and manage the commodity programs including OS codes, while streaming them to be run in non-state clients. This leads to a service-centric computing environment, in which users can select the desired services on demand, without concern for these services＇ administration, such as their installation, maintenance, management, and upgrade. In this paper, we introduce a novel concept, namely Meta OS, to support such program streaming through a distributed 4VP~ platform. Based on this platform, a pilot system has been implemented, which supports Windows and Linux environments. We verify the effectiveness of the platform through both real deployments and testbed experiments. The evaluation results suggest that the 4VP~ platform is a feasible and promising solution for the future computing infrastructure for cloud services.
