Neutrophils are the first immune responders to infection.Th ey rapidly migrate to the site of infection and phagocytose pathogens.Additionally,they release neutrophil extracellular traps(NETs)to immobilize and kill pa...Neutrophils are the first immune responders to infection.Th ey rapidly migrate to the site of infection and phagocytose pathogens.Additionally,they release neutrophil extracellular traps(NETs)to immobilize and kill pathogens via a unique form of cell death known as netosis[1,2].Recently,a groundbreaking study published in Nature reported that a subgroup of neutrophils contributes to the composition and structure of the extracellular matrix(ECM),reinforces its mechanical properties,and promotes its barrier function in both naive and wounded skin[3].The structural and functional contributions of these neutrophils support those of“professional”ECM producers(e.g.,fibroblasts)in a non-redundant manner by locally modulating the dynamics of the ECM in the skin.展开更多
基金supported by the National Natural Science Foundation of China(82222038 and 81970259)the Chongqing Science Fund for Distinguished Young Scholars(CSTB2022NSCQ-JQX0017)+1 种基金the Outstanding Young Talents of National Defense Biotechnology(2023-JCJQ-ZQ-001 and 01-SWKJYCJJ06)the Military Key Specialized Construction Projects.
文摘Neutrophils are the first immune responders to infection.Th ey rapidly migrate to the site of infection and phagocytose pathogens.Additionally,they release neutrophil extracellular traps(NETs)to immobilize and kill pathogens via a unique form of cell death known as netosis[1,2].Recently,a groundbreaking study published in Nature reported that a subgroup of neutrophils contributes to the composition and structure of the extracellular matrix(ECM),reinforces its mechanical properties,and promotes its barrier function in both naive and wounded skin[3].The structural and functional contributions of these neutrophils support those of“professional”ECM producers(e.g.,fibroblasts)in a non-redundant manner by locally modulating the dynamics of the ECM in the skin.
