Combined with the experimental results from the large tunnel of the ChongqingResearch Institute,the mechanism of gas and coal dust explosion was studied.Someconcepts about gas and coal dust explosion were introduced s...Combined with the experimental results from the large tunnel of the ChongqingResearch Institute,the mechanism of gas and coal dust explosion was studied.Someconcepts about gas and coal dust explosion were introduced such as the form conditionand influential factors.Gas and coal dust explosion propagation was researched and thelifting process of coal dust was simulated.When an explosion occurred due to great mixtureof gas and air,the maximum explosion pressure appeared in the neighborhood of theexplosion source point.Before it propagated to the tunnel of the deposited coal dust,themaximum explosion pressure appeared to be in declining trend.Part of the energy waslost in the process of raising the deposited coal dust through a shock wave,so the maximumexplosion pressure was smallest on the foreside of the deposited coal dust sector.On the deposited coal dust sector,the explosion pressure rapidly increased and droppedoff after achieving the largest peak value.Because of coal dust participation in the explosion,the flame velocity rose rapidly on the deposited coal dust and achieved a basic stablevalue;coal dust was ignited to explode by initial laminar flame,and the laminar flametransformed into turbulent flame.The turbulence transformed the flame fold into a funnelshape and the shock wave interacted with the flame,so the combustion rate rose and thepressure wave was further enhanced.The regeneration mechanism between the flamecombustion rate and the aerodynamic flowing structure achieved the final critical state forforming the detonation.展开更多
In this paper,research of aftershock mechanisms is reviewed,including heterogeneity of medium and stress,mechanical loading,fluid intrusion and stress corrosion,and ratestate dependence.Previous studies have indicated...In this paper,research of aftershock mechanisms is reviewed,including heterogeneity of medium and stress,mechanical loading,fluid intrusion and stress corrosion,and ratestate dependence.Previous studies have indicated that the heterogeneity of media and stress is the basic premise of aftershocks generated.From the point view of mechanics,transient creep and afterslip can explain the decay of aftershocks in a short time after a mainshock and the relaxation of stress tends to interpret the characteristics of long-term aftershocks.Fluid intrusion and stress corrosion control the evolution process of the aftershocks under certain conditions.The interaction between the faults perturbed by the mainshock always exists during the aftershock activities.All kinds of models and the theories want to comply with the two basic power-law relationships---the G-R law and Omori law to some extent.展开更多
Objective:To establish a progressive research strategy for“colonic components analysis-efficacy verification and mechanism exploration-gut microbiota”,screen pharmacodynamic substances,and investigate their mechanis...Objective:To establish a progressive research strategy for“colonic components analysis-efficacy verification and mechanism exploration-gut microbiota”,screen pharmacodynamic substances,and investigate their mechanism via gut microbiota.Methods:The pharmacodynamics of Gegen Qinlian decoction(GQD)were assessed using a mouse model of dextran sulfate sodium-induced ulcerative colitis(UC).Ultra-performance liquid chromatographyquadrupole-orbitrap mass spectrometer was used to identify the prototype and metabolic components of GQD in the colon during UC.To analyze the structure and function of characteristic genera of GQD and its active components,16S rRNA sequencing was performed.Results:We identified 67 prototypic and 14 metabolic components of GQD in the UC colon.The primary prototype components are flavonoids and alkaloids,including puerarin(PUE),baicalin(BAI),and berberine(BER).The metabolism was predominantly sulfonation.Efficacy verification showed that the main active components,puerarin,baicalin,and berberine,had good therapeutic effects on UC.The results of 16S rRNA gene sequencing showed that GQD improved UC by regulating the structure and function of the gut microbiota.The abundance of gut microbiota involved in the metabolism of the prototype componentswas influenced by the corresponding components.The function prediction results showed that PUE was the most comparable to GQD,with 24 consistent pathways.BAI and BER showed comparable gut microbiota regulation pathways.Characteristic pathways of BER include glucometabolic processes.Conclusion:This study focused on the key issues in the gut microbiota pathway and developed a progressive research strategy to understand the transformation mechanisms of colonic components.This research systematically analyzed the active components and metabolic transformation of GQD in the colon during the pathological state of UC,as well as changes in the structure and function of the gut microbiota,clarified the mechanism of GQD and its active components in improving UC via the gut microbiota pathway.展开更多
In this paper,we report our attempts to raise the efficiency of liquid reduction method when using high specific surface area TiO2(HSTiO2)by doping Au.Characterization of Au-HSTiO2 was conducted via XRD,UV-vis,SEM,and...In this paper,we report our attempts to raise the efficiency of liquid reduction method when using high specific surface area TiO2(HSTiO2)by doping Au.Characterization of Au-HSTiO2 was conducted via XRD,UV-vis,SEM,and photocurrent intensity.The experimental results show that Au-HSTiO2 exhibits prominently higher photocatalytic hydrogen production than TiO2 and HSTiO2.Enhanced photosynthetic hydrogen production ability of Au-HSTiO2 should be attributed to the presence of abundant surface active sites of HSTiO2,remarkably extending electronic holes in Au doping.This study provides a promising photosynthetic material for hydrogen production.展开更多
