The present work dealt with sexual reproduction capacity of three relic species of the genus Sternbergia （family AmaryUidaceae） distributed in the Caucasus, i.e., Sternbergia lutea （L.） Ker Gawl. ex Spreng., Stern...The present work dealt with sexual reproduction capacity of three relic species of the genus Sternbergia （family AmaryUidaceae） distributed in the Caucasus, i.e., Sternbergia lutea （L.） Ker Gawl. ex Spreng., Sternbergiafischeriana （Herb.） Roem and Sternbergia colchiciflora Waldst. ＆ Kit.. Under this study, the natural populations of species, which possess valuable medicinal and ornamental properties, have been assessed by experts as vulnerable, and S. colchiciflora is included in the red list of endemic plants of the Caucasus, as having status of the critically endangered species. The situation is aggravated by the poor self-regeneration capacity of these species, which is one of the main factors responsible for the sustainability of the population of this or that species in the wild. Self-regeneration capacity for sexual reproduction was investigated in the listed species of the genus Sternbergia using common methods of embryology and reproduction biology. In conditions of the National Botanical Garden of Georgia （NBGG）, the species S. lutea and S. fischeriana prove to be completely infertile and propagate vegetatively by bulblets, while S. colchiciflora revealed the ability for propagation by seed. Long-term conservation of seeds of the studied species S. colchiciflora in the Caucasus Regional Seed Bank （CRSB） and establishing of living collections of this species at the experimental plot were chosen as the method for safeguarding this critically endangered species.展开更多
Objective To develop a model based on a graph convolutional network(GCN)to achieve ef-ficient classification of the cold and hot medicinal properties of Chinese herbal medicines(CHMs).Methods After screening the datas...Objective To develop a model based on a graph convolutional network(GCN)to achieve ef-ficient classification of the cold and hot medicinal properties of Chinese herbal medicines(CHMs).Methods After screening the dataset provided in the published literature,this study includ-ed 495 CHMs and their 8075 compounds.Three molecular descriptors were used to repre-sent the compounds:the molecular access system(MACCS),extended connectivity finger-print(ECFP),and two-dimensional(2D)molecular descriptors computed by the RDKit open-source toolkit(RDKit_2D).A homogeneous graph with CHMs as nodes was constructed and a classification model for the cold and hot medicinal properties of CHMs was developed based on a GCN using the molecular descriptor information of the compounds as node features.Fi-nally,using accuracy and F1 score to evaluate model performance,the GCN model was ex-perimentally compared with the traditional machine learning approaches,including decision tree(DT),random forest(RF),k-nearest neighbor(KNN),Naïve Bayes classifier(NBC),and support vector machine(SVM).MACCS,ECFP,and RDKit_2D molecular descriptors were al-so adopted as features for comparison.Results The experimental results show that the GCN achieved better performance than the traditional machine learning approach when using MACCS as features,with the accuracy and F1 score reaching 0.8364 and 0.8453,respectively.The accuracy and F1 score have increased by 0.8690 and 0.8120,respectively,compared with the lowest performing feature combina-tion OMER(only the combination of MACCS,ECFP,and RDKit_2D).The accuracy and F1 score of DT,RF,KNN,NBC,and SVM are 0.5051 and 0.5018,0.6162 and 0.6015,0.6768 and 0.6243,0.6162 and 0.6071,0.6364 and 0.6225,respectively.Conclusion In this study,by introducing molecular descriptors as features,it is verified that molecular descriptors and fingerprints play a key role in classifying the cold and hot medici-nal properties of CHMs.Meanwhile,excellent classification performance was achieved using the GCN model,providing an important algorithmic basis for the in-depth study of the“struc-ture-property”relationship of CHMs.展开更多
The discovery and characterization of molecular targets from traditional Chinese medicine(TCM)represents a paradigm shift in contemporary drug development.This approach systematically bridges empirical TCM knowledge w...The discovery and characterization of molecular targets from traditional Chinese medicine(TCM)represents a paradigm shift in contemporary drug development.This approach systematically bridges empirical TCM knowledge with modern pharmacological principles,establishing a robust framework for rational drug design.Through integrative systems-chemical biology approaches,we can now mechanistically elucidate the therapeutic basis of TCM's bioactive properties,facilitating the accelerated identification of both novel molecular targets and conserved pharmacological pathways.This multidisciplinary strategy significantly enhances drug development efficiency while advancing therapeutic innovation to address critical unmet medical needs.With the rapid advancement of next-generation target deconvolution technologies and AI-driven computational platforms,TCM is poised to make increasingly substantial contributions to modern pharmacotherapy.展开更多
