The present study was designed to determine the chemical constituents and identify new components of the leaves of Aquilaria sinensis （Lour.） Gilg. The compounds were isolated and purified by repeated silica gel, Se...The present study was designed to determine the chemical constituents and identify new components of the leaves of Aquilaria sinensis （Lour.） Gilg. The compounds were isolated and purified by repeated silica gel, Sephadex LH-20, and ODS column chromatography and their structures were elucidated by NMR and HR-ESI-MS spectrometry. Eight megastigmane glycosides and two cucurbitacins were isolated and identified as （95） megastigma-4,7-diene-2,3,9-triol 9-O-β-D-glucopyranoside （1）, （9S） megastigma-4（13）,7-diene-3,6,9-triol 9-O-β-D-glucopyranoside （2）, macarangloside D （3）, corchoionoside C （4）, staphylionoside H （5）, （＋） 3-oxo-a-ionol-β-D-glucopyranoside （6）, （-） 3-oxo-α-ionol-β-D-glucopyranoside （7）, citroside B （8）, 2-O-β-D-glucopyranosyl cucurbitacin I （9）, bryoamaride （10）. Compounds 1 and 2 were newly identified megstigmane glucosides and reported from this genus for the first time.展开更多
基金supported by Special Program for New Drug Innovation of the Ministry of Science and Technology,China(2009ZX311-004,2009ZX0308-004)
文摘The present study was designed to determine the chemical constituents and identify new components of the leaves of Aquilaria sinensis （Lour.） Gilg. The compounds were isolated and purified by repeated silica gel, Sephadex LH-20, and ODS column chromatography and their structures were elucidated by NMR and HR-ESI-MS spectrometry. Eight megastigmane glycosides and two cucurbitacins were isolated and identified as （95） megastigma-4,7-diene-2,3,9-triol 9-O-β-D-glucopyranoside （1）, （9S） megastigma-4（13）,7-diene-3,6,9-triol 9-O-β-D-glucopyranoside （2）, macarangloside D （3）, corchoionoside C （4）, staphylionoside H （5）, （＋） 3-oxo-a-ionol-β-D-glucopyranoside （6）, （-） 3-oxo-α-ionol-β-D-glucopyranoside （7）, citroside B （8）, 2-O-β-D-glucopyranosyl cucurbitacin I （9）, bryoamaride （10）. Compounds 1 and 2 were newly identified megstigmane glucosides and reported from this genus for the first time.