The penetration behavior of topical substances in the skin not only relates to the transdermal delivery efficiency but also involves the safety and therapeutic effect of topical products,such as sunscreen and hair gro...The penetration behavior of topical substances in the skin not only relates to the transdermal delivery efficiency but also involves the safety and therapeutic effect of topical products,such as sunscreen and hair growth products.Researchers have tried to illustrate the transdermal process with diversified theories and technologies.Directly observing the distribution of topical substances on skin by characteristic imaging is the most convincing approach.Unfortunately,fluorescence labeling imaging,which is commonly used in biochemical research,is limited for transdermal research for most topical substances with a molecular mass less than 500 Da.Label-free imaging technologies possess the advantages of not requiring any macromolecular dyes,no tissue destruction and an extensive substance detection capability,which has enabled rapid development of such technologies in recent years and their introduction to biological tissue analysis,such as skin samples.Through the specific identification of topical substances and endogenous tissue components,label-free imaging technologies can provide abundant tissue distribution information,enrich theoretical and practical guidance for transdermal drug delivery systems.In this review,we expound the mechanisms and applications of the most popular label-free imaging technologies in transdermal research at present,compare their advantages and disadvantages,and forecast development prospects.展开更多
The electrocatalytic sulfur reduction reaction(SRR)and sulfur evolution reaction(SER),two fundamental multistep conversion processes in lithium–sulfur batteries(LSBs),are root-cause solutions to overcome sluggish red...The electrocatalytic sulfur reduction reaction(SRR)and sulfur evolution reaction(SER),two fundamental multistep conversion processes in lithium–sulfur batteries(LSBs),are root-cause solutions to overcome sluggish redox kinetics and the polysulfide shuttling effect.Metal–organic framework(MOF)electrocatalysts have emerged as good platforms for catalyzing SRR and SER,but their catalytic performance is challenged by poor electrical conductivity and limited chemical stability.Functionalized MOFs and their hybrids may be beneficial for stabilizing and improving the desired catalytic properties to achieve high-performance LSBs.This review provides a detailed overview of engineering principles for improving the activity,selectivity,and stability of MOFrelated electrocatalysts via composition modulation and nanostructure design as well as hybrid assembly.It presents and discusses the various advances achieved by using in situ characterization techniques,simulations,and theoretical calculations to reveal the dynamic evolution of MOF-related electrocatalysts,enabling an in-depth understanding of the catalysis mechanism at the molecular/atomic level.Lastly,prospects and possible research directions for MOF-related sulfur electrocatalysts are proposed.展开更多
Reservoir reconstructions implemented in unconventional oil and gas exploration usually adopt hydraulic fracturing techniques to inject high-pressure fluid into the reservoir and change its pore-fracture connection st...Reservoir reconstructions implemented in unconventional oil and gas exploration usually adopt hydraulic fracturing techniques to inject high-pressure fluid into the reservoir and change its pore-fracture connection structure to enhance production.Hydraulic fracturing changes the reservoir stress and causes the rocks to crack,thus generating microseismic events.One important component of microseismic research is the source mechanism inversion.Through the research on the microseismic focal mechanism,information on the source mechanisms and in-situ stress status variations can be quantitatively revealed to effectively optimize the reservoir reconstruction design for increasing production.This paper reviews the recent progress in hydraulic fracturing induced microseismic focal mechanism research.We summarize their main principles and provide a detailed introduction of the research advances in source modeling,microseismic data synthesis,and focal mechanism inversion.We also discuss the challenges and limitations in the current microseismic focal mechanism research and propose prospects for future research ideas and directions.展开更多
Objective To observe the effect of Fuzheng Kang’ai Recipe(FKR)combined with gefitinib on the proliferation and apoptosis of lung cancer A549 cells,and to study its potential synergistic mechanish with gefitinib.Metho...Objective To observe the effect of Fuzheng Kang’ai Recipe(FKR)combined with gefitinib on the proliferation and apoptosis of lung cancer A549 cells,and to study its potential synergistic mechanish with gefitinib.Methods The effects of FKR(0.211,0.316,0.474,0.711,1.067,1.600,2.400,3.600 mg/mL)combined with展开更多
The paper delved into specific causes of soil erosion during the construction phase of highway projects,analyzed the intrinsic mechanisms behind erosion formation,and examined in detail external dynamic factors contri...The paper delved into specific causes of soil erosion during the construction phase of highway projects,analyzed the intrinsic mechanisms behind erosion formation,and examined in detail external dynamic factors contributing to soil erosion,such as rainfall scouring and wind erosion.Additionally,this paper summarized the unique characteristics of soil and water loss during road construction and the potential severe hazards it may bring,aiming to provide valuable reference for professionals in related fields and to promote further development in the study of natural slope erosion.展开更多
