背景与目的:弥漫性大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)分子遗传学特征和患者治疗前^(18)F-FDG PET/CT检查评估的SUV_(max)值均与患者预后密切相关,但两者的关系及其与R-CHOP治疗方案治疗反应的相关性尚不清楚。本研究...背景与目的:弥漫性大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)分子遗传学特征和患者治疗前^(18)F-FDG PET/CT检查评估的SUV_(max)值均与患者预后密切相关,但两者的关系及其与R-CHOP治疗方案治疗反应的相关性尚不清楚。本研究旨在分析DLBCL分子遗传学特征与治疗前经^(18)F-FDG PET/CT检测的SUV_(max)值的关系及其与临床病理学特征、R-CHOP治疗反应的相关性。方法:回顾性收集复旦大学附属肿瘤医院2022-2023年同时经淋巴瘤481基因DNA panel二代测序(next-generation sequencing,NGS)和治疗前经PET/CT检查的DLBCL患者225例,本研究通过复旦大学附属肿瘤医院医学伦理委员会的审查(伦理批号:050432-4-2307E)并获得患者知情同意;除基因突变特征外,同时收集荧光原位杂交法检测的BCL2、BCL6和MYC基因易位情况;另收集该组病例的临床病理学参数以及经R-CHOP治疗后的PET/CT检查结果。结果:总计191例DLBCL患者纳入最终分析,重要基因MYD88突变、TP53突变、CDKN2A/2B拷贝数异常、CD79B突变发生率分别为24.6%、27.2%、32.5%和16.8%。治疗前SUV_(max)值范围是5.10~63.10(24.44±10.70,中位22.80)。MYD88L265P突变型DLBCL的治疗前SUV_(max)值显著高于MYD88野生型DLBCL(P=0.039),SUV_(max)值与DLBCL其他基因变异类型包括TP53突变、CDKN2A/B拷贝数减少、CD79B突变、KMT2D突变、TNFAIP3突变、B2M突变、EZH2突变、BTG1/2突变、CREBBP突变、MYC、BCL2、BCL6基因重排之间无显著的相关性。治疗前高SUV_(max)值与高血清乳酸脱氢酶(lactate dehydrogenase,LDH)水平(P=0.012)及非生发中心(non-germinal center B-cell-like,non-GCB)亚型显著相关(P=0.040),但与R-CHOP治疗反应无显著的相关性(P=0.714)。DLBCL中TP53基因突变与R-CHOP治疗反应差显著相关(P=0.001),是R-CHOP治疗后非完全代谢缓解的独立预测因子。联合TP53基因突变、Ann Arbor分期、国际预后指数(International Prognostic Index,IPI)及血清LDH水平能够更好地预测患者对R-CHOP治疗的反应。结论:在DLBCL中,MYD88L265P突变型患者具有较高的治疗前SUV_(max)值。DLBCL治疗前SUV_(max)值与R-CHOP治疗反应无关,而TP53基因突变与R-CHOP治疗反应差显著相关,并且是独立预测因子。TP53基因突变联合临床病理学参数可更好地预测R-CHOP治疗反应。关于各基因变异特征及SUV_(max)值与患者预后的关系尚需作进一步随访研究。展开更多
MAX series materials,as non-van der Waals layered multi-element compounds,contribute remarkable regulated properties and functional dimension,combining the features of metal and ceramic materials due to their inherent...MAX series materials,as non-van der Waals layered multi-element compounds,contribute remarkable regulated properties and functional dimension,combining the features of metal and ceramic materials due to their inherently laminated crystal structure that Mn+1Xn slabs are intercalated with A element layers.Oriented to the functional requirements of information,intelligence,electrification,and aerospace in the new era,how to accelerate MAX series materials into new quality productive forces?The systematic enhancement of knowledge about MAX series materials is intrinsic to understanding its low-dimensional geometric structure characteristics,and physical and chemical properties,revealing the correlation of composition,structure,and function and further realizing rational design based on simulation and prediction.Diversity also brings complexity to MAX materials research.This review provides substantial tabular information on(Ⅰ)MAX’s research timeline from 1960 to the present,(Ⅱ)structure diversity and classification convention,(Ⅲ)synthesis route exploration,(Ⅳ)prediction based on theory and machine learning,(Ⅴ)properties,and(Ⅵ)functional applications.Herein,the researchers can quickly locate research content and recognize connections and differences of MAX series materials.In addition,the research challenges for the future development of MAX series materials are highlighted.展开更多
