To investigate correlation of expressions of membrane-type 1, 2, and 3 matrix metalloproteinases (MT1, MT2, and MT3-MMP) to the invasion and metastases in laryngeal cancer. Methods Reverse transcription-polymerase cha...To investigate correlation of expressions of membrane-type 1, 2, and 3 matrix metalloproteinases (MT1, MT2, and MT3-MMP) to the invasion and metastases in laryngeal cancer. Methods Reverse transcription-polymerase chain reaction (RT-PCR) was used to examine the mRNA level of MT1, MT2, and MT3-MMP in 24 patients with laryngeal cancer. The relationships of these three MT-MMP expressions to clinico-pathology were analyzed by statistics. Results The expressions of MT1, MT2, and MT3-MMP were significantly higher in laryngeal cancer tissues than those in para-tumorous tissues (P < 0.01) and had a close relationship with invasive depth (P < 0.05). But no significantly different expressions of these three MT-MMPs were found in different primary location and different histological grade of laryngeal cancer (P > 0.05). The expression of MT1-MMP was obviously higher in patients with metastatic lymph nodes than that in patients without metastatic lymph nodes (P < 0.05). Conclusion MT1, MT2, and MT3-MMP play an important role in the progression of laryngeal cancer, and MT1-MMP may serve as a reliable marker in estimating invasive and metastatic potency of laryngeal cancer. Suppressing expressions of MT1, MT2, and MT3-MMP early may inhibit the invasion and metastases of laryngeal cancer.展开更多
To the Editor:Type IV collagen,widely distributed in multiple mammalian tissues,is important for maintaining the structural and functional integrity of vessel basement membranes(BMs).Type IV collagen abnormalities can...To the Editor:Type IV collagen,widely distributed in multiple mammalian tissues,is important for maintaining the structural and functional integrity of vessel basement membranes(BMs).Type IV collagen abnormalities can lead to a series of syndromes,such as Alport(#104200).[1]COL4A1 and COL4A2 encodeα1 andα2 chains of type IV collagen,respectivelyα2(IV)is expressed intracellularly and forms a heterotrimer with theα1(IV)protein at a ratio of 1:2(α1[IV]2α2[IV])in the endoplasmic reticulum(ER).This is secreted extracellularly via the golgi apparatus and vesicles with the aid of intracellular chaperones.[2]Previous studies have shown that variations in COL4A1/2 cause a variety of cerebral small vessel diseases,such as human porencephaly,cerebral hemorrhage,and structural malformations of the cerebral cortex.Moreover,these studies have indicated that COL4A1 variations can cause kidney,eye,and muscle dysfunction.[3]However,whether COL4A2(*120090)plays a role in the auditory system remains unclear.展开更多
文摘To investigate correlation of expressions of membrane-type 1, 2, and 3 matrix metalloproteinases (MT1, MT2, and MT3-MMP) to the invasion and metastases in laryngeal cancer. Methods Reverse transcription-polymerase chain reaction (RT-PCR) was used to examine the mRNA level of MT1, MT2, and MT3-MMP in 24 patients with laryngeal cancer. The relationships of these three MT-MMP expressions to clinico-pathology were analyzed by statistics. Results The expressions of MT1, MT2, and MT3-MMP were significantly higher in laryngeal cancer tissues than those in para-tumorous tissues (P < 0.01) and had a close relationship with invasive depth (P < 0.05). But no significantly different expressions of these three MT-MMPs were found in different primary location and different histological grade of laryngeal cancer (P > 0.05). The expression of MT1-MMP was obviously higher in patients with metastatic lymph nodes than that in patients without metastatic lymph nodes (P < 0.05). Conclusion MT1, MT2, and MT3-MMP play an important role in the progression of laryngeal cancer, and MT1-MMP may serve as a reliable marker in estimating invasive and metastatic potency of laryngeal cancer. Suppressing expressions of MT1, MT2, and MT3-MMP early may inhibit the invasion and metastases of laryngeal cancer.
基金This study was funded by grants from National Key Research and Development Project of China(No.2022YFC2703602)National Natural Science Foundation of China(Nos.82271177,82271185,and 82171158)Natural Science Foundation of Beijing(No.7242137).
文摘To the Editor:Type IV collagen,widely distributed in multiple mammalian tissues,is important for maintaining the structural and functional integrity of vessel basement membranes(BMs).Type IV collagen abnormalities can lead to a series of syndromes,such as Alport(#104200).[1]COL4A1 and COL4A2 encodeα1 andα2 chains of type IV collagen,respectivelyα2(IV)is expressed intracellularly and forms a heterotrimer with theα1(IV)protein at a ratio of 1:2(α1[IV]2α2[IV])in the endoplasmic reticulum(ER).This is secreted extracellularly via the golgi apparatus and vesicles with the aid of intracellular chaperones.[2]Previous studies have shown that variations in COL4A1/2 cause a variety of cerebral small vessel diseases,such as human porencephaly,cerebral hemorrhage,and structural malformations of the cerebral cortex.Moreover,these studies have indicated that COL4A1 variations can cause kidney,eye,and muscle dysfunction.[3]However,whether COL4A2(*120090)plays a role in the auditory system remains unclear.