[Objectives]Based on bibliometric methods,the evolution path and knowledge structure of shampoo product research in China were systematically analyzed,with a focus on the composition,efficacy,and mechanisms of traditi...[Objectives]Based on bibliometric methods,the evolution path and knowledge structure of shampoo product research in China were systematically analyzed,with a focus on the composition,efficacy,and mechanisms of traditional Chinese medicine shampoos,aiming to reveal the shifting patterns of core technological focuses at different stages and identify key future research directions.[Methods]Using a sample of 515 publications from CNKI journals between 2005 and 2025,CiteSpace 6.3.R1 was employed to construct multi-dimensional networks of authors,institutions,and keywords.Burst detection,keyword and cluster analyses,and time zone mapping were applied to track disciplinary dynamics.[Results]The analysis on the annual number of publications indicated that research on shampoo products underwent multiple phases including initial development,growth,fluctuation,peak,and adjustment from 2005 to 2025,with an overall upward trend.The significant differences between the collaboration network density of core authors and the strength of institutional cooperation indicated a need for academia to enhance cross-institutional collaborative innovation mechanisms.Keyword clustering analysis and co-occurrence mapping revealed that the research on traditional Chinese medicine shampoo products,known for their natural,mild,and non-irritating characteristics,demonstrates notable advantages in dandruff removal,anti-hair loss,hair growth,and scalp health management,which have become current research hotspots,providing data-driven decision-making support for technological upgrading and industry-academia-research integration in the field.[Conclusions]The bibliometric analysis based on 515 publications indicates that the overall development direction of shampoo products will comprehensively advance toward refined efficacy and personalized customization,greener and more natural ingredients,technological innovation and industry-academia-research collaboration,market segmentation and diversified development,as well as safety and efficacy evaluation.This study provides theoretical support for the innovation of specialized traditional Chinese medicine shampoo products.展开更多
Globalization has resulted in a notable rise in the flow of high-skilled talent from emerging countries to developed nations. Current research on transnational talent flow mainly focuses on the destination countries, ...Globalization has resulted in a notable rise in the flow of high-skilled talent from emerging countries to developed nations. Current research on transnational talent flow mainly focuses on the destination countries, with less attention given to the perspective of the sending countries, particularly lacking a dynamic discussion on its impact on technological evolution in the origin countries. Based on the OECD REGPAT database, this paper aims to explore how talent groups migrating to developed countries facilitate the return of knowledge and technology to emerging countries and achieve breakthroughs in their technological evolution paths, while further discussing the potential mechanisms involved. The findings of this paper are as follows:(1) The technological development of emerging countries is a path-dependent process, where countries often branch into new technologies related to their preexisting knowledge base. Consequently, knowledge feedback from high-skilled talents increases the likelihood of sending countries developing unrelated technologies.(2) The mobility of talents across borders fosters more international collaborations and citations for patents that are unrelated to the local knowledge base, thus enriching the technological paths of sending countries.(3) The mobility of high-skilled talents primarily affects complex technologies, which have significant economic effects that encourage imitation by other countries.However, the effect on novel technologies is less significant due to their strong geographical stickiness. In general, this paper addresses the gaps in existing research on talent outflow and the technological evolution of origin countries, providing empirical evidence for the positive role of transnational talent mobility in the technological catch-up of emerging nations.Besides, it offers recommendations for talent export, import, and innovation policy formulation in these countries.展开更多
As a transmission medium, welding arc can be modulated to emit ultrasonic energy by exerting high-frequency electric current. The frequency of exciting electric current has notable influence on the signals recorded by...As a transmission medium, welding arc can be modulated to emit ultrasonic energy by exerting high-frequency electric current. The frequency of exciting electric current has notable influence on the signals recorded by the sensors and the metallographic structures of the welds. The resonance phenomenon of arc-uitrasonic has been found in the experiment. Both the resonance mechanism and the distribution of resonance frequency are discussed by the bui|t vibration equation.展开更多
To introduce the advances of experimental research on acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome.The recent years experimental research literature of acupuncture and moxibustion for tre...To introduce the advances of experimental research on acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome.The recent years experimental research literature of acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome were reviewed.The research literatures on acupuncture treatment were major,focusing on the field of acupuncture and moxibustion regulating hypothalamic-pituitary-gonad axis and nerval-endocritic-immune net.Acupuncture and moxibustion could regulate the endocrine environment of menopausal women.Taking advantage of combination biomedicine with multi-sciences,to improve the acupuncture and moxibustion curative effct and probe the mechanism of menopausal pathology and acupuncture and moxibustion function to Women＇s Climacteric Syndrome,is the research direction afterward.展开更多
Helicobacter pylori(H.pylori)infection remains a pivotal driver of chronic gastritis,peptic ulcer,gastric mucosa-associated lymphoid tissue lymphoma and gastric cancer,yet its eradication is increasingly frustrated by...Helicobacter pylori(H.pylori)infection remains a pivotal driver of chronic gastritis,peptic ulcer,gastric mucosa-associated lymphoid tissue lymphoma and gastric cancer,yet its eradication is increasingly frustrated by climbing antibiotic resistance and intolerable side-effects of standard triple or quadruple therapies.In recent years,fecal microbiota transplantation(FMT),a strategy that reconstructs the gut ecosystem by introducing a healthy donor microbiome,has emerged as a novel adjunct or alternative.By competitively excluding H.pylori,reinforcing mucosal barrier integrity,modulating host immunity and secreting bacteriocins,FMT can raise eradication rates,relieve dyspeptic symptoms and lower recurrence.This review synthesizes up-to-date pre-clinical,pilot and controlled clinical data,dissects underlying mechanisms,compares delivery routes,donor screening protocols and safety profiles,and discusses regulatory,ethical and standardization hurdles that must be overcome before large-scale clinical application.展开更多
