1 Introduction The history of medicine in modern China has frequently been framed through a lens of“Westernization”,in which traditional Chinese medicine(TCM)is portrayed as grad-ually yielding to modern Western med...1 Introduction The history of medicine in modern China has frequently been framed through a lens of“Westernization”,in which traditional Chinese medicine(TCM)is portrayed as grad-ually yielding to modern Western medicine.Such a binary framework,however,oversimplifies the intricate realities of medical encounters in China.展开更多
In the dynamic landscape of modern healthcare and precision medicine,the digital revolution is reshaping medical industries at an unprecedented pace,and traditional Chinese medicine(TCM)is no exception[1-4].The paper...In the dynamic landscape of modern healthcare and precision medicine,the digital revolution is reshaping medical industries at an unprecedented pace,and traditional Chinese medicine(TCM)is no exception[1-4].The paper“From digits towards digitization:the past,present,and future of traditional Chinese medicine”by Academician&TCM National Master Qi WANG(王琦).展开更多
Natural herbs demonstrate significant therapeutic potential in managing chronic and complex diseases;however,their clinical application faces limitations due to low bioavailability,instability,toxicity,and herb-drug i...Natural herbs demonstrate significant therapeutic potential in managing chronic and complex diseases;however,their clinical application faces limitations due to low bioavailability,instability,toxicity,and herb-drug interactions.Furthermore,insufficient standardized evidence and global acceptance impede their widespread adoption.Liposomes,nanocarriers consisting of a phospholipid bilayer enclosing an aqueous core,present a promising approach for enhancing the pharmacokinetics and therapeutic efficacy of herbal compounds.These adaptable systems can encapsulate both hydrophilic and hydrophobic agents,enabling targeted drug delivery and enhanced stability.Moreover,liposomes can be modified to carry diagnostic and imaging agents,enabling precise disease detection and monitoring.While liposomes offer potential as an innovative delivery technology for herbal remedies,their application in Traditional Chinese Medicine(TCM)remains relatively unexplored.TCM,with its holistic,energy-based approach to health and organ function,presents distinct challenges regarding formulation and delivery.This review examines the therapeutic potential of herbal medicines,emphasizing how liposomes address delivery challenges within the TCM framework.It also investigates the integration of TCM with Western medical practices,demonstrating how liposomal systems may bridge these approaches.The review analyzes key formulation techniques for TCM-loaded liposomes,particularly the microfluidic method,which demonstrates superior control over particle size and encapsulation efficiency compared to conventional methods.The analysis addresses barriers to integrating liposomal delivery systems with TCM,including physicochemical properties,scalability issues,and regulatory challenges.Finally,this review provides strategic recommendations for overcoming these obstacles and identifies future research directions to maximize the potential of liposomal technology in enhancing TCM therapies.展开更多
Traditional Medicine(TM),particularly Traditional Chinese Medicine(TCM),is an indispensable component of the global healthcare system,offering unique insights to modern medical science.Clinical efficacy is the bedrock...Traditional Medicine(TM),particularly Traditional Chinese Medicine(TCM),is an indispensable component of the global healthcare system,offering unique insights to modern medical science.Clinical efficacy is the bedrock for the inheritance and development of TM.To meet the growing demand for high-quality healthcare,it is imperative to integrate TM with modern technology to address the issue of insufficient evidence for the efficacy of TM.展开更多
Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A p...Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A preliminary summary and evaluation were conducted on the generation and translation of clinical evidence for these treatments.This analysis aims to inform future research on clinical efficacy evaluation and guide the rational application of evidence.Methods RCTs of Chinese patent medicines and classic traditional Chinese prescriptions published in 2023 were comprehensively retrieved from the Artificial Intelligence Clinical Evi-dence Database for Chinese Patent Medicine(AICED-CPM),with supplementary searches conducted in China National Knowledge Infrastructure(CNKI),Wanfang Data,Chinese Sci-ence and Technology Journal Database(VIP),Chinese Biomedical Literature Database(SinoMed),Cochrane Library,PubMed,Embase,and Web of Science.The study characteris-tics and methodological quality of these RCTs were systematically analyzed and evaluated.Results A total of 1443 RCTs of Chinese patent medicines were included,comprising 1399 Chinese articles and 44 English articles.Additionally,334 RCTs of classic traditional Chinese medicine prescriptions were found,with 331 published in Chinese and 3 in English.196567 participants were included,covering 585 types of Chinese patent medicines(487 oral,61 in-jectable,and 37 topical)and 179 classic traditional Chinese medicine prescriptions.The in-volved studies encompassed 22 types of diseases,with research primarily focusing on dis-eases of the circulatory system,the respiratory system,and the genitourinary system.The sample sizes ranged from 18 to 3777 participants,and most studies were conducted at a sin-gle center.Methodologically,the implementation of allocation concealment and blinding re-mained insufficiently emphasized.Conclusion Overall,compared with 2022,both the number of RCT publications and their methodological quality have improved in 2023,with heightened attention to research on diseases of the genitourinary system.However,quality control and standardized management in the design and implementation processes still require enhancement to produce more high-quality clinical evidence and accelerate the translation and application of this evidence.展开更多