Due to their high-entropy effects,the high-entropy(HE)MAX-phase materials improve the comprehen-sive performance of MAX phases,opening up more possibilities for practical engineering applications.However,it is still c...Due to their high-entropy effects,the high-entropy(HE)MAX-phase materials improve the comprehen-sive performance of MAX phases,opening up more possibilities for practical engineering applications.However,it is still challenging to obtain S-containing high-entropy MAX phases because of the high volatilization behavior of sulfur,suffering from issues such as high reaction temperature and long re-action time of traditional synthesis methods.This paper proposes a novel process named as liquid metal assistant self-propagating high-temperature synthesis(LMA-SHS)for efficient synthesis of high-purity S-containing high-entropy MAX-phase materials.Low-melting-point metal(Sn or In)has been introduced into the raw mixture and melted into a liquid phase during the early stage of the SHS reaction.By serv-ing as a“binder”between transition metal atoms of the M-site due to the negative mixing enthalpy,this liquid phase can accelerate mass and heat transfer during the SHS process,ensuring a uniform solid solution of each element and realizing the synthesis of high-purity(TiNbVZr)_(2)SC in an extremely short time.The synthesis method for high-entropy MAX-phase materials developed in this study,i.e.,LMA-SHS,showing very short reaction time,low energy consumption,high yield,and low cost,has the promise to be a general energy-and resource-efficient route towards high-purity HE materials.展开更多
文摘背景与目的:弥漫性大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)分子遗传学特征和患者治疗前^(18)F-FDG PET/CT检查评估的SUV_(max)值均与患者预后密切相关,但两者的关系及其与R-CHOP治疗方案治疗反应的相关性尚不清楚。本研究旨在分析DLBCL分子遗传学特征与治疗前经^(18)F-FDG PET/CT检测的SUV_(max)值的关系及其与临床病理学特征、R-CHOP治疗反应的相关性。方法:回顾性收集复旦大学附属肿瘤医院2022-2023年同时经淋巴瘤481基因DNA panel二代测序(next-generation sequencing,NGS)和治疗前经PET/CT检查的DLBCL患者225例,本研究通过复旦大学附属肿瘤医院医学伦理委员会的审查(伦理批号:050432-4-2307E)并获得患者知情同意;除基因突变特征外,同时收集荧光原位杂交法检测的BCL2、BCL6和MYC基因易位情况;另收集该组病例的临床病理学参数以及经R-CHOP治疗后的PET/CT检查结果。结果:总计191例DLBCL患者纳入最终分析,重要基因MYD88突变、TP53突变、CDKN2A/2B拷贝数异常、CD79B突变发生率分别为24.6%、27.2%、32.5%和16.8%。治疗前SUV_(max)值范围是5.10~63.10(24.44±10.70,中位22.80)。MYD88L265P突变型DLBCL的治疗前SUV_(max)值显著高于MYD88野生型DLBCL(P=0.039),SUV_(max)值与DLBCL其他基因变异类型包括TP53突变、CDKN2A/B拷贝数减少、CD79B突变、KMT2D突变、TNFAIP3突变、B2M突变、EZH2突变、BTG1/2突变、CREBBP突变、MYC、BCL2、BCL6基因重排之间无显著的相关性。治疗前高SUV_(max)值与高血清乳酸脱氢酶(lactate dehydrogenase,LDH)水平(P=0.012)及非生发中心(non-germinal center B-cell-like,non-GCB)亚型显著相关(P=0.040),但与R-CHOP治疗反应无显著的相关性(P=0.714)。DLBCL中TP53基因突变与R-CHOP治疗反应差显著相关(P=0.001),是R-CHOP治疗后非完全代谢缓解的独立预测因子。联合TP53基因突变、Ann Arbor分期、国际预后指数(International Prognostic Index,IPI)及血清LDH水平能够更好地预测患者对R-CHOP治疗的反应。结论:在DLBCL中,MYD88L265P突变型患者具有较高的治疗前SUV_(max)值。DLBCL治疗前SUV_(max)值与R-CHOP治疗反应无关,而TP53基因突变与R-CHOP治疗反应差显著相关,并且是独立预测因子。TP53基因突变联合临床病理学参数可更好地预测R-CHOP治疗反应。关于各基因变异特征及SUV_(max)值与患者预后的关系尚需作进一步随访研究。
基金financial support by the Development Plan of Science and Technology of Jilin Province(No.YDZJ202201ZYTS305)the Natural Science Foundation of Jilin Province(No.YDZJ202401316ZYTS)the Innovation Laboratory Development Program of Education Department of Jilin Province and Industry and Information Technology Department of Jilin Province,China(The Joint Laboratory of MAX/MXene Materials).
