By using mathematical reasoning, this paper demonstrates the mathematical intervening principle: “Virtual disease is to fill his mother but real disease is to rush down his son” (虚则补其母, 实则泄其子) and “Strong...By using mathematical reasoning, this paper demonstrates the mathematical intervening principle: “Virtual disease is to fill his mother but real disease is to rush down his son” (虚则补其母, 实则泄其子) and “Strong inhibition of the same time, support the weak” (抑强扶弱) based on “Yin Yang Wu Xing” Theory in image mathematics of Traditional Chinese Mathematics (TCMath). We defined generalized relations and generalized reasoning, introduced the concept of steady multilateral systems with two non-compatibility relations, and discussed its energy properties. Later based on the intervention principle in image mathematics of TCMath and treated the research object of the image mathematics as a steady multilateral system, it has been proved that the mathematical intervening principle is true. The kernel of this paper is the existence and reasoning of the non-compatibility relations in steady multilateral systems, and it accords with the oriental thinking model.展开更多
Gambogic acid （GA） is an anticancer agent in phase IIb clinical trial in China but its mechanism of action has not been fully clarified. The present study was designed to search the possible target-related proteins ...Gambogic acid （GA） is an anticancer agent in phase IIb clinical trial in China but its mechanism of action has not been fully clarified. The present study was designed to search the possible target-related proteins of GA in cancer cells using proteomic method and establish possible network using bioinformatic analysis. Cytotoxicity and anti-migration effects of GA in MDA-MB-231 cells were checked using MTT assay, flow cytometry, wound migration assay, and chamber migration assay. Possible target-related proteins of GA at early （3 h） and late stage （24 h） of treatment were searched using a proteomic technology, two-dimensional electro- phoresis （2-DE）. The possible network of GA was established using bioinformatic analysis. The intracellular expression levels of vimentin, keratin 18, and calumenin were determined using Western blotting. GA inhibited cell proliferation and induced cell cycle arrest at G2/M phase and apoptosis in MDA-MB-231 cells. Additionally, GA exhibited anti-migration effects at non-toxic doses. In 2-DE analysis, totally 23 possible GA targeted proteins were found, including those with functions in cytoskeleton and transport, regulation of redox state, metabolism, ubiquitin-proteasome system, transcription and translation, protein transport and modification, and cytokine. Network analysis of these proteins suggested that cytoskeleton-related proteins might play important roles in the effects of GA. Results of Western blotting confirmed the cleavage of vimentin, increase in keratin 18, and decrease in calumenin levels in GA-treated cells. In summary, GA is a multi-target compound and its anti-cancer effects may be based on several target-related pro- teins such as cytoskeleton-related proteins.展开更多
In the paper, we present a detailed analysis of the takeoff mechanics of fruitflies which perform voluntary takeoff flights. Wing and body kinematics of the insects during takeoff were measured using Based on the meas...In the paper, we present a detailed analysis of the takeoff mechanics of fruitflies which perform voluntary takeoff flights. Wing and body kinematics of the insects during takeoff were measured using Based on the measured data, high-speed video techniques. inertia force acting on the insect was computed and aerodynamic force and moment of the wings were calculated by the method of computational fluid dynamics. Subtracting the aerodynamic force and the weight from the inertia force gave the leg force. The following has been shown. In its voluntary takeoff, a fruitfly jumps during the first wingbeat and becomes airborne at the end of the first wingbeat. When it is in the air, the fly has a relatively large ＂initial＂ pitch-up rotational velocity （more than 5 000~/s） resulting from the jumping, but in about 5 wingbeats, the pitch-up rotation is stopped and the fly goes into a quasi-hovering flight. The fly mainly uses the force of jumping legs to lift itself into the air （the force from the flapping wings during the jumping is only about 5%-10% of the leg force）. The main role played by the flapping wings in the takeoff is to produce a pitch-down moment to nullify the large ＂initial＂ pitch-up rotational velocity （otherwise, the fly would have kept pitching-up and quickly fallen down）.展开更多
Nowadays, license plate recognition for parking systems is a critical task to provide automatic control of customers and payment. This paper introduces a new method for automatic recognition of license plates of vehic...Nowadays, license plate recognition for parking systems is a critical task to provide automatic control of customers and payment. This paper introduces a new method for automatic recognition of license plates of vehicles by mathematical morphology. The proposed method can provide the license plate number of the plates in different light conditions, colors, sizes, and inclination （angles）. The algorithm can recognize the license plates of European Union vehicles quickly and correctly. The pattern learning of mathematical skeletons has high efficiency in the process. The performance of the algorithm is demonstrated well by the test in a parking control system.展开更多
Circadian rhythms have a period of~24 h and are manifested in almost all living organisms [1].The discovery of the molecular genetic mechanisms underlying circadian rhythmicity was one of the most exciting and inspiri...Circadian rhythms have a period of~24 h and are manifested in almost all living organisms [1].The discovery of the molecular genetic mechanisms underlying circadian rhythmicity was one of the most exciting and inspiring chapters in the history of biology and won the Nobel Prize in Physiology or Medicine in 2017 [2].Equally exciting and inspiring was the discovery that the hypothalamic suprachiasmatic nucleus (SCN) is involved in orchestrating the daily rhythmic activity of physiology。展开更多
