In this study,we conducted exposure experiments on egg-laying hens to explore the toxicokinetics and maternal transfer characteristics of lipophilic and proteinophilic halogenated organic pollutants(HOPs).The lipophil...In this study,we conducted exposure experiments on egg-laying hens to explore the toxicokinetics and maternal transfer characteristics of lipophilic and proteinophilic halogenated organic pollutants(HOPs).The lipophilic HOPs included polychlorinated biphenyls(PCBs),polybrominated diphenyl ethers(PBDEs),and dechlorane plus(DPs),while the proteinophilic HOPs included perfluorocarboxylic acids(PFCAs).The results revealed that most of lipophilic HOPs exhibit lower depuration rate(kd)than PFCAs.The kd of lipophilic HOPs correlated with the octanol−water partition coefficient(log KOW)values in a V-shaped curve,whereas that of PFCAs correlated with the protein−water partition coefficient(log KPW)values in an inverted V-shaped curve.The depuration rate,rather than the uptake rate,was a leading factor in determining the bioaccumulation potential of HOPs in hens.Although the dominant factors determining the tissue distribution of the two types of compounds were explicit(fats vs phospholipids),chemical-specific tissue distribution was still observed.The egg-maternal concentration ratio was dependent on the exposure status,concentration,and maternal tissue choice.Using a single maternal tissue may not be an appropriate method for assessing chemical maternal transfer potential.PFCAs have a greater maternal transfer potential(>80%of the total body burden)than lipophilic HOPs(approximately 30%for BDE209 and DPs,and less than 10%for the others).Their lipophilic and partly proteinophilic nature makes the toxicokinetics and maternal transfer characteristics of BDE209 and DPs different from those of other lipophilic HOPs.These findings are crucial for enhancing our understanding of the behavior and fate of HOPs in egg-laying hens.展开更多
The limitation of legacy hexabromocyclododecanes(HBCDs)and increasing usage of emerging brominated flame retardant(BFR)tetrabromobisphenol A(TBBPA)resulted in their co-exposure to organisms.In this study,domestic chic...The limitation of legacy hexabromocyclododecanes(HBCDs)and increasing usage of emerging brominated flame retardant(BFR)tetrabromobisphenol A(TBBPA)resulted in their co-exposure to organisms.In this study,domestic chicken and environmental samples collected near a BFR manufacturing zone were analyzed to determine the bioaccumulation and transfer of HBCDs and TBBPA.The mean concentrations of∑_(3)HBCDs,TBBPA,∑_(4)TBBPA-related derivatives,∑_(9)TBBPA-related byproducts,and∑_(16)TBBPA-related transformation products in chicken tissues were 1207,0.20,15087,0.96,and 6384 ng/g lipid weight,respectively.Exposure to sources of BFR contamination(soil,feed,and water)could be the main cause of high BFR levels in chickens.α-HBCD and bis-substituted TBBPA analogues have higher bioaccumulation factor levels than TBBPA and other compounds,indicating greater bioconcentration potential for substances with higher logK_(ow).HBCDs,TBBPA,and TBBPA analogues tend to be enriched in the chicken comb and spleen and can cross the blood−brain barrier into the brain.However,while these compounds accumulate in the mother,they are also subject to metabolic processes that lead to their eventual excretion.Low-persistence BFRs were more favorable to maternal transfer,while compounds with high persistence tended to be retained in the mother.Although dietary intake of BFRs through chicken consumption poses a low risk to the general population,concerns remain regarding the synergistic risk of BFRs.展开更多
Background:The breakdown of dead organic matter is driven by a diverse array of organisms and is an important process increasingly impacted by a range of contaminants.While many studies have documented how contaminant...Background:The breakdown of dead organic matter is driven by a diverse array of organisms and is an important process increasingly impacted by a range of contaminants.While many studies have documented how contaminants affect food webs that are fueled by decaying plant litters,much less is known about how contaminants affect organisms that rely on dead animal material.Here,we begin to explore the effects of food contamination—using silver nanoparticles(AgNPs)as a model contaminant—on the carrion beetle Nicrophorus vespilloides that buries carcasses of small vertebrates in soils as food source and larval nursing grounds.Results:Our data show that a single ingestion of a non-lethal dose of 1μg mL^(−1) AgNPs by adult female beetles does not affect overall gut microbial activity but results in shifts in the gut microbial community composition towards pathogens including Alcaligenes,Morganella,and Pseudomonas.While no effects were observed in offspring clutch size,some reductions were visible in clutch weight,number of larvae,and number of eclosing pupae in exposed N.vespilloides in comparison with controls.Repeated ingestion of AgNPs over several weeks led to a decrease in survival of adult beetles,suggesting that more environmentally realistic exposure scenarios can directly affect the success of carcass-feeding animals.Conclusions:Sub-lethal carcass contamination with a model pollutant can affect the gut microbial composition in female beetles and reduce offspring fitness.This encourages consideration of currently overlooked propagation routes of contaminants through necrophagous food webs and inherent consequences for ecological and evolutionary processes.展开更多
基金funded by the National Nature Science Foundation of China(Nos.U23A2056,42277267,42321003)Guangdong Major Project of Basic and Applied Basic Research(2023B0303000007)+1 种基金Guangdong Foundation for the Program of Science and Technology Research(Nos.2023B1212060049)This is a contribution No.IS-3527 from GIGCAS.