Moringa oleifera is a miracle plant rich in nutrients,antioxidants,and antibiotic properties.Present study was designed to evaluate various biochemical attributes of leaves and flowers of M.oleifera.Plant parts(leaves...Moringa oleifera is a miracle plant rich in nutrients,antioxidants,and antibiotic properties.Present study was designed to evaluate various biochemical attributes of leaves and flowers of M.oleifera.Plant parts(leaves,flowers)of M.oleifera,collected from different roadsides of Multan district,Punjab,Pakistan,were used as experimental material.Result indicates that alkaloids,saponin,carbohydrates,fats,and protein had a high value in the aqueous extract of both leaves and flowers of M.oleifera.Whereas phenol content was high in methanolic leaves extract and the phenol contents were high in aqueous extract of flowers.The extract yield of M.oleifera leaves and flowers both showed a higher percentage in aqueous extract(57.5%),followed by methanol extract and lowest in ethyl acetate extract.Flavonoids contents were higher in ethyl acetate extract of leaves(33.67%)and aqueous extract of flowers(53.71%).While crude fiber was high in methanolic extract of leaves(12.40%)and in flowers crude fiber was high in ethyl acetate extract(15.86%).The moisture contents were higher in leaves(8.87%)than flowers(7.3%)and similarly,ash percentage in flowers(52.60%)than leaves(41.84%).Ethyl acetate extracts of M.oleifera leaves show antibacterial activity against Pseudomonas aeruginosa while methanolic extract of M.oleifera flowers shows antibacterial activity against Xanthomonas sp.Maximum growth inhibits show in all extracts of leaves against Aspergillus flavus,F.oxysporum,and P.glabrum except for the concentrated aqueous extract of leaves.While in flowers maximum growth inhibits all extracts against P.glabrum,A.niger,and A.flavus except the diluted ethyl acetate extract.Phytochemicals present in different parts of moringa have significant edible and commercial potential.Moringa extracts exhibited significant antimicrobial activity,therefore have applications in pharmaceuticals.展开更多
This comprehensive review systematically examines the multifarious aspects of Nelumbo nucifera,elucidating its eco-logical,nutritional,medicinal,and biomimetic significance.Renowned both culturally and scientifically,...This comprehensive review systematically examines the multifarious aspects of Nelumbo nucifera,elucidating its eco-logical,nutritional,medicinal,and biomimetic significance.Renowned both culturally and scientifically,Nelumbo nucif-era manifests remarkable adaptability,characterized by its extensive distribution across varied climatic regions,underpinned by its robust rhizome system and prolific reproductive strategies.Ecologically,this species plays a crucial role in aquatic ecosystems,primarily through biofiltration,thereby enhancing habitat biodiversity.The rhizomes and seeds of Nelumbo nucifera are nutritionally significant,being rich sources of dietary fiber,essential vitamins,and minerals,and have found extensive culinary applications.From a medicinal perspective,diverse constituents of Nelumbo nucifera exhibit therapeutic potential,including anti-inflammatory,antioxidant,and anti-cancer properties.Recent advancements in preservation technology and culinary innovation have further underscored its role in the food industry,highlighting its nutritional versatility.In biomimetics,the unique"lotus effect"is leveraged for the development of self-cleaning materials.Additionally,the transformation of Nelumbo nucifera into biochar is being explored for its potential in sustainable environmental practices.This review emphasizes the critical need for targeted conservation strategies to protect Nelumbo nucifera against the threats posed by climate change and habitat loss,advocating for its sustainable utilization as a species of significant value.展开更多
OBJECTIVE:To explore the four Qi of Pfaffia glomerata(PG)and endow this foreign folk herb with the properties of Chinese medicine,make it Chinese medicinal and localized,and could be used as a Chinese medicine.METHODS...OBJECTIVE:To explore the four Qi of Pfaffia glomerata(PG)and endow this foreign folk herb with the properties of Chinese medicine,make it Chinese medicinal and localized,and could be used as a Chinese medicine.METHODS:The normal group,six cold herb groups,six hot herb groups,six cool herb groups,PG prescription group(PGPG),and Dangshen(Radix Codonopsis)prescription group(CPPG)were prepared with corresponding concentrations of water extracts,these herb extracts were administered by gavage to SpragueDawley rats,and the 12 h urine at night on the 29th day of the SD rats in each group were collected,Liquid Chromatograph Mass Spectrometer system was used to analyze them,the best discriminant models for the medicinal properties of cold-hot and cold-cool were set up,so as to the medicinal properties of PGPG,CPPG and PG were predicted.Based on the Progenesis QI,Human Metabolome Database,Kyoto Encyclopedia of Genes and Genomes,MetaboAnalyst 5.0 database,we enriched metabolic pathway and classification mechanism of medicinal properties of cold-cool Chinese herbs and the molecular mechanism of PG prescription.RESULTS:We established a best model of cold-hot herbal discrimination in the positive ion mode,then the probability that PGPG was predicted cold property was 88.9%.Furthermore,a model of cold-cool herbal discrimination was established,then the probability of PGPG containing the cool property was 77.8%.In addition,typical cold and cool herbs mainly affected nine biomarkers such as tyrosine-proline,(R)-3',7-Dihydroxy-2',4'-dimethoxyisoflavane in rats.The regulation trend of PGPG on markers was basically as same as the cool herbs and mainly involved in regulating the two pathways of cytochrome P450 and purine metabolism.CONCLUSION:The results showed PGPG had a cool medicinal property as same as CPPG,and the regulation trend of PGPG on markers was consistent with cool herbs.Therefore,the medicine properties PG and CP should be consistent,and the Traditional Chinese Medicine property of PG was predicted to be neutral.展开更多
