Objective:To assess the prognostic value of maximum standardized uptake value(SUVmax),metabolic tumor volume(MTV),and total lesion glycolysis(TLG)determined by 18F-fluorodeoxyglucose positron emission tomography-compu...Objective:To assess the prognostic value of maximum standardized uptake value(SUVmax),metabolic tumor volume(MTV),and total lesion glycolysis(TLG)determined by 18F-fluorodeoxyglucose positron emission tomography-computed tomography(18F-FDG PET/CT)imaging in Hodgkin’s lymphoma patients.Methods:A total of 148 Hodgkin’s lymphoma patients diagnosed with lymph node biopsy from October 2014 to October 2015 were retrospectively analyzed followed by categorizing into good(125 cases)and poor(23 cases)prognosis groups.The chi-squared test was used to analyze the clinicopathological characteristics of Hodgkin’s lymphoma patients with the semi-quantitative 18F-FDG PET/CT parameters;the Spearman method was used to analyze the correlation between the semi-quantitative parameters and clinicopathological features of Hodgkin’s lymphoma;receiver operating characteristic curve was used to analyze the predictive value of the semi-quantitative parameters for poor prognosis of Hodgkin’s lymphoma patients.Results:Mean SUVmax,MTV,and TLG of the 148 cases of Hodgkin’s lymphoma were 7.26±2.38,12.46±3.14 cm3,and 76.83±18.56 g,respectively.Significant variations in the Ann Arbor stage and clinical classification were observed with different levels of semi-quantitative parameters(P<0.05).The semi-quantitative parameters were not correlated with age and gender(P>0.05)but positively correlated with Ann Arbor stage and clinical classification(P<0.05).These parameters in the poor prognosis group were higher than those in the good prognosis group(P<0.05).The area under the curve(AUC)of SUVmax,MTV,and TLG in predicting the poor prognosis group was 0.881,0.875,and 0.838,with cut-off values of 7.264,12.898 cm3,and 74.580g,as well as specificity of 88.8%,84.0%,and 78.4%,and sensitivity of 87.0%,87.0%,and 78.3%,respectively;the AUC of the combined prediction was 0.986,with a specificity of 97.6%and sensitivity of 86.3%.Conclusion:The semi-quantitative 18F-FDG PET/CT parameters provide valuable insights for Hodgkin’s lymphoma prognosis assessment.展开更多
AIM: To investigate the prognostic significance of pretreatment standardized maximum uptake value (SUVmax) and serum carbohydrate antigen (CA)19-9 in pancreatic cancer.
Background: Postoperative early recurrence(ER) in patients with pancreatic ductal adenocarcinoma(PDAC) is frequently encountered after curative intent surgery. Nonetheless, clinical significance and risk factors of ER...Background: Postoperative early recurrence(ER) in patients with pancreatic ductal adenocarcinoma(PDAC) is frequently encountered after curative intent surgery. Nonetheless, clinical significance and risk factors of ER after surgery for PDAC have not been extensively investigated. The aim of this study was to determine preoperative risk predictors for ER in patients with PDAC after upfront surgery. Methods: Eighty-one consecutive patients with PDAC who underwent curative intent surgical resection at Kangbuk Samsung Hospital between January 2004 and May 2015 were enrolled. ER was defined as tumor relapse within 6 months after surgery. Results: ER occurred in 26 patients(32.1%), whereas 49 patients(60.5%) had late recurrence( ≥ 6 months after surgery), and 6 patients had no recurrence(7.4%). Univariate analysis showed that C-reactive protein(CRP) > 3.0 mg/dL, modified Glasgow prognostic score(mGPS) = 2, decrease of total lymphocyte count by > 50% of baseline value in the preoperative period, prognostic nutritional index(PNI) < 45, neutrophilto-lymphocyte ratio(NLR) ≥ 3, and preoperative maximum standardized uptake value(SUVmax) were significantly associated with ER. Multivariate logistic regression analysis revealed that CRP > 3.0 mg/dL, decrease of total lymphocyte count by > 50% of baseline value, and preoperative SUVmax were significant and independent contributors of ER in patients with resectable PDAC who underwent curative intent surgery. Conclusions: Postoperative ER for resectable PDAC was frequent with poor prognosis after curative intent upfront surgery. It is reasonable to suggest that there is a subgroup of resectable PDAC patients at highrisk of ER and neoadjuvant therapy should be considered in these patients in a clinical trial setting.展开更多