In order to solve the problem of intraperitoneal haemorrhage and bile leakage caused by the iatrogenic trauma, sixty-four sequence of puncture were performed on twenty canine livers and thirty-two sequences selected b...In order to solve the problem of intraperitoneal haemorrhage and bile leakage caused by the iatrogenic trauma, sixty-four sequence of puncture were performed on twenty canine livers and thirty-two sequences selected by chance were perfused with thrombin solution. The results revealed that the bleeding time was shortened and amounts lessened significantly after application of thrombin compared with counterparts of control (P< 0. 001,t test).There was no significant difference between the levels of plasma fibringgeu prc-and Post-thrombin's using (P > 0.4,t test).The thrombin clotting time of patients with obstructive jaundice was similar to that of the group of control(P> 0. 05, t test).We conclude that thrombin is characterized by the ability of rapid,effective and safe haemostasis to the traumatic channel made by the liver puncture,and it's adaptive to most of the patients with hepatobiliary disease,and worth using and developing in clinical practice.展开更多
We present high quality long slit spectra along the major and minor axes out to 1.5 effective radii of the massive galaxy NGC 4636 taken by the Hobby-Eberly Telescope. Using the Fourier Correlation Quotient method, we...We present high quality long slit spectra along the major and minor axes out to 1.5 effective radii of the massive galaxy NGC 4636 taken by the Hobby-Eberly Telescope. Using the Fourier Correlation Quotient method, we measured the stellar line-of-sight velocity distribution along the axes. Furthermore, six Lick/IDS indices （Hβ, Mgb, Fe5015, Fe5270, Fe5335, Fe5406） are derived from the clean spectrum. By comparing the measured absorption line strengths with the predictions of Simple Stellar Population （SSP） models, we derived ages, total metallicity and a abundance profiles of the galaxy. This galaxy presents old and [α/Fe] overabundant stellar populations. Indeed, using the SSP model, we obtained the broadband color profiles. The theoretical colors match well with the measured colors and present red sharp peaks at the galaxy center. The sharp peaks of the colors are mainly shaped by the high metallicity in the galaxy＇s center. Interestingly, the galaxy has steep negative metaUicity gradients, but the trend flattens outwards. This result likely suggests that the center and outer regions of the galaxy formed through different formation processes.展开更多
Introduction: Congenital diaphragmatic hernia is often detected during the prenatal or neonatal period by severe respiratory symptoms. Late-presenting congenital diaphragmatic hernia is uncommon entity resulting in fr...Introduction: Congenital diaphragmatic hernia is often detected during the prenatal or neonatal period by severe respiratory symptoms. Late-presenting congenital diaphragmatic hernia is uncommon entity resulting in frequent misdiagnosis and inappropriate treatment. Case Report: We report the case of a left congenital diaphragmatic hernia revealed by an inaugural diabetic ketoacidosis in a 9-year-old girl. She has presented progressive weight loss without loss of appetite associated with polyuro-polydipsia, then epigastric pain with vomiting. Blood glucose was 3.2 g/L, ketonuria and 2+ glycosuria. Despite a well-conducted treatment, there was persistence of dyspnea. Chest X-ray and chest CT-scan confirmed the presence of a left diaphragmatic hernia. Evolution was marked by the death of the child on day 2 post-operative from a multivisceral failure. Conclusion: Clinical and radiological signs of congenital diaphragmatic hernia after the neonatal period may be difficult to interpret and may result in delayed diagnosis, erroneous treatment and potentially fatal outcome.展开更多
：This paper uses a 7-degree-of-freedom （7-DOF） manipulator end-effector to research inverse kinematics solution, Three methods are used and compared, including fixing an angle method, the iteration method and the n...：This paper uses a 7-degree-of-freedom （7-DOF） manipulator end-effector to research inverse kinematics solution, Three methods are used and compared, including fixing an angle method, the iteration method and the neutral network method. By comparison, the iteration method is much better because of its high accuracy, fast speed and stabilization, and it does not require calculation of the pseudoinverse of the 2acobian. Thus, this control scheme is well suited for real-time im- plementation, which is essential if the end-effector trajectory is continuously modified based on sensor＇s feedback. Finally, using VC ＋ ＋ and Microsoft foundation classes （MFC） to achieve the main machine interface. Through verification, the precision meets the requirements of general control system in real-time implementation.展开更多
文摘By using mathematical reasoning, this paper demonstrates the mathematical intervening principle: “Virtual disease is to fill his mother but real disease is to rush down his son” (虚则补其母, 实则泄其子) and “Strong inhibition of the same time, support the weak” (抑强扶弱) based on “Yin Yang Wu Xing” Theory in image mathematics of Traditional Chinese Mathematics (TCMath). We defined generalized relations and generalized reasoning, introduced the concept of steady multilateral systems with two non-compatibility relations, and discussed its energy properties. Later based on the intervention principle in image mathematics of TCMath and treated the research object of the image mathematics as a steady multilateral system, it has been proved that the mathematical intervening principle is true. The kernel of this paper is the existence and reasoning of the non-compatibility relations in steady multilateral systems, and it accords with the oriental thinking model.