From the evolution of the mankind, Turmeric has been used in conventional medication. India is in lead for producing, marketing and exporting the Turmeric and its value added products. </span><i><span s...From the evolution of the mankind, Turmeric has been used in conventional medication. India is in lead for producing, marketing and exporting the Turmeric and its value added products. </span><i><span style="font-family:Verdana;">Curcuma</span></i> <i><span style="font-family:Verdana;">longa</span></i><span style="font-family:Verdana;"> (Turmeric) is an Indian rhizomatous medicinal herb from the Zingiberaceae family that is common and widely available across the globe. The components of Turmeric are curcumin, demethoxycurcumin and bisdemethoxycurcumin and these are collectively known as curcuminoids. Curcumin, the active ingredient of Turmeric is generally investigated by the scientific community for its wide range of antioxidant activity, anti-Inflammatory properties and anti-cancer activity, anti-metabolic syndrome activities, neuroprotective activity, antimicrobial </span><span style="font-family:Verdana;">effects, anti-arthritis effects, anti-viral effects, anti-asthma and anti-diabetic effects, anti-obesity, cardio and liver toxicity protection activity, anti-depression and anxiety activities.</span><span style="font-family:Verdana;"> Turmeric has been widely used as a typical household treatment for cough, sore throat, respiratory ailments and could be an effective immunity booster against SARS-CoV-2 therapy during the ongoing pandemic situation. Safety evaluation studies indicate that both turmeric and curcumin are well tolerated at a very high dose without any toxic effects. Thus, turmeric and its constituents have the potential for the development of modern medicine for the treatment of various diseases. So in this review, we describe the various metabolic roles of curcumin and activities for the benefit of human health.展开更多
Stir-frying is one of the important methods of processing medicinal materials. When stir-frying medicinal materials, no auxiliary materials are added, and only equipment is used to control the stir-frying temperature....Stir-frying is one of the important methods of processing medicinal materials. When stir-frying medicinal materials, no auxiliary materials are added, and only equipment is used to control the stir-frying temperature. Through stir-frying, expected changes in the appearance, smell and medicinal properties of the medicinal materials are promoted, and the application value of the Chinese medicinal materials is improved. In this paper, the method of stir-frying is briefly described, and the three operation methods of stir-frying yellow, stir-frying coke and stir-frying charcoal are explained. The practical application of stir-frying Chinese medicine processing is also analyzed.展开更多
Limited availability of organic matter is a problem to sustain crop growth on sodic soil. Organic soil amendments are a costeffective source of nutrients to enhance crop growth. A field study was conducted to evaluate...Limited availability of organic matter is a problem to sustain crop growth on sodic soil. Organic soil amendments are a costeffective source of nutrients to enhance crop growth. A field study was conducted to evaluate the effect of an organic soil amendment bioaugmented with plant growth-promoting fungi(SF_(OA) ) in combination with gypsum on soil properties and growth and yield attributes of Withania somnifera, one of the most valuable crops of the traditional medicinal system in the world, on a sodic soil at the Aurawan Research Farm of CSIR-National Botanical Research Institute, Lucknow, India. The SF_(OA) used was prepared by pre-enriching farm waste vermicompost with plant growth-promoting fungi before mixing with pressmud and Azadirachta indica seed cake. The application of SF_(OA) at 10 Mg ha^(-1)after gypsum(25.0 Mg ha^(-1)) treatment significantly(P < 0.05) increased root length(by 96%) and biomass(by 125%) of Withania plants compared to the control without SF_(OA) and gypsum. Similarly, the highest withanolide contents were observed in leaves and roots of Withania plants under 10 Mg ha^(-1)SF_(OA) and gypsum. Combined application of SF_(OA) and gypsum also improved physical, chemical and enzymatic properties of the soil, with the soil bulk density decreasing by 25%, water-holding capacity increasing by 121%, total organic C increasing by 90%, p H decreasing by 17% and alkaline phosphatase, β-glucosidase, dehydrogenase and cellulase activities increasing by 54%, 128%, 81% and 96%, respectively, compared to those of the control. These showed that application of the SF_(OA) tested in this study might reclaim sodic soil and further support Withania cultivation and results were better when the SF_(OA) was applied after gypsum treatment.展开更多
Through the method of literature mining,the classics of traditional Chinese medicine,materia medica works,medical cases and documents are studied.Based on common prescriptions for the treatment of diseases such as abn...Through the method of literature mining,the classics of traditional Chinese medicine,materia medica works,medical cases and documents are studied.Based on common prescriptions for the treatment of diseases such as abnormal Zang-fu viscera and qi movement,dysfunction,etc.,and combined with the theory of ascending and descending property of traditional Chinese medicine,the application of ascending and descending property of traditional Chinese medicine in clinical prescription compatibility and the factors affecting the application are summarized.The ascending and descending properties of traditional Chinese medicine have been widely used in prescription compatibility for the clinical treatment of impairment of purifying and descending function of the lung,spleen and stomach's ascending and descending disorders and heart-kidney noninteractionpatte.展开更多
Herbal remedies and related foods provide healing properties for a range of diseases,resulting in a higher standard of living.Bitter apple is extremely beneficial due to its bioactive and nutraceutical compounds.Incre...Herbal remedies and related foods provide healing properties for a range of diseases,resulting in a higher standard of living.Bitter apple is extremely beneficial due to its bioactive and nutraceutical compounds.Increasing awareness among consumers across the world about this unique fruit’s properties may provide huge opportunities for the supplier of herbal products as well as their use in the food industry.It has significant applications in the field of food technology.This review focused on the important features of bitter apple mainly,bioactive compounds,their mode of action,medical applications,chemical characteristics,chemical compounds,and the latest research on the pharmacological interventions of bitter apple extracts.This review also highlights the potential use of bitter apples in the food industry as well as their application in nanotechnology for the formation of nanoparticles.展开更多