Objective:In combination with Maximum Standardized Uptake Value(SUVmax)from SPECT/CT scans in lung cancer patients,serum alkaline phosphatase(ALP),molecular fragments in the N end of osteocalcin(N-MID),total procollag...Objective:In combination with Maximum Standardized Uptake Value(SUVmax)from SPECT/CT scans in lung cancer patients,serum alkaline phosphatase(ALP),molecular fragments in the N end of osteocalcin(N-MID),total procollagen type 1 N-terminal propeptide(TPINP),and bone mineral density(BMD)measurements to explore the clinical early diagnosis of lung cancer bone metastasis.Methods:A total of 107 patients diagnosed as lung cancer at a tertiary-level Class A hospital between January 2021 and June 2022 were enrolled,comprising 37 cases with bone metastasis and 70 cases without bone metastasis.All patients underwent relevant examinations.SPECT/CT was performed in the supine position with anterior and posterior whole-body bone imaging,using a matrix of 256×1,024,an energy peak of 140 keV,and a window width of 20%.SUVmax was measured.BMD measurement utilizes dual-energy X-ray absorptiometry to assess the first to fourth lumbar vertebrae,bilateral femoral necks,and total hip joints in the examinees,yielding bone mineral content per unit area(g/cm^(2)).Fasting blood samples in the morning were taken and a fully automated biochemical analyzer was used to measure ALP levels,and a fully automated chemiluminescence immunoassay analyzer was used to measure serum N-MID and TPINP levels.Results:Patients with bone metastasis exhibited ALP,N-MID and TPINP levels of 120.30±33.32 U/L,19.03±3.54 mg/L and 82.21±26.65 mg/L,respectively,significantly higher than those in patients without bone metastasis(94.43±30.30 U/L,15.50±4.01 mg/L,55.58±21.01 mg/L),p<.001,indicating a significant difference;The lumbar spine BMD in patients with bone metastasis was 0.82±0.12 g/cm^(2),compared to 0.89±0.14 g/cm^(2)in patients without bone metastasis,p=.011,demonstrating a statistical significance.Comparisons between patients with and without bone metastasis revealed no statistically significant differences in gender,pathological type,femoral neck BMD,or whole-body BMD(p>.05).The SUVmax value for adenocarcinoma patients was 11.45±1.98,significantly lower than 13.51±2.00 for patients with squamous cell carcinoma and 13.98±2.02 for other types(p<.001),representing a statistically significant difference.For patients with tumors with diameter>5 cm and TNM stage III-IV,SUVmax values were 13.38±1.95 and 12.99±2.00,respectively,significantly higher than those with tumors≤5 cm(11.50±2.01)and TNM stage I-II(11.77±1.93),with p<.001 and p=.002,respectively,demonstrating a statistical significance.Comparison in SUVmax of gender and age showed p>.05,indicating no statistically significant difference.In patients with TNM stage III-IV,ALP,N-MID and TPINP levels were 110.39±21.12 U/L,18.62±2.22 mg/L and 70.31±17.02 mg/L,respectively,significantly higher than those in patients with TNM stage I-II(97.45±19.82,15.12±2.14 and 60.12±15.65,respectively.The corresponding p values were.001,<.001 and.002,indicating a statistical significance.Comparison in ALP,N-MID and TPINP levels among patients of different genders,ages,pathological types and tumor diameters showed p>.05,indicating no statistically significant differences.The areas under the ROC curves for ALP,N-MID and TPINP in the diagnosis of bone metastasis were 0.695,0.734 and 0.837,respectively,with p<.05.Conclusions:Serum ALP,N-MID and TPINP levels were significantly elevated in patients with bone metastasis of lung cancer in comparison to those without bone metastasis,while SUVmax showed no significant difference.SUVmax,ALP,N-MID and TPINP are associated with certain clinical and pathological characteristics in lung cancer patients.Among these,ALP,N-MID and TPINP demonstrate a potential diagnostic value for detecting bone metastasis in lung cancer.展开更多
基金Social Science Foundation of Xinjiang Uygur Autonomous Region(Project No.:19BGL110)State Key Laboratory of Pathogenesis,Prevention,Treatment of Central Asian High Incidence Diseases Fund(SKL-HIDCA-2021-28).