This paper explores the historical development and modern transformation of traditional Chinese medicine(TCM)to dispel the misconception that it is merely“traditional,ancient,backward and unscientific”.TCM,with root...This paper explores the historical development and modern transformation of traditional Chinese medicine(TCM)to dispel the misconception that it is merely“traditional,ancient,backward and unscientific”.TCM,with roots in ancient times,has evolved into a comprehensive medical system through the integration of empirical knowledge and theoretical frameworks.This review summarizes TCM’s development from three aspects:(1)Ancient Medical Development:From the Spring and Autumn to Han-Tang periods(770 B.C.E.-907 C.E.),the focus was on summarizing experience.A clear disciplinary classification emerged during the Song and Ming Dynasties(960 C.E.-1644 C.E.),and a complete medical system was established in the Qing Dynasty(1636 C.E.-1912 C.E.).(2)Modern Medical Development:Influenced by the European Industrial Revolution,new natural sciences-based technologies enhanced Western medicine’s diagnostic and treatment efficiency.The promotion of Western medicine in China and its metrological concepts,which underpin metrology-based medicine(MBM),in turn propelled the development of TCM.(3)The integration of modern TCM with metrology science has significantly changed TCM’s treatment and pharmaceutical fields.In recent decades,the introduction of western medicine has advanced TCM,creating a combined approach that leverages the advantages of both traditions.Supported by metrology and modern sciences,this integration has provided new tools for TCM quantification,standardization,and quality control.The paper emphasizes key milestones in TCM history,the impact of Western medicine and metrology on its modernization,and the potential of integrated approaches for complex medical challenges.It highlights the importance of preserving traditional knowledge while innovating to enhance TCM’s efficacy and safety.Future prospects suggest that TCM,combined with Metrology-based medicine,may play a crucial role in treating complex diseases,as modern Chinese medicine(MCM)has evolved with scientific advancements and integration of contemporary techniques.展开更多
Modern western medicine typically focuses on treating specific symptoms or diseases,and traditional Chinese medicine(TCM)emphasizes the interconnections of the body’s various systems under external environment and ta...Modern western medicine typically focuses on treating specific symptoms or diseases,and traditional Chinese medicine(TCM)emphasizes the interconnections of the body’s various systems under external environment and takes a holistic approach to preventing and treating diseases.Phenomics was initially introduced to the field of TCM in 2008 as a new discipline that studies the laws of integrated and dynamic changes of human clinical phenomes under the scope of the theories and practices of TCM based on phenomics.While TCM Phenomics 1.0 has initially established a clinical phenomic system centered on Zhenghou(a TCM definition of clinical phenome),bottlenecks remain in data standardization,mechanistic interpretation,and precision intervention.Here,we systematically elaborates on the theoretical foundations,technical pathways,and future challenges of integrating digital medicine with TCM phenomics under the framework of“TCM phenomics 2.0”,which is supported by digital medicine technologies such as artificial intelligence,wearable devices,medical digital twins,and multi-omics integration.This framework aims to construct a closed-loop system of“Zhenghou–Phenome–Mechanism–Intervention”and to enable the digitization,standardization,and precision of disease diagnosis and treatment.The integration of digital medicine and TCM phenomics not only promotes the modernization and scientific transformation of TCM theory and practice but also offers new paradigms for precision medicine.In practice,digital tools facilitate multi-source clinical data acquisition and standardization,while AI and big data algorithms help reveal the correlations between clinical Zhenghou phenomes and molecular mechanisms,thereby improving scientific rigor in diagnosis,efficacy evaluation,and personalized intervention.Nevertheless,challenges persist,including data quality and standardization issues,shortage of interdisciplinary talents,and insufficiency of ethical and legal regulations.Future development requires establishing national data-sharing platforms,strengthening international collaboration,fostering interdisciplinary professionals,and improving ethical and legal frameworks.Ultimately,this approach seeks to build a new disease identification and classification system centered on phenomes and to achieve the inheritance,innovation,and modernization of TCM diagnostic and therapeutic patterns.展开更多
Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developme...Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developments and research achievements in the fields of traditional medicine resources,medicinal material processing,pharmacognosy,natural medicinal chemistry,quality control,pharmacology,pharmacy,and clinical efficacy.It has columns for monographs,reviews,full research articles,short articles,newsletters and clinical case reports of traditional Chinese medicines.展开更多
Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developme...Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developments and research achievements in the fields of traditional medicine resources,medicinal material processing,pharmacognosy,natural medicinal chemistry,quality control,pharmacology,pharmacy,and clinical efficacy.It has columns for monographs,reviews,full research articles,short articles,newsletters and clinical case reports of traditional Chinese medicines.展开更多