As the traditional Chinese medicine(TCM)therapy,moxibustion includes many techniques,such as Chinese herb-isolated moxibustion,heat-sensitive moxibustion,mild moxibustion and warming needling.Through multiple function...As the traditional Chinese medicine(TCM)therapy,moxibustion includes many techniques,such as Chinese herb-isolated moxibustion,heat-sensitive moxibustion,mild moxibustion and warming needling.Through multiple functions of moxibustion,e.g.heat stimulation,meridian conductivity and drug effect,moxibustion brings the therapeutic effect into play,thus,it displays a certain advantage in treatment of Irritable bowel syndrome(IBS).In clinical practice,moxibustion therapy is widely used in the treatment of IBS and has achieved certain therapeutic effect.It is found in clinical and experimental researches that moxibustion may achieve the therapeutic effect by means of the intervention of visceral hypersensitivity,gastrointestinal hormone,gastrointestinal motility,brain-gut axis,intestinal flora,etc.But,the specific mechanism remains to be further explored.In this paper,the current status of treatment and research progress are summarized and reflected so as to provide ideas for future research and application.展开更多
A kind of high impermeable and crack-resistance chemical admixture ( HICRCA) was prepared , which is a compound chemical admixture composed of an expansion ingredient, density ingredient, and organic hydrophobic poreb...A kind of high impermeable and crack-resistance chemical admixture ( HICRCA) was prepared , which is a compound chemical admixture composed of an expansion ingredient, density ingredient, and organic hydrophobic poreblocking ingredient. The results of the experiments indicate that the addition of HICRCA improves mortar and concrete in the following performances: (1) perfect workability: slump is more than 22cm, theslump afar 3h is about 16cm; (2) high impermeability:for the mortar, the pervious height under a water pressure of 1.5MPa is 1.5cm,for the concrete, the pervious height under a water pressure of 5.0MPa is 2. 2cm;(3) high crack-resistance: there is a micro-expansion at the age of 90d; (4) high compressivestrength: compared with the controlled concrete, the compressive strengths at the age of 3d and 2Sd are improved by 66.4% and 62.0% , respectively. At the same time, the effects of different curing condition on mortar and concrete expansive andshrinkage performance were studied. In addition, the impermeable and crack-resistance mechanism, was investigatedin the present paper.展开更多
PEO-based all-solid-state electrolytes are extensively utilized and researched owing to their exceptional safety,low-mass-density,and cost-effectiveness.However,the low oxidation potential of PEO makes the interface p...PEO-based all-solid-state electrolytes are extensively utilized and researched owing to their exceptional safety,low-mass-density,and cost-effectiveness.However,the low oxidation potential of PEO makes the interface problem with the high-voltage cathode extremely severe.In this work,the impedance of PEO-based all-solid-state batteries with high-voltage cathode(NCM811)was studied at different potentials.The Nyquist plots displayed a gyrate arc at low-frequencies for NCM811/PEO interface.Based on the kinetic modeling,it was deduced that there is a decomposition reaction of PEO-matrix in addition to de-embedded reaction of NCM811,and the PEO intermediate product(dehydra-PEO)adsorbed on the electrode surface leading to low-frequency inductive arcs.Furthermore,the distribution of relaxation time shows the dehydra-PEO results in the kinetic tardiness of the charge transfer process in the temporal dimension.Hence,an artificial interface layer(CEI_(x))was modified on the surface of NCM811 to regulate the potential of cathode/electrolyte interface to prevent the high-voltage deterioration of PEO.NCM/CEI_(x)/PEO batteries exhibit capacity retentions of 96.0%,84.6%,and 76.8%after undergoing 100 cycles at cut-off voltages of 4.1,4.2,and 4.3 V,respectively.Therefore,here the failure mechanism of high-voltage PEO electrolyte is investigated by EIS and a proposed solving strategy is presented.展开更多
Background:Baoyuan decoction is used clinically as an adjuvant treatment for lung cancer.However,the underlying mechanism remains unclear.Therefore,this study aimed to explore the mechanism of action of Baoyuan decoct...Background:Baoyuan decoction is used clinically as an adjuvant treatment for lung cancer.However,the underlying mechanism remains unclear.Therefore,this study aimed to explore the mechanism of action of Baoyuan decoction in lung cancer treatment using network pharmacology and molecular docking technology.Methods:The Traditional Chinese Medicines Systems Pharmacology Database and Analysis Platform and SwissTargetPrediction databases were used to screen the active ingredients of Baoyuan decoction and their relevant targets.Lung cancer-related targets were obtained from the GeneCards,Online Mendelian Inheritance in Man,and DrugBank databases.Protein-protein interaction network of the common targets was constructed using the STRING database and analyzed using Cytoscape software 3.10.1.Furthermore,Gene Ontology enrichment,Kyoto Encyclopedia of Genes and Genomes pathway analyses and visualization of common genes were performed using the R software.Finally,molecular docking of the selected key ingredients and targets was performed,and the results were verified using AutoDock Vina software.Results:We identified 142 potential active ingredients,3624 potential lung cancer-related targets,and 341 common drug targets.A total of 72 core targets were identified,of which AKT1,TP53,interleukin-6,epithelial growth factor receptor,and signal transducer and activator of transcription 3 were key.A total of 4116 items were obtained via Gene Ontology enrichment analyses.Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses revealed 189 related signaling pathways,including the PI3K-Akt,AGE-RAGE signaling pathways in diabetic complications,FOXO,and TH signaling pathways,which are involved in cell proliferation,autophagy,metastasis,invasion,radiation resistance,and chemotherapy resistance in the lung cancer microenvironment.The molecular docking results suggested that the key ingredients had a strong affinity for key targets.Conclusion:This study demonstrates that Baoyuan decoction plays a key therapeutic role in a complex manner involving multiple ingredients,targets,and pathways in lung cancer.Our findings are anticipated to provide new ideas for follow-up experimental research and clinical application.展开更多