文摘Objective:To assess the prognostic value of maximum standardized uptake value(SUVmax),metabolic tumor volume(MTV),and total lesion glycolysis(TLG)determined by 18F-fluorodeoxyglucose positron emission tomography-computed tomography(18F-FDG PET/CT)imaging in Hodgkin’s lymphoma patients.Methods:A total of 148 Hodgkin’s lymphoma patients diagnosed with lymph node biopsy from October 2014 to October 2015 were retrospectively analyzed followed by categorizing into good(125 cases)and poor(23 cases)prognosis groups.The chi-squared test was used to analyze the clinicopathological characteristics of Hodgkin’s lymphoma patients with the semi-quantitative 18F-FDG PET/CT parameters;the Spearman method was used to analyze the correlation between the semi-quantitative parameters and clinicopathological features of Hodgkin’s lymphoma;receiver operating characteristic curve was used to analyze the predictive value of the semi-quantitative parameters for poor prognosis of Hodgkin’s lymphoma patients.Results:Mean SUVmax,MTV,and TLG of the 148 cases of Hodgkin’s lymphoma were 7.26±2.38,12.46±3.14 cm3,and 76.83±18.56 g,respectively.Significant variations in the Ann Arbor stage and clinical classification were observed with different levels of semi-quantitative parameters(P<0.05).The semi-quantitative parameters were not correlated with age and gender(P>0.05)but positively correlated with Ann Arbor stage and clinical classification(P<0.05).These parameters in the poor prognosis group were higher than those in the good prognosis group(P<0.05).The area under the curve(AUC)of SUVmax,MTV,and TLG in predicting the poor prognosis group was 0.881,0.875,and 0.838,with cut-off values of 7.264,12.898 cm3,and 74.580g,as well as specificity of 88.8%,84.0%,and 78.4%,and sensitivity of 87.0%,87.0%,and 78.3%,respectively;the AUC of the combined prediction was 0.986,with a specificity of 97.6%and sensitivity of 86.3%.Conclusion:The semi-quantitative 18F-FDG PET/CT parameters provide valuable insights for Hodgkin’s lymphoma prognosis assessment.
基金Supported by Fundamental Research Funds for the Central Universities of China,No.2012N01
文摘AIM: To investigate the prognostic significance of pretreatment standardized maximum uptake value (SUVmax) and serum carbohydrate antigen (CA)19-9 in pancreatic cancer.
文摘Background: Postoperative early recurrence(ER) in patients with pancreatic ductal adenocarcinoma(PDAC) is frequently encountered after curative intent surgery. Nonetheless, clinical significance and risk factors of ER after surgery for PDAC have not been extensively investigated. The aim of this study was to determine preoperative risk predictors for ER in patients with PDAC after upfront surgery. Methods: Eighty-one consecutive patients with PDAC who underwent curative intent surgical resection at Kangbuk Samsung Hospital between January 2004 and May 2015 were enrolled. ER was defined as tumor relapse within 6 months after surgery. Results: ER occurred in 26 patients(32.1%), whereas 49 patients(60.5%) had late recurrence( ≥ 6 months after surgery), and 6 patients had no recurrence(7.4%). Univariate analysis showed that C-reactive protein(CRP) > 3.0 mg/dL, modified Glasgow prognostic score(mGPS) = 2, decrease of total lymphocyte count by > 50% of baseline value in the preoperative period, prognostic nutritional index(PNI) < 45, neutrophilto-lymphocyte ratio(NLR) ≥ 3, and preoperative maximum standardized uptake value(SUVmax) were significantly associated with ER. Multivariate logistic regression analysis revealed that CRP > 3.0 mg/dL, decrease of total lymphocyte count by > 50% of baseline value, and preoperative SUVmax were significant and independent contributors of ER in patients with resectable PDAC who underwent curative intent surgery. Conclusions: Postoperative ER for resectable PDAC was frequent with poor prognosis after curative intent upfront surgery. It is reasonable to suggest that there is a subgroup of resectable PDAC patients at highrisk of ER and neoadjuvant therapy should be considered in these patients in a clinical trial setting.