The inappropriate activation of complement system may cause some life-threatening symptoms such as rheumatoid arthritis,systemic lupus erythematosus(SLE)and acute respiratory distress syndrome(ARDS).In our efforts to ...The inappropriate activation of complement system may cause some life-threatening symptoms such as rheumatoid arthritis,systemic lupus erythematosus(SLE)and acute respiratory distress syndrome(ARDS).In our efforts to obtain natural anticomplement agents from traditional Chinese medicines(TCMs)for prevention and treatment of the complement-associated diseases。展开更多
Medicated diets,a health regimen that integrates the medicinalproperties of herbs with the nutritional benefits of food,aredesigned to facilitate health maintenance and disease prevention,following the principles of T...Medicated diets,a health regimen that integrates the medicinalproperties of herbs with the nutritional benefits of food,aredesigned to facilitate health maintenance and disease prevention,following the principles of Traditional Chinese Medicine in dietarypreparation.The concept of medicated diets is deeply rooted inhuman civilization.According to Zhou Li Tian Guan,as early asthe Zhou Dynasty(256 BC–11th century),royal physicians weredivided into four distinct specializations,with dietetic physiciansranked foremost.These physicians were responsible for managingthe dietary health of the emperor and empress,highlighting thecritical role of diet in health maintenance,which marks the formative stage of the medicated diet concept.展开更多
Kudzu root,when steamed,has a pleasantly sweet flavor and possesses remarkable medicinal properties.Its medicinal value has been recorded in the Bencao Gangmu(Compendium of Materia Medica),a monumental encyclopedia of...Kudzu root,when steamed,has a pleasantly sweet flavor and possesses remarkable medicinal properties.Its medicinal value has been recorded in the Bencao Gangmu(Compendium of Materia Medica),a monumental encyclopedia of traditional Chinese medicine(TCM)compiled by Ming Dynasty(1368-1644)physician Li Shizhen over 27 years-and finally published in 1593.展开更多
Edible mushrooms are ubiquitous around the world due to their enormous health benefits.Mushrooms have been used as folk medicine and healthy food from ancient times but their health-promoting effects have not been exp...Edible mushrooms are ubiquitous around the world due to their enormous health benefits.Mushrooms have been used as folk medicine and healthy food from ancient times but their health-promoting effects have not been explored.As a superfood,mushroom powder is an essential component of the human diet for improving health and immunity.Bioactive components present in them such as proteins,polysaccharides,terpenes,and lipids have recently sparked much attention to exhibit therapeutic properties such as anti-cancer,immunomodulatory,antihypercholesterolemia,antiviral,antidiabetic,and anti-inflammatory effects.Moreover,these isolated compounds have the potentiality to be used in dietary supplements and medicines.In addition,numerous bioactive compounds such as ergosterol,gallic acid,and cordycepin proved to be essential in preventing or reducing the severity of COVID-19.This review unveils a comprehensive understanding of the nutraceutical as well as the medicinal potential of mushrooms and their applications in food products for human wellness.展开更多
Camel milk is the mainstay for millions of people in arid and semi-arid environments.In these areas,it is mainly consumed raw or after it spontaneously turns sour.Although some attempts have been made to produce dairy...Camel milk is the mainstay for millions of people in arid and semi-arid environments.In these areas,it is mainly consumed raw or after it spontaneously turns sour.Although some attempts have been made to produce dairy products from camel milk,processing of camel milk is generally considered to be difficult and the quality of the final products made from camel milk do not correspond to their bovine milk counterparts.This paper reports a comprehensive analysis of the literature on camel milk products and presents synthesis of the latest developments,limitations pertaining processing and opportunities for development of new and improved camel milk products.The protein composition and colloidal structure of camel milk differs from cow milk.It is characterized by absence of β-lactoglobulin,lowκ-casein content,high proportion of β-casein,larger casein micelles and smaller fat globules.These differences lead to the difficulty of making dairy products from camel milk using the same technologies as for bovine milk.Some of the challenges of camel milk processing include poor stability of the milk during UHT treatment,impaired rennetability,formation of weak and fragile curd during coagulation,longer fermentation time,and low thermal stability of the milk during drying.Despite these difficulties,it has now become possible to produce a range of commercial and traditional dairy products from camel milk.Some of the strategies that could be applied to improve the quality and characteristics of camel milk products are discussed.展开更多