This paper explores how traditional Chinese medicine(TCM),in the absence of modern medical instruments,employed observation and perception to understand and diagnose malignant tumors(cancer).It also reviews the evolut...This paper explores how traditional Chinese medicine(TCM),in the absence of modern medical instruments,employed observation and perception to understand and diagnose malignant tumors(cancer).It also reviews the evolution of relevant knowledge and treatment approaches since the introduction of Western medical technology.In ancient times,TCM primarily relied on external symptoms,palpation,and patient-reported experiences to infer internal masses,with a focus on gynecological disorders.Ancient TCM practitioners deduced internal conditions through patterns such as menstrual irregularities,abdominal masses,and abnormal discharges.Early descriptions of malignant tumors employed the character“癌(cancer)”to symbolize rock-like cavities,yet the descriptions were chiefly limited to external manifestations,with limited understanding of internal pathology.With the introduction of Western medicine,Chinese society gradually expanded its comprehension of cancer and adopted surgical as well as other therapies.In contrast,modern TCM has increasingly emphasized its own therapeutic effects,even promoting claims of cancer cure,warranting further investigation.The paper highlights the transition in TCM from a diagnostic model based mainly on observation and perception to another model increasingly combined with modern imaging and laboratory techniques.The transition underscores the need for innovation in TCM’s future development,while also revealing the diagnostic experience of ancient practice.Understanding TCM’s historical recognition of malignant tumors from the perspective of history of medicine may provide insights for contemporary TCM approaches to cancer treatment.展开更多
Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developme...Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developments and research achievements in the fields of traditional medicine resources,medicinal material processing,pharmacognosy,natural medicinal chemistry,quality control,pharmacology,pharmacy,and clinical efficacy.It has columns for monographs,reviews,full research articles,short articles,newsletters and clinical case reports of traditional Chinese medicines.展开更多
This article examines the complex interplay between Chinese medical and pharmaceutical practices and the introduction of Western medicine and pharmacy in China,with a particular focus on the British administration’s ...This article examines the complex interplay between Chinese medical and pharmaceutical practices and the introduction of Western medicine and pharmacy in China,with a particular focus on the British administration’s efforts to marginalizing Chinese medicine in Hong Kong from 1842 to 1941.Soon after the British occupation of Hong Kong in 1841,the Hong Kong government promulgated laws and regulations governing the sale,supply,distribution,and manufacture of opium and potent medicines(aka“poisons”).These laws,based on parliamentary acts passed in Westminster,marginalized Chinese medicine and pharmacy and empowered Western medical doctors,chemists,and druggists as the sole providers of these services.Despite this,Chinese medicine and pharmacy remained the preferred therapeutic system of the local Chinese population.However,minimal resources were allocated to the sector or support for practitioners of Chinese medicine and pharmacy,even though they served most of the population.The British Hong Kong administration seized two key opportunities which shifted the balance in favor of Western medicine and pharmacy.The first was during the 1894 bubonic plague,when the British Hong Kong administration funded a Western medicine clinic at the Tung Wah Hospital in Sheung Wan,with a short-lived effect.The second,with lasting impact,was the mass influx of refugees fleeing Kwangtung(now Guangdong)to Hong Kong in 1938,which led to the three independently managed Tung Wah hospitals(the Hospitals)merging into one Hospital Group at the urging of the British Hong Kong administration,due to funding issues by local philanthropists.Western medicine thus became the mainstream therapeutic system for in-patients at the Hospital Group.展开更多
Traditional Chinese medicines(TCMs)have been used for centuries to treat and manage various diseases.However,their effective delivery to targeted sites may be a major challenge due to their poor water solubility,low b...Traditional Chinese medicines(TCMs)have been used for centuries to treat and manage various diseases.However,their effective delivery to targeted sites may be a major challenge due to their poor water solubility,low bio-availability,and potential toxicity.Nanocarriers,such as liposomes,polymeric nanoparticles,inorganic nanoparticles,and organic/inorganic nanohybrids based on active constituents from TCMs have been extensively studied as a promising strategy to improve the delivery of active constituents from TCMs to achieve a higher therapeutic effect with fewer side effects compared to conventional formulations.This article summarizes the recent progress in nanocarrier-based delivery systems.Nanotechnology can broaden the scope of applications of traditional Chinese medicine.The concept of nano-traditional Chinese medicine(nano-TCM)is introduced,and the progress of nanomedicine,the advantages,and the development direction of nano-TCM are reviewed,providing new ideas for the development of nano-TCM.展开更多
This paper discusses the engagement of modern Western medicine in the development of traditional Chinese medicine(TCM)during the 1950s,specifically in its efforts on and research in modernizing TCM.Through complementi...This paper discusses the engagement of modern Western medicine in the development of traditional Chinese medicine(TCM)during the 1950s,specifically in its efforts on and research in modernizing TCM.Through complementing the studies of the 1950s with data and cases that have not been well studied in the previous publications,the author argues that modern Western medicine played an active and instrumental role in modernizing and scientizing TCM in the 1950s.TCM obtained attention not as merely a national treasure but underwent fast development of modernization in the 1950s.In modernizing TCM,Western medicine was not a bystander but served as an active partner.The professionals of Western medicine made good use of their strength in scientific studies in the development of TCM.Though scientization is part of modernization,the paper points out the scientific research by providing cases in the TCM research boom and discusses the significance.The scientific research not only linked TCM with modern scientific concepts and research methodology,but also expanded the research scope of the Western medicine,leading to breakthroughs in TCM medicines in the 1960s–1970s and to building the landscape of medicine in China.展开更多
