Hepatitis C virus(HCV)infection is a major cause of end-stage liver disease,including decompensated cirrhosis and hepatocellular carcinoma.Over 95%of patients with HCV infection have achieved sustained virologic respo...Hepatitis C virus(HCV)infection is a major cause of end-stage liver disease,including decompensated cirrhosis and hepatocellular carcinoma.Over 95%of patients with HCV infection have achieved sustained virologic response at 12 weeks under the treatment of several pan-genotypic regimens approved for patients with HCV infection.The glecaprevir/pibrentasvir(G/P)regimen has some features that distinguish it from others and is the only 8-week regimen approved for treatment-naive patients and patients experienced in regimens containing(peg)interferon,ribavirin,and/or sofosbuvir,without an HCV NS3/4A protease inhibitor or NS5A inhibitor(except those with genotype 3).This review aims to summarize the efficacy and safety of G/P in HCV-infected patients from clinic trials and real-world studies,including those who have historically been considered difficult to cure.展开更多
基金supported in part by the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University.
文摘Hepatitis C virus(HCV)infection is a major cause of end-stage liver disease,including decompensated cirrhosis and hepatocellular carcinoma.Over 95%of patients with HCV infection have achieved sustained virologic response at 12 weeks under the treatment of several pan-genotypic regimens approved for patients with HCV infection.The glecaprevir/pibrentasvir(G/P)regimen has some features that distinguish it from others and is the only 8-week regimen approved for treatment-naive patients and patients experienced in regimens containing(peg)interferon,ribavirin,and/or sofosbuvir,without an HCV NS3/4A protease inhibitor or NS5A inhibitor(except those with genotype 3).This review aims to summarize the efficacy and safety of G/P in HCV-infected patients from clinic trials and real-world studies,including those who have historically been considered difficult to cure.