基金Supported by the National Basic Research Program(973)(2005CB221506)National Natural Science Foundation of Chongqing(CSTC,2007BA6018)National Key Technology R&D Program(2006ABK03B04)
文摘Combined with the experimental results from the large tunnel of the ChongqingResearch Institute,the mechanism of gas and coal dust explosion was studied.Someconcepts about gas and coal dust explosion were introduced such as the form conditionand influential factors.Gas and coal dust explosion propagation was researched and thelifting process of coal dust was simulated.When an explosion occurred due to great mixtureof gas and air,the maximum explosion pressure appeared in the neighborhood of theexplosion source point.Before it propagated to the tunnel of the deposited coal dust,themaximum explosion pressure appeared to be in declining trend.Part of the energy waslost in the process of raising the deposited coal dust through a shock wave,so the maximumexplosion pressure was smallest on the foreside of the deposited coal dust sector.On the deposited coal dust sector,the explosion pressure rapidly increased and droppedoff after achieving the largest peak value.Because of coal dust participation in the explosion,the flame velocity rose rapidly on the deposited coal dust and achieved a basic stablevalue;coal dust was ignited to explode by initial laminar flame,and the laminar flametransformed into turbulent flame.The turbulence transformed the flame fold into a funnelshape and the shock wave interacted with the flame,so the combustion rate rose and thepressure wave was further enhanced.The regeneration mechanism between the flamecombustion rate and the aerodynamic flowing structure achieved the final critical state forforming the detonation.
基金sponsored by the National Key Technology R&D Program of China(2012BAK19B0205)Key Foundation of Earthquake Administration of Shandong Province(JJ1308Y)
文摘In this paper,research of aftershock mechanisms is reviewed,including heterogeneity of medium and stress,mechanical loading,fluid intrusion and stress corrosion,and ratestate dependence.Previous studies have indicated that the heterogeneity of media and stress is the basic premise of aftershocks generated.From the point view of mechanics,transient creep and afterslip can explain the decay of aftershocks in a short time after a mainshock and the relaxation of stress tends to interpret the characteristics of long-term aftershocks.Fluid intrusion and stress corrosion control the evolution process of the aftershocks under certain conditions.The interaction between the faults perturbed by the mainshock always exists during the aftershock activities.All kinds of models and the theories want to comply with the two basic power-law relationships---the G-R law and Omori law to some extent.
基金supported by Fundamental Research Funds for the Central Universities(2022-ZXFZJJ-028).
文摘Objective:To establish a progressive research strategy for“colonic components analysis-efficacy verification and mechanism exploration-gut microbiota”,screen pharmacodynamic substances,and investigate their mechanism via gut microbiota.Methods:The pharmacodynamics of Gegen Qinlian decoction(GQD)were assessed using a mouse model of dextran sulfate sodium-induced ulcerative colitis(UC).Ultra-performance liquid chromatographyquadrupole-orbitrap mass spectrometer was used to identify the prototype and metabolic components of GQD in the colon during UC.To analyze the structure and function of characteristic genera of GQD and its active components,16S rRNA sequencing was performed.Results:We identified 67 prototypic and 14 metabolic components of GQD in the UC colon.The primary prototype components are flavonoids and alkaloids,including puerarin(PUE),baicalin(BAI),and berberine(BER).The metabolism was predominantly sulfonation.Efficacy verification showed that the main active components,puerarin,baicalin,and berberine,had good therapeutic effects on UC.The results of 16S rRNA gene sequencing showed that GQD improved UC by regulating the structure and function of the gut microbiota.The abundance of gut microbiota involved in the metabolism of the prototype componentswas influenced by the corresponding components.The function prediction results showed that PUE was the most comparable to GQD,with 24 consistent pathways.BAI and BER showed comparable gut microbiota regulation pathways.Characteristic pathways of BER include glucometabolic processes.Conclusion:This study focused on the key issues in the gut microbiota pathway and developed a progressive research strategy to understand the transformation mechanisms of colonic components.This research systematically analyzed the active components and metabolic transformation of GQD in the colon during the pathological state of UC,as well as changes in the structure and function of the gut microbiota,clarified the mechanism of GQD and its active components in improving UC via the gut microbiota pathway.
基金financially supported by the National Natural Science Foundation of China(Nos.31540035,61308095,21801092,and 11904128)the Program for the Development of Science and Technology of Jilin Province(Nos.20180520002JH and 20190103100JH)+1 种基金the 13th Five-Year Program for Science and Technology of Education Department of Jilin Province(Nos.JJKH20180769KJ and JJKH20180778KJ)the Graduate Innovation Project of Jilin Normal University(No.201941)。
文摘In this paper,we report our attempts to raise the efficiency of liquid reduction method when using high specific surface area TiO2(HSTiO2)by doping Au.Characterization of Au-HSTiO2 was conducted via XRD,UV-vis,SEM,and photocurrent intensity.The experimental results show that Au-HSTiO2 exhibits prominently higher photocatalytic hydrogen production than TiO2 and HSTiO2.Enhanced photosynthetic hydrogen production ability of Au-HSTiO2 should be attributed to the presence of abundant surface active sites of HSTiO2,remarkably extending electronic holes in Au doping.This study provides a promising photosynthetic material for hydrogen production.