Objective：To test whether Shenfu Injection（参附注射液,SFI）might attenuate the impact of cerebral energy dysfunction after resuscitation in a pig model of cardiac arrest（CA）.Methods：Thirty-four Wuzhishan miniatur...Objective：To test whether Shenfu Injection（参附注射液,SFI）might attenuate the impact of cerebral energy dysfunction after resuscitation in a pig model of cardiac arrest（CA）.Methods：Thirty-four Wuzhishan miniature inbred pigs were randomly divided into three groups：the SFI group（n=12）,the saline group（SA group,n=12）,and the sham-operated group（sham group,n=10）.Following successful return of spontaneous circulation（ROSC）from 8-min untreated ventricular fibrillation,animals received a continuous infusion of either SFI（0.2 mL/min）or saline for 6 h.Cerebral performance category score was evaluated at 24and 48 h after ROSC,followed by positron emission tomography and computed tomography scans of cerebral glucose uptake.Surviving pigs were euthanized 48 h after ROSC,and the brains were removed for detecting mitochondrial function.Results：Compared with the SA group,SFI treatment produced a better neurologic outcome48 h after ROSC（P〈0.05）.However,there was no significant difference of survival rate between the SA and SFI groups（83.3%vs.81.8%,P〉0.05）.After ROSC,the SA group showed a decrease in the maximum standardized uptake value of different regions in the brain tissue,where SFI treatment can ameliorate these decreases（P〈0.01or P〈0.05）.Improved mitochondrial respiratory properties and higher mitochondrial membrane potential were also found following SFI treatment compared with the SA group at 48 h after ROSC（P〈0.05 or P〈0.01）.Conclusion：SFI treatment after resuscitation has significant neuroprotective effects against disruption of cerebral energy metabolism from CA by improving glucose uptake and by normalizing mitochondrial function.展开更多
文摘The present work dealt with sexual reproduction capacity of three relic species of the genus Sternbergia （family AmaryUidaceae） distributed in the Caucasus, i.e., Sternbergia lutea （L.） Ker Gawl. ex Spreng., Sternbergiafischeriana （Herb.） Roem and Sternbergia colchiciflora Waldst. ＆ Kit.. Under this study, the natural populations of species, which possess valuable medicinal and ornamental properties, have been assessed by experts as vulnerable, and S. colchiciflora is included in the red list of endemic plants of the Caucasus, as having status of the critically endangered species. The situation is aggravated by the poor self-regeneration capacity of these species, which is one of the main factors responsible for the sustainability of the population of this or that species in the wild. Self-regeneration capacity for sexual reproduction was investigated in the listed species of the genus Sternbergia using common methods of embryology and reproduction biology. In conditions of the National Botanical Garden of Georgia （NBGG）, the species S. lutea and S. fischeriana prove to be completely infertile and propagate vegetatively by bulblets, while S. colchiciflora revealed the ability for propagation by seed. Long-term conservation of seeds of the studied species S. colchiciflora in the Caucasus Regional Seed Bank （CRSB） and establishing of living collections of this species at the experimental plot were chosen as the method for safeguarding this critically endangered species.
基金Hunan Provincial Natural Science Foundation(2022JJ30438)Natural Science Foundation of Changsha(kq2202260)Hunan Province Traditional Chinese Medicine Research Project(B2023039).
文摘Objective To develop a model based on a graph convolutional network(GCN)to achieve ef-ficient classification of the cold and hot medicinal properties of Chinese herbal medicines(CHMs).Methods After screening the dataset provided in the published literature,this study includ-ed 495 CHMs and their 8075 compounds.Three molecular descriptors were used to repre-sent the compounds:the molecular access system(MACCS),extended connectivity finger-print(ECFP),and two-dimensional(2D)molecular descriptors computed by the RDKit open-source toolkit(RDKit_2D).A homogeneous graph with CHMs as nodes was constructed and a classification model for the cold and hot medicinal properties of CHMs was developed based on a GCN using the molecular descriptor information of the compounds as node features.Fi-nally,using accuracy and F1 score to evaluate model performance,the GCN model was ex-perimentally compared with the traditional machine learning approaches,including decision tree(DT),random forest(RF),k-nearest neighbor(KNN),Naïve Bayes classifier(NBC),and support vector machine(SVM).MACCS,ECFP,and RDKit_2D molecular descriptors were al-so adopted as features for comparison.Results The experimental results show that the GCN achieved better performance than the traditional machine learning approach when using MACCS as features,with the accuracy and F1 score reaching 0.8364 and 0.8453,respectively.The accuracy and F1 score have increased by 0.8690 and 0.8120,respectively,compared with the lowest performing feature combina-tion OMER(only the combination of MACCS,ECFP,and RDKit_2D).The accuracy and F1 score of DT,RF,KNN,NBC,and SVM are 0.5051 and 0.5018,0.6162 and 0.6015,0.6768 and 0.6243,0.6162 and 0.6071,0.6364 and 0.6225,respectively.Conclusion In this study,by introducing molecular descriptors as features,it is verified that molecular descriptors and fingerprints play a key role in classifying the cold and hot medici-nal properties of CHMs.Meanwhile,excellent classification performance was achieved using the GCN model,providing an important algorithmic basis for the in-depth study of the“struc-ture-property”relationship of CHMs.
基金supported by the National Key R&D Program of China(No.2024YFC3506600)the National Natural Science Foundation of China(Nos.82474198 and 82274184)。
文摘The discovery and characterization of molecular targets from traditional Chinese medicine(TCM)represents a paradigm shift in contemporary drug development.This approach systematically bridges empirical TCM knowledge with modern pharmacological principles,establishing a robust framework for rational drug design.Through integrative systems-chemical biology approaches,we can now mechanistically elucidate the therapeutic basis of TCM's bioactive properties,facilitating the accelerated identification of both novel molecular targets and conserved pharmacological pathways.This multidisciplinary strategy significantly enhances drug development efficiency while advancing therapeutic innovation to address critical unmet medical needs.With the rapid advancement of next-generation target deconvolution technologies and AI-driven computational platforms,TCM is poised to make increasingly substantial contributions to modern pharmacotherapy.
