Four eburicane-type triterpenoids with malonyl modifications,namely irpexoates A-D(1-4),were isolated from the fruiting bodies of the medicinal fungus Irpex lacteus.The structures of the new compounds were established...Four eburicane-type triterpenoids with malonyl modifications,namely irpexoates A-D(1-4),were isolated from the fruiting bodies of the medicinal fungus Irpex lacteus.The structures of the new compounds were established by extensive spectroscopic methods,including 1D and 2D NMR,HRESIMS spectroscopic analysis.Irpexoate B(2)displayed weak cytotoxicity against four human cancer cell lines(A-549,SMMC-7721,MCF-7,SW480)with IC50 values varying from 22.9 to 34.0 pM,and irpexoate D(4)showed weak cytotoxicity against the human cancer cell line SW480 with an IC50 value of 35.2μM.展开更多
A new irlactane-type,namely irlactin K(1),and 22 tremulane-type sesquiterpenes including fourteen previously undescribed ones,namely irpexolactins A-N(2-15),and a known irlactane-type sesquiterpenoid,were isolated fro...A new irlactane-type,namely irlactin K(1),and 22 tremulane-type sesquiterpenes including fourteen previously undescribed ones,namely irpexolactins A-N(2-15),and a known irlactane-type sesquiterpenoid,were isolated from the fermentation broth of the medicinal fungus Irpex lacteus HFG1102.The structures of all the isolates were characterized by extensive spectroscopic methods,including 1D and 2D NMR and MS spectroscopic analysis.The absolute configurations of irlactin K and the known compound conocenol B(20)were established by single-crystal X-ray diffraction analysis.The vasorelaxant effects of irlactin K(1),irpexolactins A(2),C(4),K(12),and irlactam(22)were evaluated.展开更多
Six previously undescribed 5,6-seco-tremulane analogues,together with two known ones,were isolated from the culture broth of the medicinal fungus Irpex lacteus HFG1102.The structures of the new compounds were elucidat...Six previously undescribed 5,6-seco-tremulane analogues,together with two known ones,were isolated from the culture broth of the medicinal fungus Irpex lacteus HFG1102.The structures of the new compounds were elucidated via extensive spectroscopic methods,including NMR and HRMS spectroscopic analyses.展开更多
基金supported by National Natural Science Foundation of China(81561148013)the Key Projects of Technological Innovation of Hubei Province(2016ACA138)the Fundamental Research Funds for the Central University,South-Central University for Nationalities(CZT18014,CZT18013).
文摘Four eburicane-type triterpenoids with malonyl modifications,namely irpexoates A-D(1-4),were isolated from the fruiting bodies of the medicinal fungus Irpex lacteus.The structures of the new compounds were established by extensive spectroscopic methods,including 1D and 2D NMR,HRESIMS spectroscopic analysis.Irpexoate B(2)displayed weak cytotoxicity against four human cancer cell lines(A-549,SMMC-7721,MCF-7,SW480)with IC50 values varying from 22.9 to 34.0 pM,and irpexoate D(4)showed weak cytotoxicity against the human cancer cell line SW480 with an IC50 value of 35.2μM.
基金supported by National Natural Science Foundation of China(Nos.81903512,21961142008).
文摘A new irlactane-type,namely irlactin K(1),and 22 tremulane-type sesquiterpenes including fourteen previously undescribed ones,namely irpexolactins A-N(2-15),and a known irlactane-type sesquiterpenoid,were isolated from the fermentation broth of the medicinal fungus Irpex lacteus HFG1102.The structures of all the isolates were characterized by extensive spectroscopic methods,including 1D and 2D NMR and MS spectroscopic analysis.The absolute configurations of irlactin K and the known compound conocenol B(20)were established by single-crystal X-ray diffraction analysis.The vasorelaxant effects of irlactin K(1),irpexolactins A(2),C(4),K(12),and irlactam(22)were evaluated.
基金supported by National Natural Science Foundation of China(81561148013)the Key Projects of Technological Innovation of Hubei Province(No.2016ACA138)the Fundamental Research Funds for the Central University,South-Central University for Nationalities(CZT18014,CZT18013).
文摘Six previously undescribed 5,6-seco-tremulane analogues,together with two known ones,were isolated from the culture broth of the medicinal fungus Irpex lacteus HFG1102.The structures of the new compounds were elucidated via extensive spectroscopic methods,including NMR and HRMS spectroscopic analyses.