Qin Medicine,referring to the traditional medicinal system and geo-authentic herbs originating from Shaanxi Province and its surrounding regions,has played a pivotal role in the evolution of Chinese medicine.Rooted in...Qin Medicine,referring to the traditional medicinal system and geo-authentic herbs originating from Shaanxi Province and its surrounding regions,has played a pivotal role in the evolution of Chinese medicine.Rooted in the distinct biogeographical landscape of the“Three Qin”region-comprising northern Shaanxi’s Loess Plateau,the Guanzhong Plain,and the southern Qinling-Bashan Mountains-Qin Medicine embodies the synergistic convergence of endemic biodiversity,empirical therapeutic traditions,and regional cultural identity[1].The distinct biogeographical landscape of the“Three Qin”region profoundly shaped Qin Medicine’s development.The arid Loess Plateau of northern Shaanxi,characterized by drought-tolerant flora,yields herbs such as Huangqi(Astragalus membranaceus)and Dahuang(Rheum palmatum)in harsh environments.In contrast,the biodiverse,humid Qinling-Bashan Mountains fostered a wealth of herbs for clearing heat,resolving dampness,and calming the spirit,such as Huanglian(Coptis chinensis),Fuling(Poria cocos),and Tianma(Gastrodia elata).The fertile Guanzhong Plain supported the cultivation of herbs such as Baishao(Paeonia lactiflora)and Danggui(Angelica sinensis)[2].This article traces the historical trajectory of Qin Medicine,systematically analyzing its formation,development,and modern advancements.展开更多
Component-based Chinese Medicine(CCM)stands as a pivotal endeavor in modernizing traditional Chinese medicine(TCM).By integrating classical TCM theories with modern scientific methodologies,CCM aims to achieve herbal ...Component-based Chinese Medicine(CCM)stands as a pivotal endeavor in modernizing traditional Chinese medicine(TCM).By integrating classical TCM theories with modern scientific methodologies,CCM aims to achieve herbal formulas with“defined components,clarified mechanisms,and controllable quality.”This approach not only transitions TCM development from empirical tradition to evidence-based science but also positions it for global recognition.Drawing on recent advancements in CCM,this editorial explores key insights and challenges shaping its trajectory.展开更多
Microneedles(MNs)have attracted increasing attention as a transdermal delivery system(TDDS)[1].However,traditional volatile Chinese medicines cannot be dissolved in conventional soluble MN materials,such as hyaluronic...Microneedles(MNs)have attracted increasing attention as a transdermal delivery system(TDDS)[1].However,traditional volatile Chinese medicines cannot be dissolved in conventional soluble MN materials,such as hyaluronic acid and chitosan,making it difficult for many traditional Chinese medicine ingredients to be applied to MN.Elemene(ELE)was successfully isolated from Curcuma longa,and has numerous antitumor and curative effects[2].展开更多
1 IntroductionChinese Medicine and Natural Products(CMNP)a quar-terly,open-access publication that is funded officially by 2017 Project for Enhancing International Impact of China STM Journals.CMNP is devoted to publi...1 IntroductionChinese Medicine and Natural Products(CMNP)a quar-terly,open-access publication that is funded officially by 2017 Project for Enhancing International Impact of China STM Journals.CMNP is devoted to publishing the theoretical and clinical research achievements in the field of Chinese medicine so as to promote the academic exchange of Chinese medicine.展开更多
Traditional Chinese medicine (TCM) with its millenniaold wisdom rooted in the principles of holistic Yin-Yang balance and “Bianzheng Lunzhi”[辨证论治, Zhenghou(证候) differentiation and treatment], has long offered ...Traditional Chinese medicine (TCM) with its millenniaold wisdom rooted in the principles of holistic Yin-Yang balance and “Bianzheng Lunzhi”[辨证论治, Zhenghou(证候) differentiation and treatment], has long offered a unique lens to understand human health and disease.However, the modern scientific interpretation of TCM remains at the stage of “knowing that it works, but not knowing why it works”.展开更多
Chinese medicine,with its rich historical roots and holistic approach,has been a fundamental aspect of healthcare in East Asia and is now gaining global recognition.Founded on centuries of empirical knowledge and phil...Chinese medicine,with its rich historical roots and holistic approach,has been a fundamental aspect of healthcare in East Asia and is now gaining global recognition.Founded on centuries of empirical knowledge and philosophical insight,Chinese medicine draws heavily from classical texts to guide its practices in herbal medicine and acupuncture.Despite its cultural and historical significance,integrating Chinese medicine into global healthcare systems presents challenges,notably the need for evidence-based practices to enhance credibility,ensure patient safety,and foster broader acceptance within the medical community.This paper explores how Chinese medicine can adopt evidence-based practices by incorporating principles of Western medicine into its research methodologies.It reviews the origins and philosophical foundations of Chinese medicine,examining its reliance on classical texts and empirical methods.The paper also highlights the differences between the personalised approach of Chinese medicine,which tailors treatments to individual needs,and the standardised protocols typical of Western medicine.Additionally,it addresses methodological challenges in Chinese medicine research,such as inconsistent diagnostic criteria and insufficient design rigour.To bridge these gaps,innovative research methodologies that respect the unique variability of Chinese medicine are needed.By adopting evidence-based practices and rigorous scientific validation,Chinese medicine can enhance its legitimacy and facilitate its integration into the global healthcare landscape.展开更多
文摘1 Introduction The history of medicine in modern China has frequently been framed through a lens of“Westernization”,in which traditional Chinese medicine(TCM)is portrayed as grad-ually yielding to modern Western medicine.Such a binary framework,however,oversimplifies the intricate realities of medical encounters in China.
