Mendelian randomization(MR)is widely used in causal mediation analysis to control unmeasured confounding effects,which is valid under some strong assumptions.It is thus of great interest to assess the impact of violat...Mendelian randomization(MR)is widely used in causal mediation analysis to control unmeasured confounding effects,which is valid under some strong assumptions.It is thus of great interest to assess the impact of violations of these MR assumptions through sensitivity analysis.Sensitivity analyses have been conducted for simple MR-based causal average effect analyses,but they are not available for MR-based mediation analysis studies,and we aim to fill this gap in this paper.We propose to use two sensitivity parameters to quantify the effect due to the deviation of the IV assumptions.With these two sensitivity parameters,we derive consistent indirect causal effect estimators and establish their asymptotic propersties.Our theoretical results can be used in MR-based mediation analysis to study the impact of violations of MR as-sumptions.The finite sample performance of the proposed method is illustrated through simulation studies,sensitivity ana-lysis,and application to a real genome-wide association study.展开更多
目的：借助循证医学的方法为1例急性痛风性关节炎患者制定循证治疗方案。方法：在充分评估患者的情况后,提出临床问题,检索Medline（1990年1月-2009年10月）、Cochrane图书馆（2009年第3期）及CBMWeb（1990年1月-2009年10月）。检索主...目的：借助循证医学的方法为1例急性痛风性关节炎患者制定循证治疗方案。方法：在充分评估患者的情况后,提出临床问题,检索Medline（1990年1月-2009年10月）、Cochrane图书馆（2009年第3期）及CBMWeb（1990年1月-2009年10月）。检索主题词：中西医结合疗法（TCM-WMtherapy）;急性（acute）;痛风性关节炎（Gouty arthritis）;治疗（treat ment ORtherapy）;随机对照试验（RCT）;Meta-分析（Meta-analysis）;系统评价（systematic review）;人类（human）。结果：检索发现,关于急性痛风型关节炎132篇RCT,0篇SR,通过分析检索结果、结合临床经验及患者实际情况,为患者制定了循证治疗方案。通过半年随访证实,该方案适合患者。结论：对急性痛风性关节炎患者,采用循证治疗的方法,可有效提高治疗效果,改善患者的预后。展开更多
基金This work was supported by the National Natural Science Foundation of China(12171451,72091212).
文摘Mendelian randomization(MR)is widely used in causal mediation analysis to control unmeasured confounding effects,which is valid under some strong assumptions.It is thus of great interest to assess the impact of violations of these MR assumptions through sensitivity analysis.Sensitivity analyses have been conducted for simple MR-based causal average effect analyses,but they are not available for MR-based mediation analysis studies,and we aim to fill this gap in this paper.We propose to use two sensitivity parameters to quantify the effect due to the deviation of the IV assumptions.With these two sensitivity parameters,we derive consistent indirect causal effect estimators and establish their asymptotic propersties.Our theoretical results can be used in MR-based mediation analysis to study the impact of violations of MR as-sumptions.The finite sample performance of the proposed method is illustrated through simulation studies,sensitivity ana-lysis,and application to a real genome-wide association study.
文摘目的：借助循证医学的方法为1例急性痛风性关节炎患者制定循证治疗方案。方法：在充分评估患者的情况后,提出临床问题,检索Medline（1990年1月-2009年10月）、Cochrane图书馆（2009年第3期）及CBMWeb（1990年1月-2009年10月）。检索主题词：中西医结合疗法（TCM-WMtherapy）;急性（acute）;痛风性关节炎（Gouty arthritis）;治疗（treat ment ORtherapy）;随机对照试验（RCT）;Meta-分析（Meta-analysis）;系统评价（systematic review）;人类（human）。结果：检索发现,关于急性痛风型关节炎132篇RCT,0篇SR,通过分析检索结果、结合临床经验及患者实际情况,为患者制定了循证治疗方案。通过半年随访证实,该方案适合患者。结论：对急性痛风性关节炎患者,采用循证治疗的方法,可有效提高治疗效果,改善患者的预后。