基金supported by the Twelfth Five-Year National Science & Technology Support Program(No.2012BAI 29B06)Shanghai Science & Technology Support Program(No.13431900 401)+4 种基金China Postdoctoral Science Foundation Funded Project(No.2012M5 10907)Shanghai Postdoctoral Scientific Program(No.13R21417800)the Postdoctor Research Program of Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences(No.2012KIP516)the Sanofi-Aventis-Shanghai Institutes for Biological Sciences Scholarship Programthe National Nature Science Foundation(Nos.81302809 and 81373964)
文摘Gambogic acid （GA） is an anticancer agent in phase IIb clinical trial in China but its mechanism of action has not been fully clarified. The present study was designed to search the possible target-related proteins of GA in cancer cells using proteomic method and establish possible network using bioinformatic analysis. Cytotoxicity and anti-migration effects of GA in MDA-MB-231 cells were checked using MTT assay, flow cytometry, wound migration assay, and chamber migration assay. Possible target-related proteins of GA at early （3 h） and late stage （24 h） of treatment were searched using a proteomic technology, two-dimensional electro- phoresis （2-DE）. The possible network of GA was established using bioinformatic analysis. The intracellular expression levels of vimentin, keratin 18, and calumenin were determined using Western blotting. GA inhibited cell proliferation and induced cell cycle arrest at G2/M phase and apoptosis in MDA-MB-231 cells. Additionally, GA exhibited anti-migration effects at non-toxic doses. In 2-DE analysis, totally 23 possible GA targeted proteins were found, including those with functions in cytoskeleton and transport, regulation of redox state, metabolism, ubiquitin-proteasome system, transcription and translation, protein transport and modification, and cytokine. Network analysis of these proteins suggested that cytoskeleton-related proteins might play important roles in the effects of GA. Results of Western blotting confirmed the cleavage of vimentin, increase in keratin 18, and decrease in calumenin levels in GA-treated cells. In summary, GA is a multi-target compound and its anti-cancer effects may be based on several target-related pro- teins such as cytoskeleton-related proteins.
基金supported by the National Natural Science Foundation of China(11232002)the 111 Project(B07009)
文摘In the paper, we present a detailed analysis of the takeoff mechanics of fruitflies which perform voluntary takeoff flights. Wing and body kinematics of the insects during takeoff were measured using Based on the measured data, high-speed video techniques. inertia force acting on the insect was computed and aerodynamic force and moment of the wings were calculated by the method of computational fluid dynamics. Subtracting the aerodynamic force and the weight from the inertia force gave the leg force. The following has been shown. In its voluntary takeoff, a fruitfly jumps during the first wingbeat and becomes airborne at the end of the first wingbeat. When it is in the air, the fly has a relatively large ＂initial＂ pitch-up rotational velocity （more than 5 000~/s） resulting from the jumping, but in about 5 wingbeats, the pitch-up rotation is stopped and the fly goes into a quasi-hovering flight. The fly mainly uses the force of jumping legs to lift itself into the air （the force from the flapping wings during the jumping is only about 5%-10% of the leg force）. The main role played by the flapping wings in the takeoff is to produce a pitch-down moment to nullify the large ＂initial＂ pitch-up rotational velocity （otherwise, the fly would have kept pitching-up and quickly fallen down）.
基金supported by the University of Alicante Project under Grant No.PPC–1928273/A
文摘Nowadays, license plate recognition for parking systems is a critical task to provide automatic control of customers and payment. This paper introduces a new method for automatic recognition of license plates of vehicles by mathematical morphology. The proposed method can provide the license plate number of the plates in different light conditions, colors, sizes, and inclination （angles）. The algorithm can recognize the license plates of European Union vehicles quickly and correctly. The pattern learning of mathematical skeletons has high efficiency in the process. The performance of the algorithm is demonstrated well by the test in a parking control system.