基金Taif University Researchers Supporting Project No.(TURSP-2020/139),Taif University,Taif,Saudi Arabia。
文摘Moringa oleifera is a miracle plant rich in nutrients,antioxidants,and antibiotic properties.Present study was designed to evaluate various biochemical attributes of leaves and flowers of M.oleifera.Plant parts(leaves,flowers)of M.oleifera,collected from different roadsides of Multan district,Punjab,Pakistan,were used as experimental material.Result indicates that alkaloids,saponin,carbohydrates,fats,and protein had a high value in the aqueous extract of both leaves and flowers of M.oleifera.Whereas phenol content was high in methanolic leaves extract and the phenol contents were high in aqueous extract of flowers.The extract yield of M.oleifera leaves and flowers both showed a higher percentage in aqueous extract(57.5%),followed by methanol extract and lowest in ethyl acetate extract.Flavonoids contents were higher in ethyl acetate extract of leaves(33.67%)and aqueous extract of flowers(53.71%).While crude fiber was high in methanolic extract of leaves(12.40%)and in flowers crude fiber was high in ethyl acetate extract(15.86%).The moisture contents were higher in leaves(8.87%)than flowers(7.3%)and similarly,ash percentage in flowers(52.60%)than leaves(41.84%).Ethyl acetate extracts of M.oleifera leaves show antibacterial activity against Pseudomonas aeruginosa while methanolic extract of M.oleifera flowers shows antibacterial activity against Xanthomonas sp.Maximum growth inhibits show in all extracts of leaves against Aspergillus flavus,F.oxysporum,and P.glabrum except for the concentrated aqueous extract of leaves.While in flowers maximum growth inhibits all extracts against P.glabrum,A.niger,and A.flavus except the diluted ethyl acetate extract.Phytochemicals present in different parts of moringa have significant edible and commercial potential.Moringa extracts exhibited significant antimicrobial activity,therefore have applications in pharmaceuticals.
基金support provided by various funding sources,including the National Natural Science Foundation of China(No.51709254,No.32201384)Youth Innovation Promotion Association,Chinese Academy of Sciences(No.2020335)+1 种基金Key Research and Development Program of Hubei Province,China(2020BCA073)National Science&Technology Fundamental Resources Investigation Program of China(2019FY100600).
文摘This comprehensive review systematically examines the multifarious aspects of Nelumbo nucifera,elucidating its eco-logical,nutritional,medicinal,and biomimetic significance.Renowned both culturally and scientifically,Nelumbo nucif-era manifests remarkable adaptability,characterized by its extensive distribution across varied climatic regions,underpinned by its robust rhizome system and prolific reproductive strategies.Ecologically,this species plays a crucial role in aquatic ecosystems,primarily through biofiltration,thereby enhancing habitat biodiversity.The rhizomes and seeds of Nelumbo nucifera are nutritionally significant,being rich sources of dietary fiber,essential vitamins,and minerals,and have found extensive culinary applications.From a medicinal perspective,diverse constituents of Nelumbo nucifera exhibit therapeutic potential,including anti-inflammatory,antioxidant,and anti-cancer properties.Recent advancements in preservation technology and culinary innovation have further underscored its role in the food industry,highlighting its nutritional versatility.In biomimetics,the unique"lotus effect"is leveraged for the development of self-cleaning materials.Additionally,the transformation of Nelumbo nucifera into biochar is being explored for its potential in sustainable environmental practices.This review emphasizes the critical need for targeted conservation strategies to protect Nelumbo nucifera against the threats posed by climate change and habitat loss,advocating for its sustainable utilization as a species of significant value.
基金2018 National Key Research and Development Project:Research on Four Modes of Exploitation of New Sources of Rare and Endangered Chinese Medicine Resources-Research on Foreign Medicinal Materials(No.2018YFC1706100)Jiangxi Provincial Natural Science Foundation Key Project:Synthesis and Properties of Polysaccharide Moleculally-Imprinted Core-shell Microspheres based on Magnetic Micelle Technology(No.20192ACBL20028)。
文摘OBJECTIVE:To explore the four Qi of Pfaffia glomerata(PG)and endow this foreign folk herb with the properties of Chinese medicine,make it Chinese medicinal and localized,and could be used as a Chinese medicine.METHODS:The normal group,six cold herb groups,six hot herb groups,six cool herb groups,PG prescription group(PGPG),and Dangshen(Radix Codonopsis)prescription group(CPPG)were prepared with corresponding concentrations of water extracts,these herb extracts were administered by gavage to SpragueDawley rats,and the 12 h urine at night on the 29th day of the SD rats in each group were collected,Liquid Chromatograph Mass Spectrometer system was used to analyze them,the best discriminant models for the medicinal properties of cold-hot and cold-cool were set up,so as to the medicinal properties of PGPG,CPPG and PG were predicted.Based on the Progenesis QI,Human Metabolome Database,Kyoto Encyclopedia of Genes and Genomes,MetaboAnalyst 5.0 database,we enriched metabolic pathway and classification mechanism of medicinal properties of cold-cool Chinese herbs and the molecular mechanism of PG prescription.RESULTS:We established a best model of cold-hot herbal discrimination in the positive ion mode,then the probability that PGPG was predicted cold property was 88.9%.Furthermore,a model of cold-cool herbal discrimination was established,then the probability of PGPG containing the cool property was 77.8%.In addition,typical cold and cool herbs mainly affected nine biomarkers such as tyrosine-proline,(R)-3',7-Dihydroxy-2',4'-dimethoxyisoflavane in rats.The regulation trend of PGPG on markers was basically as same as the cool herbs and mainly involved in regulating the two pathways of cytochrome P450 and purine metabolism.CONCLUSION:The results showed PGPG had a cool medicinal property as same as CPPG,and the regulation trend of PGPG on markers was consistent with cool herbs.Therefore,the medicine properties PG and CP should be consistent,and the Traditional Chinese Medicine property of PG was predicted to be neutral.