文摘MAX series materials,as non-van der Waals layered multi-element compounds,contribute remarkable regulated properties and functional dimension,combining the features of metal and ceramic materials due to their inherently laminated crystal structure that Mn+1Xn slabs are intercalated with A element layers.Oriented to the functional requirements of information,intelligence,electrification,and aerospace in the new era,how to accelerate MAX series materials into new quality productive forces?The systematic enhancement of knowledge about MAX series materials is intrinsic to understanding its low-dimensional geometric structure characteristics,and physical and chemical properties,revealing the correlation of composition,structure,and function and further realizing rational design based on simulation and prediction.Diversity also brings complexity to MAX materials research.This review provides substantial tabular information on(Ⅰ)MAX’s research timeline from 1960 to the present,(Ⅱ)structure diversity and classification convention,(Ⅲ)synthesis route exploration,(Ⅳ)prediction based on theory and machine learning,(Ⅴ)properties,and(Ⅵ)functional applications.Herein,the researchers can quickly locate research content and recognize connections and differences of MAX series materials.In addition,the research challenges for the future development of MAX series materials are highlighted.
基金supported by the Shanghai Local Capacity Building Program(No.23010500700)the Project of Shanghai Municipal Science and Technology Commission(No.22DZ2291100)the Qinglan Project of Jiangsu Province,and the Open Project of Jiangsu Provincial Key Laboratory of Eco-Environmental Materials.
文摘Due to their high-entropy effects,the high-entropy(HE)MAX-phase materials improve the comprehen-sive performance of MAX phases,opening up more possibilities for practical engineering applications.However,it is still challenging to obtain S-containing high-entropy MAX phases because of the high volatilization behavior of sulfur,suffering from issues such as high reaction temperature and long re-action time of traditional synthesis methods.This paper proposes a novel process named as liquid metal assistant self-propagating high-temperature synthesis(LMA-SHS)for efficient synthesis of high-purity S-containing high-entropy MAX-phase materials.Low-melting-point metal(Sn or In)has been introduced into the raw mixture and melted into a liquid phase during the early stage of the SHS reaction.By serv-ing as a“binder”between transition metal atoms of the M-site due to the negative mixing enthalpy,this liquid phase can accelerate mass and heat transfer during the SHS process,ensuring a uniform solid solution of each element and realizing the synthesis of high-purity(TiNbVZr)_(2)SC in an extremely short time.The synthesis method for high-entropy MAX-phase materials developed in this study,i.e.,LMA-SHS,showing very short reaction time,low energy consumption,high yield,and low cost,has the promise to be a general energy-and resource-efficient route towards high-purity HE materials.