基金supported by the National Key R&D Program of China(2019YFA0802400)the National Natural Science Foundation of China(31961133026,31871187,and 81570171)the Priority Academic Program Development of Jiangsu Higher Education Institutions(YX13400214)。
文摘Circadian rhythms have a period of~24 h and are manifested in almost all living organisms [1].The discovery of the molecular genetic mechanisms underlying circadian rhythmicity was one of the most exciting and inspiring chapters in the history of biology and won the Nobel Prize in Physiology or Medicine in 2017 [2].Equally exciting and inspiring was the discovery that the hypothalamic suprachiasmatic nucleus (SCN) is involved in orchestrating the daily rhythmic activity of physiology。
文摘In order to solve the problem of intraperitoneal haemorrhage and bile leakage caused by the iatrogenic trauma, sixty-four sequence of puncture were performed on twenty canine livers and thirty-two sequences selected by chance were perfused with thrombin solution. The results revealed that the bleeding time was shortened and amounts lessened significantly after application of thrombin compared with counterparts of control (P< 0. 001,t test).There was no significant difference between the levels of plasma fibringgeu prc-and Post-thrombin's using (P > 0.4,t test).The thrombin clotting time of patients with obstructive jaundice was similar to that of the group of control(P> 0. 05, t test).We conclude that thrombin is characterized by the ability of rapid,effective and safe haemostasis to the traumatic channel made by the liver puncture,and it's adaptive to most of the patients with hepatobiliary disease,and worth using and developing in clinical practice.
基金Supported by the National Natural Science Foundation of China rant No. 10821061the National Basic Research Program of China (Grant Nos. 11033008 nd 2007CB815406)the pport of the Chinese Academy of Sciences (Grant No. KJCX2-YW-T24)
文摘We present high quality long slit spectra along the major and minor axes out to 1.5 effective radii of the massive galaxy NGC 4636 taken by the Hobby-Eberly Telescope. Using the Fourier Correlation Quotient method, we measured the stellar line-of-sight velocity distribution along the axes. Furthermore, six Lick/IDS indices （Hβ, Mgb, Fe5015, Fe5270, Fe5335, Fe5406） are derived from the clean spectrum. By comparing the measured absorption line strengths with the predictions of Simple Stellar Population （SSP） models, we derived ages, total metallicity and a abundance profiles of the galaxy. This galaxy presents old and [α/Fe] overabundant stellar populations. Indeed, using the SSP model, we obtained the broadband color profiles. The theoretical colors match well with the measured colors and present red sharp peaks at the galaxy center. The sharp peaks of the colors are mainly shaped by the high metallicity in the galaxy＇s center. Interestingly, the galaxy has steep negative metaUicity gradients, but the trend flattens outwards. This result likely suggests that the center and outer regions of the galaxy formed through different formation processes.
文摘Introduction: Congenital diaphragmatic hernia is often detected during the prenatal or neonatal period by severe respiratory symptoms. Late-presenting congenital diaphragmatic hernia is uncommon entity resulting in frequent misdiagnosis and inappropriate treatment. Case Report: We report the case of a left congenital diaphragmatic hernia revealed by an inaugural diabetic ketoacidosis in a 9-year-old girl. She has presented progressive weight loss without loss of appetite associated with polyuro-polydipsia, then epigastric pain with vomiting. Blood glucose was 3.2 g/L, ketonuria and 2+ glycosuria. Despite a well-conducted treatment, there was persistence of dyspnea. Chest X-ray and chest CT-scan confirmed the presence of a left diaphragmatic hernia. Evolution was marked by the death of the child on day 2 post-operative from a multivisceral failure. Conclusion: Clinical and radiological signs of congenital diaphragmatic hernia after the neonatal period may be difficult to interpret and may result in delayed diagnosis, erroneous treatment and potentially fatal outcome.
基金Shandong Province Science and Technology Development Plan(No. 2011SJGZ02)Shandong University of Science and Technology Graduate Innovation Fund(No.YCA120355)
文摘：This paper uses a 7-degree-of-freedom （7-DOF） manipulator end-effector to research inverse kinematics solution, Three methods are used and compared, including fixing an angle method, the iteration method and the neutral network method. By comparison, the iteration method is much better because of its high accuracy, fast speed and stabilization, and it does not require calculation of the pseudoinverse of the 2acobian. Thus, this control scheme is well suited for real-time im- plementation, which is essential if the end-effector trajectory is continuously modified based on sensor＇s feedback. Finally, using VC ＋ ＋ and Microsoft foundation classes （MFC） to achieve the main machine interface. Through verification, the precision meets the requirements of general control system in real-time implementation.
