Mechanical stimuli are known to play critical roles in mediating tissue repair and regeneration. Recently, thisknowledge has led to a paradigm shift toward proactive programming of biological functionalities of biomat...Mechanical stimuli are known to play critical roles in mediating tissue repair and regeneration. Recently, thisknowledge has led to a paradigm shift toward proactive programming of biological functionalities of biomaterialsby leveraging mechanics–geometry–biofunction relationships, which are beginning to shape the newly emergingfield of mechanobiomaterials. To profile this emerging field, this article aims to elucidate the fundamentalprinciples in modulating biological responses with material–tissue mechanical interactions, illustrate recentfindings on the relationships between material properties and biological responses, discuss the importance ofmathematical/physical models and numerical simulations in optimizing material properties and geometry, andoutline design strategies for mechanobiomaterials and their potential for tissue repair and regeneration. Giventhat the field of mechanobiomaterials is still in its infancy, this article also discusses open questions and challengesthat need to be addressed.展开更多
基金supported by the National Natural Science Foundation of China(grant numbers 82025025,U23A6008,32171321,32371385,81802155,51672184 and 81622032)National Key Research and Development Project of China(grant number 2023YFC2412300)+7 种基金Natural Science Foundation of Hebei Province of China(grant number H2022202007)Full-time Talents Program of Hebei Province of China(grant number 2020HBQZYC012)Natural Science Foundation of Tianjin of China(grant number 21JCZDJC01110,21JCYBJC01030)Academician Expert Workstation of Yunnan Province of China(202205AF150025)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)Key Laboratory of Orthopaedics of Suzhou(SZS2022017)Scientific Research Project of Tianjin Education Commission(2022KJ096)Science and Technology Innovation Project of Foshan City(1920001000025).
文摘Mechanical stimuli are known to play critical roles in mediating tissue repair and regeneration. Recently, thisknowledge has led to a paradigm shift toward proactive programming of biological functionalities of biomaterialsby leveraging mechanics–geometry–biofunction relationships, which are beginning to shape the newly emergingfield of mechanobiomaterials. To profile this emerging field, this article aims to elucidate the fundamentalprinciples in modulating biological responses with material–tissue mechanical interactions, illustrate recentfindings on the relationships between material properties and biological responses, discuss the importance ofmathematical/physical models and numerical simulations in optimizing material properties and geometry, andoutline design strategies for mechanobiomaterials and their potential for tissue repair and regeneration. Giventhat the field of mechanobiomaterials is still in its infancy, this article also discusses open questions and challengesthat need to be addressed.