文摘In the dynamic landscape of modern healthcare and precision medicine,the digital revolution is reshaping medical industries at an unprecedented pace,and traditional Chinese medicine(TCM)is no exception[1-4].The paper“From digits towards digitization:the past,present,and future of traditional Chinese medicine”by Academician&TCM National Master Qi WANG(王琦).
基金the Project of Hunan ScienceTechnology(Nos.2020JJ9011、2020JJ9020、2021JJ80078).
文摘Natural herbs demonstrate significant therapeutic potential in managing chronic and complex diseases;however,their clinical application faces limitations due to low bioavailability,instability,toxicity,and herb-drug interactions.Furthermore,insufficient standardized evidence and global acceptance impede their widespread adoption.Liposomes,nanocarriers consisting of a phospholipid bilayer enclosing an aqueous core,present a promising approach for enhancing the pharmacokinetics and therapeutic efficacy of herbal compounds.These adaptable systems can encapsulate both hydrophilic and hydrophobic agents,enabling targeted drug delivery and enhanced stability.Moreover,liposomes can be modified to carry diagnostic and imaging agents,enabling precise disease detection and monitoring.While liposomes offer potential as an innovative delivery technology for herbal remedies,their application in Traditional Chinese Medicine(TCM)remains relatively unexplored.TCM,with its holistic,energy-based approach to health and organ function,presents distinct challenges regarding formulation and delivery.This review examines the therapeutic potential of herbal medicines,emphasizing how liposomes address delivery challenges within the TCM framework.It also investigates the integration of TCM with Western medical practices,demonstrating how liposomal systems may bridge these approaches.The review analyzes key formulation techniques for TCM-loaded liposomes,particularly the microfluidic method,which demonstrates superior control over particle size and encapsulation efficiency compared to conventional methods.The analysis addresses barriers to integrating liposomal delivery systems with TCM,including physicochemical properties,scalability issues,and regulatory challenges.Finally,this review provides strategic recommendations for overcoming these obstacles and identifies future research directions to maximize the potential of liposomal technology in enhancing TCM therapies.
文摘Traditional Medicine(TM),particularly Traditional Chinese Medicine(TCM),is an indispensable component of the global healthcare system,offering unique insights to modern medical science.Clinical efficacy is the bedrock for the inheritance and development of TM.To meet the growing demand for high-quality healthcare,it is imperative to integrate TM with modern technology to address the issue of insufficient evidence for the efficacy of TM.
基金National Multidisciplinary Innovation Team of Traditional Chinese Medicine (ZYYCXTD-D-202204)Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine (22HHZYSS00013)。
文摘Objective Randomized controlled trials(RCTs)of Chinese patent medicines and classic tra-ditional Chinese medicine prescriptions were systematically reviewed from both Chinese and English journals published in 2023.A preliminary summary and evaluation were conducted on the generation and translation of clinical evidence for these treatments.This analysis aims to inform future research on clinical efficacy evaluation and guide the rational application of evidence.Methods RCTs of Chinese patent medicines and classic traditional Chinese prescriptions published in 2023 were comprehensively retrieved from the Artificial Intelligence Clinical Evi-dence Database for Chinese Patent Medicine(AICED-CPM),with supplementary searches conducted in China National Knowledge Infrastructure(CNKI),Wanfang Data,Chinese Sci-ence and Technology Journal Database(VIP),Chinese Biomedical Literature Database(SinoMed),Cochrane Library,PubMed,Embase,and Web of Science.The study characteris-tics and methodological quality of these RCTs were systematically analyzed and evaluated.Results A total of 1443 RCTs of Chinese patent medicines were included,comprising 1399 Chinese articles and 44 English articles.Additionally,334 RCTs of classic traditional Chinese medicine prescriptions were found,with 331 published in Chinese and 3 in English.196567 participants were included,covering 585 types of Chinese patent medicines(487 oral,61 in-jectable,and 37 topical)and 179 classic traditional Chinese medicine prescriptions.The in-volved studies encompassed 22 types of diseases,with research primarily focusing on dis-eases of the circulatory system,the respiratory system,and the genitourinary system.The sample sizes ranged from 18 to 3777 participants,and most studies were conducted at a sin-gle center.Methodologically,the implementation of allocation concealment and blinding re-mained insufficiently emphasized.Conclusion Overall,compared with 2022,both the number of RCT publications and their methodological quality have improved in 2023,with heightened attention to research on diseases of the genitourinary system.However,quality control and standardized management in the design and implementation processes still require enhancement to produce more high-quality clinical evidence and accelerate the translation and application of this evidence.