文摘From the evolution of the mankind, Turmeric has been used in conventional medication. India is in lead for producing, marketing and exporting the Turmeric and its value added products. </span><i><span style="font-family:Verdana;">Curcuma</span></i> <i><span style="font-family:Verdana;">longa</span></i><span style="font-family:Verdana;"> (Turmeric) is an Indian rhizomatous medicinal herb from the Zingiberaceae family that is common and widely available across the globe. The components of Turmeric are curcumin, demethoxycurcumin and bisdemethoxycurcumin and these are collectively known as curcuminoids. Curcumin, the active ingredient of Turmeric is generally investigated by the scientific community for its wide range of antioxidant activity, anti-Inflammatory properties and anti-cancer activity, anti-metabolic syndrome activities, neuroprotective activity, antimicrobial </span><span style="font-family:Verdana;">effects, anti-arthritis effects, anti-viral effects, anti-asthma and anti-diabetic effects, anti-obesity, cardio and liver toxicity protection activity, anti-depression and anxiety activities.</span><span style="font-family:Verdana;"> Turmeric has been widely used as a typical household treatment for cough, sore throat, respiratory ailments and could be an effective immunity booster against SARS-CoV-2 therapy during the ongoing pandemic situation. Safety evaluation studies indicate that both turmeric and curcumin are well tolerated at a very high dose without any toxic effects. Thus, turmeric and its constituents have the potential for the development of modern medicine for the treatment of various diseases. So in this review, we describe the various metabolic roles of curcumin and activities for the benefit of human health.
文摘Stir-frying is one of the important methods of processing medicinal materials. When stir-frying medicinal materials, no auxiliary materials are added, and only equipment is used to control the stir-frying temperature. Through stir-frying, expected changes in the appearance, smell and medicinal properties of the medicinal materials are promoted, and the application value of the Chinese medicinal materials is improved. In this paper, the method of stir-frying is briefly described, and the three operation methods of stir-frying yellow, stir-frying coke and stir-frying charcoal are explained. The practical application of stir-frying Chinese medicine processing is also analyzed.
文摘Limited availability of organic matter is a problem to sustain crop growth on sodic soil. Organic soil amendments are a costeffective source of nutrients to enhance crop growth. A field study was conducted to evaluate the effect of an organic soil amendment bioaugmented with plant growth-promoting fungi(SF_(OA) ) in combination with gypsum on soil properties and growth and yield attributes of Withania somnifera, one of the most valuable crops of the traditional medicinal system in the world, on a sodic soil at the Aurawan Research Farm of CSIR-National Botanical Research Institute, Lucknow, India. The SF_(OA) used was prepared by pre-enriching farm waste vermicompost with plant growth-promoting fungi before mixing with pressmud and Azadirachta indica seed cake. The application of SF_(OA) at 10 Mg ha^(-1)after gypsum(25.0 Mg ha^(-1)) treatment significantly(P < 0.05) increased root length(by 96%) and biomass(by 125%) of Withania plants compared to the control without SF_(OA) and gypsum. Similarly, the highest withanolide contents were observed in leaves and roots of Withania plants under 10 Mg ha^(-1)SF_(OA) and gypsum. Combined application of SF_(OA) and gypsum also improved physical, chemical and enzymatic properties of the soil, with the soil bulk density decreasing by 25%, water-holding capacity increasing by 121%, total organic C increasing by 90%, p H decreasing by 17% and alkaline phosphatase, β-glucosidase, dehydrogenase and cellulase activities increasing by 54%, 128%, 81% and 96%, respectively, compared to those of the control. These showed that application of the SF_(OA) tested in this study might reclaim sodic soil and further support Withania cultivation and results were better when the SF_(OA) was applied after gypsum treatment.
基金University-level Scientific Research Project of Guangxi University of Chinese Medicine(2015MS011)Guangxi Key Laboratory of Zhuang Yao Medicine(20-065-14)Key Laboratory of Basic and Applied Research of Zhuang Traditional Medicine in Collages and Universities in Guangxi(GJKY[2017]23 zyfy201707).
文摘Through the method of literature mining,the classics of traditional Chinese medicine,materia medica works,medical cases and documents are studied.Based on common prescriptions for the treatment of diseases such as abnormal Zang-fu viscera and qi movement,dysfunction,etc.,and combined with the theory of ascending and descending property of traditional Chinese medicine,the application of ascending and descending property of traditional Chinese medicine in clinical prescription compatibility and the factors affecting the application are summarized.The ascending and descending properties of traditional Chinese medicine have been widely used in prescription compatibility for the clinical treatment of impairment of purifying and descending function of the lung,spleen and stomach's ascending and descending disorders and heart-kidney noninteractionpatte.
基金Institutions of Eminence(IoE)scheme,Banaras Hindu University,Varanasi(Uttar Pradesh)India,for financial support under Incentive to Senior Faculties under IoE.
文摘Herbal remedies and related foods provide healing properties for a range of diseases,resulting in a higher standard of living.Bitter apple is extremely beneficial due to its bioactive and nutraceutical compounds.Increasing awareness among consumers across the world about this unique fruit’s properties may provide huge opportunities for the supplier of herbal products as well as their use in the food industry.It has significant applications in the field of food technology.This review focused on the important features of bitter apple mainly,bioactive compounds,their mode of action,medical applications,chemical characteristics,chemical compounds,and the latest research on the pharmacological interventions of bitter apple extracts.This review also highlights the potential use of bitter apples in the food industry as well as their application in nanotechnology for the formation of nanoparticles.