文摘The penetration behavior of topical substances in the skin not only relates to the transdermal delivery efficiency but also involves the safety and therapeutic effect of topical products,such as sunscreen and hair growth products.Researchers have tried to illustrate the transdermal process with diversified theories and technologies.Directly observing the distribution of topical substances on skin by characteristic imaging is the most convincing approach.Unfortunately,fluorescence labeling imaging,which is commonly used in biochemical research,is limited for transdermal research for most topical substances with a molecular mass less than 500 Da.Label-free imaging technologies possess the advantages of not requiring any macromolecular dyes,no tissue destruction and an extensive substance detection capability,which has enabled rapid development of such technologies in recent years and their introduction to biological tissue analysis,such as skin samples.Through the specific identification of topical substances and endogenous tissue components,label-free imaging technologies can provide abundant tissue distribution information,enrich theoretical and practical guidance for transdermal drug delivery systems.In this review,we expound the mechanisms and applications of the most popular label-free imaging technologies in transdermal research at present,compare their advantages and disadvantages,and forecast development prospects.
基金supported by the National Key R&D Program of China(2021YFB3800300)Beijing Outstanding Young Scientists Program(BJJWZYJH01201910007023)Yuanguang Scholars Program,Hebei University of Technology(282022554).
文摘The electrocatalytic sulfur reduction reaction(SRR)and sulfur evolution reaction(SER),two fundamental multistep conversion processes in lithium–sulfur batteries(LSBs),are root-cause solutions to overcome sluggish redox kinetics and the polysulfide shuttling effect.Metal–organic framework(MOF)electrocatalysts have emerged as good platforms for catalyzing SRR and SER,but their catalytic performance is challenged by poor electrical conductivity and limited chemical stability.Functionalized MOFs and their hybrids may be beneficial for stabilizing and improving the desired catalytic properties to achieve high-performance LSBs.This review provides a detailed overview of engineering principles for improving the activity,selectivity,and stability of MOFrelated electrocatalysts via composition modulation and nanostructure design as well as hybrid assembly.It presents and discusses the various advances achieved by using in situ characterization techniques,simulations,and theoretical calculations to reveal the dynamic evolution of MOF-related electrocatalysts,enabling an in-depth understanding of the catalysis mechanism at the molecular/atomic level.Lastly,prospects and possible research directions for MOF-related sulfur electrocatalysts are proposed.
基金the National Natural Science Foundation of China(Grant Nos.41974156 and 41804050)the National Science and Technology Major Project(Grant No.2017ZX05049002)。
文摘Reservoir reconstructions implemented in unconventional oil and gas exploration usually adopt hydraulic fracturing techniques to inject high-pressure fluid into the reservoir and change its pore-fracture connection structure to enhance production.Hydraulic fracturing changes the reservoir stress and causes the rocks to crack,thus generating microseismic events.One important component of microseismic research is the source mechanism inversion.Through the research on the microseismic focal mechanism,information on the source mechanisms and in-situ stress status variations can be quantitatively revealed to effectively optimize the reservoir reconstruction design for increasing production.This paper reviews the recent progress in hydraulic fracturing induced microseismic focal mechanism research.We summarize their main principles and provide a detailed introduction of the research advances in source modeling,microseismic data synthesis,and focal mechanism inversion.We also discuss the challenges and limitations in the current microseismic focal mechanism research and propose prospects for future research ideas and directions.
文摘Objective To observe the effect of Fuzheng Kang’ai Recipe(FKR)combined with gefitinib on the proliferation and apoptosis of lung cancer A549 cells,and to study its potential synergistic mechanish with gefitinib.Methods The effects of FKR(0.211,0.316,0.474,0.711,1.067,1.600,2.400,3.600 mg/mL)combined with
基金Supported by Fundamental Research Fund for the Central Universities(2452021088,2452021081)Science and Technology Project of State Grid Shandong Electric Power Company(5200-202416091A-1-1-ZN)Sanmenxia Science and Technology Major Projec(2023L01002).
文摘The paper delved into specific causes of soil erosion during the construction phase of highway projects,analyzed the intrinsic mechanisms behind erosion formation,and examined in detail external dynamic factors contributing to soil erosion,such as rainfall scouring and wind erosion.Additionally,this paper summarized the unique characteristics of soil and water loss during road construction and the potential severe hazards it may bring,aiming to provide valuable reference for professionals in related fields and to promote further development in the study of natural slope erosion.
基金Supported by Undergraduate Innovation and Entrepreneurship Program of Faculty of Chinese Medicine Science of Guangxi University of Chinese Medicine (Autonomous Region Level) (S202413643051)Guangxi First-class Discipline Construction Project (GJKY[2022]1).