文摘This paper explores the historical development and modern transformation of traditional Chinese medicine(TCM)to dispel the misconception that it is merely“traditional,ancient,backward and unscientific”.TCM,with roots in ancient times,has evolved into a comprehensive medical system through the integration of empirical knowledge and theoretical frameworks.This review summarizes TCM’s development from three aspects:(1)Ancient Medical Development:From the Spring and Autumn to Han-Tang periods(770 B.C.E.-907 C.E.),the focus was on summarizing experience.A clear disciplinary classification emerged during the Song and Ming Dynasties(960 C.E.-1644 C.E.),and a complete medical system was established in the Qing Dynasty(1636 C.E.-1912 C.E.).(2)Modern Medical Development:Influenced by the European Industrial Revolution,new natural sciences-based technologies enhanced Western medicine’s diagnostic and treatment efficiency.The promotion of Western medicine in China and its metrological concepts,which underpin metrology-based medicine(MBM),in turn propelled the development of TCM.(3)The integration of modern TCM with metrology science has significantly changed TCM’s treatment and pharmaceutical fields.In recent decades,the introduction of western medicine has advanced TCM,creating a combined approach that leverages the advantages of both traditions.Supported by metrology and modern sciences,this integration has provided new tools for TCM quantification,standardization,and quality control.The paper emphasizes key milestones in TCM history,the impact of Western medicine and metrology on its modernization,and the potential of integrated approaches for complex medical challenges.It highlights the importance of preserving traditional knowledge while innovating to enhance TCM’s efficacy and safety.Future prospects suggest that TCM,combined with Metrology-based medicine,may play a crucial role in treating complex diseases,as modern Chinese medicine(MCM)has evolved with scientific advancements and integration of contemporary techniques.
基金Science and Technology strategic cooperation Programs of Luzhou Municipal People’s Government and Southwest Medical University (2019LZXNYD-P01DUAN)National Key R&D Program of China (2024YFC3505400)Regional Key R&D Program of Ningxia Hui Autonomous Region (2024BEG01003)。
文摘Modern western medicine typically focuses on treating specific symptoms or diseases,and traditional Chinese medicine(TCM)emphasizes the interconnections of the body’s various systems under external environment and takes a holistic approach to preventing and treating diseases.Phenomics was initially introduced to the field of TCM in 2008 as a new discipline that studies the laws of integrated and dynamic changes of human clinical phenomes under the scope of the theories and practices of TCM based on phenomics.While TCM Phenomics 1.0 has initially established a clinical phenomic system centered on Zhenghou(a TCM definition of clinical phenome),bottlenecks remain in data standardization,mechanistic interpretation,and precision intervention.Here,we systematically elaborates on the theoretical foundations,technical pathways,and future challenges of integrating digital medicine with TCM phenomics under the framework of“TCM phenomics 2.0”,which is supported by digital medicine technologies such as artificial intelligence,wearable devices,medical digital twins,and multi-omics integration.This framework aims to construct a closed-loop system of“Zhenghou–Phenome–Mechanism–Intervention”and to enable the digitization,standardization,and precision of disease diagnosis and treatment.The integration of digital medicine and TCM phenomics not only promotes the modernization and scientific transformation of TCM theory and practice but also offers new paradigms for precision medicine.In practice,digital tools facilitate multi-source clinical data acquisition and standardization,while AI and big data algorithms help reveal the correlations between clinical Zhenghou phenomes and molecular mechanisms,thereby improving scientific rigor in diagnosis,efficacy evaluation,and personalized intervention.Nevertheless,challenges persist,including data quality and standardization issues,shortage of interdisciplinary talents,and insufficiency of ethical and legal regulations.Future development requires establishing national data-sharing platforms,strengthening international collaboration,fostering interdisciplinary professionals,and improving ethical and legal frameworks.Ultimately,this approach seeks to build a new disease identification and classification system centered on phenomes and to achieve the inheritance,innovation,and modernization of TCM diagnostic and therapeutic patterns.
文摘Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developments and research achievements in the fields of traditional medicine resources,medicinal material processing,pharmacognosy,natural medicinal chemistry,quality control,pharmacology,pharmacy,and clinical efficacy.It has columns for monographs,reviews,full research articles,short articles,newsletters and clinical case reports of traditional Chinese medicines.
文摘Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developments and research achievements in the fields of traditional medicine resources,medicinal material processing,pharmacognosy,natural medicinal chemistry,quality control,pharmacology,pharmacy,and clinical efficacy.It has columns for monographs,reviews,full research articles,short articles,newsletters and clinical case reports of traditional Chinese medicines.