基金The National Natural Science Foundation of China(NO.81330089 and 30925042)
文摘The inappropriate activation of complement system may cause some life-threatening symptoms such as rheumatoid arthritis,systemic lupus erythematosus(SLE)and acute respiratory distress syndrome(ARDS).In our efforts to obtain natural anticomplement agents from traditional Chinese medicines(TCMs)for prevention and treatment of the complement-associated diseases。
基金supported by the National Natural Science Foundation of China(82274053 and 82325049)the Scientific and Technological Innovation Project of China Academy of Chinese MedicalSciences(CI2021A04001)the CACMS Innovation Fund(CI2023E002 and CI2023D001).
文摘Medicated diets,a health regimen that integrates the medicinalproperties of herbs with the nutritional benefits of food,aredesigned to facilitate health maintenance and disease prevention,following the principles of Traditional Chinese Medicine in dietarypreparation.The concept of medicated diets is deeply rooted inhuman civilization.According to Zhou Li Tian Guan,as early asthe Zhou Dynasty(256 BC–11th century),royal physicians weredivided into four distinct specializations,with dietetic physiciansranked foremost.These physicians were responsible for managingthe dietary health of the emperor and empress,highlighting thecritical role of diet in health maintenance,which marks the formative stage of the medicated diet concept.
文摘Kudzu root,when steamed,has a pleasantly sweet flavor and possesses remarkable medicinal properties.Its medicinal value has been recorded in the Bencao Gangmu(Compendium of Materia Medica),a monumental encyclopedia of traditional Chinese medicine(TCM)compiled by Ming Dynasty(1368-1644)physician Li Shizhen over 27 years-and finally published in 1593.
基金funded by Science and Engineering Research Board,Department of Science and Technology(SERB/EEQ/2018/000131)。
文摘Edible mushrooms are ubiquitous around the world due to their enormous health benefits.Mushrooms have been used as folk medicine and healthy food from ancient times but their health-promoting effects have not been explored.As a superfood,mushroom powder is an essential component of the human diet for improving health and immunity.Bioactive components present in them such as proteins,polysaccharides,terpenes,and lipids have recently sparked much attention to exhibit therapeutic properties such as anti-cancer,immunomodulatory,antihypercholesterolemia,antiviral,antidiabetic,and anti-inflammatory effects.Moreover,these isolated compounds have the potentiality to be used in dietary supplements and medicines.In addition,numerous bioactive compounds such as ergosterol,gallic acid,and cordycepin proved to be essential in preventing or reducing the severity of COVID-19.This review unveils a comprehensive understanding of the nutraceutical as well as the medicinal potential of mushrooms and their applications in food products for human wellness.
文摘Camel milk is the mainstay for millions of people in arid and semi-arid environments.In these areas,it is mainly consumed raw or after it spontaneously turns sour.Although some attempts have been made to produce dairy products from camel milk,processing of camel milk is generally considered to be difficult and the quality of the final products made from camel milk do not correspond to their bovine milk counterparts.This paper reports a comprehensive analysis of the literature on camel milk products and presents synthesis of the latest developments,limitations pertaining processing and opportunities for development of new and improved camel milk products.The protein composition and colloidal structure of camel milk differs from cow milk.It is characterized by absence of β-lactoglobulin,lowκ-casein content,high proportion of β-casein,larger casein micelles and smaller fat globules.These differences lead to the difficulty of making dairy products from camel milk using the same technologies as for bovine milk.Some of the challenges of camel milk processing include poor stability of the milk during UHT treatment,impaired rennetability,formation of weak and fragile curd during coagulation,longer fermentation time,and low thermal stability of the milk during drying.Despite these difficulties,it has now become possible to produce a range of commercial and traditional dairy products from camel milk.Some of the strategies that could be applied to improve the quality and characteristics of camel milk products are discussed.
基金Supported by the Beijing Natural Science Foundation(No.7132092)Beijing Scientific Research Project for Outstanding Doctoral Thesis Guidance Teacher(No.20121002501)
文摘Objective：To test whether Shenfu Injection（参附注射液,SFI）might attenuate the impact of cerebral energy dysfunction after resuscitation in a pig model of cardiac arrest（CA）.Methods：Thirty-four Wuzhishan miniature inbred pigs were randomly divided into three groups：the SFI group（n=12）,the saline group（SA group,n=12）,and the sham-operated group（sham group,n=10）.Following successful return of spontaneous circulation（ROSC）from 8-min untreated ventricular fibrillation,animals received a continuous infusion of either SFI（0.2 mL/min）or saline for 6 h.Cerebral performance category score was evaluated at 24and 48 h after ROSC,followed by positron emission tomography and computed tomography scans of cerebral glucose uptake.Surviving pigs were euthanized 48 h after ROSC,and the brains were removed for detecting mitochondrial function.Results：Compared with the SA group,SFI treatment produced a better neurologic outcome48 h after ROSC（P〈0.05）.However,there was no significant difference of survival rate between the SA and SFI groups（83.3%vs.81.8%,P〉0.05）.After ROSC,the SA group showed a decrease in the maximum standardized uptake value of different regions in the brain tissue,where SFI treatment can ameliorate these decreases（P〈0.01or P〈0.05）.Improved mitochondrial respiratory properties and higher mitochondrial membrane potential were also found following SFI treatment compared with the SA group at 48 h after ROSC（P〈0.05 or P〈0.01）.Conclusion：SFI treatment after resuscitation has significant neuroprotective effects against disruption of cerebral energy metabolism from CA by improving glucose uptake and by normalizing mitochondrial function.