文摘[Objectives]Based on bibliometric methods,the evolution path and knowledge structure of shampoo product research in China were systematically analyzed,with a focus on the composition,efficacy,and mechanisms of traditional Chinese medicine shampoos,aiming to reveal the shifting patterns of core technological focuses at different stages and identify key future research directions.[Methods]Using a sample of 515 publications from CNKI journals between 2005 and 2025,CiteSpace 6.3.R1 was employed to construct multi-dimensional networks of authors,institutions,and keywords.Burst detection,keyword and cluster analyses,and time zone mapping were applied to track disciplinary dynamics.[Results]The analysis on the annual number of publications indicated that research on shampoo products underwent multiple phases including initial development,growth,fluctuation,peak,and adjustment from 2005 to 2025,with an overall upward trend.The significant differences between the collaboration network density of core authors and the strength of institutional cooperation indicated a need for academia to enhance cross-institutional collaborative innovation mechanisms.Keyword clustering analysis and co-occurrence mapping revealed that the research on traditional Chinese medicine shampoo products,known for their natural,mild,and non-irritating characteristics,demonstrates notable advantages in dandruff removal,anti-hair loss,hair growth,and scalp health management,which have become current research hotspots,providing data-driven decision-making support for technological upgrading and industry-academia-research integration in the field.[Conclusions]The bibliometric analysis based on 515 publications indicates that the overall development direction of shampoo products will comprehensively advance toward refined efficacy and personalized customization,greener and more natural ingredients,technological innovation and industry-academia-research collaboration,market segmentation and diversified development,as well as safety and efficacy evaluation.This study provides theoretical support for the innovation of specialized traditional Chinese medicine shampoo products.
基金National Natural Science Foundation of China,No.42122006, No.41971154, No.42271201Key Project of National Natural Science Foundation of China,No.41731278。
文摘Globalization has resulted in a notable rise in the flow of high-skilled talent from emerging countries to developed nations. Current research on transnational talent flow mainly focuses on the destination countries, with less attention given to the perspective of the sending countries, particularly lacking a dynamic discussion on its impact on technological evolution in the origin countries. Based on the OECD REGPAT database, this paper aims to explore how talent groups migrating to developed countries facilitate the return of knowledge and technology to emerging countries and achieve breakthroughs in their technological evolution paths, while further discussing the potential mechanisms involved. The findings of this paper are as follows:(1) The technological development of emerging countries is a path-dependent process, where countries often branch into new technologies related to their preexisting knowledge base. Consequently, knowledge feedback from high-skilled talents increases the likelihood of sending countries developing unrelated technologies.(2) The mobility of talents across borders fosters more international collaborations and citations for patents that are unrelated to the local knowledge base, thus enriching the technological paths of sending countries.(3) The mobility of high-skilled talents primarily affects complex technologies, which have significant economic effects that encourage imitation by other countries.However, the effect on novel technologies is less significant due to their strong geographical stickiness. In general, this paper addresses the gaps in existing research on talent outflow and the technological evolution of origin countries, providing empirical evidence for the positive role of transnational talent mobility in the technological catch-up of emerging nations.Besides, it offers recommendations for talent export, import, and innovation policy formulation in these countries.
基金the National Natural Science Foundation of China !(Grallt No.59775061).
文摘As a transmission medium, welding arc can be modulated to emit ultrasonic energy by exerting high-frequency electric current. The frequency of exciting electric current has notable influence on the signals recorded by the sensors and the metallographic structures of the welds. The resonance phenomenon of arc-uitrasonic has been found in the experiment. Both the resonance mechanism and the distribution of resonance frequency are discussed by the bui|t vibration equation.
文摘To introduce the advances of experimental research on acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome.The recent years experimental research literature of acupuncture and moxibustion for treatment of Women＇s Climacteric Syndrome were reviewed.The research literatures on acupuncture treatment were major,focusing on the field of acupuncture and moxibustion regulating hypothalamic-pituitary-gonad axis and nerval-endocritic-immune net.Acupuncture and moxibustion could regulate the endocrine environment of menopausal women.Taking advantage of combination biomedicine with multi-sciences,to improve the acupuncture and moxibustion curative effct and probe the mechanism of menopausal pathology and acupuncture and moxibustion function to Women＇s Climacteric Syndrome,is the research direction afterward.
基金the 2026 Health Commission Fund of Guizhou Province,China.the freestatistics suite for its technical support.
文摘Helicobacter pylori(H.pylori)infection remains a pivotal driver of chronic gastritis,peptic ulcer,gastric mucosa-associated lymphoid tissue lymphoma and gastric cancer,yet its eradication is increasingly frustrated by climbing antibiotic resistance and intolerable side-effects of standard triple or quadruple therapies.In recent years,fecal microbiota transplantation(FMT),a strategy that reconstructs the gut ecosystem by introducing a healthy donor microbiome,has emerged as a novel adjunct or alternative.By competitively excluding H.pylori,reinforcing mucosal barrier integrity,modulating host immunity and secreting bacteriocins,FMT can raise eradication rates,relieve dyspeptic symptoms and lower recurrence.This review synthesizes up-to-date pre-clinical,pilot and controlled clinical data,dissects underlying mechanisms,compares delivery routes,donor screening protocols and safety profiles,and discusses regulatory,ethical and standardization hurdles that must be overcome before large-scale clinical application.