文摘This paper explores how traditional Chinese medicine(TCM),in the absence of modern medical instruments,employed observation and perception to understand and diagnose malignant tumors(cancer).It also reviews the evolution of relevant knowledge and treatment approaches since the introduction of Western medical technology.In ancient times,TCM primarily relied on external symptoms,palpation,and patient-reported experiences to infer internal masses,with a focus on gynecological disorders.Ancient TCM practitioners deduced internal conditions through patterns such as menstrual irregularities,abdominal masses,and abnormal discharges.Early descriptions of malignant tumors employed the character“癌(cancer)”to symbolize rock-like cavities,yet the descriptions were chiefly limited to external manifestations,with limited understanding of internal pathology.With the introduction of Western medicine,Chinese society gradually expanded its comprehension of cancer and adopted surgical as well as other therapies.In contrast,modern TCM has increasingly emphasized its own therapeutic effects,even promoting claims of cancer cure,warranting further investigation.The paper highlights the transition in TCM from a diagnostic model based mainly on observation and perception to another model increasingly combined with modern imaging and laboratory techniques.The transition underscores the need for innovation in TCM’s future development,while also revealing the diagnostic experience of ancient practice.Understanding TCM’s historical recognition of malignant tumors from the perspective of history of medicine may provide insights for contemporary TCM approaches to cancer treatment.
文摘Editorial Policy Asian Journal of Traditional Medicines is an international journal devoted to the advancement of research on traditional medicines.The followed areas are covered:scientific and technological developments and research achievements in the fields of traditional medicine resources,medicinal material processing,pharmacognosy,natural medicinal chemistry,quality control,pharmacology,pharmacy,and clinical efficacy.It has columns for monographs,reviews,full research articles,short articles,newsletters and clinical case reports of traditional Chinese medicines.
文摘This article examines the complex interplay between Chinese medical and pharmaceutical practices and the introduction of Western medicine and pharmacy in China,with a particular focus on the British administration’s efforts to marginalizing Chinese medicine in Hong Kong from 1842 to 1941.Soon after the British occupation of Hong Kong in 1841,the Hong Kong government promulgated laws and regulations governing the sale,supply,distribution,and manufacture of opium and potent medicines(aka“poisons”).These laws,based on parliamentary acts passed in Westminster,marginalized Chinese medicine and pharmacy and empowered Western medical doctors,chemists,and druggists as the sole providers of these services.Despite this,Chinese medicine and pharmacy remained the preferred therapeutic system of the local Chinese population.However,minimal resources were allocated to the sector or support for practitioners of Chinese medicine and pharmacy,even though they served most of the population.The British Hong Kong administration seized two key opportunities which shifted the balance in favor of Western medicine and pharmacy.The first was during the 1894 bubonic plague,when the British Hong Kong administration funded a Western medicine clinic at the Tung Wah Hospital in Sheung Wan,with a short-lived effect.The second,with lasting impact,was the mass influx of refugees fleeing Kwangtung(now Guangdong)to Hong Kong in 1938,which led to the three independently managed Tung Wah hospitals(the Hospitals)merging into one Hospital Group at the urging of the British Hong Kong administration,due to funding issues by local philanthropists.Western medicine thus became the mainstream therapeutic system for in-patients at the Hospital Group.
基金supported by Young Talent Program of The Affiliated Hospital of Xuzhou Medical University,Advanced Program of The Affiliated Hospital of Xuzhou Medical University(PYJH2024210)Medical Research Project of Jiangsu Provincial Health Commission(H2023050)National Natural Science Foundation of China(No.32301278).
文摘Traditional Chinese medicines(TCMs)have been used for centuries to treat and manage various diseases.However,their effective delivery to targeted sites may be a major challenge due to their poor water solubility,low bio-availability,and potential toxicity.Nanocarriers,such as liposomes,polymeric nanoparticles,inorganic nanoparticles,and organic/inorganic nanohybrids based on active constituents from TCMs have been extensively studied as a promising strategy to improve the delivery of active constituents from TCMs to achieve a higher therapeutic effect with fewer side effects compared to conventional formulations.This article summarizes the recent progress in nanocarrier-based delivery systems.Nanotechnology can broaden the scope of applications of traditional Chinese medicine.The concept of nano-traditional Chinese medicine(nano-TCM)is introduced,and the progress of nanomedicine,the advantages,and the development direction of nano-TCM are reviewed,providing new ideas for the development of nano-TCM.
文摘This paper discusses the engagement of modern Western medicine in the development of traditional Chinese medicine(TCM)during the 1950s,specifically in its efforts on and research in modernizing TCM.Through complementing the studies of the 1950s with data and cases that have not been well studied in the previous publications,the author argues that modern Western medicine played an active and instrumental role in modernizing and scientizing TCM in the 1950s.TCM obtained attention not as merely a national treasure but underwent fast development of modernization in the 1950s.In modernizing TCM,Western medicine was not a bystander but served as an active partner.The professionals of Western medicine made good use of their strength in scientific studies in the development of TCM.Though scientization is part of modernization,the paper points out the scientific research by providing cases in the TCM research boom and discusses the significance.The scientific research not only linked TCM with modern scientific concepts and research methodology,but also expanded the research scope of the Western medicine,leading to breakthroughs in TCM medicines in the 1960s–1970s and to building the landscape of medicine in China.