基金funded by the Health and Hygiene Research Project of the Metallurgical Safety and Health Branch of the China Metallurgical Society(No.jkws202368).
文摘Objective:In combination with Maximum Standardized Uptake Value(SUVmax)from SPECT/CT scans in lung cancer patients,serum alkaline phosphatase(ALP),molecular fragments in the N end of osteocalcin(N-MID),total procollagen type 1 N-terminal propeptide(TPINP),and bone mineral density(BMD)measurements to explore the clinical early diagnosis of lung cancer bone metastasis.Methods:A total of 107 patients diagnosed as lung cancer at a tertiary-level Class A hospital between January 2021 and June 2022 were enrolled,comprising 37 cases with bone metastasis and 70 cases without bone metastasis.All patients underwent relevant examinations.SPECT/CT was performed in the supine position with anterior and posterior whole-body bone imaging,using a matrix of 256×1,024,an energy peak of 140 keV,and a window width of 20%.SUVmax was measured.BMD measurement utilizes dual-energy X-ray absorptiometry to assess the first to fourth lumbar vertebrae,bilateral femoral necks,and total hip joints in the examinees,yielding bone mineral content per unit area(g/cm^(2)).Fasting blood samples in the morning were taken and a fully automated biochemical analyzer was used to measure ALP levels,and a fully automated chemiluminescence immunoassay analyzer was used to measure serum N-MID and TPINP levels.Results:Patients with bone metastasis exhibited ALP,N-MID and TPINP levels of 120.30±33.32 U/L,19.03±3.54 mg/L and 82.21±26.65 mg/L,respectively,significantly higher than those in patients without bone metastasis(94.43±30.30 U/L,15.50±4.01 mg/L,55.58±21.01 mg/L),p<.001,indicating a significant difference;The lumbar spine BMD in patients with bone metastasis was 0.82±0.12 g/cm^(2),compared to 0.89±0.14 g/cm^(2)in patients without bone metastasis,p=.011,demonstrating a statistical significance.Comparisons between patients with and without bone metastasis revealed no statistically significant differences in gender,pathological type,femoral neck BMD,or whole-body BMD(p>.05).The SUVmax value for adenocarcinoma patients was 11.45±1.98,significantly lower than 13.51±2.00 for patients with squamous cell carcinoma and 13.98±2.02 for other types(p<.001),representing a statistically significant difference.For patients with tumors with diameter>5 cm and TNM stage III-IV,SUVmax values were 13.38±1.95 and 12.99±2.00,respectively,significantly higher than those with tumors≤5 cm(11.50±2.01)and TNM stage I-II(11.77±1.93),with p<.001 and p=.002,respectively,demonstrating a statistical significance.Comparison in SUVmax of gender and age showed p>.05,indicating no statistically significant difference.In patients with TNM stage III-IV,ALP,N-MID and TPINP levels were 110.39±21.12 U/L,18.62±2.22 mg/L and 70.31±17.02 mg/L,respectively,significantly higher than those in patients with TNM stage I-II(97.45±19.82,15.12±2.14 and 60.12±15.65,respectively.The corresponding p values were.001,<.001 and.002,indicating a statistical significance.Comparison in ALP,N-MID and TPINP levels among patients of different genders,ages,pathological types and tumor diameters showed p>.05,indicating no statistically significant differences.The areas under the ROC curves for ALP,N-MID and TPINP in the diagnosis of bone metastasis were 0.695,0.734 and 0.837,respectively,with p<.05.Conclusions:Serum ALP,N-MID and TPINP levels were significantly elevated in patients with bone metastasis of lung cancer in comparison to those without bone metastasis,while SUVmax showed no significant difference.SUVmax,ALP,N-MID and TPINP are associated with certain clinical and pathological characteristics in lung cancer patients.Among these,ALP,N-MID and TPINP demonstrate a potential diagnostic value for detecting bone metastasis in lung cancer.
