The application scope and future development directions of machine learning models(supervised learning, transfer learning, and unsupervised learning) that have driven energy material design are discussed.
IEC materials promote climate action and affect community behavior. The purpose of the study was to find out how local communities perceived about IEC materials on community-based adaptation techniques and ecosystem-b...IEC materials promote climate action and affect community behavior. The purpose of the study was to find out how local communities perceived about IEC materials on community-based adaptation techniques and ecosystem-based approaches to combating climate change. It also examined the relationship be-tween respondents’ sociodemographic characteristics and the IEC materials’ attributes. Forty-two (42) coastal barangays in Zambales yielded 640 responses using survey questionnaires. Data analysis included frequency, percentage, and correlation. IEC materials were effective in comprehension, relevance, content, visual appeal, acceptance, and impact. Respondents were able to swiftly understand simple statements concerning climate change. Respondents were significantly impacted by attractiveness, visually appealing and recognizable images about adaptation and mitigation strategies for climate change. Municipalities were associated with practically all IEC material attributes. Education and respondent type influenced some IEC material characteristics. Coastal municipalities had different views on IEC material attributes. Because of IEC materials’ effectiveness, coastal communities are more inspired and motivated to take climate action. IEC materials give local populations useful knowledge about climate change that they may apply even in the absence of formal education.展开更多
Knee osteoarthritis(KOA),characterized by heterogeneous arthritic manifestations and complex peripheral joint disorder,is one of the leading causes of disability worldwide,which has become a high burden due to the mul...Knee osteoarthritis(KOA),characterized by heterogeneous arthritic manifestations and complex peripheral joint disorder,is one of the leading causes of disability worldwide,which has become a high burden due to the multifactorial nature and the deficiency of available disease-modifying treatments.The application of mesenchymal stem/stromal cells(MSCs)as therapeutic drugs has provided novel treatment options for diverse degenerative and chronic diseases including KOA.However,the complexity and specificity of the“live”cells have posed challenges for MSC-based drug development and the concomitant scale-up preparation from laboratory to industrialization.For instance,despite the considerable progress in ex vivo cell culture technology for fulfilling the robust development of drug conversion and clinical trials,yet significant challenges remain in obtaining regulatory approvals.Thus,there’s an urgent need for the research and development of MSC drugs for KOA.In this review,we provide alternative solution strategies for the preparation of MSC drugs on the basis of the principle of quality by design,including designing the cell production processes,quality control,and clinical applications.In detail,we mainly focus on the quality by design method for MSC manufacturing in standard cell-culturing factories for the treatment of KOA by using the Quality Target Product Profile as a starting point to determine potential critical quality attributes and to establish relationships between critical material attributes and critical process parameters.Collectively,this review aims to meet product performance and robust process design,and should help to reduce the gap between compliant products and the production of compliant good manufacturing practice.展开更多
基金supported by the National Key R&D Program of China(Grant No.2021YFC2100100)the National Natural Science Foundation of China(Grant No.21901157)+1 种基金the Shanghai Science and Technology Project of China(Grant No.21JC1403400)the SJTU Global Strategic Partnership Fund(Grant No.2020 SJTUHUJI)。
文摘The application scope and future development directions of machine learning models(supervised learning, transfer learning, and unsupervised learning) that have driven energy material design are discussed.
文摘IEC materials promote climate action and affect community behavior. The purpose of the study was to find out how local communities perceived about IEC materials on community-based adaptation techniques and ecosystem-based approaches to combating climate change. It also examined the relationship be-tween respondents’ sociodemographic characteristics and the IEC materials’ attributes. Forty-two (42) coastal barangays in Zambales yielded 640 responses using survey questionnaires. Data analysis included frequency, percentage, and correlation. IEC materials were effective in comprehension, relevance, content, visual appeal, acceptance, and impact. Respondents were able to swiftly understand simple statements concerning climate change. Respondents were significantly impacted by attractiveness, visually appealing and recognizable images about adaptation and mitigation strategies for climate change. Municipalities were associated with practically all IEC material attributes. Education and respondent type influenced some IEC material characteristics. Coastal municipalities had different views on IEC material attributes. Because of IEC materials’ effectiveness, coastal communities are more inspired and motivated to take climate action. IEC materials give local populations useful knowledge about climate change that they may apply even in the absence of formal education.
基金Supported by Taishan Scholar Special Funding,No.tsqnz20240858Medical and Health Technology Project of Shandong Province,No.202402050122+4 种基金Science and Technology Development Plan of Jinan Municipal Health Commission,No.2024301008Clinical Medical Science and Technology Innovation Program of Jinan Science and Technology Bureau,No.202430055Natural Science Foundation of Jiangxi Province,No.20224BAB206077Gansu Provincial Hospital Intra-Hospital Research Fund Project,No.22GSSYB-6and the 2022 Master/Doctor/Postdoctoral Program of National Health Commission Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor,No.NHCDP2022004 and No.NHCDP2022008.
文摘Knee osteoarthritis(KOA),characterized by heterogeneous arthritic manifestations and complex peripheral joint disorder,is one of the leading causes of disability worldwide,which has become a high burden due to the multifactorial nature and the deficiency of available disease-modifying treatments.The application of mesenchymal stem/stromal cells(MSCs)as therapeutic drugs has provided novel treatment options for diverse degenerative and chronic diseases including KOA.However,the complexity and specificity of the“live”cells have posed challenges for MSC-based drug development and the concomitant scale-up preparation from laboratory to industrialization.For instance,despite the considerable progress in ex vivo cell culture technology for fulfilling the robust development of drug conversion and clinical trials,yet significant challenges remain in obtaining regulatory approvals.Thus,there’s an urgent need for the research and development of MSC drugs for KOA.In this review,we provide alternative solution strategies for the preparation of MSC drugs on the basis of the principle of quality by design,including designing the cell production processes,quality control,and clinical applications.In detail,we mainly focus on the quality by design method for MSC manufacturing in standard cell-culturing factories for the treatment of KOA by using the Quality Target Product Profile as a starting point to determine potential critical quality attributes and to establish relationships between critical material attributes and critical process parameters.Collectively,this review aims to meet product performance and robust process design,and should help to reduce the gap between compliant products and the production of compliant good manufacturing practice.