文摘In this study,we conducted exposure experiments on egg-laying hens to explore the toxicokinetics and maternal transfer characteristics of lipophilic and proteinophilic halogenated organic pollutants(HOPs).The lipophilic HOPs included polychlorinated biphenyls(PCBs),polybrominated diphenyl ethers(PBDEs),and dechlorane plus(DPs),while the proteinophilic HOPs included perfluorocarboxylic acids(PFCAs).The results revealed that most of lipophilic HOPs exhibit lower depuration rate(kd)than PFCAs.The kd of lipophilic HOPs correlated with the octanol−water partition coefficient(log KOW)values in a V-shaped curve,whereas that of PFCAs correlated with the protein−water partition coefficient(log KPW)values in an inverted V-shaped curve.The depuration rate,rather than the uptake rate,was a leading factor in determining the bioaccumulation potential of HOPs in hens.Although the dominant factors determining the tissue distribution of the two types of compounds were explicit(fats vs phospholipids),chemical-specific tissue distribution was still observed.The egg-maternal concentration ratio was dependent on the exposure status,concentration,and maternal tissue choice.Using a single maternal tissue may not be an appropriate method for assessing chemical maternal transfer potential.PFCAs have a greater maternal transfer potential(>80%of the total body burden)than lipophilic HOPs(approximately 30%for BDE209 and DPs,and less than 10%for the others).Their lipophilic and partly proteinophilic nature makes the toxicokinetics and maternal transfer characteristics of BDE209 and DPs different from those of other lipophilic HOPs.These findings are crucial for enhancing our understanding of the behavior and fate of HOPs in egg-laying hens.
基金supported by the Shandong Province Natural Science Foundation(ZR2022MB002)the National Natural Science Foundation of China(No.22176105,No.22325606).
文摘The limitation of legacy hexabromocyclododecanes(HBCDs)and increasing usage of emerging brominated flame retardant(BFR)tetrabromobisphenol A(TBBPA)resulted in their co-exposure to organisms.In this study,domestic chicken and environmental samples collected near a BFR manufacturing zone were analyzed to determine the bioaccumulation and transfer of HBCDs and TBBPA.The mean concentrations of∑_(3)HBCDs,TBBPA,∑_(4)TBBPA-related derivatives,∑_(9)TBBPA-related byproducts,and∑_(16)TBBPA-related transformation products in chicken tissues were 1207,0.20,15087,0.96,and 6384 ng/g lipid weight,respectively.Exposure to sources of BFR contamination(soil,feed,and water)could be the main cause of high BFR levels in chickens.α-HBCD and bis-substituted TBBPA analogues have higher bioaccumulation factor levels than TBBPA and other compounds,indicating greater bioconcentration potential for substances with higher logK_(ow).HBCDs,TBBPA,and TBBPA analogues tend to be enriched in the chicken comb and spleen and can cross the blood−brain barrier into the brain.However,while these compounds accumulate in the mother,they are also subject to metabolic processes that lead to their eventual excretion.Low-persistence BFRs were more favorable to maternal transfer,while compounds with high persistence tended to be retained in the mother.Although dietary intake of BFRs through chicken consumption poses a low risk to the general population,concerns remain regarding the synergistic risk of BFRs.
文摘Background:The breakdown of dead organic matter is driven by a diverse array of organisms and is an important process increasingly impacted by a range of contaminants.While many studies have documented how contaminants affect food webs that are fueled by decaying plant litters,much less is known about how contaminants affect organisms that rely on dead animal material.Here,we begin to explore the effects of food contamination—using silver nanoparticles(AgNPs)as a model contaminant—on the carrion beetle Nicrophorus vespilloides that buries carcasses of small vertebrates in soils as food source and larval nursing grounds.Results:Our data show that a single ingestion of a non-lethal dose of 1μg mL^(−1) AgNPs by adult female beetles does not affect overall gut microbial activity but results in shifts in the gut microbial community composition towards pathogens including Alcaligenes,Morganella,and Pseudomonas.While no effects were observed in offspring clutch size,some reductions were visible in clutch weight,number of larvae,and number of eclosing pupae in exposed N.vespilloides in comparison with controls.Repeated ingestion of AgNPs over several weeks led to a decrease in survival of adult beetles,suggesting that more environmentally realistic exposure scenarios can directly affect the success of carcass-feeding animals.Conclusions:Sub-lethal carcass contamination with a model pollutant can affect the gut microbial composition in female beetles and reduce offspring fitness.This encourages consideration of currently overlooked propagation routes of contaminants through necrophagous food webs and inherent consequences for ecological and evolutionary processes.