基金General Program of National Natural Science Foundation of China:81774066。
文摘As the traditional Chinese medicine(TCM)therapy,moxibustion includes many techniques,such as Chinese herb-isolated moxibustion,heat-sensitive moxibustion,mild moxibustion and warming needling.Through multiple functions of moxibustion,e.g.heat stimulation,meridian conductivity and drug effect,moxibustion brings the therapeutic effect into play,thus,it displays a certain advantage in treatment of Irritable bowel syndrome(IBS).In clinical practice,moxibustion therapy is widely used in the treatment of IBS and has achieved certain therapeutic effect.It is found in clinical and experimental researches that moxibustion may achieve the therapeutic effect by means of the intervention of visceral hypersensitivity,gastrointestinal hormone,gastrointestinal motility,brain-gut axis,intestinal flora,etc.But,the specific mechanism remains to be further explored.In this paper,the current status of treatment and research progress are summarized and reflected so as to provide ideas for future research and application.
基金Funded by Natural Science Foundation of Hubei Province (No.2000J027)
文摘A kind of high impermeable and crack-resistance chemical admixture ( HICRCA) was prepared , which is a compound chemical admixture composed of an expansion ingredient, density ingredient, and organic hydrophobic poreblocking ingredient. The results of the experiments indicate that the addition of HICRCA improves mortar and concrete in the following performances: (1) perfect workability: slump is more than 22cm, theslump afar 3h is about 16cm; (2) high impermeability:for the mortar, the pervious height under a water pressure of 1.5MPa is 1.5cm,for the concrete, the pervious height under a water pressure of 5.0MPa is 2. 2cm;(3) high crack-resistance: there is a micro-expansion at the age of 90d; (4) high compressivestrength: compared with the controlled concrete, the compressive strengths at the age of 3d and 2Sd are improved by 66.4% and 62.0% , respectively. At the same time, the effects of different curing condition on mortar and concrete expansive andshrinkage performance were studied. In addition, the impermeable and crack-resistance mechanism, was investigatedin the present paper.
基金financially supported by the National Natural Science Foundation of China (Nos. 51972023, 11210304)
文摘PEO-based all-solid-state electrolytes are extensively utilized and researched owing to their exceptional safety,low-mass-density,and cost-effectiveness.However,the low oxidation potential of PEO makes the interface problem with the high-voltage cathode extremely severe.In this work,the impedance of PEO-based all-solid-state batteries with high-voltage cathode(NCM811)was studied at different potentials.The Nyquist plots displayed a gyrate arc at low-frequencies for NCM811/PEO interface.Based on the kinetic modeling,it was deduced that there is a decomposition reaction of PEO-matrix in addition to de-embedded reaction of NCM811,and the PEO intermediate product(dehydra-PEO)adsorbed on the electrode surface leading to low-frequency inductive arcs.Furthermore,the distribution of relaxation time shows the dehydra-PEO results in the kinetic tardiness of the charge transfer process in the temporal dimension.Hence,an artificial interface layer(CEI_(x))was modified on the surface of NCM811 to regulate the potential of cathode/electrolyte interface to prevent the high-voltage deterioration of PEO.NCM/CEI_(x)/PEO batteries exhibit capacity retentions of 96.0%,84.6%,and 76.8%after undergoing 100 cycles at cut-off voltages of 4.1,4.2,and 4.3 V,respectively.Therefore,here the failure mechanism of high-voltage PEO electrolyte is investigated by EIS and a proposed solving strategy is presented.
文摘Background:Baoyuan decoction is used clinically as an adjuvant treatment for lung cancer.However,the underlying mechanism remains unclear.Therefore,this study aimed to explore the mechanism of action of Baoyuan decoction in lung cancer treatment using network pharmacology and molecular docking technology.Methods:The Traditional Chinese Medicines Systems Pharmacology Database and Analysis Platform and SwissTargetPrediction databases were used to screen the active ingredients of Baoyuan decoction and their relevant targets.Lung cancer-related targets were obtained from the GeneCards,Online Mendelian Inheritance in Man,and DrugBank databases.Protein-protein interaction network of the common targets was constructed using the STRING database and analyzed using Cytoscape software 3.10.1.Furthermore,Gene Ontology enrichment,Kyoto Encyclopedia of Genes and Genomes pathway analyses and visualization of common genes were performed using the R software.Finally,molecular docking of the selected key ingredients and targets was performed,and the results were verified using AutoDock Vina software.Results:We identified 142 potential active ingredients,3624 potential lung cancer-related targets,and 341 common drug targets.A total of 72 core targets were identified,of which AKT1,TP53,interleukin-6,epithelial growth factor receptor,and signal transducer and activator of transcription 3 were key.A total of 4116 items were obtained via Gene Ontology enrichment analyses.Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses revealed 189 related signaling pathways,including the PI3K-Akt,AGE-RAGE signaling pathways in diabetic complications,FOXO,and TH signaling pathways,which are involved in cell proliferation,autophagy,metastasis,invasion,radiation resistance,and chemotherapy resistance in the lung cancer microenvironment.The molecular docking results suggested that the key ingredients had a strong affinity for key targets.Conclusion:This study demonstrates that Baoyuan decoction plays a key therapeutic role in a complex manner involving multiple ingredients,targets,and pathways in lung cancer.Our findings are anticipated to provide new ideas for follow-up experimental research and clinical application.