基金supported by the National Natural Science Foundation of China(Grant No.82274313)Project of Shaanxi Administration of Traditional Chinese Medicine(Grant No.2022-SLRH-YQ-010).
文摘Qin Medicine,referring to the traditional medicinal system and geo-authentic herbs originating from Shaanxi Province and its surrounding regions,has played a pivotal role in the evolution of Chinese medicine.Rooted in the distinct biogeographical landscape of the“Three Qin”region-comprising northern Shaanxi’s Loess Plateau,the Guanzhong Plain,and the southern Qinling-Bashan Mountains-Qin Medicine embodies the synergistic convergence of endemic biodiversity,empirical therapeutic traditions,and regional cultural identity[1].The distinct biogeographical landscape of the“Three Qin”region profoundly shaped Qin Medicine’s development.The arid Loess Plateau of northern Shaanxi,characterized by drought-tolerant flora,yields herbs such as Huangqi(Astragalus membranaceus)and Dahuang(Rheum palmatum)in harsh environments.In contrast,the biodiverse,humid Qinling-Bashan Mountains fostered a wealth of herbs for clearing heat,resolving dampness,and calming the spirit,such as Huanglian(Coptis chinensis),Fuling(Poria cocos),and Tianma(Gastrodia elata).The fertile Guanzhong Plain supported the cultivation of herbs such as Baishao(Paeonia lactiflora)and Danggui(Angelica sinensis)[2].This article traces the historical trajectory of Qin Medicine,systematically analyzing its formation,development,and modern advancements.
文摘Component-based Chinese Medicine(CCM)stands as a pivotal endeavor in modernizing traditional Chinese medicine(TCM).By integrating classical TCM theories with modern scientific methodologies,CCM aims to achieve herbal formulas with“defined components,clarified mechanisms,and controllable quality.”This approach not only transitions TCM development from empirical tradition to evidence-based science but also positions it for global recognition.Drawing on recent advancements in CCM,this editorial explores key insights and challenges shaping its trajectory.
基金supported by Shandong Provincial Natural Science Foundation Innovation and Development Joint Project,China(Grant No.:ZR2021LZY039)Zhejiang Provincial Traditional Chinese Medicine Science and Technology Plan,China(Grant No.:2021ZB184)。
文摘Microneedles(MNs)have attracted increasing attention as a transdermal delivery system(TDDS)[1].However,traditional volatile Chinese medicines cannot be dissolved in conventional soluble MN materials,such as hyaluronic acid and chitosan,making it difficult for many traditional Chinese medicine ingredients to be applied to MN.Elemene(ELE)was successfully isolated from Curcuma longa,and has numerous antitumor and curative effects[2].
文摘1 IntroductionChinese Medicine and Natural Products(CMNP)a quar-terly,open-access publication that is funded officially by 2017 Project for Enhancing International Impact of China STM Journals.CMNP is devoted to publishing the theoretical and clinical research achievements in the field of Chinese medicine so as to promote the academic exchange of Chinese medicine.
文摘Traditional Chinese medicine (TCM) with its millenniaold wisdom rooted in the principles of holistic Yin-Yang balance and “Bianzheng Lunzhi”[辨证论治, Zhenghou(证候) differentiation and treatment], has long offered a unique lens to understand human health and disease.However, the modern scientific interpretation of TCM remains at the stage of “knowing that it works, but not knowing why it works”.
文摘Chinese medicine,with its rich historical roots and holistic approach,has been a fundamental aspect of healthcare in East Asia and is now gaining global recognition.Founded on centuries of empirical knowledge and philosophical insight,Chinese medicine draws heavily from classical texts to guide its practices in herbal medicine and acupuncture.Despite its cultural and historical significance,integrating Chinese medicine into global healthcare systems presents challenges,notably the need for evidence-based practices to enhance credibility,ensure patient safety,and foster broader acceptance within the medical community.This paper explores how Chinese medicine can adopt evidence-based practices by incorporating principles of Western medicine into its research methodologies.It reviews the origins and philosophical foundations of Chinese medicine,examining its reliance on classical texts and empirical methods.The paper also highlights the differences between the personalised approach of Chinese medicine,which tailors treatments to individual needs,and the standardised protocols typical of Western medicine.Additionally,it addresses methodological challenges in Chinese medicine research,such as inconsistent diagnostic criteria and insufficient design rigour.To bridge these gaps,innovative research methodologies that respect the unique variability of Chinese medicine are needed.By adopting evidence-based practices and rigorous scientific validation,Chinese medicine can enhance its legitimacy and facilitate its integration into the global healthcare landscape.
