BACKGROUND Mesonephric-like adenocarcinoma(MLA)is a rare and highly malignant disease that occurs in the uterine body or ovaries.We report a case of a MLA that was considered to have originated in the fallopian tube a...BACKGROUND Mesonephric-like adenocarcinoma(MLA)is a rare and highly malignant disease that occurs in the uterine body or ovaries.We report a case of a MLA that was considered to have originated in the fallopian tube and presented with malignant peritonitis.CASE SUMMARY A 57-year-old female presented with a chief complaint of abdominal pain that began 2 months prior.Cancerous peritonitis was suspected.During exploratory laparoscopy,the right fallopian tube was found to be enlarged,with widespread disseminated lesions extending from the pelvic cavity to the upper abdomen.Histopathological examination of the peritoneal tissue obtained by biopsy showed tumor cells with a high nuclear/cellular ratio and proliferation of papillary tubular to pedunculated solid nests.Immunohistochemical testing was positive for GATA-binding protein 3,thyroid transcription factor 1,cluster of differentiation 10,and paired box protein-8,and negative for estrogen receptor,Wilms’tumor 1,and wild-type p53,leading to the diagnosis of MLA.Subsequently,debulking surgery was performed,and no macroscopic residual tumors were identified.The pathological diagnosis was right tubal carcinoma,mesonephric adenocarcinoma(International Federation of Gynecology and Obstetrics stage IIIC),and pT3cNXM0.Adjuvant chemotherapy was administered postoperatively;however,recurrence was noted,and the patient died 1 year and 6 months after the initial treatment.CONCLUSION MLA is a very rare disease with poor prognosis.Further studies are necessary to identify effective treatment options.展开更多
BACKGROUND Mesonephric adenocarcinoma(MNAC)is an extremely rare malignancy in the female genital tract.Only a few cases have been reported in the literature,and most of them occurred in the cervix,with extremely rare ...BACKGROUND Mesonephric adenocarcinoma(MNAC)is an extremely rare malignancy in the female genital tract.Only a few cases have been reported in the literature,and most of them occurred in the cervix,with extremely rare cases in the uterine body and ovary.MNAC has never been reported to arise in the fallopian tube.CASE SUMMARY A 45-year-old woman was referred to our institution with a history of abdominal pain.Ultrasound revealed a cystic and solid mass in left adnexal region.The patient underwent complete staging surgery when intraoperative pathological examination demonstrated that the mass was malignant.The final histological and immunohistochemical results confirmed the diagnosis of MNAC originating from the fallopian tube.Then she received four cycles of combination chemotherapy with carboplatin plus paclitaxel.The tumor recurred with hepatic metastases 4 mo after initial surgery,and second resection of the tumors in the liver plus partial hepatectomy was performed.She was supplemented with five courses of a new combination chemotherapy with gemcitabine plus carboplatin,and there was no evidence of recurrence within the 22-mo follow-up period after the second surgery.CONCLUSION MNAC originating from the fallopian tube is an extremely rare and high malignancy with a poor prognosis.It can be very aggressive,even at early stage.Little is known about the clinical characteristics,pathological diagnosis,prognosis,and optimal management strategy of MNAC originating from the fallopian tube.Herein we report the first case of primary MNAC deriving from the fallopian tube.展开更多
文摘BACKGROUND Mesonephric-like adenocarcinoma(MLA)is a rare and highly malignant disease that occurs in the uterine body or ovaries.We report a case of a MLA that was considered to have originated in the fallopian tube and presented with malignant peritonitis.CASE SUMMARY A 57-year-old female presented with a chief complaint of abdominal pain that began 2 months prior.Cancerous peritonitis was suspected.During exploratory laparoscopy,the right fallopian tube was found to be enlarged,with widespread disseminated lesions extending from the pelvic cavity to the upper abdomen.Histopathological examination of the peritoneal tissue obtained by biopsy showed tumor cells with a high nuclear/cellular ratio and proliferation of papillary tubular to pedunculated solid nests.Immunohistochemical testing was positive for GATA-binding protein 3,thyroid transcription factor 1,cluster of differentiation 10,and paired box protein-8,and negative for estrogen receptor,Wilms’tumor 1,and wild-type p53,leading to the diagnosis of MLA.Subsequently,debulking surgery was performed,and no macroscopic residual tumors were identified.The pathological diagnosis was right tubal carcinoma,mesonephric adenocarcinoma(International Federation of Gynecology and Obstetrics stage IIIC),and pT3cNXM0.Adjuvant chemotherapy was administered postoperatively;however,recurrence was noted,and the patient died 1 year and 6 months after the initial treatment.CONCLUSION MLA is a very rare disease with poor prognosis.Further studies are necessary to identify effective treatment options.
文摘BACKGROUND Mesonephric adenocarcinoma(MNAC)is an extremely rare malignancy in the female genital tract.Only a few cases have been reported in the literature,and most of them occurred in the cervix,with extremely rare cases in the uterine body and ovary.MNAC has never been reported to arise in the fallopian tube.CASE SUMMARY A 45-year-old woman was referred to our institution with a history of abdominal pain.Ultrasound revealed a cystic and solid mass in left adnexal region.The patient underwent complete staging surgery when intraoperative pathological examination demonstrated that the mass was malignant.The final histological and immunohistochemical results confirmed the diagnosis of MNAC originating from the fallopian tube.Then she received four cycles of combination chemotherapy with carboplatin plus paclitaxel.The tumor recurred with hepatic metastases 4 mo after initial surgery,and second resection of the tumors in the liver plus partial hepatectomy was performed.She was supplemented with five courses of a new combination chemotherapy with gemcitabine plus carboplatin,and there was no evidence of recurrence within the 22-mo follow-up period after the second surgery.CONCLUSION MNAC originating from the fallopian tube is an extremely rare and high malignancy with a poor prognosis.It can be very aggressive,even at early stage.Little is known about the clinical characteristics,pathological diagnosis,prognosis,and optimal management strategy of MNAC originating from the fallopian tube.Herein we report the first case of primary MNAC deriving from the fallopian tube.
